論文

• Fumitaka Kudo, Kazuma Tsuboi, Mutsumi Ikezaki, Daiki Nagayama, Koichi Kawamura, Taishi Ando, Akimasa Miyanaga, Tadashi Eguchi. The Post-Polyketide Synthase Modification Mechanism in Hitachimycin Biosynthesis, ChemBioChem, Vol. 25, e202400405, June 2024.
• Fumitaka Kudo. Biosynthesis of macrolactam antibiotics with β-amino acid polyketide starter units, J. Antibiot., Vol. 77, No. 8, pp. 486-498, May 2024.
• Dawei Wang, Akimasa Miyanaga, Taichi Chisuga, Fumitaka Kudo, Tadashi Eguchi. Engineering the Substrate Specificity of (S)-β-Phenylalanine Adenylation Enzyme HitB, ChemBioChem, Vol. 25, e202400383, May 2024.
• Akimasa Miyanaga, Kenji Nagata, Joji Nakajima, Taichi Chisuga, Fumitaka Kudo, Tadashi Eguchi. Structural Basis of Amide-Forming Adenylation Enzyme VinM in Vicenistatin Biosynthesis, ACS Chem. Biol., Vol. 18, No. 11, pp. 2343-2348, Oct. 2023.
• Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Cross-Linking of the Nonribosomal Peptide Synthetase Adenylation Domain with a Carrier Protein Using a Pantetheine-Type Probe, Non-Ribosomal Peptide Biosynthesis and Engineering: Methods and Protocols, pp. 207-217, May 2023.
• Taichi Chisuga, satoshi murakami, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Structure-Based Analysis of Transient Interactions between Ketosynthase-like Decarboxylase and Acyl Carrier Protein in a Loading Module of Modular Polyketide Synthase, ACS Chem. Biol., Vol. 18, No. 6, pp. 1398-1404, May 2023.
• Fumitaka Kudo, Takuji Chikuma, Mizuki Nambu, Taichi Chisuga, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Akimasa Miyanaga, Tadashi Eguchi. Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii, ACS Chem. Biol., Vol. 18, No. 4, pp. 875-883, Mar. 2023.
• Fumitaka Kudo, Kosuke Kishikawa, Kazuma Tsuboi, Takafusa Kido, Takeo Usui, Junko Hashimoto, Kazuo Shin-ya, Akimasa Miyanaga, Tadashi Eguchi. Acyltransferase Domain Exchanges between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics, ChemBioChem, Vol. 24, No. 6, e202200670, Mar. 2023.
• Akimasa Miyanaga, Koichi Kawada, Taichi Chisuga, Fumitaka Kudo, Tadashi Eguchi. Structural Basis of Transient Interactions of the Acyltransferase VinK with the Loading Acyl Carrier Protein of the Vicenistatin Modular Polyketide Synthase, BIOCHEMISTRY, Vol. 62, No. 1, pp. 17-21, Jan. 2023.
• Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Recent Advances in Structural Analysis of Adenylation Domain in Natural Product Biosynthesis, Curr. Opin. Chem. Biol., Vol. 71, No. 12, e102212, Dec. 2022.
• Fumitaka Kudo, Atsushi Minato, Shusuke Sato, Nayuta Nagano, Chitose Maruyama, Yoshimitsu Hamano, Junko Hashimoto, Ikuko Kozone, Kazuo Shin-ya, Tadashi Eguchi. Mechanism of S-Adenosyl-L-methionine C-Methylation by Cobalamin-dependent Radical S-Adenosyl-L-methionine Methylase in 1-Amino-2-methylcyclopropanecarboxylic Acid Biosynthesis, ORG LETT, Vol. 24, No. 49, pp. 8975-8979, Dec. 2022.
• Fumitaka Kudo, Tadashi Eguchi. Biosynthesis of Cyclitols, Nat. Prod. Rep, Vol. 39, No. 8, pp. 1622-1642, Aug. 2022.
• Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi. Characterization of the Cobalamin-Dependent Radical SAM C-Methyltransferase Fom3 in Fosfomycin Biosynthesis, Methods Enymol., Vol. 669, pp. 45-70, May 2022.
• Taichi Chisuga, Akira Nagai, Akimasa Miyanaga, Ena Goto, Kosuke Kishikawa, Fumitaka Kudo, Tadashi Eguchi. Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases, ACS Chem. Biol., Vol. 17, No. 1, pp. 198-206, Jan. 2022.
• Akimasa Miyanaga, Risako Ouchi, Fumitaka Kudo, Tadashi Eguchi. Complex Structure of the Acyltransferase VinK and the Carrier Protein VinL with a Pantetheine Cross-linking Probe, Acta Crystallogr F Struct. Biol. Commun., Vol. F77, No. 9, pp. 294–302, Sept. 2021.
• Shusuke Sato, Fumitaka Kudo, Michel Rohmer, Tadashi Eguchi. Biochemical and Mutational Analysis of Radical SAM Adenosylhopane Synthase HpnH Derived from Zymomonas mobilis Reveals that the Conserved Cysteine-106 Residue Reduces a Radical Intermediate and Determines the Stereochemistry, Biochemistry, Vol. 60, No. 38, pp. 2865-2874, Sept. 2021.
• Fumitaka Kudo, Yukinobu Kitayama, Akimasa Miyanaga, Mario Numakura, Tadashi Eguchi. Stepwise Post-glycosylation Modification of Sugar Moieties in Kanamycin Biosynthesis, ChemBioChem, Vol. 22, No. 9, pp. 1668–1675, May 2021.
• Fumitaka Kudo, Sotaro Takahashi, Akimasa Miyanaga, Yuichiro Nakazawa, Kota Nishino, Yuki Hayakawa, Koichi Kawamura, Fumihiro Ishikawa, Naeko Iwai, Yoko Nagumo, Takeo Usui, Tadashi Eguchi. Mutational Biosynthesis of the Hitachimycin Analogs Regulated by β-Phenylalanine Selective Adenylation Enzyme HitB, ACS Chemical Biology, Vol. 16, No. 3, pp. 539-547, Mar. 2021.
• Fumitaka Kudo, Ayaka Mori, Mai Koide, Ryo Yajima, Ryohei Takeishi, Akimasa Miyanaga, Tadashi Eguchi. One-pot Enzymatic Synthesis of 2-Deoxy-scyllo-inosose from D-Glucose and Polyphosphate, Biosci. Biotechnol. Biochem., Vol. 85, No. 1, pp. 108-114, Jan. 2021.
• Akimasa Miyanaga, Ryoma Takaku, Makoto Takaishi, Etsu Tashiro, Fumitaka Kudo, Tadashi Eguchi. Generation of Incednine Derivatives by Mutasynthesis, J. Antibiot., Vol. 73, No. 11, pp. 794-797, Nov. 2020.
• Akimasa Miyanaga, Shohei Kurihara, Taichi Chisuga, Fumitaka Kudo, Tadashi Eguchi. Structural Characterization of Complex of Adenylation Domain and Carrier Protein by using Pantetheine Cross-linking Probe, ACS Chem. Biol., Vol. 15, No. 7, pp. 1808-1812, July 2020.
• Chitose Maruyama, Yukiko Chinone, Shusuke Sato, Fumitaka Kudo, Kosuke Ohsawa, Junya Kubota, Junko Hashimoto, Ikuko Kozone, Takayuki Doi, Kazuo Shin-ya, Tadashi Eguchi, Yoshimitsu Hamano. C-Methylation of S-Adenosyl-L-methionine Occurs prior to Cyclopropanation in the Biosynthesis of a Bacterial 1-Amino-2-methylcyclopropanecarboxylic Acid (Norcoronamic acid) in a Bacterium, Biomolecules, Vol. 10, No. 5, E775, May 2020.
• 工藤史貴, 江口正. 生体内におけるラジカル反応：ラジカル酵素による炭素–炭素結合形成反応, 化学, 化学同人, Vol. 75, No. 4, pp. 72-73, Apr. 2020.
• Fumitaka Kudo, Yukinobu Kitayama, Akimasa Miyanaga, Akane Hirayama, Tadashi Eguchi. Biochemical and Structural Analysis of a Dehydrogenase KanD2 and an Aminotransferase KanS2 that are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis, Biochemistry, Vol. 59, No. 15, pp. 1470-1473, Apr. 2020.
• Shusuke Sato, Fumitaka Kudo, Michel Rohmer, Tadashi Eguchi. Characterization of Radical SAM Adenosylhopane Synthase, HpnH, which Catalyzes the 5’-Deoxyadenosyl Radical Addition to Diploptene in the Biosynthesis of C35 Bacteriohopanepolyols, Angew. Chem. Int. Ed., Vol. 59, No. 1, pp. 237-241, Jan. 2020.
• Daisuke Kawasaki, Akimasa Miyanaga, Taichi Chisuga, Fumitaka Kudo, Tadashi Eguchi. Functional and Structural Analyses of Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin, Biochemistry, Vol. 58, No. 48, pp. 4799-4803, Dec. 2019.
• Fumitaka Kudo, Takeshi Tsunoda, Kaito Yamaguchi, Akimasa Miyanaga, Tadashi Eguchi. Stereochemistry in the Reaction of the myo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis, Biochemistry, Vol. 58, No. 51, pp. 5112-5116, Dec. 2019.
• Fumitaka Kudo, Jiahao Zhang, Shusuke Sato, Akane Hirayama, Tadashi Eguchi. Functional Characterization of 3-Aminobenzoic Acid Adenylation Enzyme PctU and UDP-N-Acetyl-D-Glucosamine: 3-Aminobenzoyl-ACP Glycosyltransferase PctL in Pactamycin Biosynthesis, ChemBioChem, Vol. 20, No. 19, pp. 2458-2462, Oct. 2019.
• 佐藤秀亮, 工藤史貴, 江口正. 抗生物質ホスホマイシン生合成の全貌解明, バイオサイエンスとインダストリー, Vol. 77, No. 5, pp. 378-379, Oct. 2019.
• Daisuke Kawasaki, Taichi Chisuga, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Structural Analysis of Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis, BIOCHEMISTRY, Vol. 58, No. 24, pp. 2706-2709, June 2019.
• Fumihiro Ishikawa, Akimasa Miyanaga, Hinano Kitayama, Shinya Nakamura, Isao Nakanishi, Fumitaka Kudo, Tadashi Eguchi, Genzoh Tanabe. An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket, Angew. Chem. Int. Ed., Vol. 58, No. 21, pp. 6906-6910, May 2019.
• Xiaoli Zhang, Wei Chen, Qiong Gao, Junsheng Yang, Xueni Yan, Han Zhao, Lin Su, Meimei Yang, Chenlang Gao, Yao Yao, Ken Inoki, Dan Li, Rong Shao, Shiyi Wang, Nirakar Sahoo, Fumitaka Kudo, Tadashi Eguchi, Benfang Ruan, Haoxing Xu. Rapamycin Directly Activates Lysosomal Mucolipin TRP Channels Independent of mTOR, PLOS Biol., Vol. 17, No. 5, p. e3000252, May 2019.
• Jolanta Cieślak, Akimasa Miyanaga, Makoto Takaishi, Fumitaka Kudo, Tadashi Eguchi. Functional and Structural Characterization of Adenylation Enzyme IdnL7 Involved in Incednine Biosynthesis, Acta Crystallogr. F Struct. Biol. Commun., Vol. F75, No. 4, pp. 299-306, Apr. 2019.
• Fumitaka Kudo, Akimasa Miyanaga, Tadashi Eguchi. Structural Basis of Nonribosomal Codes for Nonproteinogenic Amino Acid Selective Adenylation Enzymes in the Biosynthesis of Natural Products, J. Ind. Microbiol. Biotechnol., Vol. 46, No. 3-4, pp. 515-536, Mar. 2019.
• M. Ninomiya, Yoshio Ando, Fumitaka Kudo, K. Ohmori, KEISUKE SUZUKI. Total Synthesis of Actinorhodin, Angewandte Chemie-International Edition, Vol. 58, No. 13, pp. 4264-4270, Feb. 2019.  公式リンク  
  
• Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Protein-Protein Interactions in Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrid Assembly Lines, Nat. Prod. Rep., Vol. 35, No. 11, pp. 1185-1209, Nov. 2018.
• Shusuke Sato, Akimasa Miyanaga, Seung-Young Kim, Tomohisa Kuzuyama, Fumitaka Kudo, Tadashi Eguchi. Biochemical and Structural Analysis of FomD that Catalyzes the Hydrolysis of Cytidylyl (S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis, BIOCHEMISTRY, Vol. 57, No. 32, pp. 4858-4866, Aug. 2018.
• Shusuke Sato, Fumitaka Kudo, Tomohisa Kuzuyama, Friedrich Hammerschmidt, Tadashi Eguchi. C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-Adenosyl-L-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration, BIOCHEMISTRY, Vol. 57, No. 33, pp. 4963-4966, Aug. 2018.
• Akimasa Miyanaga, Risako Ouchi, Fumihiro Ishikawa, Ena Goto, Genzoh Tanabe, Fumitaka Kudo, Tadashi Eguchi. Structural Basis of Protein-Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis, J. Am. Chem. Soc., Vol. 140, No. 25, pp. 7970-7978, June 2018.
• Satoru Watanabe, Hiroaki Ozawa, Hiroaki Kato, Kaori Nimura-Matsune, Toshifumi Hirayama, Fumitaka Kudo, Tadashi Eguchi, Katsumi Kakinuma, Hirofumi Yoshikawa. Carbon-free Production of 2-Deoxy-scyllo-inosose (DOI) in Cyanobacterium Synechococcus elongatus PCC 7942, Biosci. Biotechnol. Biochem., Vol. 82, No. 1, pp. 161-165, Jan. 2018.
• Akane Hirayama, Jinmiao Chu, Ena Goto, Fumitaka Kudo, Tadashi Eguchi. NAD(+)-Dependent Dehydrogenase PctP and PLP-Dependent Aminotransferase PctC Catalyze the First Post-glycosylation Modification of Sugar Intermediate in Pactamycin Biosynthesis, ChemBioChem, Vol. 19, No. 2, pp. 126-130, Jan. 2018.
• Akimasa Miyanaga, Ryuichi Takayanagi, Takashi Furuya, Ayano Kawamata, Tomohiro Itagaki, Yoshiharu Iwabuchi, Naoki Kanoh, Fumitaka Kudo, Tadashi Eguchi. Substrate Recognition by a Dual-Function P450 Monooxygenase Involved in FD-891 Biosynthesis, ChemBioChem, Vol. 18, No. 21, pp. 2179-2187, Nov. 2017.
• Su-Hee Cho, Seung-Young Kim, Takeo Tomita, Taro Shiraishi, Jin-Soo Park, Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi, Nobutaka Funa, Makoto Nishiyama, Tomohisa Kuzuyama. Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme, ACS Chem. Biol., Vol. 12, No. 8, pp. 2209-2215, Aug. 2017.
• Chisuga T, Miyanaga A, Kudo F, Eguchi T. Structural analysis of the dual function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an α,β-unsaturated thioester, J Biol Chem, Vol. 292, No. 26, pp. 10926-10937, July 2017.
• Shusuke Sato, Fumitaka Kudo, Seung-Young Kim, Tomohisa Kuzuyama, Tadashi Eguchi. Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis, Biochemistry, Vol. 56, No. 28, pp. 3519-3522, July 2017.
• Cieślak J, Miyanaga A, Takaku R, Takaishi M, Amagai K, Kudo F, Eguchi T. Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6, Proteins: Structure, Function, and Bioinformatics, Vol. 85, No. 7, pp. 1238-1247, July 2017.
• Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi, Kazuo Shin-ya. Identification of a Gene Cluster for Telomestatin Biosynthesis and Heterologous Expression Using a Specific Promotor in a Clean Host, Sci. Rep., Vol. 7, Number 3382, June 2017.
• Fumitaka Kudo, Takahiro Tokumitsu, Tadashi Eguchi. Substrate Specificity of Radical S-Adenosyl-L-methionine Dehydratase AprD4 and Its Partner Reductase AprD3 in the C3′-Deoxygenation of Aminoglycoside Antibiotics, J. Antibiot., Vol. 70, No. 4, pp. 423-428, Mar. 2017.
• Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Mechanisms of β-Amino Acid Incorporation in Polyketide Macrolactam Biosynthesis, Curr. Opin. Chem. Biol., Vol. 35, pp. 58-64, Dec. 2016.
• Fumitaka Kudo, Takeshi Tsunoda, Makoto Takashima, Tadashi Eguchi. Five-membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Ortholog in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin, ChemBioChem, Vol. 17, No. 22, pp. 2143-2148, Nov. 2016.
• 宮永顕正, 工藤史貴, 江口正. 天然物生合成酵素によるキャリアータンパク質の認識機構, バイオサイエンスとインダストリー, Vol. 74, No. 5, pp. 382-387, Sept. 2016.
• Fumitaka Kudo, Yasunori Matsuura, Takaaki Hayashi, Masayuki Fukushima, Tadashi Eguchi. Genome Mining of the Sordarin Biosynthetic Gene Cluster from Sordaria araneosa Cain ATCC 36386: Characterization of Cycloaraneosene Synthase and GDP-6-Deoxyaltrose Transferase, J. Antibiot., Vol. 69, No. 7, pp. 541-548, July 2016.
• Akimasa Miyanaga, Yuki Hayakawa, Mario Numakura, Junko Hashimoto, Kuniko Teruya, Takashi Hirano, Kazuo Shin-ya, Fumitaka Kudo, Tadashi Eguchi. Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadula fulva subsp. indica ATCC 53714: Substrate Specificity of β-amino Acid Selective Adenylating Enzyme FlvN, Biosci. Biotechnol. Biochem., Vol. 80, No. 5, pp. 935-941, May 2016.
• Yuko Nishiyama, Tomohiro Ohmichi, Sayaka Kazami, Hiroki Iwasaki, Kousuke Mano, Yoko Nagumo, Fumitaka Kudo, Sosaku Ichikawa, Yoshiharu Iwabuchi, Naoki Kanoh, Tadashi Eguchi, Hiroyuki Osada, Takeo Usui. Vicenistatin Induces the Early Endosome-derived Vacuole Formation in Mammalian Cells, Biosci. Biotechnol. Biochem., Vol. 80, No. 5, pp. 902-910, May 2016.
• Naoki Kanoh, Tomohiro Itagaki, Ayano Kawamata, Miho Takeuchi, Keisuke Hamada, Yoshiharu Iwabuchi, Tadashi Eguchi, Fumitaka Kudo, Takeo Usui. Synthesis and Structure-activity Relationship Study of FD891: Importance of the Side Chain and C8-C9 Epoxide for Cytotoxic Activity against Cancer Cells, J. Antibiot., Vol. 69, No. 4, pp. 287-293, Apr. 2016.
• Akimasa Miyanaga, Shohei Iwasawa, Yuji Shinohara, Fumitaka Kudo, Tadashi Eguchi. Structure-based Analysis of the Molecular Interactions between Acyltransferase and Acyl Carrier Protein in Vicenistatin Biosynthesis, Proc. Natl. Acad. Sci. USA, Vol. 133, No. 7, pp. 1802-1807, Feb. 2016.
• Fumitaka Kudo, Koichi Kawamura, Takashi Furuya, Hiroto Yamanishi, Atsushi Motegi, Akiko Komatsubara, Mario Numakura, Akimasa Miyanaga, Tadashi Eguchi. Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890, ChemBioChem, Vol. 17, No. 3, pp. 233-238, Feb. 2016.
• Fumitaka Kudo, Tadashi Eguchi. Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinary of Old Drugs, Chem. Rec., Vol. 16, No. 1, pp. 4-18, Feb. 2016.
• Akane Hirayama, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Mechanism-based Trapping of the Quinonoid Intermediate Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin, ChemBioChem, Vol. 16, No. 17, pp. 2484-2490, Nov. 2015.
• Fumitaka Kudo, Koichi Kawamura, Asuka Uchino, Akimasa Miyanaga, Mario Numakura, Ryuichi Takayanagi, Tadashi Eguchi. Genome Mining of Hitachimycin Biosynthetic Gene Cluster; Involvement of Phenylalanine-2,3-aminomutase in the Biosynthesis, ChemBioChem, Vol. 16, No. 6, pp. 909-914, Apr. 2015.
• Ryohei Takeishi, Fumitaka Kudo, Mario Numakura, Tadashi Eguchi. Epimerization at C-3’’ in Butirosin Biosynthesis by an NAD(+)-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF, ChemBioChem, Vol. 16, No. 3, pp. 487-495, Feb. 2015.
• Akimasa Miyanaga, Jolanta Cieślak, Yuji Shinohara, Fumitaka Kudo, Tadashi Eguchi. The Crystal Structure of Adenylation Enzyme VinN Reveals a Unique β-Amino Acid Recognition Mechanism, J. Biol. Chem., Vol. 289, No. 45, pp. 31448-31457, Nov. 2014.
• Fumitaka Kudo, Shota Hoshi, Taiki Kawashima, Toshiaki Kamachi, Tadashi Eguchi. Characterization of a Radical S‑Adenosyl‑L‑methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis, J. Am. Chem. Soc., Vol. 136, No. 39, pp. 13909-13915, Oct. 2014.
• Fumitaka Kudo, Akimasa Miyanaga, Tadashi Eguchi. Biosynthesis of Natural Products Containing β-Amino Acids, Nat. Prod. Rep., Vol. 31, No. 8, pp. 1056-1073, Aug. 2014.
• Yuji Shinohara, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. The Crystal Structure of the Amidohydrolase VinJ Shows a Unique Hydrophobic Tunnel for its Interaction with Polyketide Substrates, FEBS Lett, Vol. 588, No. 6, pp. 995-1000, Mar. 2014.
• Makoto Takaishi, Fumitaka Kudo, Tadashi Eguchi. Identification of Incednine Biosynthetic Gene Cluster: Characterization of Novel β-Glutamate-β-decarboxylase IdnL3, J. Antibiot., Vol. 66, No. 12, pp. 691-699, Dec. 2013.
• Mai Koide, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Characterization of Polyphosphate Glucokinase SCO5059 from Streptomyces coelicolor A3(2), Biosci. Biotechnol. Biochem, Vol. 77, No. 11, pp. 2322-2324, Nov. 2013.
