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Title
Japanese:Enantioselective synthesis of α,α-disubstituted α-amino acids by Rh-catalyzed [2+2+2] cycloaddition of 1,6-diynes with protected dehydroamino acid. 
English:Enantioselective synthesis of α,α-disubstituted α-amino acids by Rh-catalyzed [2+2+2] cycloaddition of 1,6-diynes with protected dehydroamino acid. 
Author
Japanese: Ken Tanaka, Maho Takahashi, Hidetomo Imase, Takuya Osaka, Keiichi Noguchi, Masao. Hirano.  
English: Ken Tanaka, Maho Takahashi, Hidetomo Imase, Takuya Osaka, Keiichi Noguchi, Masao. Hirano.  
Language English 
Journal/Book name
Japanese:Tetrahedron 
English:Tetrahedron 
Volume, Number, Page Vol. 64    No. 27    pp. 6289-6293
Published date 2008 
Publisher
Japanese:Elsevier Ltd. 
English:Elsevier Ltd. 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1016/j.tet.2008.04.107
Abstract We have detd. that a cationic rhodium(I)/BINAP complex catalyzes a [2+2+2] cycloaddn. of 1,6-diynes with protected dehydroamino acids, leading to protected ﾎｱ-amino acids bearing a quaternary carbon center in high yield with high enantioselectivity. Thus, aminoisoindolecarboxylate I (Ts = tosyl) was obtained in 96% yield and 97 ee by cycloaddn. reaction of TsN(CH2C竕｡CMe)2 with AcNHC(:CH2)CO2Me using Rh(cod)2BF4/(R)-BINAP. [on SciFinder(R)]

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