論文

• G.P. Rossi, S. Colonna, A.S. Belloni, C. Savoia, G. Albertin, G.G. Nussdorfer, H. Hagiwara, S. Rubattu, M. Volpe. Altered Regulation of Endothelin A Receptor Subtype in the Cerebral Arterioles in Response to a Japanese-style Diet, in Stroke-prone Hypertensive Rats., Journal of Hypertension, Vol. 21, pp. 105-113, 2003.
• M. Naruse, E. Otsuka, M. Naruse, Y. Ishihara, S. Miyagawa-Tomita, H. Hagiwara. Inhibition of Osteoclast Formation by 3-Methylcholanthrene, a Ligand for Arylhydrocarbon Receptor: Suppression of Osteoclast Differentiation Factor in Osteogenic Cells., Biochemical Pharmacology, Vol. in press, 2003.
• Eri Otsuka, Michitaka Notoya, Hiromi Hagiwara. Treatment of myoblastic C2C12 cells with BMP-2 stimulates vitamin D-induced formation of osteoclasts., Calcified Tissue International, Vol. in press, 2003.
• M. Ishizuka, H. Ohshima, N. Tamura, T. Nakata, A. Inoue, S. Hirose, H. Hagiwara. Molecular Cloning and Chracteristics of a Novel Zinc Finger Protein and Its Splice Variant Whose Transcripts Are Expressed during Spermatogenesis., Biochemical and Biophysical Research Communications, Vol. 301, pp. 1079-1085, 2003.
• S.D. Rogers, C.M. Peters, J.D. Pomonis, H. Hagiwara, J.R. Ghilardi, P.W. Mantyh. Endothelin B Receptors Are Expressed by Astrocytes and Regulate Astrocyte Hypertrophy in the Normal and Injured CNS., Glia, Vol. 41, pp. 180-190, 2003.
• Masae Naruse, Yoko Ishihara, Sachiko Miyagawa-Tomita, Atsushi Koyama, Hiromi Hagiwara. 3-Methylcjolanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo., Endocrinology, Vol. 143, No. 9, pp. 3575-3581, 2002.
• Atsuto Inoue, Yuki Kobayashi, Masamichi Ishizuka, Shigehisa Hirose, Hiromi Hagiwara. Identification of a novel osteoblastic gene, inducible by C-type natriuretic peptide, whose transcript might function in mineralization as a noncoding RNA., Calcified Tissue International, Vol. 70, pp. 111-116, 2002.
• 伊藤剛, 田村久美子, 萩原啓実. 遺伝子解析による新しい健康影響評価法, 自動車研究, Vol. 23, No. 3, pp. 152-156, 2001.
• Hiromi Hagiwara, Eri Otsuka, Atsushi Koyama, Atsuto Inoue. Intracellular production of cGMP stimulates the differentiation of osteoblastic cells., Bone, Vol. 28, No. 5, pp. S12, 2001.
• Shigehisa Hirose, Hiromi Hagiwara, Yoshio Takei. Comparative molecular biology of natriuretic peptide receptors., Can. J. Physiol. Pharmacol., Vol. 79, No. 8, pp. 665-672, 2001.
• Takumi Yamagishi, Eri Otsuka, Hiromi Hagiwara. Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis., Endocrinology, Vol. 142, No. 8, pp. 3632-3637, 2001.
• Atsuto Inoue, Asako Kamiya, Atsushi Ishiji, Yoshiharu Hiruma, Shigehisa Hirose, Hiromi Hagiwara. Vasoactive peptide-regulated gene expression during osteoblastic differentiation. , Journal of Cardiovascular Pharmacology, Vol. 36, pp. S286-S289, 2000.
• Yasuji Yamashita, Kazuhiko Takeshige, Atsuto Inoue, Shigehisa Hirose, Ako Takamori, Hiromi Hagiwara. Condensation of mRNA for the natriuretic peptide receptor-C in hypertrophic chondrocytes of the fetal mouse tibia., Journal of Biochemistry, Vol. 127, pp. 177-179, 2000.