• Keita Amagai, Ryoma Takaku, Fumitaka Kudo, Tadashi Eguchi. A Unique Amino Transfer Mechanism for Constructing the β-Amino Fatty Acid Starter Unit in the Biosynthesis of Macrolactam Antibiotic Cremimycin, ChemBioChem, Vol. 14, No. 15, pp. 1998-2006, Oct. 2013.
• Akane Hirayama, Tadashi Eguchi, Fumitaka Kudo. A Single PLP-Dependent Enzyme PctV Catalyzes the Transformation of 3-Dehydroshikimate into 3-Aminobenzoate in the Biosynthesis of Pactamycin, ChemBioChem, Vol. 14, No. 10, pp. 1198-1203, July 2013.
• Makoto Takaishi, Fumitaka Kudo, Tadashi Eguchi. A Unique Pathway for the 3-Aminobutyrate Starter Unit from L-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine, Org. Lett., Vol. 14, No. 17, pp. 4591-4593, Sept. 2012.
• Fumitaka Kudo, Yusaku Asou, Moe Watanabe, Takashi Kitayama, Tadashi Eguchi. Potent Oligomerization and Macrocyclization Activity of the Thioesterase Domain of Vicenistatin Polyketide Synthase, Synlett, Vol. 23, No. 12, pp. 1843-1846, July 2012.
• Hilda Sucipto, Fumitaka Kudo, Tadashi Eguchi. The Last Step of Kanamycin Biosynthesis: Unique Deamination Reaction Catalyzed by the α-Ketoglutarate-dependent Nonheme Iron Dioxygenase KanJ and the NADPH Dependent Reductase KanK, Angew. Chem. Int. Ed., Vol. 51, No. 14, pp. 3428-3431, Apr. 2012.
• Keita Amagai, Fumitaka Kudo, Tadashi Eguchi. Biosynthetic Pathway of Macrolactam Polyketide Antibiotic Cremimycin, Tetrahedron, Vol. 67, No. 44, pp. 8559-8563, Nov. 2011.
• Yuji Shinohara, Fumitaka Kudo, Tadashi Eguchi. A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics, J. Am. Chem. Soc., Vol. 133, No. 45, pp. 18134–18137, Nov. 2011.
• Chiaki Nakano, Fumitaka Kudo, Tadashi Eguchi, Yasuo Ohnishi. Genome Mining Reveals Two Novel Bacterial Sesquiterpene Cyclases: (-)-epi-α-Bisabolol and (-)-Germacradiene-4-ol Synthases from Streptomyces citricolor, ChemBioChem, Vol. 12, No. 15, pp. 2271-2275, Oct. 2011.
• Fumitaka Kudo, Takanori Yonezawa, Akiko Komatsubara, Kazutoshi Mizoue, Tadashi Eguchi. Cloning of the Biosynthetic Gene Cluster for Naphtoxanthene Antibiotic FD-594 from Streptomyces sp. TA-0256, J. Antibiot., Vol. 64, No. 1, pp. 123-132, Jan. 2011.
• Fumitaka Kudo, Atsushi Motegi, Kazutoshi Mizoue, Tadashi Eguchi. Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation, ChemBioChem, Vol. 11, No. 11, pp. 1574-1582, July 2010.
• Fumitaka Kudo, Hilda Sucipto, Tadashi Eguchi. Enzymatic Activity of a Glycosyltransferase KanM2 Encoded in the Kanamycin Biosynthetic Gene Cluster, J. Antibiot., 62, 12, 707-710, Dec. 2009.
• Fumitaka Kudo, Taiki Kawashima, Kenichi Yokoyama, Tadashi Eguchi. Enzymatic Preparation of Neomycin C from Ribostamycin, J. Antibiot., 62, 11, 643-646, Nov. 2009.
• Fumitaka Kudo, Tadashi Eguchi. Biosynthetic Genes for Aminoglycoside Antibiotics, J. Antibiot., Vol. 62, No. 9, pp. 471-481, Sept. 2009.
• Kenichi Yokoyama, Daijiro Ohmori, Fumitaka Kudo, Tadashi Eguchi. Mechanistic Study on the Reaction of a Radical SAM Dehydrogenase BtrN by Electron Paramagnetic Resonance Spectroscopy, Biochemistry, Vol. 47, No. 34, 8950-8960, Aug. 2008.
• Makoto Takaishi, Fumitaka Kudo, Tadashi Eguchi. Biosynthetic Pathway of 24-Membered Macrolactam Glycoside Incednine, Tetrahedron, Vol. 64, No. 28, pp. 6651-6656, July 2008.
• Kenichi Yokoyama, Yasuhito Yamamoto, Fumitaka Kudo, Tadashi Eguchi. Involvement of Two Distinct N-Acetylglucosaminyltransferases and a Dual-Function Deacetylase in Neomycin Biosynthesis, ChemBioChem, Vol. 9, No. 6, pp. 865-869, Apr. 2008.
• Kenichi Yokoyama, Mario Numakura, Fumitaka Kudo, Daijiro Ohmori, Tadashi Eguchi. Characterization and Mechanistic Study of a Radical SAM Dehydrogenase in the Biosynthesis of Butirosin, J. Am. Chem. Soc., Vol. 129, No. 49, pp. 15147-15155, Dec. 2007.
• Fumitaka Kudo, Yuko Kasama, Toshifumi Hirayama, Tadashi Eguchi. Cloning of the Pactamycin Biosynthetic Gene Cluster and Characterization of a Crucial Glycosyltransferase prior to a Unique Cyclopentane Ring Formation, J. Antibiot., Vol. 60, No. 8, pp. 492-503, Aug. 2007.
• Fumitaka Kudo, Takuya Fujii, Shunsuke Kinoshita, Tadashi Eguchi. Unique O-Ribosylation in the Biosynthesis of Butirosin, Bioorg. Med. Chem., Vol. 15, No. 13, pp. 4360-4368, July 2007.
• Toshifumi Hirayama, Fumitaka Kudo, Zhen Huang, Tadashi Eguchi. Role of Glutamate 243 in the Active Site of 2-Deoxy-scyllo-inosose Synthase from Bacilllus circulans, Bioorg. Med. Chem., Vol. 15, pp. 418-423, June 2007.
• Toshifumi Hirayama, Hideyuki Tamegai, Fumitaka Kudo, Kazumasa Kojima, Katsumi Kakinuma, Tadashi Eguchi. Biosynthesis of 2-Deoxystreptamine-containing Antibiotics in Streptoalloteichus hindudtanus JCM 3268: Characterization of 2-Deoxy-scyllo-inosose Synthase, J. Antibiot., Vol. 59, No. 6, pp. 358-361, June 2006.
• Fumitaka Kudo, Takashi Kitayama, Tadashi Eguchi, Katsumi Kakinuma. Macrolactam Formation Catalyzed by the Thioesterase Domain of Vicenistatin Polyketide Synthase, Tetrahedron Lett., Vol. 47, No. 10, pp. 1529-1532, Apr. 2006.
• Fumitaka Kudo, Yasuhito Yamamoto, Kenichi Yokoyama, Tadashi Eguchi, Katsumi Kakinuma. Biosynthesis of 2-Deoxystreptamine by Three Crucial Enzymes in Streptomyces fradiae NBRC12773, J. Antibiot., Vol. 58, No. 12, pp. 766-774, Dec. 2005.
• Fumitaka Kudo, Mario Numakura, Hideyuki Tamegai, Hideki Yamamoto, Tadashi Eguchi, Katsumi Kakinuma. Extended Sequence and Functional Analysis of the Butirosin Biosynthetic Gene Cluster in Bacillus circulans SANK 72073, J. Antibitot., Vol. 58, No. 6, pp. 373-379, June 2005.
• Kenichi Yokoyama, Fumitaka Kudo, Mieko Kuwahara, Kousuke Inomata, Hideyuki Tamegai, Tadashi Eguchi, Katsumi Kakinuma. Stereochemical Recognition of Doubly Functional Aminotransferase in 2-Deoxystreptamine Biosynthesis, J. Am. Chem. Soc., Vol. 127, No. 16, pp. 5869-5874, May 2005.
• Fumitaka Kudo, Kenichi Kawabe, Hisako Kuriki, Tadashi Eguchi, Katsumi Kakinuma. A New family of Pathways for Glucose-1-phosphate/Glucosamine-1-phosphate Nucleotidylyltransferase in the Biosynthetic Antibiotics, J. Am. Chem. Soc., Vol. 127, No. 6, pp. 1711-1718, Mar. 2005.
• Eriko Nango, Fumitaka Kudo, Tadashi Eguchi, Katsumi Kakinuma. Reaction Stereochemistry of 2-Deoxy-scyllo-inosose Synthase. The Key Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics, Chem. Lett., Vol. 32, No. 5, pp. 438-439, May 2003.
• Hideyuki Tamegai, Eriko Nango, Ayumi Koike-Takeshita, Fumitaka Kudo, Katsumi Kakinuma. Significance of the 20 kDa Subunit of Heterodimeric 2-Deoxy-scyllo-inosose Synthase for the Biosynthesis of Butirosin Antibiotics in Bacillus circulans, Bioscience, Biotechnololgy, and Biochemistry, Vol. 66, No. 7, pp. 1538-1545, July 2002.
• Yasumasa Ota, Hideyuki Tamegai, Fumitaka Kudo, Hisako Kuriki, Aumi Koike-Takeshita, Tadashi Eguchi, Katsumi Kakinuma. Butirosin-biosynthetic Gene Cluster from Bacillus circulans, J. Antibiot., Vol. 53, No. 10, pp. 1158-1167, Oct. 2000.
• Nicholas Wu, Fumitaka Kudo, David E. Cane, Chaitan Khosla. Analysis of the Molecular Recognition Features of Individual Modules Derived from the Erythromycin Polyketide Synthase, Journal of the American Chemical Society, Vol. 122, No. 20, pp. 4847, June 2000.
• Katsumi Kakinuma, Eriko Nango, Fumitaka Kudo, Yoshitaka Matsushima, Tadashi Eguchi. An Expeditious Chemo-enzymatic Route from Glucose to Catechol by the Use of 2-Deoxy-scyllo-inosose Synthase, Tetrahedron Letters, Vol. 41, No. 12, pp. 1935-1938, Apr. 2000.
• Fumitaka Kudo, Yoshihiro Hosomi, Hideyuki Tamegai, Katsumi Kakinuma. Purification and Characterization of 2-Deoxy-scyllo-inosose Synthase Derived from Bacillus circulans. A Crucial Carbocyclization Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics, Journal of Antibiotics, Vol. 52, No. 2, pp. 81, Feb. 1999.
• Noriaki Iwase, Fumitaka Kudo, Noriaki Yamauchi, Katsumi Kakinuma. Biochemical Studies on 2-Deoxy-scyllo-inosose, an Early Intermediate in the Biosynthesis of 2-Deoxystreptamine. VII. Substrate Specificity of 2-Deoxy-scyllo-inosose Synthase, the Starter Enzyme for 2-Deoxystreptamine Biosynthesis, toward Deoxyglucose-6-phosphates and Proposed Mechanism, Bioscience, Biotechnology, and Biochemistry, Vol. 62, No. 12, pp. 2396-2407, Dec. 1998.

