@book{CTT100895702, author = {Junichi Yamamoto and Tomoko Asatsuma and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {History of IMiDs and Protein Degradation as a Pharmacological Modality}, publisher = {}, year = 2022, } @article{CTT100879617, author = {Nobuyuki Shimizu and Tomoko Asatsuma-Okumura and Junichi Yamamoto and Yuki Yamaguchi and Hiroshi Handa and Takumi Ito}, title = {PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates}, journal = {Commun. Biol.}, year = 2021, } @article{CTT100832156, author = {Junichi Yamamoto and Tetsufumi Suwa and Yuki Murase and Shunpei Tateno and Hirotaka Mizutome and Tomoko Asatsuma-Okumura and Nobuyuki Shimizu and Tsutomu Kishi and Shuji Momose and Masahiro Kizaki and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells}, journal = {Nature Chemical Biology}, year = 2020, } @article{CTT100819548, author = {Shunpei Tateno and Midori Iida and Satoshi Fujii and Miki Katayama and Haruka Tokuyama and Junichi Yamamoto and Takumi Ito and Satoshi Sakamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide }, journal = {Scientific Reports}, year = 2020, } @article{CTT100819420, author = {Takahashi H and Ranjan A and Chen S and Suzuki H and Shibata M and Hirose T and Hirose H and Sasaki K and Abe R and Chen K and He Y and Zhang Y and Takigawa I and Tsukiyama T and Watanabe M and Fujii S and Iida M and Yamamoto J and Yamaguchi Y and Suzuki Y and Matsumoto M and Nakayama KI and Washburn MP and Saraf A and Florens L and Sato S and Tomomori-Sato C and Conaway RC and Conaway JW and Hatakeyama S}, title = {The role of Mediator and Little Elongation Complex in transcription termination}, journal = {Nat Commun.}, year = 2020, } @article{CTT100807675, author = {Asatsuma-Okumura T and Ando H and De Simone M and Yamamoto J and Sato T and Shimizu N and Asakawa K and Yamaguchi Y and Takumi Ito and Guerrini L and Hiroshi Handa}, title = {p63 is a cereblon substrate involved in thalidomide teratogenicity}, journal = {Nature Chemical Biology}, year = 2019, } @article{CTT100798250, author = {Ando, H. and Sato, T. and Ito, T. and Yamamoto, J. and Sakamoto, S. and Nitta, N. and Asatsuma-Okumura, T. and Shimizu, N. and Mizushima, R. and Aoki, I. and Imai, T. and Yamaguchi, Y. and Berk, A.J. and Hiroshi Handa}, title = {Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation}, journal = {iScience}, year = 2019, } @article{CTT100723497, author = {Qing-Fu Cao and Junichi Yamamoto and Tomoyasu Isobe and Shunpei Tateno and Yuki Murase and Yexi Chen and Hiroshi Handa and Yuki Yamaguchi}, title = {Characterization of the human transcription elongation factor Rtf1: evidence for non-overlapping functions of Rtf1 and the Paf1 complex}, journal = {Mol. Cell. Biol.}, year = 2015, } @article{CTT100695284, author = {Tatsuya Fukushima and Junichi Yamamoto and Masashi Fukuchi and Shuzo Hirata and Heo Hyo Jung and Osamu Hirata and Yuki Shibano and Chihaya Adachi and Hironori Kaji*}, title = {Material degradation of liquid organic semiconductors analyzed by nuclear magnetic resonance spectroscopy}, journal = {AIP Advances}, year = 2015, } @article{CTT100723499, author = {Junichi Yamamoto and Yuri Hagiwara and Kunitoshi Chiba and Tomoyasu Isobe and Takashi Narita and Hiroshi Handa and Yuki Yamaguchi}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.}, journal = {Nat. Commun.}, year = 2014, } @article{CTT100614755, author = {Kunitoshi Chiba and Junichi Yamamoto and Yuki Yamaguchi and Hiroshi Handa}, title = {Promoter-proximal pausing and its release: molecular mechanisms and physiological functions}, journal = {Exp. Cell Res.}, year = 2010, } @article{CTT100614756, author = {Sol Kim and Junichi Yamamoto and Yexi Chen and Masatoshi Aida and Tadashi Wada and Hiroshi Handa and Yuki Yamaguchi}, title = {Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation}, journal = {Genes Cells}, year = 2010, } @article{CTT100597661, author = {Yexi Chen and Yuki Yamaguchi and Yuta Tsugeno and Junichi Yamamoto and Tomoko Yamada and Mitsuhiro Nakamura and Koji Hisatake and Hiroshi Handa}, title = {DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation}, journal = {Genes Dev.}, year = 2009, } @article{CTT100549875, author = {Takashi Narita and Yung, T.M.C. and Junichi Yamamoto and Tsuboi, Y. and Tanabe, H. and Tanaka, K. and Yamaguchi, Y. and HIROSHI HANDA and and }, title = {NELF interacts with CBC and participates in 3'-end processing of replication-dependent histone mRNAs}, journal = {Mol. Cell}, year = 2007, } @inproceedings{CTT100884046, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {レナリドマイド耐性多発性骨髄腫細胞の生存に重要なポマリドマイド依存性CRL4CRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100879605, author = {山本淳一}, title = {ポマリドミド依存的なCRLCRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100879610, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {ポマリドミド依存的なCRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100879603, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {ポマリドミド依存的な