Home >

news Help

Publication Information


Title
Japanese: 
English:Induced-fit Expansion and Contraction of a Self-Assembled Nanocube Finely Responding to Neutral and Anionic Quests 
Author
Japanese: Yi-Yang Zhan, Tatsuo Kojima, Takashi Nakamura, Toshihiro Takahashi, Satoshi Takahashi, Yohei Haketa, 庄子 良晃, Hiromitsu Maeda, 福島 孝典, Shiuichi Hiraoka.  
English: Yi-Yang Zhan, Tatsuo Kojima, Takashi Nakamura, Toshihiro Takahashi, Satoshi Takahashi, Yohei Haketa, Yoshiaki Shoji, Hiromitsu Maeda, Takanori Fukushima, Shiuichi Hiraoka.  
Language English 
Journal/Book name
Japanese: 
English:Nature Communications 
Volume, Number, Page Vol. 9    Issue 4530   
Published date Oct. 31, 2018 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL https://www.nature.com/articles/s41467-018-06874-y
 
DOI https://doi.org/10.1038/s41467-018-06874-y
Abstract Induced-fit or conformational selection is of profound significance in biological regulation. Biological receptors alter their conformation to respond to the shape and electrostatic surfaces of guest molecules. Here we report a water-soluble artificial molecular host that can sensitively respond to the size, shape, and charged state of guest molecules. The molecular host, i.e. nanocube, is an assembled structure consisting of six gear-shaped amphiphiles (GSAs). This nanocube can expand or contract its size upon the encapsulation of neutral and anionic guest molecules with a volume ranging from 74 to 535 Å3 by induced-fit. The responding property of this nanocube, reminiscent of a feature of biological molecules, arises from the fact that the GSAs in the nanocubes are connected to each other only through the hydrophobic effect and very weak intermolecular interactions such as van der Waals and cation-π interactions.

©2007 Tokyo Institute of Technology All rights reserved.