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Title
Japanese:Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers: mechanisms underlying the effect of lateral packing density on bioinertness 
English:Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers: mechanisms underlying the effect of lateral packing density on bioinertness 
Author
Japanese: 関根泰斗, アサティアスシーファ, Chikako Sato, Shigeaki Morita, 田中賢, 林智広.  
English: Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi.  
Language English 
Journal/Book name
Japanese:Journal of Biomaterials Science: Polymer Edition 
English:Journal of Biomaterials Science: Polymer Edition 
Volume, Number, Page 28    10-12    1231-1243
Published date Mar. 29, 2017 
Publisher
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English: 
Conference name
Japanese: 
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Conference site
Japanese: 
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Official URL https://www.ncbi.nlm.nih.gov/pubmed/28278040
 
DOI https://doi.org/10.1080/09205063.2017.1303120
Abstract Unequivocal dependence of bioinertness of self-assembled monolayers of methoxy-tri(ethylene glycol)-terminated alkanethiol (EG3-OMe SAMs) on their packing density has been a mystery for more than two decades. We tackled this long-standing question by performing surface force and surface-enhanced infrared absorption (SEIRA) spectroscopic measurements. Our surface force measurements revealed a physical barrier of interfacial water in the vicinity of the Au-supported EG3-OMe SAM (low packing density), whereas the Ag-supported one (high packing density) did not possess such interfacial water. In addition, the results of SEIRA measurements clearly exhibited that hydrogen bonding states of the interfacial water differ depending on the substrates. We also characterized the bioinertness of these SAMs by protein adsorption tests and adhesion assays of platelet and human umbilical vein endothelial cells. The hydrogen bonding states of the interfacial water and water-induced interaction clearly correlated with the bioinertness of the SAMs, suggesting that the interfacial water plays an important role determining the interaction of the SAMs with biomolecules and cells.

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