論文

• Kim, J., Fukuda, H., Hirasawa, T., Nagahisa, K., Nagai, K., Wachi, M., Shimizu, H.. Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum, Appl. Microbiol. Biotechnol., 86, 911-920, Jan. 2010.
• Susumu Inaba, Tadashi Eguchi, Atsushi Motegi, Kazutoshi Mizoue, Takeo Usui, Kazuo Nagai, Takao Kataoka. The Cytotoxic Macrolide FD-891 Induces Caspase-8-dependent Mitochondrial Release of Cytochrome c and Subsequent Apoptosis in Human Leukemia Jurkat Cells, J. Antibiot., 62, 9, 507-512, Sept. 2009.
• Taro Sakai, Naoko Nakamura, Genryou Umitsuki, Kazuo Nagai, Masaaki Wachi. Increased production of pyruvic acid by Escherichia coli RNase G mutants in combination with cra mutations, Appl. Microbiol. Biotechnol., Vol. 76, No. 1, pp. 183-192, Aug. 2007.
• Hiroshi Nakagawa, Hasumi, K., Takami, M., Aida-Hyugaji, S., Woo, J. T., Kazuo Nagai, Toshihisa Ishikawa, Masaaki Wachi. Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture, Biochem. Pharmacol., Vol. 73, No. 1, pp. 34-43, Jan. 2007.
• Ayako Takada, Genryou Umitsuki, Kazuo Nagai, Masaaki Wachi. RNase E is required for induction of the glutamate-dependent acid resistance system in Escherichia coli, Biosci. Biotechnol. Biochem., Vol. 71, No. 1, pp. 158-164, Jan. 2007.
• Masaaki Wachi, Kazuyoshi Osaka, Tomoko Kohama, Kumi Sasaki, Iwao Ohtsu, Noritaka Iwai, Ayako Takada, Kazuo Nagai. Transcriptional analysis of the Escherichia coli mreBCD genes responsible for morphogenesis and chromosome segregation, Biosci. Biotechnol. Biochem., Vol. 70, No. 11, pp. 2712-2719, Nov. 2006.
• Oyamada, Y., Ito, H., Fujimoto-Nakamura, M., Tanitame, A., Iwai, N., Nagai, K., Yamagishi, J., Wachi, M.. Anucleate cell blue assay: a useful tool for identifying novel type II topoisomerase inhibitors, Antimicrob. Agents Chemother., Vol. 50, No. 1, pp. 348-350, Jan. 2006.
• Kumagai, Y., Hirasawa, T., Hayakawa, K., Nagai, K., Wachi, M.. Fluorescent phospholipid analogs as microscopic probes for detection of the mycolic acid-containing layer in Corynebacterium glutamicum: Detecting alterations in the mycolic acid-containing layer following ethambutol treatment, Biosci. Biotechnol. Biochem., Vol. 69, No. 11, pp. 2051-2056, Nov. 2005.
• Awa, Y., Iwai, N., Ueda, T., Suzuki, K., Asano, S., Yamagishi, J., Nagai, K., Wachi, M.. Isolation of a new antibiotic, alaremycin, structurally related to 5-aminolevulinic acid from Streptomyces sp. A012304, Biosci. Biotechnol. Biochem., Vol. 69, No. 9, pp. 1721-1725, Sept. 2005.
• Ayako Takada, Kazuo Nagai, Masaaki Wachi. A decreased level of FtsZ is responsible for inviability of RNase E-deficient cells, Genes Cells, Vol. 10, No. 7, pp. 733-741, July 2005.
• Tanitame, A., Oyamada, Y., Ofuji, K., Fujimoto, M., Suzuki, K., Ueda, T., Terauchi H., Kawasaki, M., Nagai, K., Wachi, M., Yamagishi, J.. Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring, Bioorg. Med. Chem., Vol. 12, No. 21, pp. 5515-5524, Nov. 2004.
• Iwai, N., Ebata, T., Nagura, H., Kitazume, T., Nagai, K., Wachi, M.. Structure-activity relationship of S-benzylisothiourea derivatives to induce spherical cells in Escherichia coli, Biosci. Biotechnol. Biochem., Vol. 68, No. 11, pp. 2265-2269, Nov. 2004.
• Nakagawa, H., Hasumi, K., Woo, J.-T., Nagai, K., Wachi, M.. Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate, Carcinogenesis, Vol. 25, No. 9, pp. 1567-1574, Sept. 2004.
