In this study, shake-table tests were conducted on a three-story RC structural frame with FIX windows and sliding windows as test specimens at E-Defense facility. Windows were set on 2nd and 3rd floor of the specimen. The inertia force and story-drift applied to the windows differed by floor. By comparing this difference with damage observation results in the experiments, the effects of inertia force and story-drift on the damage to windows discussed.