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Title
Japanese:Resting-state EEG features modulated by depressive state in healthy individuals: insights from theta PSD, theta-beta ratio, frontal-parietal PLV, and sLORETA 
English:Resting-state EEG features modulated by depressive state in healthy individuals: insights from theta PSD, theta-beta ratio, frontal-parietal PLV, and sLORETA 
Author
Japanese: LIPENGCHENG, 横山実桜, 岡本大輝, 中谷裕教, 八木透.  
English: Pengcheng Li, Mio Yokoyama, Daiki Okamoto, Hironori Nakatani, Tohru Yagi.  
Language English 
Journal/Book name
Japanese: 
English:Frontiers in Human Neuroscience 
Volume, Number, Page        
Published date Aug. 12, 2024 
Publisher
Japanese: 
English:Frontiers 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1384330/full
 
DOI https://doi.org/10.3389/fnhum.2024.1384330
Abstract Depressive states in both healthy individuals and those with major depressive disorder exhibit differences primarily in symptom severity rather than symptom type, suggesting that there is a spectrum of depressive symptoms. The increasing prevalence of mild depression carries lifelong implications, emphasizing its clinical and social significance, which parallels that of moderate depression. Early intervention and psychotherapy have shown effective outcomes in subthreshold depression. Electroencephalography serves as a non-invasive, powerful tool in depression research, with many studies employing it to discover biomarkers and explore underlying mechanisms for the identification and diagnosis of depression. However, the efficacy of these biomarkers in distinguishing various depressive states in healthy individuals and in understanding the associated mechanisms remains uncertain. In our study, we examined the power spectrum density and the region-based phase-locking value in healthy individuals with various depressive states during their resting state. We found significant differences in neural activity, even among healthy individuals. Participants were categorized into high, middle, and low depressive state groups based on their response to a questionnaire, and eyes-open resting-state electroencephalography was conducted. We observed significant differences among the different depressive state groups in theta- and beta- band power, as well as correlations in the theta–beta ratio in the frontal lobe and phase-locking connections in the frontal, parietal, and temporal lobes. Standardized low-resolution electromagnetic tomography analysis for source localization comparing the differences in resting-state networks among the three depressive state groups showed significant differences in the frontal and temporal lobes. We anticipate that our study will contribute to the development of effective biomarkers for the early detection and prevention of depression.

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