• Ogino, H., Wachi, M., Ishii, A., Iwai, N., Nishida, T., Yamada, S., Nagai, K., Sugai, M.. FtsZ-dependent localization of GroEL protein at possible division sites, Genes Cells, Vol. 9, No. 9, pp. 765-771, Sept. 2004.
• Tanitame, A., Oyamada, Y., Ofuji, K., Fujimoto, M., Iwai, N., Hiyama, Y., Suzuki, K., Ito, H., Terauchi, H., Kawasaki, M., Nagai, K., Wachi, M., Yamagishi, J.. Synthesis and antibacterial activity of a novel series of petent DNA gyrase inhibitors. Pyrazole derivatives, J. Med. Chem., Vol. 47, No. 14, pp. 3693-3696, July 2004.
• Genryou Umitsuki, Masaaki Wachi, Ayako Takada, Takafusa Hikichi, Kazuo Nagai. Involvement of RNase G in in vivo mRNA metabolism in Escherichia coli, Genes Cells, Vol. 6, pp. 403-410, May 2001.
• T.Kataoka, K.Nagai. Involvement of FK506-senseitive and insensitive granule exocytosis pathways in perfolin-dependent target cell lysis mediated by CD8+CTL clone, Immunology Letters, Vol. 72, pp. 49-52, 2000.
• Takashi Hirasawa, Masaaki Wachi, Kazuo Nagai. A mutation in the Corynebcterium glutamicum ltsA gene causes susuceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production, Journal of Bacteriology, Vol. 182, pp. 2696-2701, 2000.
• Ayako Takada, Masaaki Wachi, Kazuo Nagai. Negative regulatory role of the Escherichia coli hfq gene in cell division, Biochem. Biophys. Res. Commun., Vol. 266, pp. 579-583, Dec. 1999.
• Masaaki Wachi, Ayako Takada, Kazuo Nagai. Overproduction of the outer-membrane proteins FepA and FhuE responsible for iron transport in Escherichia coli hfq::cat mutant, Biochem. Biophys. Res. Commun., Vol. 264, pp. 525-529, Oct. 1999.
• Masaaki Wachi, Genryou Umitsuki, Miwa Shimizu, Ayako Takada, Kazuo Nagai. Escherichia coli cafA gene encodes a novel RNase designated as RNase G, involved in processing of the 5' end of 16S rRNA, Biochem. Biophys. Res. Commun., Vol. 259, pp. 483-488, June 1999.
• Kohji Nagano, Masaaki Wachi, Ayako Takada, Fumie Takaku, Takashi Hirasawa, Kazuo Nagai. fcsA29 mutation ia an allele of polA gene of Escherichia coli, Biosci. Biotechnol. Biochem., Vol. 63, No. 2, pp. 427-429, Feb. 1999.
• M. Wachi, N. Iwai, A. Kunihisa, K. Nagai . Irregular nuclear localization and anucleate cell production in Escherichia coli induced by a Ca^２＋ , chelator, EGTA, Biochimie, 81, 909-913(1999), Vol. 81, pp. 909-913, 1999.
• Ayako Takada, Masaaki Wachi, Kazuo Nagai . Negative regulatory role of the Escher ichia coli hfq gene in cell division , Biochemical and Biophysical Research Communications, 266, 579-583(1999), Vol. 226, pp. 579-583, 1999.
• Masamichi Takami, Je-Tae Woo, Kazuo Nagai . Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production , Cell Tissue Res, Vol. 298, pp. 327-334, 1999.
• KAZUO NAGAI. Eschrichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of 5' end of 16S rRNA, Biochem. Biophys. Res. Commun., Vol. 259, pp. 483-488, 1999.
• KAZUO NAGAI. A murC gene from coryneform bacteria, Appl. Microbiol. Biotechnol., Vol. 51, pp. 223-228, 1999.
• KAZUO NAGAI. fcsA mutation is an allele of polA gene of Escherichia coli, Biosci. Biotechnol. Biochem., Vol. 63, pp. 427-429, 1999.
• KAZUO NAGAI. Selective induction of interleukin-1 production and tumor killing activity of macrophages through apoptosis by the inhibition of oxidative respiration, Biosci. Biotechnol. Biochem., Vol. 62, pp. 1115-1121, 1998.
• KAZUO NAGAI. Requirement of osteoblastic cells for the fusion of preosteoclasts, J. Bone Miner. Metab., Vol. 16, pp. 151-157, 1998.
