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和文: 
英文:Selective Accumulation To Tumor Cells With Coacervate Droplets Formed From Water-Insoluble Acrylate Polymer 
著者
和文: 西田 慶, Shin-nosuke Nishimura, 田中 賢.  
英文: Kei Nishida, Shin-nosuke Nishimura, Masaru Tanaka.  
言語 English 
掲載誌/書名
和文: 
英文:Biomacromolecules 
巻, 号, ページ Vol. 23    No. 4    pp. 1569–1580
出版年月 2022年1月28日 
出版者
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英文: 
会議名称
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開催地
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DOI https://doi.org/10.1021/acs.biomac.1c01343
アブストラクト Selective targeting of specific cells without the use of biological ligands has not been achieved. In the present study, we revealed that the coacervate droplets formed from poly(2-methoxyethyl acrylate) (PMEA) and its derivatives selectively accumulated to tumor cells. PMEA derivatives, which are insoluble acrylate polymers, induced coacervation in water to form polymer-dense droplets via hydrophobic interaction. Interestingly, the accumulation of coacervate droplets to tumor cells was involved in the bound water content of PMEA derivatives. Coacervate droplets with a high bound water content accumulated and internalized up to 36.6-fold higher in HeLa cervical tumor cells than in normal human fibroblasts (NHDF). Moreover, the interactions between coacervate droplets and plasma membrane components such as CD44 played a key role in this accumulation process. Therefore, coacervate droplets formed from PMEA derivatives have great clinical potential in tumor cell detection, development of alternative tumor-targeting ligands, and optimization of drug delivery carriers.

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