The use of methanol for the selective
methylation of aromatic amines with RuHCl(CO)(PNHP)
(PNHP = bis(2-diphenylphosphinoethyl)amine) is reported.
Various aromatic amines were transformed into their
corresponding monomethylated secondary amines in high
yields at 150 °C with a very low catalyst loading (0.02−0.1
mol %) in the presence of KOtBu (20−60 mol %). The catalyst precursor, RuHCl(CO)(PNHP), was converted to [RuH(CO)2(PNHP)]+ under the catalytic conditions and also serves as a highly effective catalyst. The robustness of this catalyst contributes to its outstanding catalytic activity, even under reaction conditions, in which CO is liberated from methanol.
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