• Nobuyuki Kijima, Dinesh Goyal, Ayako Takada, Masaaki Wachi, Kazuo Nagai. Induction of only limited elongation instead of filamentation by inhibition of cell division in Corynebacterium glutamicum, Appl. Microbiol. Biotechnol., Vol. 50, pp. 227-232, 1998.
• Masaaki Wachi, Genryou Umitsuki, Kazuo Nagai. Functional relationship between Escherichia coli RNaseE and the CafA protein, Mol. Gen. Genet., Vol. 253, pp. 515-519, Jan. 1997.
• KAZUO NAGAI. An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream form of Trypanosoma brucei brucei, Mol. Biotech. Parasitol., Vol. 84, pp. 271-280, 1997.
• KAZUO NAGAI. Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) controls the timing of cell division in Escherichia coli, Genes to Cells, Vol. 2, pp. 401-413, 1997.
• KAZUO NAGAI. Prodingiosin 25-C and metacycloprodigiosin suppress the bone resorption by osteoclasts, Bioscience, biotechnology, and Biochemistry, Vol. 60, No. 2, pp. 400-402, 1997.
• KAZUO NAGAI. Characterization of a series of vacuolar type H┣D1+┫D1-ATPase inhibitors on CTL-mediated cytotoxicity, Immunology Letters, Vol. 55, No. 1, pp. 139-144, 1997.
• KAZUO NAGAI. Functional relationship between Escherichia coli RNase and the CafA protein, Molecular and General Genetics, Vol. 253, No. 3, pp. 515-519, 1997.
• KAZUO NAGAI. Immunomodulating activities of polysaccharide fractions from dried safflower pedals, Cytotechnology, Vol. 25, pp. 205-211, 1997.
• KAZUO NAGAI. Concanamycin A, vacuolar type H+-ATPase inhibitor, induces cell death in activated CD8+ CTL, Cytotechnology, Vol. 25, pp. 127-135, 1997.
• Ayako Takada, Masaaki Wachi, Akihiro Kaidow, Makoto Takamura, Kazuo Nagai. DNA binding properties of the hfg gene product of Escherichia coli, Biochem. Biophys. Res. Commun., Vol. 236, pp. 576-579, 1997.
• KAZUO NAGAI. structure-activity relationship within a series of degradation products of tauto mycin, Bioscience,Biotechnology, and Biochemistry, Vol. 60, No. 1, pp. 103-107, 1996.
• KAZUO NAGAI. Immunosuppressive activity of Streptonigrin in vitro and in vivo, Bioscience,Biotechnology, and Biochemistry, Vol. 60, No. 5, pp. 789-793, 1996.
• KAZUO NAGAI. Concanamycin A, a powerful tool for characterization and estimation of contribution of perfolin- and Fas-based lytic pathways in cell-mediated cytotoxicity, Journal of Immunology, Vol. 156, No. 10, pp. 3678-3686, 1996.
• KAZUO NAGAI. A cryptic plasmid pBL1 from Brevibacterium lactofermentum causes growth inhibition and filamentation in Escherichia coli, Plasmid, Vol. 32, No. 1/, pp. 62-66, 1996.
• KAZUO NAGAI. Identification of low molecular weight probes on perfolin- and Fas-based killing mediated by cytotoxic T lymphocytes, Bioscience, Biotechnology, and Biochemistry, Vol. 60, No. 10, pp. 1726-1728, 1996.
• KAZUO NAGAI. Estimation of pH and the number of lytic granules in a CD8┣D1+┫D1 CTL clone treated with an inhibitor of vacuolar type H┣D1+┫D1-ATPase, concanamycin A, Bioscience, Biotechnology, and Biochemistry, Vol. 60, No. 10, pp. 1729-1731, 1996.
• KAZUO NAGAI. Suppression of apoptotic cell death of IL-3-dependent cell lines by ER/SR Ca┣D1+┫D1-ATPase inhibitors upon IL-3 deprivation, Experimental Cell Research, Vol. 228, No. 1, pp. 92-97, 1996.
• KAZUO NAGAI. Anucleate cell production by Escherichia coli Δhns mutant lacking a histone-like protein,H-NS, Journal of Bacteriology, Vol. 177, No. 12, pp. 3589-3592, 1995.
• KAZUO NAGAI. Thiol-protease inhibitors selectively inhibit presentation of antigen incorporated through B cell antigen receptors, Biochemical and Biophysical Research Communicatons, Vol. 210, pp. 2324-2328, 1995.