著書

• Fumitaka Kudo. Biosynthesis of Aminoglycoside Antibiotics, Comprehensive Natural Products III (Editor Hung-Wen Liu, Tadhg P. Begley), Elsevier, Vol. 2, pp. 588-612, 2020.
• 市村 禎二郎, 藤本 善徳, 小松 隆之, 鈴木 正, 原 典行, 松下 慶寿, 小澤 健一, 工藤 史貴, 高井 和之, 水上 真由美, 追中 寛, 岩井 敦子. 理工系大学 基礎化学実験 第3版, 講談社サイエンティフィク, Nov. 2008.

国際会議発表 (査読有り)

• Fumitaka Kudo, Takahiro Tokumitsu, Tadashi Eguchi. Functional analysis of radical SAM enzyme AprD4 and reductase AprD3 in the C3′-deoxygenation in apramycin biosynthesis, Directing Biosynthesis V, Mar. 2017.
• Ping Zhao, Jun-ya Ueda, Ikuko Kozone, Shuhei Chijiwa, Motoki Takagi, Fumitaka Kudo, Makoto Nishiyama, Kazuo Shin-ya, Tomohisa Kuzuyama. New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083–SVS6, Org. Biomol. Chem., Vol. 7, No. 7, Page 1450-1460, Apr. 2009.

国内会議発表 (査読有り)

• 千菅太一, 岸川皓典, 永井瑛, 坪井一馬, 村上聡, 臼井 健郎, 橋本絢子, 新家 一男, 宮永顕正, 工藤史貴, 江口正. 放線菌Streptomyces graminofaciens A-8890が生産する マクロライド抗生物質の生合成における ポリケチド合成酵素の機能解析とエンジニアリング, 第65回天然有機化合物討論会, Sept. 2023.
• 宮永顕正, 高橋壯太朗, 川村紘一, 栗原将平, 中澤雄一郎, 岩井南会子, 南雲陽子, 臼井健郎, 工藤史貴, 江口正. マクロラクタム抗生物質ヒタチマイシンの生合成研究, 第64回天然有機化合物討論会, Sept. 2022.
• 佐藤 秀亮, 工藤 史貴, Rohmer Michel, 江口 正. バクテリオホパンポリオール生合成において炭素-炭素結合形成反応を触媒するラジカルSAM 酵素 HpnH の機能解析, 第53回天然有機化合物討論会, Sept. 2021.
• 宮永顕正, 千菅太一, 川﨑大輔, 工藤史貴, 江口正. クレミマイシン生合成における3-アミノノナン酸ユニット構築に関わる酵素の構造機能解析, 第61回天然有機化合物討論会, Sept. 2019.
• Shusuke Sato, Fumitaka Kudo, Tomohisa Kuzuyama, Tadashi Eguchi. Radical SAM C-Methylation in Fosfomycin Biosynthesis, 日本化学会第９９春季年会, Mar. 2019.
• 工藤 史貴, 平山 茜, 張 家浩, 宮永 顕正, 江口 正. 抗腫瘍抗生物質パクタマイシンの生合成研究, 第60回天然有機化合物討論会, Sept. 2018.
• 佐藤 秀亮, Kim Seung-Young, 葛山 智久, 工藤 史貴, 江口 正. ホスホマイシン生合成における C-メチル化機構, 第59回天然有機化合物討論会, Sept. 2017.
• 宮永顕正, 篠原雄治, 岩沢翔平, Jolanta Cieślak, 工藤史貴, 江口正. マクロラクタム抗生物質ビセニスタチン生合成酵素の構造機能解析に基づくβ-アミノ酸スターター部位構築機構の解明, 第57回天然有機化合物討論会, Sept. 2015.

国際会議発表 (査読なし・不明)

