論文

• Takayuki Enomoto, Koji Wakui, Junji Hirota. Bcl11b is required for proper odorant receptor expression in the mouse septal organ, Cell and Tissue Research, 384, 643-653, Mar. 2021.
• Junji Hirota. A class I odorant receptor enhancer shares a functional motif with class II enhancers, Scientific Reports, Jan. 2021.
• Makoto Ohmoto, Satsuki Kitamoto, Junji Hirota. Expression of Eya1 in mouse taste buds, Cell and Tissue Research, Vol. 382, No. 3, in press, Nov. 2020.
• Makoto Ohmoto, Weiwei Lei, Junpei Yamashita, Junji Hirota, Peihua Jiang, Ichiro Matsumoto. SOX2 regulates homeostasis of taste bud cells and lingual epithelial cells in posterior tongue, PLOS ONE, Oct. 2020.
• Takayuki Enomoto, Hidefumi Nishida, Tetsuo Iwata, Akito Fujita, Kanako Nakayama, Takahiro Kashiwagi, Yasue Hatanaka, Hiro Kondo, Rei Kajitani, Takehiko Itoh, Makoto Ohmoto, Ichiro Matsumoto, Junji Hirota. Bcl11b controls the odorant receptor class choice in mice, Communications Biology, Springer Nature, 2, 1, 296, Aug. 2019.
• Hikoyuu Suzuki, Hidefumi Nishida, Hiro Kondo, Ryota Yoda, Tetsuo Iwata, Kanako Nakayama, Takayuki Enomoto, Jiaqi Wu, Keiko Moriya-Ito, Masao Miyazaki, Yoshihiro Wakabayashi, Takushi Kishida, Masataka Okabe, Yutaka Suzuki, Takehiko Itoh, Junji Hirota, Masato Nikaido. A Single Pheromone Receptor Gene Conserved across 400 My of Vertebrate Evolution, Molecular biology and evolution, Oxford University Press, Vol. 35, No. 12, 2928-2939, Sept. 2018.
• Junpei Yamashita, Makoto Ohmoto, Tatsuya Yamaguchi, Ichiro Matsumoto, Junji Hirota. Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice, PLOS ONE, Dec. 2017.  公式リンク  
  
• Tetsuo Iwata, Yoshihito Niimura, Chizuru Kobayashi, Daichi Shirakawa, Hikoyuu Suzuki, Takayuki Enomoto, Kazushige Touhara, Yoshihiro Yoshihara, Junji Hirota. A Long-Range cis-Regulatory Element for Class I Odorant Receptor Genes, Nature Communications, Oct. 2017.  公式リンク  
  