• Atsuto Inoue, Asako Kamiya, Atsushi Ishiji, Yoshiharu Hiruma, Shigahisa Hirose, Hiromi Hagiwara. Vasoactive peptide-regulated gene expression during osteoblastic differentiation., J. Cardiovasc. Pharmacol., Vol. 36, pp. S286-S289, 2000.
• Eri Otsuka, Yoshihisa Kato, Shigehisa Hirose, Hiromi Hagiwara. Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix., Endocrinology, Vol. 141, pp. 3006-3011, 2000.
• Atsuto Inoue, Atsushi Ishiji, Satoshi Kasagi, Masamichi Ishizuka, Shigehisa Hirose, Hiromi Hagiwara. The transcript for a novel protein with a zinc finger motif is expressed as specific stages of mouse spermatogenesis., Biochemical and Biophysical Research Communications, Vol. 273, pp. 398-403, 2000.
• Atsushi Koyama, Eri Otsuka, Atsuto Inoue, Shigehisa Hirose, Hiromi Hagiwara. Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E2., European Journal of Pharmacology, Vol. 391, pp. 225-231, 2000.
• Sachiko YUHARA, Satoshi KASAGI, Atsuto INOUE, Eri OTSUKA, Shigehisa HIROSE, Hiromi HAGIWARA. The Effects of Nicotine on Cultured Cells Suggest That It Can Influence the Formation and Resorption of Bone., Eur. J. Pharmacol., Vol. 383, pp. 387-393, 1999.
• Hiromi HAGIWARA, Mitsuhide NARUSE, Chika ADACHI, Atsuto INOUE, Yoshiharu HIRUMA, Eri OTSUKA, et al.. Ipriflavone Down-regulates the Expression of Endothelin Receptors during the Differentiation of Rat Calvarial Osteoblast-like Cells., J. Biochem., Vol. 126, pp. 168-173, 1999.
• Eri OTSUKA, Akira YAMAGUCHI, Shigehisa HIROSE, Hiromi HAGIWARA. Characterization of Osteoblastic Differentiation of Stromal Line ST2 That Is Induced by Ascorbic Acid., Am. J. Physiol., Vol. 277, pp. C132-C138, 1999.
• Atsuto INOUE, TomokoHAYAKAWA, Eri Otsuka, Asako KAMIYA, Yoshiro SUZUKI, Shigehisa HIROSE, Hiromi HAGIWARA. Correlation between Induction of Expression of Biglycan and Mineralization by C-type Natriuretic Peptidein Osteoblastic Cells., J. Biochem., Vol. 125, pp. 103-108, 1999.
• HIROMI HAGIWARA. Effect of nitric oxide form exogenous nitric oxide donors on osteoblatic metabolism., Eur. J. Pharmacol., Vol. 349, pp. 345-350, 1998.
• HIROMI HAGIWARA. Endothelins Inhibit the Mineralization of Osteobalastic MC3T3-E1 Cells through the A-type endothelin Receptor., Am. J. Physiol. (Reguratory Integrative Comp. Physiol. 44), Vol. 275, pp. R1099-R1105, 1998.
• HIROMI HAGIWARA. Deceleration by Angiotensin II of the Proliferation and Differentiation of Rat Calvarial Osteobalst-like Cells., J. Endocrinol., Vol. 156, pp. 543-550, 1998.
• HIROMI HAGIWARA. Partial cloning of the hormone-binding domain of the cortisol receptor in tilapia, oreochromis mossambicus, and changes in the mRNAA level during embryonic development., Gener. Comp Endocrinol., Vol. 108, pp. 132-140, 1997.
• HIROMI HAGIWARA. Angiotensin II Stimulates the Proliferation of Osteoblast-Rich Populations of Cells from Rat Calvariae, Biochem. Biophys. Res. Commun., Vol. 230, pp. 176, 1997.
• HIROMI HAGIWARA. Gene Expression of Nitric oxide Synthase Iaozymwa in Various Tissues of Stroke-Prone Spontaneously Hypertensive Rats, Hypertens. Res., Vol. 20, pp. 43, 1997.
• HIROMI HAGIWARA. Interrelation between Nitric Oxide Synthase and Heme Oxygenase in Rat Endothelial Cells., Eur J. Pharmacol., Vol. 331, pp. 87-91, 1997.