• Fumitaka Kudo. Biosynthesis of Macrolactams with β-Amino Acid Polyketide Starter Unit, Directing Biosynthesis VII, July 2024.
• Fumitaka Kudo. Mechanistic Enzymology in Microbial Natural Product Biosynthesis Using Organic Chemistry Approaches, 1st Japan-Korea Actinomycetes Symposium, June 2024.
• Fumitaka Kudo. Functional analysis of radical enzymes in natural product biosynthesis, Japan–German Joint Symposium on Natural Product Biosynthesis, Apr. 2023.
• Fumitaka Kudo, Michel Rohmer, TADASHI EGUCHI. Biosynthesis of bacteriohopanepolyols: characterization of radical SAM adenosylation enzyme HpnH, 2022 Meeting of the International Society for the Biology of Actinomycetes (ISBA), June 2022.
• Fumitaka Kudo. Characterization of radical SAM enzymes in natural product biosynthesis, The 6th A3 Foresight Online Symposium on Chemical & Synthetic Biology of Natural Products, Dec. 2021.
• Fumitaka Kudo. Biosynthetic studies on hybrid nonribosomal peptide-polyketide natural products, PacifiChem2021, Dec. 2021.
• Fumitaka Kudo, Yukinobu Kitayama, Akimasa Miyanaga, Tadashi Eguchi. Kanamycin biosynthesis – Post-glycosylation modification of sugar moieties, Directing biosynthesis online, Apr. 2021.
• Fumitaka Kudo. Biosynthetic studies on β-amino acid-containing macrolactam antibiotics, The 5th A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, Oct. 2020.
• Fumihiro Ishikawa, Akimasa Miyanaga, Hinano Kitayama, Fumitaka Kudo, Tadashi Eguchi, Genzoh Tanabe. Reprogramming aryl acid adenylation domains for non-native building blocks, 258th National Meeting of the American Chemical Society, Aug. 2019.
• Daisuke Kawasaki, Taichi Chisuga, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Biosynthetic studies on 3-aminononanoic acid starter unit of cremimycin, The 4th A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, July 2019.
• Fumitaka Kudo. Biosynthetic studies of macrocyclic polyketide antibiotics in Actinomycetes, The 4th A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, July 2019.
• Kosuke Kishikawa, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Engineering of macrocyclic polyketides biosynthesis in Streptomyces graminofaciens, The 4th A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, July 2019.
• Sotaro Takahashi, Yuichiro Nakazawa, Koichi Kawamura, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Engineering of hitachimycin biosynthesis, The 4th A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, July 2019.
• Fumitaka Kudo. Study on radical SAM C-methyltransferase Fom3 in fosfomycin biosynthesis, 2nd China-Japan Joint Symposium on Natural Product Biosynthesis, Jan. 2019.
• Shusuke Sato, Fumitaka Kudo, Tomohisa Kuzuyama, Tadashi Eguchi. C-Methylation mechanism in fosfomycin biosynthesis, 3rd European Conference on Natural Products, Sept. 2018.
• Fumitaka Kudo, Akimasa Miyanaga, Ryuichi Takayanagi, Takashi Furuya, Atsushi Motegi, Tadashi Eguchi. Study on a dual functional cytochrome P450 in the biosynthesis of macrolide antibiotic FD-891, 3rd European Conference on Natural Products, Sept. 2018.
• Fumitaka Kudo. Biosynthesis of aminoglycoside antibiotics, 1st German–Japan biosynthesis seminar, Sept. 2018.
• Daisuke Kawasaki, Taichi Chisuga, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Biosynthesis of 3-aminofatty acid starter units of macrolactam antibiotics, The 3rd A3 Foresight Symposium on "Chemical & Synthetic Biology of Natural Products, July 2018.
• Ena Goto, Risako Ouchi, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Cross-linking reaction to investigate protein-protein interaction in polyketide synthases, The 3rd A3 Foresight Symposium on "Chemical & Synthetic Biology of Natural Products, July 2018.
• Kosuke Kishikawa, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Biosynthesis of two macrolides produced by Streptomyces graminofaciens, The 3rd A3 Foresight Symposium on "Chemical & Synthetic Biology of Natural Products", July 2018.
• Fumitaka Kudo, Shuusuke Satou, TADASHI EGUCHI. Radical SAM enzymes in natural products biosynthesis, The 3rd A3 Foresight Symposium on "Chemical & Synthetic Biology of Natural Products, July 2018.
• Fumitaka Kudo. Biosynthesis of β-amino acid containing macrolactam antibiotics, Natural Product Discovery and Development in the Genomic Era, Jan. 2018.
• Fumitaka Kudo. Biosynthesis of Carbocyclic Nucleoside Aristeromycin, 1st China-Japan Joint Symposium on Natural Product Biosynthesis, Oct. 2017.
• Fumitaka Kudo. Radical SAM Enzymes Involved in Natural Product Biosynthesis, 18th International Symposium on the Biology of Actinomycetes (ISBA18), May 2017.
• Fumitaka Kudo, Akimasa Miyanaga, Tadashi Eguchi. Biosynthesis of Macrolactam Antibiotics in Actinomycetes, 13th International Symposium on the Genetics of Industrial Microorganisms, Oct. 2016.
• Fumitaka Kudo. Biosynthetic Study of Macrocyclic Polyketide Antibiotics, The 1st A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Aug. 2016.
• Akane Hirayama, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Characterization of PLP-dependent 3-aminobenzoate synthase PctV in pactamycin biosynthesis, PACIFICHEM 2015, Dec. 2015.
• Akimasa Miyanaga, Jolanta Cieślak, Yuji Shinohara, Fumitaka Kudo, Tadashi Eguchi. Functional and structural of β-amino acid-activating adenylation enzymes in macrolactam biosynthesis, PACIFICHEM 2015, Dec. 2015.

国内会議発表 (査読なし・不明)