• Makoto Ohmoto, Wenwen Ren, Yugo Nishiguchi, Junji Hirota, Peihua Jiang, Ichiro Matsumoto. Genetic Lineage Tracing in Taste Tissues Using Sox2-CreERT2 Strain, Chemical Senses, June 2017.
• Yamashita, Junpei, Ohmoto, Makoto, Yamaguchi, Tatsuya, Matsumoto, Ichiro, Junji Hirota. Pou2f3/Skn-1a is required for the functional differentiation of Trpm5-expressing cells in multiple tissues, 17th International Symposium on Olfaction and Taste (ISOT), CHEMICAL SENSES, OXFORD UNIV PRESS, Vol. 41, No. 9, pp. E136-E136, Nov. 2016.
• Yugo Nishiguchi, Makoto Ohmoto, Jun Koki, Takayuki Enomoto, Ryo Kominami, Ichiro Matsumoto, Junji Hirota. Bcl11b/Ctip2 is required for development of lingual papillae in mice, Developmental Biology, 416, 98-110, June 2016.
• Ogawa T., Iwata T., Kaneko S., Itaya M., Hirota J.. An inducible recA expression Bacillus subtilis genome vector for stable manipulation of large DNA fragments., BMC Genomics, Vol. 16, p. 209, Mar. 2015.
• Tatsuya Yamaguchi, Junpei Yamashita, Makoto Ohmoto, Imad Aoudé, Tatsuya Ogura, Wangmei Luo, Alexander A Bachmanov, Weihong Lin, Ichiro Matsumoto, Junji Hirota. Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium, BMC Neuroscience, 15, 13, 2014.
• Makoto Ohmoto, Tatsuya Yamaguchi, Junpei Yamashita, Alexander A Bachmanov, Junji Hirota, Ichiro Matsumoto. Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity, Bioscience Biotechnology and Biochemistry, 77, 10, 2154-2156, Oct. 2013.
• Iwata T., Kaneko S., Shiwa Y., Enomoto T., Yoshikawa H., *Hirota J.. Bacillus subtilis genome vector-based complete manipulation and reconstruction of genomic DNA for mouse transgenesis., BMC Genomics, Vol. 14, No. 1, p. 300, May 2013.
• Takayuki Enomoto, Makoto Ohmoto, Tetsuo Iwata, Ayako Uno, Masato Saitou, Tatsuya Yamaguchi, Ryo Kominami, Ichiro Matsumoto, Junji Hirota. Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice, Journal of Neuroscience, 2011.
• 榎本孝幸, 木南凌, 廣田順二. マウス嗅覚系におけるBcl11b遺伝子発現解析, 日本味と匂学会誌, Vol. 15, No. 3, pp. 569-572, Dec. 2008.
• 榎本孝幸, 木南凌, 廣田順二. 鋤鼻神経系におけるBcl11bの機能解析, 日本味と匂学会誌, Vol. 14, No. 3, pp. 553-556, Dec. 2007.
• 廣田順二, 大村真代, Peter Mombaerts. Lhx2遺伝子欠損マウスにおけるクラス依存的な嗅覚受容体遺伝子発現, 日本味と匂学会誌, Vol. 14, No. 3, pp. 549-52, Dec. 2007.
• Junji Hirota, Masayo Omura, Peter Mombaerts. Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse, Molecular and Cellular Neuroscience, Vol. 34, pp. 679-688, 2007.
• Andrea Rothman, Junji Hirota, Paul Feinstein, Peter Mombaerts. The Promoter of the mouse odorant receptor gene M71, Molecular and Cellular Neuroscience, Vol. 28, pp. 535-548, 2005.
• Junji Hirota, Peter Mombaerts. The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons, Proceeding of National Academy of Science, USA, Vol. 101, No. 23, pp. 8751-8755, June 2004.
• Piero Carninci, Kazunori Waki, Toshiyuki Shiraki, Hideaki Konno, Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Takahiro Arakawa, Yoshiyuki Ishii, Daisuke Sasaki, Hidemasa Bono, Shinji Kondo, Yuichi Sugahara, Rintaro Saito, Naoki Osato, Shiro Fukuda, Kenjiro Sato, Akira Watahiki, Tomoko Hirozane-Kishikawa, Mari Nakamura, Yuko Shibata, Ayako Yasunishi, Noriko Kikuchi, Atsushi Yoshiki, Moriaki Kusakabe, Stefano Gustincich, Kirk Beisel, William Pavan, Vassilis Aidinis, Akira Nakagawara, William A. Held, Hiroo Iwata, Tomohiro Kono, Hiromitsu Nakauchi, Paul Lyons, Christine Wells, David A. Hume, Michela Fagiolini, Takao K. Hensch, Michelle Brinkmeier, Sally Camper, Junji Hirota, Peter Mombaerts, Masami Muramatsu, Yasushi Okazaki, Jun Kawai, Yoshihide Hayashizaki. Targeting a complex transcriptome: The construction of the mouse full-length cDNA encyclopedia, Genome Research, Cold Spring Harbor Laboratory Press, Vol. 13, No. 6B, pp. 1273-1289, 2004.