• HIROMI HAGIWARA. Stimulation by Retinoids of Natriuretic Peptide System of Osteoblastic MC3T3-E1 Cells, Biochem. Biophys. Res. Commun., Vol. 228, pp. 182, 1996.
• HIROMI HAGIWARA. Change in the expression of C-type natriuretic peptide and its receptor,B-type natriuretic peptide receptor, during dedifferenction of chondrocytes into fibroblast-like cells., J. Biochem., Vol. 119, pp. 264, 1996.
• HIROMI HAGIWARA. cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells., Am. J. Physiol., Vol. 270, pp. C1311, 1996.
• HIROMI HAGIWARA. Stimulation by C-type natriuretic peptide of the differentiation of clonal osteoblastic MC313-E1 cells., Biochem. Biophys. Res.Commun., Vol. 221, pp. 703, 1996.
• HIROMI HAGIWARA. Inhibition of proliferation of chondrocytes by specific receptors in response to retinoids., Biochem. Biophys. Res.Commun., Vol. 222, pp. 220, 1996.
• HIROMI HAGIWARA. Angiotensin Coverting Enzyme Inhibitor Normalizes Vascular Natriuretic Peptide Type A Receptor Gene Expression via Bradykinin-Dependent Mechanism in Hypertesive Rats, Biochem. Biophys. Res. Commun., Vol. 218, pp. 50, 1996.
• HIROMI HAGIWARA. In Situ identification of messenger RNA of endothelial type natric oxide synthase in rat cardiac myocytes, Biochem. Biophys. Res. Commun., Vol. 218, pp. 601, 1996.
• HIROMI HAGIWARA. Angiotensin II-dependent Down-regulation of Vascular Natriuretic Peptide Type C Receptor Gene Expression in Hypertensive Rats, Endocrinology, Vol. 137, pp. 1102, 1996.
• HIROMI HAGIWARA. Whole-body Autoradiography and Microautoradiography in Eels after Intra-arterial Administration of┣D1125┫D1I-Eel ANP, Am. J. Physiol. (Regulatory Integrative Comp. Physiol. ), Vol. 271, pp. R926, 1996.
• HIROMI HAGIWARA. Differential Gene Expression of Vascular Natriuretic Peptide Receptor Subtype in Artery and Vein, Biochem. Biophys. Res. Commun., Vol. 216, pp. 535, 1995.
• HIROMI HAGIWARA. Cloning and Properties of a Novel Eel Natriuretic Peptide Receptor, NPR-D, Eur. J. Biochem., Vol. 233, pp. 102, 1995.
• HIROMI HAGIWARA. Localization and Characterization of a Novel Receptor for Endothelin in the Gill of the Rainbow Trout, J. Biochem., Vol. 118, pp. 376, 1995.
• HIROMI HAGIWARA. Modulation of Vascular Natriuretic Peptide Receptor Gene Expression in Hypertensive and Obese Hyperglycemic Rats, Endocrinology, Vol. 136, pp. 2427, 1995.
• HIROMI HAGIWARA. Eel Natriuretic Peptide Receptor NPR-C : Cloning, Properties, Site-directed Mutagenensis Analysis of the Subunit Structure, Tissue Distibution and Regulation of Expression of the Type-C Eel Natiruretic Peptide Receptor, Eur. J. Biochem., Vol. 227, pp. 673, 1995.
• HIROMI HAGIWARA. Reciprocal regulation by cyclic nucleotides of differentiation of rat osteoblast-like cells and mineralization of nodules., Biochem. Biophys. Res. Commun., Vol. 215, pp. 1104, 1995.
• HIROMI HAGIWARA. Natriuretic peptides and their receptors (review), Zoological Science, Vol. 12, pp. 141, 1995.
• HIROMI HAGIWARA. Perichondrial localization of ET┣D2A┫D2 receptor in rat tracheal and xiphoid cartilage and in fetal rat epiphysis., Am. J. Physiol, Vol. 268, pp. C496, 1995.
• HIROMI HAGIWARA. His┣D1145┫D1-Trp┣D1146┫D1 residues and the disulfide-linked loops in atrial natriuretic peptide receptor are critical for the ligand-binding activity, J. Biochem, pp. 115, 1994.
