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Title
Japanese:Synthesis of Isocoumarins via Light‐Driven Carboxylative Cyclization Reaction of o‐Ethynyl Aryl Bromides with CO2 
English:Synthesis of Isocoumarins via Light‐Driven Carboxylative Cyclization Reaction of o‐Ethynyl Aryl Bromides with CO2 
Author
Japanese: 前田千尋, Rio Tanaka, Nanaka Higuchi, Shunsuke Kiguchi, Tadashi Ema.  
English: Chihiro Maeda, Rio Tanaka, Nanaka Higuchi, Shunsuke Kiguchi, Tadashi Ema.  
Language English 
Journal/Book name
Japanese:Chemistry – A European Journal 
English:Chemistry – A European Journal 
Volume, Number, Page        
Published date May 5, 2025 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://dx.doi.org/10.1002/chem.202500563
 
DOI https://doi.org/10.1002/chem.202500563
Abstract <jats:p>Isocoumarins are an important class of bicyclic lactones, which are seen in natural products, drugs, and bioactive compounds, and a variety of synthetic methods of isocoumarins have been developed. However, the synthesis of isocoumarins via the catalytic CO2 fixation has been scarcely reported despite the potential incorporation of CO2 into the lactone moiety. Here, we developed the light‐driven carboxylative cyclization reaction of o‐ethynyl aryl bromides with CO2, which selectively produced isocoumarins. Control experiments revealed that photoirradiation promoted the cyclization process with high selectivity.</jats:p>

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