• 立花 春香, 小田切楓, 鹿島 騰真, 伏信 進矢, 工藤史貴, 江口正, 宮永顕正. Ⅰ型ポリケタイド合成酵素における脱水酵素ドメインとアシルキャリアタンパク質間の相互作用解析, 日本農芸化学会関東支部2024年度大会, Aug. 2024.
• Fumitaka Kudo. Biosynthesis of Bacteriohopanepolyols - Enhancement of Solubility of Lipophilic Compounds in Aqueous Environments-, 2024 US-Japan Seminar on the biosynthesis of Natural Products, May 2024.
• 金子黎音, 佐藤秀亮, Rohmer Michel, 江口正, 工藤史貴. Zymomonas mobilisが生産するバクテリオホパンポリオール生合成におけるサイクリトール部位の構築に関わる酵素の機能解析, 日本化学会第104春季年会, Mar. 2024.
• 坪井一馬, 池崎睦実, 川村紘一, 江口正, 工藤史貴. マクロラクタム抗生物質ヒタチマイシン生合成における推定異性化酵素の機能解析, 日本化学会第104春季年会, Mar. 2024.
• 千菅太一, 翔太 滝浪, 廖 増威, 中野 祥吾, 伊藤 創平, 宮永顕正, 工藤史貴, 江口正. 祖先型設計法を活用したモジュール型ポリケタイド合成酵素の構造解析, 日本農芸化学会2024年度大会, Mar. 2024.
• 工藤 史貴. アミノグリコシド系抗生物質とポリケチド系抗生物質の構造多様性創出機構解明に向けた精密酵素機能解析, 住木・梅澤記念賞 受賞講演, Nov. 2023.
• 平野健太朗, 岸川皓典, 坪井一馬, 宮永顕正, 工藤史貴, 江口正. マクロライド抗生物質FD-891 と virustomycin Aの生合成遺伝子改変, 日本化学会第103春季年会, Mar. 2023.
• 小田切楓, 川崎大輔, 千菅太一, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質クレミマイシン生合成における脱水酵素とアシルキャリアタンパク質間の相互作用解析, 日本農芸化学会2023年度大会, Mar. 2023.
• 千菅太一, 宮永顕正, 工藤史貴, 江口正. I型ポリケチド合成酵素におけるケト合成酵素様脱炭酸酵素とアシルキャリアタンパク質間相互作用の解明, 日本農芸化学会2023年度大会, Mar. 2023.
• 横内大河, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質ビリデノマイシンの生合成研究, 日本化学会第103春季年会, Mar. 2023.
• WANGDAWEI, 千菅太一, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質ヒタチマイシン生合成におけるアデニル化酵素HitBの基質特異性の改変, 日本化学会第103春季年会, Mar. 2023.
• 池崎睦実, 坪井一馬, 千菅太一, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質ヒタチマイシン生合成における脱水素酵素HitM4の構造機能解析, 日本化学会第103春季年会, Mar. 2023.
• 安冨里菜, 工藤史貴, 江口正. アミノグリコシド系抗生物質イスタマイシンとスポラリシンの生合成研究, 日本化学会第103春季年会, Mar. 2023.
• 坂本葵, 千菅太一, 宮永顕正, 工藤史貴, 江口正. アミノグリコシド系抗生物質4′-デオキシブチロシンの生合成研究, 日本化学会第103春季年会, Mar. 2023.
• 野原麻耶, 宮野夏妃, 倉本怜季, 宮永顕正, 木下佳奈, 石川文洋, 高島克輝, 工藤史貴, 江口正, 田邉元三. 拡張型基質結合部位をもつアデニル化酵素の機能·構造解析および非天然型誘導体合成への応用, 第9回食品薬学シンポジウム, Oct. 2022.
• 楠部瑞樹, 竹間琢自, 岩﨑有紘, 末永聖武, 宮永顕正, 工藤史貴, 江口正. リングビアペプチンB推定生合成遺伝子クラスター中の二鉄含有酸化酵素の機能解析, 日本化学会第102春季年会, Mar. 2022.
• 岩井南会子, 南雲 陽子, 工藤史貴, 江口正, 臼井 健郎. Hitachimycinによる膜機能破綻のメカニズム検討, 日本農芸化学会2022年度大会（京都、オンライン）, Mar. 2022.
• 湊敦志, 佐藤秀亮, 丸山 千登勢, 濱野 吉十, 工藤史貴, 江口正. 1-アミノ-2-メチルシクロプロパンカルボン酸生合成におけるメチル基転移酵素の機能解析, 日本化学会第102春季年会, Mar. 2022.
• 千菅太一, 永井瑛, 宮永顕正, 工藤史貴, 江口正. I型ポリケチド合成酵素ローディングモジュールにおけるケト合成酵素様脱炭酸酵素の機能構造解析, 日本農芸化学会2022年度大会, Mar. 2022.
• 永井瑛, 千菅太一, 宮永顕正, 工藤史貴, 江口正. I型ポリケチド合成酵素ローディングモジュールにおけるケト合成酵素様脱炭酸酵素の変異体解析, 日本農芸化学会2022年度大会, Mar. 2022.
• 永田健司, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質生合成におけるアデニル化酵素とアシルキャリアタンパク質間の相互作用解析, 日本化学会第102春季年会, Mar. 2022.
• 伏見政人, 千菅太一, 宮永顕正, 工藤史貴, 江口正. I型ポリケチド合成酵素における同一モジュールのアシル基転移酵素とアシルキャリアタンパク質の相互作用解析, 日本化学会第102春季年会, Mar. 2022.
• 岩井 南会子, 南雲 陽子, 髙橋壯太朗, 工藤史貴, 江口正, 臼井 健郎. Hitachimycinによる出芽酵母細胞内pHホメオスタシス障害, 日本農芸化学会2021年度大会, Mar. 2021.
• 岡田一歩, 平山茜, 工藤史貴, 江口正. 抗腫瘍抗生物質パクタマイシン生合成における脱水素酵素PctPの基質特異性, 日本化学会第101春季年会, Mar. 2021.
• 平山太一, 工藤史貴, 江口正. アナモックス菌の細胞膜成分ラダラン脂質の推定生合成中間体の合成研究, 日本化学会第101春季年会, Mar. 2021.
• 武藤舞, 工藤史貴, 江口正. ジテルペングリコシド抗生物質ソルダリンの麹菌異種発現系を用いた生合成解析, 日本化学会第101春季年会, Mar. 2021.
• 佐藤秀亮, 工藤史貴, 江口正. バクテリオホパンポリオール生合成において炭素-炭素結合形成反応を触媒するラジカルSAM酵素HpnHの機能解析, 日本化学会第101春季年会, Mar. 2021.
• 宮永顕正, 北山幸延, 工藤史貴, 江口正. カナマイシン生合成酵素KanD2とKanJの結晶構造解析, 2020年度量子ビームサイエンスフェスタ, Mar. 2021.
• 千菅太一, 宮永顕正, 栗原将平, 安達成彦, 川崎政人, 守屋俊夫, 千田俊哉, 工藤史貴, 江口正. マクロラクタム抗生物質ヒタチマイシン生合成におけるアデニル化酵素とキャリアタンパク質間相互認識機構, 2020年度量子ビームサイエンスフェスタ, Mar. 2021.
• 永山大希, 中澤雄一郎, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質ヒタチマイシン生合成におけるポストPKS修飾酵素の機能解析, 日本化学会第101春季年会, Mar. 2021.
• 石川文洋, 宮永顕正, 北山陽菜乃, 工藤史貴, 江口正, 田邉 元三. アデニル化酵素の基質特異性の拡張および構造的基盤, 第61回天然有機化合物討論会, Sept. 2019.
• 石川文洋, 宮永顕正, 北山陽菜乃, 工藤史貴, 江口正, 田邉 元三. アデニル化酵素のエンジニアリングによる基質許容性の拡張および構造的基盤, 第13回バイオ関連化学シンポジウム2019, Sept. 2019.