• Junji Hirota, Ishii Tomohiro, Mombaerts Peter. Combinatorial Coexpression of Neural and Immune Multigene Families in Mouse Vomeronasal Sensory Neurons, Current Biology, Elsevier Science Ltd., Vol. 13, pp. 394-400, Mar. 2003.
• Junji Hirota, Hideaki Ando, Kozo Hamada, Katsuhiko Mikoshiba. Carbonic Anhydrase-Related Protein is a Novel Binding Protein for Inositol 1,4,5-Trisphosphate Receptor Type 1, Biochemical Journal, Vol. 372, pp. 435-441, 2003.
• Kozo Hamada, Tomoko Miyata, Kouta Mayanagi, Junji Hirota, Katsuhiko Mikoshiba. Two-state Conformational Changes in Inositol 1,4,5-Trisphosphate Receptor Regulated by Calcium, Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, Vol. 277, No. 24, pp. 21115-21118, June 2002.
• Junji Hirota, Teiichi Furuichi, Katsuhiko Mikoshiba. Inositol 1,4,5-Trisphosphate Receptor Type 1, a Newly Identified Substrate for Caspase-3, is Cleaved by Caspase-3 during Apoptosis, Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, Vol. 274, pp. 34433-34437, 2002.
• Takayuki Michikawa, Junji Hirota, Seiko Kawano, Masayasu Hiraoka, Maki Yamada, Teiichi Furuichi, Katsuhiko Mikoshiba. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor, Neuron, Cell Press, Vol. 23, pp. 799-808, Aug. 1999.
• Junji Hirota, Takayuki Michikawa, Tohru Natsume, Teiichi Furuichi, Katsuhiko Mikoshiba. Calmodulin Inhibits Inositol 1,4,5-Trisphosphate-induced Ca2+ Release by the Purified and Reconstituted Inositol 1,4,5-Trisphosphate Receptor Type 1, FEBS Letters, Federation of European Biochemical Societies, Vol. 456, pp. 322-326, 1999.
• Tohru Natsume, Junji Hirota, Fumio Yoshikawa, Teiichi Furuichi, Katsuhiko Mikoshiba. Realtime Kinetic Analysis of the Interaction between Inositol 1,4,5-Trisphosphate Receptor and its Ligand, Biochemical and Biophysical Research Communications, Academic Press, Vol. 260, pp. 527-533, 1999.
• Junji Hirota, Masashi Baba, Mineo Matsumoto, Teiichi Furuichi, Kiyoshi Takatsu, Katsuhiko Mikoshiba. T-cell Receptor Signalling in Inositol 1,4,5-Trisphosphate Receptor Type 1 Deficient Mice. Is IP3R type 1 essential for TCR signalling?, Biochemical Journal, Vol. 333, pp. 615-619, 1998.
• Junji Hirota, Takayuki Michikawa, Atsushi Miyawaki, Teiichi Furuichi, Ichiro Okura, Katsuhiko Mikoshiba. Kinetics of calcium release by the immunoaffinity-purified inositol 1,4,5-trisphosphate receptor reconstituted into lipid vesicles, Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, Vol. 270, No. 32, pp. 19046-19051, Aug. 1995.
• Junji Hirota, Takayuki Michikawa, Atsushi Miyawaki, Masaaki Takahashi, Kazuhiko Tanzawa, Ichiro Okura, Teiichi Furuichi, Katsuhiko Mikoshiba. Adenophostin-mediated quantal Ca2+ release in the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1, FEBS Letters, Federation of European Biochemical Societies, Vol. 368, pp. 248-252, 1995.
• Junji Hirota, ICHIRO OKURA. Photoinduced intramolecular electron transfer in bisviologen-linked porphyrin in acetonitrile, Porphyrins, Vol. 3, No. 4, pp. 383-388, Dec. 1994.
• Junji Hirota, ICHIRO OKURA, toshiaki kamachi. Characterization of sulfonated zinc phthalocyanines as photosensitizers for photodynamic therapy, Lasers in the Life Sciences, Harwood Academic Publishers, Vol. 6, No. 3, pp. 173-179, May 1994.
• Junji Hirota, Tetsu Takeno, ICHIRO OKURA. Preparation and characterization of bisviologen-linked porphyrin and bisviologen-linked zinc porphyrin, Journal of Photochemistry and Photobiology A: Chemistry,, Elsevier, Vol. 77, pp. 29-35, Jan. 1994.
• Junji Hirota, ICHIRO OKURA. Photoinduced intramolecular electron transfer in bisviologen-linked porphyrin in acetonitrile, Journal of Physical Chemistry, American Chemical Society, Vol. 97, No. 26, pp. 6867-6870, 1993.