CRBN のネオ基質 ARID2 の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100879607, author = {山本淳一}, title = {ポマリドミドの新規作用機序の解明 ~新規創薬標的ARID2の発見~}, booktitle = {}, year = 2021, } @inproceedings{CTT100777907, author = {山本 淳一 and Fajar Muhamad and 瑞慶覧 安里 and 舘野 峻平 and 半田宏 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位の選択機構の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777904, author = {Fajar Muhamad and Ari Zukeran and Shunpei Tateno and Junichi Yamamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Mechanisms that affect post-transcriptional fate of RNA polymerase II-transcribed genes}, booktitle = {}, year = 2017, } @inproceedings{CTT100779805, author = {高橋 秀尚 and 柴田 美音 and 瀧川 一学 and 渡部 昌 and 築山 忠維 and 山本 淳一 and 山口 雄輝 and 藤井聡 and 飯田緑 and Amol Ranjan and Shigeo Sato and Chieri Tomomori-Sato and Joan Conaway and Ronald Conaway and 畠山 鎮次}, title = {メディエーター複合体による転写終結制御機構}, booktitle = {}, year = 2017, } @inproceedings{CTT100777901, author = {Shunpei Tateno and Ari Zukeran and Junichi Yamamoto and Yuki Yamaguchi}, title = {Molecular mechanisms for polyadenylation site selection by NELF and related factors}, booktitle = {}, year = 2017, } @inproceedings{CTT100777375, author = {瑞慶覧 安里 and 舘野 峻平 and 山本淳一 and 山口 雄輝}, title = {RNAポリメラーゼⅡ転写産物の長さを決める3’末端プロセシングの制御メカニズムの解明}, booktitle = {}, year = 2017, } @inproceedings{CTT100779848, author = {瑞慶覧 安里 and 山本 淳一 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位選択のメカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100779847, author = {瑞慶覧 安里 and 山本 淳一 and 山口 雄輝}, title = {How Pol II termination and 3' processing sites are precisely determined in higher eukaryotes.高等真核生物においてPol IIの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか}, booktitle = {}, year = 2016, } @inproceedings{CTT100777373, author = {瑞慶覧 安里 and 長谷川 冴妃子 and 舘野 峻平 and 山本淳一 and 山口 雄輝}, title = {高等真核生物においてPOL Ⅱの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか}, booktitle = {}, year = 2016, } @inproceedings{CTT100777374, author = {瑞慶覧 安里 and 舘野 峻平 and 山本淳一 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位選択のメカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100779846, author = {伊藤 拓水 and 朝妻 知子 and 山本 淳一 and 安藤 秀樹 and 佐藤 智美 and 山口 雄輝 and 半田 宏}, title = {リガンド依存的ユビキチンリガーゼCRBNの制御機構}, booktitle = {}, year = 2016, } @inproceedings{CTT100777366, author = {瑞慶覧 安里 and 山本 淳一 and 磯部 智康 and 山口 雄輝}, title = {NELFを中心としたRNAの品質管理のメカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100777370, author = {山口 雄輝 and 伊藤拓水 and 山本淳一 and 半田宏}, title = {サリドマイドの多様な薬理作用の分子メカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100777361, author = {瑞慶覧 安里 and 山本 淳一 and 磯部智康 and 山口 雄輝}, title = {NELFを中心としたmRNAの品質管理のメカニズム}, booktitle = {}, year = 2015, } @inproceedings{CTT100777357, author = {山口 雄輝 and 磯部智康 and 曹 青福 and 山本 淳一}, title = {転写伸長段階の制御メカニズム:新たな制御因子の探索}, booktitle = {}, year = 2015, } @inproceedings{CTT100777829, author = {Yuki Yamaguchi and Junichi Yamamoto}, title = {Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes}, booktitle = {}, year = 2015, } @inproceedings{CTT100779842, author = {山本淳一 and 半田宏 and 山口 雄輝}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes}, booktitle = {}, year = 2015, } @inproceedings{CTT100777355, author = {Yuki Yamaguchi and Junichi Yamamoto}, title = {Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes}, booktitle = {}, year = 2014, } @inproceedings{CTT100777063, author = {山口雄輝 and 山本淳一 and 半田宏}, title = {ヒトRNA ポリメラーゼII 転写産物のプロセシング経路の選択機構}, booktitle = {}, year = 2014, } @inproceedings{CTT100779840, author = {山本淳一 and 半田宏 and 山口雄輝}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes}, booktitle = {}, year = 2014, } @misc{CTT100879615, author = {Junichi Yamamoto and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.}, year = 2022, } @misc{CTT100693459, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, year = 2014, } @misc{CTT100693511, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, year = 2014, } @misc{CTT100693382, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, year = 2014, } @misc{CTT100693438, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, year = 2014, } @misc{CTT100877450, author = {山口雄輝 and 山本淳一 and 半田 宏  and 伊藤 拓水 }, title = {抗骨髄腫剤および抗骨髄腫剤のスクリーニング方法}, howpublished = {公開特許}, year = 2022, month = {}, note = {特願2020-141689(2020/08/25), 特開2022-037510(2022/03/09)} } @phdthesis{CTT100693459, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, school = {東京工業大学}, year = 2014, } @phdthesis{CTT100693511, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, school = {東京工業大学}, year = 2014, } @phdthesis{CTT100693382, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, school = {東京工業大学}, year = 2014, } @phdthesis{CTT100693438, author = {山本淳一}, title = {RNA ポリメラーゼII転写産物の3’末端プロセシング経路の運命決定機構に関する研究}, school = {東京工業大学}, year = 2014, }