論文

• R. Sonobe, P. Yang, M.M. Suzuki, K. Shinjo, K. Iijima, N. Nishiyama, K. Miyata, K. Kataoka, H. Kajiyama, Y. Kondo. Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta, Cancer Science, Vol. 115, No. 6, pp. 1910-1923, Apr. 2024.
• Y. Hattori, T. Andoh, S. Kawabata, N. Hu, H. Michiue, H. Nakamura, T. Nomoto, M. Suzuki, T. Takata, H. Tanaka, T. Watanabe, K. Ono. Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy, Journal of Radiation Research, vol. 64, No. 6, p. 859, Nov. 2023.
• Shan Gao, Y. Miura, A. Sumiyoshi, S. Ohno, K. Ogata, T. Nomoto, M. Matsui, Y. Honda, M. Suzuki, M. Iiyama, K. Osada, I. Aoki, N. Nishiyama. Self-folding macromolecular drug carrier for cancer imaging and therapy, Advanced Science, Vol. 11, No. 7, pp. e2304171, Nov. 2023.
• H. Kashiwagi, S. Kawabata, K. Yoshimura, Y. Fukuo, T. Kanemitsu, K. Takeuchi, R. Hiramatsu, K. Nishimura, K. Kawai, T. Takata, H. Tanaka, T. Watanabe, M. Suzuki, S. Miyatake, H. Nakamura, M. Wanibuchi. Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model, Investigational new drugs, Nov. 2021.
• H. Yanagie, M. Yanagawa, K. Mouri, Y. Morishita, A. Shinohara, N. Dewi, Y. Nonaka, Y. Furuya, R. Mizumachi, Y. Murata, H. Nakamura, M. Suzuki, Y. Sakurai, H. Tanaka, S. Masunaga, K. Ono, T. Sugihara, M. Nashimoto, H. Yamauchi, M. Ono, J. Nakajima, H. Terada, H. Takahashi. Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems, In Vivo, Vol. 35, no. 6, pp. 3125–3135, Nov. 2021.
• Paviter Singh, Manjot Kaur, Kulwinder Singh, Gurpreet Kaur, Ramovatar Meena, Manpreet Kaur, Bikramjeet Singh, Anup Thakur, Jeewan Sharma, Ajay Singh, Manjeet Kumar, Ju-Hyung Yun, Fumiko Nakagawa, Minoru Suzuki, Hiroyuki Nakamura, Akshay Kumar. Fluorescent Boron Carbide Quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy, Physica E: Low-Dimensional Systems and Nanostructures., 132, 114766, Apr. 2021.
• Takahiro Nomoto, Ying Yao, Yukiya Inoue, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama. Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy, Journal of Controlled Release, Vol. 332, pp. 184-193, Feb. 2021.  公式リンク  
  
• Kazuki Kawai, Kai Nishimura, Satoshi Okada, Shinichi Sato, Minoru Suzuki, T. Takata, Hiroyuki Nakamura. Cyclic RGD-Functionalized closo-Dodecaborate Albumin Conjugates as Integrin Targeting Boron Carriers for Neutron Capture Therapy, Mol. Pharm., Vol. 17, No. 10, pp. 3740–3747, Aug. 2020.
• T. Kanemitsu S. Kawabata, M. Fukumura, G. Futamura, R. Hiramatsu, N. Nonoguchi, F. Nakagawa, T. Takata, H. Tanaka, M. Suzuki, S.-I. Masunaga, K. Ono, S.-I. Miyatake, H. Nakamura, T. Kuroiwa. Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats., Radiat. Environ. Biophys, Vol. 58, No. 1, Page 59-67, Nov. 2018.
• P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka, N. Nishiyama. Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors, J. Control. Release, Vol. 254, pp. 1-9, May 2017.
• Shunsuke Kikuchi, Daisuke Kanoh, Shinichi Sato, Yoshinori Sakurai, Minoru Suzuki, Hiroyuki Nakamura. Maleimide-Functionalized closo-Dodecaborate Albumin Conjugates (MID-AC): The Unique Ligation at both Cysteine and Lysine Residues Enabling to Efficient Boron Delivery to Tumor for Neutron Capture Therapy, J. CONTROL. RELEASE, Vol. 237, No. 10, pp. 160-167, July 2016.
• Masao Sasai, Hiroyuki Nakamura, Nagao Sougawa, Yoshinori Sakurai, Minoru Suzuki, Chun Man Lee. Novel Hyaluronan Formulation Enhances the Efficacy of Boron Neutron Capture Therapy for Murine Mesothelioma, Anticancer research, Vol. 36, No. 3, pp. 907-911, Feb. 2016.
• Novriana Dewi, Peng Mi, Hironobu Yanagie, Yuriko Sakurai, Yasuyuki Morishita, Masashi Yanagawa, Takayuki Nakagawa, Atsuko Shinohara, Takehisa Mastukawa, Kazuhito Yokoyama, Cabral Horacio, Minoru Suzuki, Yoshinori Sakurai, Hiroki Tanaka, Koji Ono, Nobuhiro Nishiyama, Kazunori Kataoka, Hiroyuki Takahashi. In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent, Journal of Cancer Research and Clinical Oncology, Vol. 142, No. 4, pp. 767-775, Dec. 2015.  公式リンク  
  