• 石川文洋, 宮永顕正, 北山陽菜乃, 工藤史貴, 江口正, 田邉元三. アデニル化酵素の基質特異性の拡張および構造的基盤, 日本ケミカルバイオロジー学会 第14回年会, June 2019.
• 川﨑大輔, 千菅太一, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質クレミマイシン生合成におけるsplit DHドメインの機能解析, 日本化学会第99春季年会, Mar. 2019.
• Jolanta Cieslak, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi. Functional and structural analysis of unique adenylation enzyme IdnL7 involved in biosynthesis of macrolactam antibiotic incednine, 日本化学会第99春季年会, Mar. 2019.
• 北山幸延, 宮永顕正, 工藤史貴, 江口正. カナマイシン生合成における脱水素酵素KanD2の基質認識機構, 日本化学会第99春季年会, Mar. 2019.
• 岸川皓典, 宮永顕正, 工藤史貴, 江口正. 18員環マクロライド抗生物質Virustomycin Aの生合成遺伝子クラスター, 日本化学会第99春季年会, Mar. 2019.
• 佐藤秀亮, 宮永顕正, 葛山智久, 工藤史貴, 江口正. ホスホマイシン生合成における新規加水分解酵素FomDの機能解析, 日本農芸化学会2019年度大会, Mar. 2019.
• 後藤絵菜, 大内理紗子, 宮永顕正, 工藤史貴, 江口正. ジソラゾール生合成におけるアシル基転移酵素とアシルキャリアプロテイン間の相互作用解析, 日本化学会第99春季年会, Mar. 2019.
• 北山幸延, 平山茜, 宮永顕正, 工藤史貴, 江口正. カナマイシン生合成におけるカノサミン部位の構築機構, 日本化学会第98春季年会, Mar. 2018.
• 山口海斗, 角田毅, 宮永顕正, 工藤史貴, 江口正. ヌクレオシド系抗生物質アリステロマイシンの生合成における炭素五員環形成の立体, 日本化学会第98春季年会, Mar. 2018.
• 中澤雄一郎, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質ヒタチマイシンの生合成におけるATP依存リガーゼHitBの基質特異性, 日本化学会第98春季年会, Mar. 2018.
• 大内理紗子, 石川文洋, 後藤絵菜, 木村真希, 宮永顕正, 田邉元三, 工藤史貴, 江口正. ポリケチド生合成におけるアシル基転移酵素とアシルキャリアタンパク質のクロスリンク反応の検討, 日本化学会第98春季年会, Mar. 2018.
• 平山茜, 工藤史貴, 江口正. 抗腫瘍抗生物質パクタマイシンの生合成におけるアミノ基導入機構, 日本化学会第97春季年会, Mar. 2017.
• 佐藤秀亮, 工藤史貴, 江口正, 葛山智久. ホスホマイシン生合成におけるラジカルS-アデノシル-L-メチオニンC-メチル化酵素の機能解析, 日本化学会第97春季年会, Mar. 2017.
• 髙栁龍一, 古谷隆, 宮永顕正, 工藤史貴, 江口正, 川又綾乃, 岩渕好治, 叶直樹. マクロライド系抗生物質FD-891の生合成におけるシトクロムP450酸化酵素GfsFの基質特異性, 日本化学会第97春季年会, Mar. 2017.
• 千菅太一, 宮永顕正, 工藤史貴, 江口正. Ⅲ型チオエステラーゼ SAV606の構造機能解析, 2016年度量子ビームサイエンスフェスタ, Mar. 2017.
• 千菅太一, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質クレミマイシンの生合成における開始基質3-アミノノナン酸の構築機構-FAD依存酸化酵素CmiS2の構造機能解析, 第6回CSJ化学フェスタ2016, Nov. 2016.
• Jolanta Cieslak, 宮永顕正, 工藤史貴, 江口正. Structural analysis of hydrophobic β-amino acid adenylation enzymes CmiS6 and IdnL1, 第6回CSJ化学フェスタ2016, Nov. 2016.
• 千菅太一, 宮永顕正, 工藤史貴, 江口正. III 型チオエステラーゼの構造機構解析, 第31回日本放線菌学会大会, Sept. 2016.
• 宮永顕正, 早川雄基, 沼倉真理緒, 橋本絢子, 新家一男, 工藤史貴, 江口正. Fluvirucin B2生合成遺伝子クラスターの同定と機能解析, 第31回日本放線菌学会大会, Sept. 2016.
• 工藤史貴, 角田毅, 宮永顕正, 高島惇, 江口正. ヌクレオシド系抗生物質アリステロマイシンの生合成遺伝子のゲノムマイニング, 第58回天然有機化合物討論会, Sept. 2016.
• 安藤大史, 川村紘一, 工藤史貴, 宮永顕正, 江口正. ポリケチド抗生物質ヒタチマイシン生合成における PKS 後修飾機構解明に向けた遺伝子破壊実験, 日本化学会第96春期年会, Mar. 2016.
• 西野晃太, 宮永顕正, 工藤史貴, 江口正. 生合成遺伝子破壊株を利用したヒタチマイシン類縁体生産の試み, 第5回CSJ化学フェスタ2015, Oct. 2015.
• 岩沢翔平, 宮永顕正, 篠原雄治, 工藤史貴, 江口正. マクロラクタム抗生物質ビセニスタチン生合成に関わるアシル基転移酵素VinKの基質認識機構解析, 第5回CSJ化学フェスタ2015, Oct. 2015.
• 古谷隆, 川村紘一, 宮永顕正, 工藤史貴, 江口正. マクロライド系抗生物質FD-891生合成におけるポストPKS修飾酵素の機能解析, 日本化学会第95春期年会, Mar. 2015.
• 宮永顕正, 古谷隆, 工藤史貴, 江口正. FD-891生合成に関わるシトクロムP450酸化酵素GfsFの結晶構造解析, 日本農芸化学会2015年度大会, Mar. 2015.
• 川村紘一, 宮永顕正, 工藤史貴, 江口正. ポリケチド抗生物質ヒタチマイシンの生合成遺伝子の機能解析, 日本化学会第95春期年会, Mar. 2015.
• 角田毅, 高島惇, 宮永顕正, 工藤史貴, 江口正. ヌクレオシド系抗生物質アリステロマイシン生合成に関わるOrf2の機能解析, 日本農芸化学会2015年度大会, Mar. 2015.
• 平山茜, 宮永顕正, 工藤史貴, 江口正. パクタマイシン生合成における3-アミノ安息香酸合成酵素の反応, 日本化学会第95春期年会, Mar. 2015.
• 森彩花, 小出麻依, 宮永顕正, 工藤史貴, 江口正. 糖質から炭素六員環化合物への酵素的変換, 日本化学会第95春期年会, Mar. 2015.
• 早川雄基, 川村紘一, 宮永顕正, 工藤史貴, 江口正. 非天然型基質投与によるヒタチマイシン類縁体生産, 日本化学会第95春期年会, Mar. 2015.
• 内野飛翔, 沼倉真理緒, 宮永顕正, 江口正, 工藤史貴. マクロラクタム抗生物質ヒタチマイシンのスターター部位構築に関わる酵素の機能解析, 日本農芸化学会2014年度大会, Mar. 2014.
• 宮永顕正, 篠原雄治, 工藤史貴, 江口正. ビセニスタチン生合成におけるATP依存性リガーゼVinNの結晶構造解析, 日本農芸化学会2014年度大会, Mar. 2014.
• 篠原雄治, 宮永顕正, 工藤史貴, 江口正. マクロラクタム抗生物質ビセニスタチン生合成に関わるペプチダーゼVinJのX線結晶構造解析, 第3回CSJ化学フェスタ2013, Oct. 2013.
• Fumitaka Kudo. Molecular Analysis of the Biosynthesis of 2-Deoxystreptamine-Containing Antibiotics, 40th SAJ Regular Colloquium, Actinomycetologicia, Vol. 19, No. 1, pp. S8-S10, Oct. 2005.

