Home >

news Help

Publication Information


Title
Japanese:Osmotic stress induces the formation of migrasome‐like vesicles 
English:Osmotic stress induces the formation of migrasome‐like vesicles 
Author
Japanese: Koki Yoshikawa, Shogo Saito, Tetsuya Kadonosono, 田中祐圭, Mina Okochi.  
English: Koki Yoshikawa, Shogo Saito, Tetsuya Kadonosono, Masayoshi Tanaka, Mina Okochi.  
Language English 
Journal/Book name
Japanese:FEBS Letters 
English:FEBS Letters 
Volume, Number, Page        
Published date Feb. 2024 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://dx.doi.org/10.1002/1873-3468.14816
 
DOI https://doi.org/10.1002/1873-3468.14816
Abstract <jats:p>Migrasomes are extracellular vesicles that form on the retraction fibers of migrating cells. In this study, we report the formation of migrasome‐like vesicles enriched in tetraspanin 4 and containing cytoplasmic components in response to hypoosmotic stress. When migrating cells were subjected to hypoosmotic stress, vesicles with a size distribution of 0.5 to 2 μm formed on the retraction fibers, and vanished in a few minutes. The vesicles are rich in cholesterol, and their number was reduced when cells were pretreated with lipoprotein‐deficient serum. The formation of migrasome‐like vesicles upon hypoosmotic stress may provide biophysical cues regarding the cellular response to this external stimulus in cells and tissues.</jats:p>

©2007 Institute of Science Tokyo All rights reserved.