• KAZUO NAGAI. Prodigiosin 25-C perturbs permiation of acetate in a cultured cell line, Bioscience,Biotechnology, and Biochemistry, Vol. 59, No. 10, pp. 1891-1895, 1995.
• KAZUO NAGAI. Prodigiosin 25-C uncouples vacuolar type H┣D1+┫D1-ATPase, inhibits acidification and affects glycoprotein processing, FEBS Letters, Vol. 359, No. 1, pp. 53-59, 1995.
• KAZUO NAGAI. Prodigiosin 25-C suppression of cytotoxic T cells in vitro and vivo similar to that of concanamycin B,a specific inhibitor of vacuolar type H┣D1+┫D1-ATpase, Bioscience,Biotechnology, and Biochemistry, Vol. 59, No. 8, pp. 1417-1421, 1995.
• KAZUO NAGAI. Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes, Bioscience,Biotechnology, and Biochemistry, Vol. 59, No. 11, pp. 2064-2067, 1995.
• KAZUO NAGAI. 1'-acetoxychavicol acetate as an inhibitor of phagositosis of macrophages, Bioscience,Biotechnology, and Biochemistry, Vol. 59, No. 8, pp. 1566-1567, 1995.
• KAZUO NAGAI. Promoter region of mouse Tcrg genes, immunogenetics, Vol. 43, No. 1, pp. 68-71, 1995.
• KAZUO NAGAI. A murC gene in Porphyromonas gingivalis 381, Microbiology, Vol. 141, pp. 2047-2052, 1995.
• KAZUO NAGAI. Cell cycle control : Procaryotic solutions to eucaryotic problems。, Journal of Theoretical Biology, Vol. 168, No. 2, pp. 227-230, 1994.
• KAZUO NAGAI. The pcsA gene is identical to dinD in Escherichia coli, Journal of Bacteriology, Vol. 177, No. 1, pp. 156-165, 1994.
• KAZUO NAGAI. Presentation of exogenous antigen by macrophages but not by spleen cells is inhibited by leupeptin and antipain, Bioscience, Biotechnology, and Biochemistry, Vol. 58, No. 11, pp. 2033-2035, 1994.
• KAZUO NAGAI. Enhancement of B cell function as antigen-presenting cell during interplay with Th cells, Immunobiology, Vol. 190, No. 3, pp. 317-332, 1994.
• KAZUO NAGAI. Development and characterization of macrophage hybridomas derived from murine peritoneal exudate cells, Bioscience, Biotechnology, and Biochemistry, Vol. 58, No. 5, pp. 839-842, 1994.
• KAZUO NAGAI. Cytoplasmic axial filaments in Escherichia coli cells : Possible function in the mechanism of chromosome segregation and cell division, Journal of Bacteriology, Vol. 176, No. 3, pp. 917-922, 1994.
• KAZUO NAGAI. Screening for specific inhibitors of phagocytosis of thioglycollate-elicited macrophages, Bioscience, Biotechnology, and Biochemistry, Vol. 58, No. 1, pp. 104-107, 1994.
• KAZUO NAGAI. Effects of microbial products on glucose consumption and morphocogy of macrohages, Bioscience, Brotechuology, and Biochemistry, Vol. 57, No. 10, pp. 1628-1631, 1993.
• KAZUO NAGAI. Immunomodulators in microbial metabolites, 蛋白質・核酸,酵素, Vol. 38, No. 11, pp. 1659-1670, 1993.
• KAZUO NAGAI. Melastin, a novel product of Streptomyces that selectively inhibits leukemia cell growth, Bioscierce, Biotechnology, and Biochemistry, Vol. 57, No. 6, pp. 969-972, 1993.
• KAZUO NAGAI. Morphological changes and reorgarization of actinfilaments in human myecoid leukemia cells induced by a nouel protein phosphatase inhibitor, tautomycin, Cell Structute and Function, No. 18, pp. 33-39, 1993.
• Akihiro Kaidow, Takao Kataoka, Masaaki Wachi, Ayako Takada, Makari Yamasaki, Kazuo Nagai. The 55-kilodalton protein in an oriC complex fraction is glycogen synthase, J. Bacteriol., Vol. 174, No. 16, pp. 5454-5456, Aug. 1992.
• KAZUO NAGAI. Effects of prodigiosin 25-C on cultured cell lines : Its similarity to monovalent polyether ionophores and vacuolar type H┣D1+┫D1-ATPase inhibitors, Journal of Antibiotics, Vol. 45, No. 10, pp. 1618-1625, 1992.