• Peng Mi, Novriana Dewi, Hironobu Yanagie, Daisuke Kokuryo, Minoru Suzuki, Yoshinori Sakurai, Yanmin Li, Ichio Aoki, Koji Ono, Hiroyuki Takahashi, Cabral Horacio, Nobuhiro Nishiyama, Kazunori Kataoka. Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy, Acs Nano, Vol. 9, No. 6, pp. 5913-5921, June 2015.  公式リンク  
  
• Hiroyuki Nakamura, Koganei Hayato, Miyoshi Tatsuro, Sakurai Yoshinori, Ono Koji, Suzuki Minoru. Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT, Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 2, pp. 172-174, Dec. 2014.

国際会議発表 (査読有り)

• Kai Nishimura, Taiki Morita, Satoshi Okada, Takumi Ogawara, Takushi Takata, Minoru Suzuki, Hiroyuki Nakamura. Development of an albumin-based boron delivery system for neutron capture therapy, The 13th AFMC International Medicinal Chemistry Symposium (AIMECS-2021), Nov. 2021.
• Takahiro Nomoto, Yukiya Inoue, Ying Yao, Kaito Kanamori, Minoru Suzuki, Kakeru Konarita, Makoto Matsui, Nobuhiro Nishiyama. Synthesis of functional polymers boosting therapeutic potential of p-boronophenylalanine and analysis of the effect of their physicochemical properties on pharmacokinetics, 19th International Congress on Neutron Capture Therapy (19th ICNCT), Sept. 2021.
• Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama. Poly(vinyl alcohol) for enhancing therapeutic effects of p-boronophenylalanine in neutron capture therapy, International Symposium on Biomedical Materials for Drug/Gene Delivery, Feb. 2020.
• 野本貴大, 井上透矢, YAOYing, 鈴木実, 金盛開人, 武元宏泰, 松井誠, 友田敬士郎, 西山伸宏. Metabolism-controlled boron delivery systems composed of biocompatible polymers and boronophenylalanine for neutron capture therapy, Abstracts of Papers of the American Chemical Society, 2019.  公式リンク  
  
• Ying Yao, Takahiro Nomoto, Yukiya Inoue, Minoru Suzuki, Makoto Matsui, Hiroyasu Takemoto, Keishiro Tomoda, Nobuhiro Nishiyama. Enhanced tumor-targeted delivery of p-boronophenylalanine using fructose-functionalized polymers for boron neutron capture therapy, 18th International Congress on Neutron Capture Therapy, Oct. 2018.
• Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama. Metabolism-controlled boron delivery systems composed of p-boronophenylalanine and poly(vinyl alcohol), 18th International Congress on Neutron Capture Therapy, Oct. 2018.

国内会議発表 (査読有り)

• 野本貴大, 井上透矢, YAOYing, 金盛開人, 鈴木実, 小成田翔, 松井誠, 西山伸宏. 側鎖に糖構造を有する高分子とボロノフェニルアラニンから構成される薬物送達システムの設計, 第17回日本中性子捕捉療法学会学術大会, July 2021.
• Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Kakeru Konarita, Hiroyasu Takemoto, Makoto Matsui, Nobuhiro Nishiyama. Development of functional polymers to boost therapeutic potential of boronophenylalanine in neutron capture therapy, 第69回高分子討論会, Sept. 2020.

国際会議発表 (査読なし・不明)

• Kai Nishimura, Taiki Morita, Satoshi Okada, Takumi Ogawara, Takushi Takata, Minoru Suzuki, Hiroyuki Nakamura. Development of an albumin-based boron delivery system for neutron capture therapy, The 19th International Congress on Neutron Capture Therapy (ICNCT 19), Sept. 2021.
• Hiroyuki Nakamura, Kazuki Kawai, Kai Nishimura, Satoshi Okada, Takushi Takata, Minoru Suzuki. Albumin-Based Boron Delivery for Active Targeting to Tumor, 22nd Taiwan-Japan Neutron Capture Therapy Academic Conference of Elite, oral (online, Taiwan), Oct. 2020.
• Hiroyuki Nakamura, Kazuki Kawai, Takushi Takata, Minoru Suzuki. Development of Cyclic RGD-functionalized Maleimide-closo-dodecaborate Albumin Conjugate (cRGD-MID-AC) as a Tumor Targeting Boron Carrier, yBNCT10, Sept. 2019.
• Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Makoto Matsui, Hiroyasu Takemoto, Nobuhiro Nishiyama. Boosting Therapeutic Potential of p-Boronophenylalanine Using Biocompatible Polymers, The 10th Young Member’s Boron Neutron Capture Therapy (10th YBNCT), Sept. 2019.
• Kaito Kanamori, Takahiro Nomoto, Minoru Suzuki, Hiroyasu Takemoto, Makoto Matsui, Nobuhiro Nishiyama. Boron Delivery Using Sugar-Modified Polymers for Neutron Capture Therapy, The 3rd Workshop for Japan-Korea Young Scientists on Pharceutics, 2019.
• Yuto Honda, Naoki Yamada, Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama. Tumor cell-targeting glutamine-derived polymer that can interact with high density glutamine transporter based on aberrant glutamine metabolism., The 12th SPSJ International Polymer Conference (IPC2018), Dec. 2018.