• HIROMI HAGIWARA. Autocrine regulation of rat chondrocyte proliferation by natriuretic peptide C and its receptor NPR-B, J. Biol Chem, 1994.
• HIROMI HAGIWARA. Mutational analysis of disulfide bridges in the type Catrial natriuretic peptide receptor, J. Biol Chem, 1994.
• HIROMI HAGIWARA. Similarities of Soluble angiotensin-binding protein and liver microsomal endopeptidase suggest that they are identical and represent a new member of the thimet oligopeptidase family which includsmelalloedopeptidase 24.15., Eur. J. Biochem, 1994.
• HIROMI HAGIWARA. Immunochemical characterization and localization of ET┣D2B┫D2 receptor, Am. J. Physiol, No. 264, pp. 777-783, 1993.
• HIROMI HAGIWARA. High-density localization of ANP receptors in chondrocytes of eel gill cartilage, Am. J. Physiol, No. 265, pp. 474-479, 1993.
• HIROMI HAGIWARA. A dramatic pH-dependent alteration in ANP receptor density : A note for using cultured cells, Am. J. Physiol, No. 264, pp. 1345-1349, 1993.
• HIROMI HAGIWARA. Properties and Localization of Endothelin-1 Specific Receptors in Rat Testis, American Journal of Physiology, pp. 263, 1992.
• HIROMI HAGIWARA. Modulation by Nacl of Atrial Natriuretic Peptide Receptor Levels and Cyclic GMP Responsiveness to Atrial Natriuretic Peptide of Cultured Vascular Endothelial Cells, The Journal of Biological Chemistry, Vol. 267, pp. 11, 1992.
• HIROMI HAGIWARA. Purification and Characterization of Bovine Lung Endothelin Receptors, The Journal of Biological Chemistry, Vol. 266, pp. 25, 1991.
• HIROMI HAGIWARA. Cloning and Sequence Analysis of cDNA Clones for Bovine Aortic Endothelial Cell Transglutaminase, European Journal of Biochemistry, pp. 202, 1991.
• HIROMI HAGIWARA. Primary Structure of Bovine Endothelin ET┣D2B┫D2 Receptor and Identification of Signal Peptidose and Metal Proteinase Cleavage Sites, The Journal of Biological Chemistry, Vol. 266, pp. 34, 1991.
• HIROMI HAGIWARA. Structure of the Bovine Atrial Natriuretic Peptide Receptor(Type C) Gene, The Journal of Biological Chemistry, Vol. 266, pp. 17, 1991.
• HIROMI HAGIWARA. Retinol-induced Morphological Changes of Cultured Bovine Endothelial Cells Are Accompanied by a Marked Increase in Transglutaminase, The Journal of Biological Chemistry, Vol. 264, pp. 32, 1989.
• HIROMI HAGIWARA. Purification and Characterization of Angiotensinbinding Protein from Porcine Liver Cytosolic Fraction, European Journal of Biochemistry, pp. 185, 1989.
• HIROMI HAGIWARA. Purification of Atrial Natriuretic Peptide Receptor from Bovine Lung, The Journal of Biological Chemistry, Vol. 262, pp. 12, 1987.
• HIROMI HAGIWARA. Visualization of ANP Receptor on Glomeruli of Bovine Kidney by Use of a Specific Antiserum, American Journal of Physiology, pp. 253, 1987.

著書

• 萩原啓実. 動物実験に関する心得, 基礎生化学実験法　第１巻　基本操作, 基礎生化学実験法　第１巻　基本操作, Vol. 1, pp. 205-208, 2001.
• 萩原啓実. 骨粗鬆症と高血圧との関連, 東京工業大学クロニクル, 東京工業大学クロニクル, Vol. 334, pp. 3-4, 1999.

学位論文

• Studies on Endothelial cell -Ca²⁺ - or Mg²⁺ -ATPase and Plasminogen Activator-,  Thesis,  Doctor of Science,  Tokyo Institute of Technology,  1984/03/26,   
• ,  Master of Science,  東京工業大学,  1981/--/--, 

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