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Title
Japanese: 
English:Topology Effect of AIEgen-Appended Poly(acrylic acid) with Biocompatible Segments on Ca2+-Sensing and Protein-Adsorption-Resistance Properties 
Author
Japanese: 石割 文崇, 坂本 南美, 松村 聡子, 福島 孝典.  
English: F. Ishiwari, M. Sakamoto, S. Matsumura, T. Fukushima.  
Language English 
Journal/Book name
Japanese: 
English:ACS Macro Letters 
Volume, Number, Page Vol. 7    Issue 6    Page 711-715
Published date June 4, 2018 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL https://pubs.acs.org/doi/abs/10.1021/acsmacrolett.8b00291
 
DOI https://doi.org/10.1021/acsmacrolett.8b00291
Abstract We recently reported that tetraphenylethene-appended poly(acrylic acid) derivatives (e.g., PAA-TPE0.02) can serve as fluorescent Ca2+ sensors in the presence of physiological concentrations of biologically relevant ions, amino acids, and sugars. However, in the presence of basic proteins such as albumins, the Ca2+-sensing property of the polymer is significantly impaired due to the nonspecific adsorption of protein molecules, which competes with binding to Ca2+. To solve this problem, we explored new designs by focusing on the polymer-chain topology of PAA-TPE0.02 with biocompatible segments. Here, we report the Ca2+-sensing and protein-adsorption-resistance properties of various types of PAA-TPE0.02 copolymers with a poly(oligoethylene glycol acrylate) (polyOEGA) segment, featuring a random, diblock, triblock, or 4-armed-star-block structure. Through this study, we show an interesting topology effect; i.e., a branch-shaped PAA-TPE0.02-co-polyOEGA with biocompatible segments at every terminal (i.e., 4-armed-star-block copolymer) exhibits both good Ca2+-sensing and protein-adsorption-resistance properties.

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