国内会議発表 (査読なし・不明)

• 登倉大貴, 小成田翔, 鈴木実, 本田雄士, 西山伸宏, 野本貴大. PHPMA を基盤としたホウ素中性子捕捉療法用薬物送達システムの開発, 第72回高分子討論会, Sept. 2023.
• 中村浩之, 西村開, 盛田大輝, 岡田智, 三浦一輝, 柏木秀基, 福尾祐介, 松本孔貴, 鈴木実, 中井啓, 川端信司. 中性子捕捉療法のための血清アルブミンを利用したホウ素キャリアの開発, 第27 回癌治療増感研究会, Apr. 2022.
• 西村開, 盛田大輝, 岡田智, 三浦一輝, 柏木秀基, 福尾祐介, 松本孔貴, 高田卓志, 鈴木実, 中井啓, 川端信司, 中村浩之. 中性子捕捉療法のための、アルブミンリガンドを基軸としたホウ素キャリアの開発, 日本薬学会142春季年会, Mar. 2022.
• 西村開, 盛田大輝, 岡田智, 小川原巧, 柏木秀基, 福尾祐介, 松本孔貴, 高田卓志, 鈴木実, 中井啓, 川端信司, 中村浩之. 中性子捕捉療法のためのアルブミンをプラットホームとした低分子ホウ素薬剤PBC-IPの開発, 第17回日本中性子捕捉療法学会, July 2021.
• 野本貴大, 小成田翔, 鈴木実, 松井誠, 西山伸宏. ポリビニルアルコールを利用したボロノフェニルアラニンの中性子捕捉療法における治療効果向上, 第37回日本DDS学会学術集会, June 2021.
• 小成田翔, 野本貴大, 金盛開人, 鈴木実, 松井誠, 三浦裕, 西山伸宏. Poly(vinyl alcohol)と D-4-boronophenylalanine から構成される 薬物送達システムによるホウ素中性子捕捉療法の検討, 第70回高分子学会年次大会, May 2021.
• 野本貴大, 井上透矢, YAOYing, 金盛開人, 鈴木実, 武元宏泰, 松井誠, 西山伸宏. 生体適合性高分子とボロノフェニルアラニンから構成される中性子捕捉療法用代謝制御型ホウ素送達システム, 第41回日本バイオマテリアル学会大会, Nov. 2019.
• 野本貴大, 井上透矢, YAOYing, 金盛開人, 鈴木実, 武元宏泰, 松井誠, 友田敬士郎, 西山伸宏. 生体適合性高分子とp-boronophenylalanineから構成されるホウ素送達システムの開発と構成高分子の物性が体内動態と治療効果に与える影響に関する考察, 第16回日本中性子捕捉療法学会, Sept. 2019.
• 金盛開人, 野本貴大, 鈴木実, 武元宏泰, 松井誠, 西山伸宏. ボロン酸エステルを利用したホウ素薬物送達キャリアの開発, 第35回日本DDS学会学術集会, July 2019.
• 中村浩之, 川井一輝, 高田卓志, 鈴木実. cRGDペプチドを利用したアルブミンーホウ素キャリアの腫瘍ターゲティング, 第25回癌治療増感研究会, June 2019.
• 金盛開人, 野本貴大, 鈴木実, 武元宏泰, 松井誠, 西山伸宏. 糖修飾高分子とホウ素薬物から構成される薬物送達システムの開発, 第68回高分子学会年次大会, May 2019.
• Takuya Kanemitsu, Shinji Kawabata, Masao Fukumura, GenFutamura, Ryo Hiramatsu, Fumiko Nakagawa, Takushi Takata, Hiroki Tanaka Yoshinori Sakurai, Minoru Suzuki, Ono Koji, Toshihiko Kuroiwa, Shin-Ichi Miyatake, Hiroyuki Nakamura. Evalutaion of folate receptor targeted novel boron compound for boron neutron capture therapy using rat brain tumor model, 18th International Congress on Neutron Capture Therapy, Oct. 2018.
• 野本 貴大, 井上 透矢, Yao Ying, 鈴木 実, 金盛 開人, 武元 宏泰, 松井 誠, 友田 敬士郎, 西山 伸宏. 生体適合性機能性高分子によるボロノフェニルアラニンの代謝制御と治療効果の向上, 第15回日本中性子捕捉療法学会学術大会, Sept. 2018.
• yao ying, 野本貴大, 井上透矢, 鈴木実, 松井誠, 武元宏泰, 友田敬士郎, 西山伸宏. Tumor-targeted delivery of BPA using functional polymers for boron neutron capture therapy, 第34回日本DDS学会学術集会, June 2018.

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