その他の論文・著書など

• Fumitaka Kudo. Biosynthesis of Macrocyclic Polyketide Antibiotics, Feb. 2020.
• Fumitaka Kudo. Carbon-carbon Bond Forming Radical SAM Enzymes in the Biosynthesis of Natural Products, The weekly organic chemistry seminar, the Chemistry Department, University of Strasbourg, Feb. 2020.
• Fumitaka Kudo. Biosynthesis of Macrocyclic Polyketide Antibiotics, Feb. 2020.
• Fumitaka Kudo. Carbon-carbon Bond Forming Radical SAM Enzymes in the Biosynthesis of Natural Products, The weekly organic chemistry seminar, the Chemistry Department, University of Strasbourg, Feb. 2020.
• Fumitaka Kudo. Trends in drug discovery from natural sources -History of antibiotics-, the Maison Universitaire France Japon, Feb. 2020.
• Fumitaka Kudo. Biosynthesis of macrocyclic polyketide antibiotics, Dec. 2018.
• Fumitaka Kudo. Biosynthesis of macrocyclic polyketide antibiotics, Nov. 2018.
• Fumitaka Kudo. Biosynthesis of macrocyclic polyketide antibiotics, Aug. 2018.
• 工藤史貴. 抗腫瘍性マクロライド抗生物質 生合成マシナリーのリデザイン, 新学術領域研究「生合成リデザイン」第４回公開シンポジウム, May 2018.
• 工藤史貴. 天然物生合成に関わる ケミカルバイオロジー研究, 東京大学大学院薬学系研究科 大学院講義「ケミカルバイオロジー特論」, Nov. 2017.
• 工藤史貴. マジックマッシュルームはどのように幻覚剤であるシロシビンを作るのか？, 現代化学, Vol. 11, Oct. 2017.
• 工藤史貴. ポリケチド生合成マシナリーの 精密解析, Aug. 2017.
• 工藤史貴. 抗腫瘍性マクロライド抗生物質生合成マシナリーのリデザイン, 新学術領域研究「生合成リデザイン」第２回公開シンポジウム, Aug. 2017.
• Fumitaka Kudo. Recent Biosynthetic Study of Natural Products, 2017 Asian International Symposium for Outstanding Young Scientists, Natural Products Chemistry and Biofunctional Chemistry and Biotechnology, Mar. 2017.
• 工藤史貴, 宮永顕正, 江口正. β-アミノ酸含有マクロラクタム抗生物質の生合成, 化学と生物, Vol. 52, No. 12, pp. 830-835, Dec. 2014.
• 工藤史貴. ネオマイシン生合成酵素の機能解析から見えてきた生合成工学による構造多様化の可能性, バイオサイエンスとインダストリー = Bioscience & industry, バイオインダストリー協会, Vol. 70, No. 2, pp. 120-123, Mar. 2012.
• Fumitaka Kudo, Tadashi Eguchi. Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin, Methods Enymol., 459, 493-519, Apr. 2009.
• 工藤史貴, 江口正. 天然有機化合物の生合成に学ぶ アミノグリコシド抗生物質生合成研究の進歩, 化学と生物, Vol. 44, No. 1, pp. 49-55, Jan. 2006.

特許など

• 江口正, 工藤史貴. ２－デオキシ－scyllo－イノソースの調製法 . 特許. 公開. 国立大学法人東京工業大学. 2012/09/26. 特願2012-211752. 2014/04/17. 特開2014-064513. 2014.
• 柿沼勝己, 工藤史貴, 江口正. ラクタム及びラクトン合成酵素. 特許. 公開. 国立大学法人東京工業大学. 2005/01/27. 特願2005-019886. 2006/08/10. 特開2006-204169. 2006.

学位論文

• アミノ配糖体抗生物質の生合成における2-デオキシ-scyllo-イノソース合成酵素に関する研究,  本文,  博士（理学）,  東京工業大学,  1999/03/26,    (Organization name: Tokyo Institute of Technology)

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