著書

• 廣田順二. 嗅覚受容体のクラス選択と遺伝子発現機構の分子メカニズム, 「においのセンシング、分析とその可視化、数値化」, 技術情報協会, pp. 17-25, Oct. 2020.

国際会議発表 (査読有り)

• Takayuki Enomoto, Hidefumi Nishida, Tetsuo Iwata, Akito Fujita, Kanako Nakayama, Takahiro Kashiwagi, Yasue Hatanaka, Hiro Kondo, Rei Kajitani, Takehiko Itoh, Makoto Ohmoto, Ichiro Matsumoto, Junji Hirota. Mechanism of odorant receptor class choice in mice, The 48th Naito Conference on Integrated Sensory Sciences - Pain, Itch, Smell and Taste, Oct. 2019.

国際会議発表 (査読なし・不明)

• Junji Hirota. Odorant receptor class choice and olfactory behaviors, International Symposium on “Environmental Response Mechanisms in Plants and Animals, Jan. 2020.
• Junji Hirota. Mechanism of odorant receptor class choice in mice, Association for Chemoreception Sciences, Apr. 2019.
• Junji Hirota. Mechanism of odorant receptor class choice in mice, The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Nov. 2018.
• Junji Hirota. Bcl11b Governs the Binary Fate of Olfactory Sensory Neurons, The 14th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Fukuoka, Dec. 2016.
• Tetsuo Iwata, Shinya Kaneko, Ogawa, Takafumi, Kobayashi, Chizuru, Shiwa, Yuh, Enomoto, Takayuki, Yoshikawa, Hirofumi, Junji Hirota. Studies on the cis-element for mouse class I odorant receptor genes using the Bacillus subtilis genome vector, 17th International Symposium on Olfaction and Taste (ISOT), CHEMICAL SENSES, OXFORD UNIV PRESS, Vol. 41, No. 9, pp. E208-E208, Nov. 2016.
• Kanako Nakayama, Hikoyu Suzuki, Masato Nikaido, Takayuki Enomoto, Junji Hirota. Expression analysis of Bcl11b in Xenopus tropicalis olfactory epithelium, The 17th International Symposium on Olfaction and Taste, June 2016.
• Chizuru Kobayashi, Tetsuo Iwata, Niles Galjart, Junji Hirota. Functional analysis of CTCF in odorant receptor gene expression in mice, The 17th International Symposium on Olfaction and Taste, June 2016.

国内会議発表 (査読なし・不明)

