Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library

Nurkanto Arif; Riyo Imamura; Yulia Rahmawati; Erwahyuni Endang Prabandari; Danang Waluyo; Takeshi Annoura; Kazuki Yamamoto; Masakazu Sekijima; Yuki Nishimura; Takayoshi Okabe; Tomoo Shiba; Norio Shibata; Hirotatsu Kojima; James Duffy; Tomoyoshi Nozaki

doi:https://doi.org/10.1128/aac.00420-22

論文・著書情報

タイトル

和文:	Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library
英文:	Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library

著者

和文:	Nurkanto Arif, Riyo Imamura, Yulia Rahmawati, Erwahyuni Endang Prabandari, Danang Waluyo, Takeshi Annoura, Kazuki Yamamoto, 関嶋政和, Yuki Nishimura, Takayoshi Okabe, Tomoo Shiba, Norio Shibata, Hirotatsu Kojima, James Duffy, Tomoyoshi Nozaki.
英文:	Nurkanto Arif, Riyo Imamura, Yulia Rahmawati, Erwahyuni Endang Prabandari, Danang Waluyo, Takeshi Annoura, Kazuki Yamamoto, Masakazu Sekijima, Yuki Nishimura, Takayoshi Okabe, Tomoo Shiba, Norio Shibata, Hirotatsu Kojima, James Duffy, Tomoyoshi Nozaki.

言語

English

掲載誌/書名

和文:	Antimicrobial Agents and Chemotherapy
英文:	Antimicrobial Agents and Chemotherapy

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出版年月

2022年10月31日

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英文:

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公式リンク

http://dx.doi.org/10.1128/aac.00420-22

DOI

https://doi.org/10.1128/aac.00420-22

アブストラクト

Malaria is a mosquito-borne fatal infectious disease that affects humans and is caused by Plasmodium parasites, primarily Plasmodium falciparum . Widespread drug resistance compels us to discover novel compounds and alternative drug discovery targets.

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