• KAZUO NAGAI. Ennancement by concanavalin A of the suppressive effect of prodigiosin 25-C on proliferation of murine splenocytes, Journal of Antibiotics, Vol. 45, No. 8, pp. 1303-1312, 1992.
• KAZUO NAGAI. Immanosuppressive effect of prodigiosin 25-C on cardiac transplantation, 自治医大紀要, No. 15, pp. 93-96, 1992.
• KAZUO NAGAI. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental modols of inflammation, Bioscience, Biotechnology, and Biochemistry, Vol. 56, No. 12, pp. 2034-2036, 1992.
• KAZUO NAGAI. Immunomodulationg properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxc T cells, Journal of Antibiotics, Vol. 45, pp. 8, 1992.
• KAZUO NAGAI. ATPase activity of SopA, a protein essential for active partitioning of F plasmid, Molecular and General Genetics, No. 234, pp. 346-352, 1992.
• KAZUO NAGAI. Association of oriC region of Escherichia coli chromosome with outer membrane : Effects of culture condition, Bichemical and Biophysical Research Communications, Vol. 180, No. 2, pp. 970-975, 1992.
• KAZUO NAGAI. Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist, Bioscience, Biotechnology, and Biochemistry, Vol. 56, No. 10, pp. 1686-1689, 1992.
• KAZUO NAGAI. A novel in vivo screening method for immunomodulating substances : Development of an assay system, Bioscience, Biotechnology, and Biochemistry, Vol. 56, No. 9, pp. 1497-1498, 1992.
• KAZUO NAGAI. Enhancement by concanavalin A of the suppressive effect of prodigiosin 25-C on proliferation of murine splenocytes, Journal of Antibiotics, Vol. 45, No. 8, pp. 1303-1312, 1992.
• KAZUO NAGAI. Only oriC and its flanking region are recovered from the complex formed at the time of inhitiation of chromosome replication in Escherichia coli, Research in Microbiology, Vol. 142, No. 2, pp. 3, 1991.
• KAZUO NAGAI. Selective suppression of prodigiosin 25-C and FK506 in the murine immune system, Journal of Antibiotics, Vol. 43, pp. 10, 1990.
• KAZUO NAGAI. Supprission of cytotoxic T cell induction in vivo by prodigiosin 25-C, Transplantation, Vol. 47, pp. 6, 1989.
• KAZUO NAGAI. Purification and characteization of the sopB gene product which is responsible for stable maintenance of mini-F plasmid, Moecular and General Genltics, Vol. 218, pp. 3, 1989.
• KAZUO NAGAI. Antitumor and antimetastastatic activity of an antibiotic, ascofuranone, and activation of phagocytes, Journal of Antibiotics, Vol. 41, pp. 7, 1988.
• KAZUO NAGAI. Suppression of hypertriglyceridemia of Ehrlich carcinoma bearing mice by an antibiotic, ascofuranone, Cancer Research, Vol. 47, pp. 1, 1987.
• KAZUO NAGAI. Selective suppression by prodigiosin of the mitogenic response of murine splencytes, Journal of Antibiotics, Vol. 39, pp. 8, 1986.

著書

• Kazuo Nagai, Takao Kataoka. Bioprobes, Springer-Verlag, Springer-Verlag, 2000.
• KAZUO NAGAI. Microbial Technology, 講談社サイエンティフィク, 講談社サイエンティフィク, 1996.
• 永井和夫, 中森茂, 虎谷哲夫, 掘越弘毅. 微生物工学, 講談社サイエンティフィック, 講談社サイエンティフィック, 1996.
• KAZUO NAGAI. Structure of bacterial chromosome, 微生物機能の多様性(学会出版センター), 微生物機能の多様性(学会出版センター), 1995.
• 永井和夫, 大森斉. 細胞工学, 講談社サイエンティフィック, 講談社サイエンティフィック, 1993.
• KAZUO NAGAI. Cell technology, 化学ハンドブック(朝倉書店), 化学ハンドブック(朝倉書店), 1993.
• KAZUO NAGAI. Suppression of killer T cell induction by prodigiosin 25-C, Animal Cell Technology : Basic & Applied Aspects, Animal Cell Technology : Basic & Applied Aspects, 1993.
• KAZUO NAGAI. Cell Technology, 講談社サイエンティフィク, 講談社サイエンティフィク, 1992.

学位論文

• 抗腫瘍抗生物質ブレオマイシンの作用機構,  本文,  Doctor of Agriculture,  東京大学,  1969/--/--, 

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