Residual deformation can potentially impact the seismic behavior of base-isolated buildings. Although the presence of residual deformation in tall base-isolated structures during typhoons is well-documented, there remain several unresolved aspects in this regard. Thus, the objective of this study is to establish a connection between the response of a 3D model and a MDOF model using long-term wind forces generated from typhoon simulations. Through a wind-induced responses analysis encompassing along-wind, across-wind, and torsional effects, it has been clarified that the input of multi-directional wind forces is imperative for accurate residual deformation estimation. Furthermore, the study also discussed the effect of torsion on the base isolation layer when using the 3D model.