• 北本颯希, 應本真, 廣田順二. 味細胞に発現する転写因子の探索, Oct. 2020.
• 近藤宏, 岩田哲郎, 村田 健, 鈴木彦有, 東原和成, 二階堂雅人, 廣田順二. 広範な脊椎動物に保存される新規V1R遺伝子ancV1Rの機能解析, 日本味と匂学会第54回大会, Oct. 2020.
• 廣田順二. 嗅覚受容体のクラス選択と嗅覚行動, 日本味と匂学会第54回大会, Oct. 2020.
• 廣田順二. 嗅覚受容体の遺伝子発現制御機構, 第92回日本生化学会大会, Sept. 2019.
• 久保田理子, 永嶌鮎美, 宮崎雅雄, 廣田順二. 羊水中脂肪酸の匂いがもたらすマウスの生理行動とその分子基盤の解明, 日本味と匂い学会第53回大会, Sept. 2019.
• 近藤宏, 岩田哲郎, 鈴木彦有, 永嶌鮎美, 村田健, 東原和成, 二階堂雅人, 廣田順二. 新規鋤鼻受容体候補分子ancV1R のフェロモン受容における役割, 日本味と匂い学会第53回大会, Sept. 2019.
• 岩田哲郎, 榎本孝幸, 廣田順二. Class I嗅覚受容体遺伝子の発現制御機構, 日本味と匂い学会第53回大会, Sept. 2019.
• 久保田理子, 永嶌鮎美, 廣田順二. 羊水中の匂い分子がマウスの生理行動を促す分子基盤の解明, Mar. 2019.
• 岩田哲郎, 留岡諭志, 廣田順二. Class I嗅覚受容体遺伝子転写調節領域の機能解明, 第６回ケモビ研究会, Mar. 2019.
• 近藤宏, 二階堂雅人, 廣田順二. 新規フェロモン受容体候補分子ancV1Rの機能解, 第６回ケモビ研究会, Mar. 2019.
• 廣田順二. 嗅神経細胞の個性決定の分子機構, 5th NCU Life Science Seminar, Jan. 2019.
• 柏木貴裕, 榎本孝幸, 岩田哲郎, 廣田順二. 転写因子Bcl11bによる嗅神経細胞の二者択一的運命決定の制御機構の解明, 日本味と匂学会第52回大会, Oct. 2018.
• 近藤宏, 岩田哲郎, 鈴木彦有, 永嶌鮎美, 二階堂雅人, 廣田順二. 新規フェロモン受容体候補分子ancV1Rの機能解明, 日本味と匂学会第52回大会, Oct. 2018.
• 留岡諭志, 岩田哲郎, 廣田順二. Class I 嗅覚受容体遺伝子の転写調節領域の機能解析, 日本味と匂学会第52回大会, Oct. 2018.
• 猪爪舞花, 岩田哲郎, Saiku Daniel, 齋藤真人, 飯塚遥香, 小澤悠太, 永嶌鮎美, 廣田順二. 嗅覚受容体遺伝子発現における転写因子Ldb1の機能解析, 日本味と匂学会第52回大会, Oct. 2018.
• 岩田哲郎, 新村芳人, 小林千鶴, 白川大地, 鈴木彦有, 榎本孝幸, 東原和成, 吉原良浩, 廣田順二. 嗅覚受容体巨大遺伝子クラスターを制御する長距離シスエレメント, 日本遺伝学会第90回大会, Sept. 2018.
• 依田涼太, 鈴木彦有, 岩田哲郎, 廣田順二, 二階堂雅人. 広範な脊椎動物に共通に存在するフェロモン受容体遺伝子の進化解析, 日本進化学会第20回大会, Aug. 2018.
• 鈴木彦有, 佐久間敦丈, 依田涼太, 岡部 正隆, 伊藤武彦, 廣田順二, 二階堂雅人. 脊椎動物の４億年以上に渡る進化の過程で保持されてきたフェロモン受容体, 第8回 Tokyo Vertebrate Morphology Meeting, Aug. 2018.
• Tetsuo Iwata, Yoshihito Niimura, Chizuru Kobayashi, Daichi Shirakawa, Hikoyu Suzuki, Takayuki Enomoto, Kazushige Touhara, Yoshihiro Yoshihara, Junji Hirota. An extraordinary long-range cis-regulatory element for class I odorant receptor genes, ゲノム編集学会第3回大会, June 2018.
• 鈴木彦有, 依田涼太, 岩田哲郎, 廣田順二, 二階堂雅人. 広範な脊椎動物が共有する新規フェロモン受容体の進化と機能, 日本動物学会第88回大会, Sept. 2017.
• 鈴木彦有, 岩田哲郎, 依田涼太, 廣田順二, 二階堂雅人. 広範な脊椎動物が共有する新規フェロモン受容体の進化と機能, 日本進化学会第19回大会, Aug. 2017.
• 鈴木彦有, 西田秀史, 廣田順二, 二階堂雅人. 全ての脊椎動物に共通な新規フェロモン受容体の機能解明, 日本動物学会第86回大会, Sept. 2015.
• 小河貴郁, 岩田哲郎, 金子真也, 板谷光泰, 廣田順二. RecA誘導型枯草菌ゲノムベクターシステムの開発とトランスジェネシスへの応用, 第37回日本分子生物学会年会, Nov. 2014.
• 鈴木彦有, 西田秀史, 廣田順二, 二階堂雅人. 脊椎動物に保存された新規V1R 遺伝子の機能と進化, 第16回日本進化学会, Aug. 2014.
• 小河貴郁, 岩田哲郎, 金子真也, 廣田順二. RecA誘導型枯草菌ゲノムベクターシステムの開発とトランスジェネシスへの応用, 第36回日本分子生物学会年会, Dec. 2013.
• 岩田哲郎, 金子真也, 廣田順二. 合成ゲノムベクターを用いたマウスゲノム改変, 日本農芸化学会2012年度(平成24年度)大会 シンポジウム, Mar. 2012.
• Tetsuo Iwata, Shinya Kaneko, Junji Hirota. Generation of transgenic mouse using the Bacillus subtilis genome vector system., 第34回日本分子生物学会年会, Dec. 2011.
• 金子真也, 岩田哲郎, 廣田順二, 板谷光泰. ゲノムベクターを用いたマウス遺伝子改変操作への適用, 日本遺伝学会第83回大会 ワークショップ, Sept. 2011.
• 吉村文孝, 廣田順二, 中村一隆, 若井史博, 吉本護, 小田原修, 和田裕之. バイオイメージングに向けた長残光ナノ粒子の作製と光学特性, 第48回セラミックス基礎科学討論会, 12C17, Jan. 2010.

その他の論文・著書など

• 榎本孝幸, 廣田順二. 嗅覚受容体のクラス選択の制御機構と嗅覚の陸棲適応, アロマリサーチ, レグレランスジャーナル社, Vol. 21, No. 1, p. 76-81, Jan. 2020.
• 岩田哲郎, 廣田順二. 嗅覚受容体の遺伝子クラスター, Clinical Neuroscience, 中外医学社, Vol. 37, p. 1432-1435, Dec. 2019.
• 廣田順二. 香りを感知する嗅神経細胞の多様性創出のメカニズム, 香料, 日本香料協会, Vol. 284, p. 59-65, Dec. 2019.
• 山下純平, 廣田順二. 舌だけではない！体を守る味細胞, academist Journal, Dec. 2018.  公式リンク  
  
• 岩田哲郎, 廣田順二. 匂い受容体遺伝子の新たな発現制御領域の発見, アロマリサーチ, 19, 2, 32-33, Nov. 2018.
• 岩田哲郎, 廣田順二. ゲノム最大級の巨大遺伝子クラスターを制御するゲノム領域の発見, バイオサイエンスとインダストリー, 76, 3, 232-233, May 2018.
• 廣田順二. 遺伝子からみた匂いの感覚, アロマリサーチ, 16, 2, 172-175, Dec. 2015.
• 廣田順二. 心に触れる匂いの記憶, 日本味と匂学会誌, 日本味と匂学会, Vol. 20, No. 3, pp. 189-190, Dec. 2013.
• 廣田順二. 水棲から陸棲へ、嗅覚受容体の分子進化と遺伝子発現制御, 日本味と匂学会誌, Vol. 14, No. 2, pp. 179-186, 2007.

特許など

• 小野寺 裕司, 布川 貴史, 中村一隆, 廣田順二, 小田原修, 和田裕之. 蛍光粒子およびその製造方法. 特許. 公開. 国立大学法人東京工業大学. 2011/07/01. 特願2011-147041. 2013/01/24. 特開2013-014651. 2013. Jan.

学位論文

• Kinetic studies on calcium release by the inositol 1,4,5-trisphosphate receptor,  Thesis,  Doctor of Engineering,  Tokyo Institute of Technology,  1995/09/30,   

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