@book{CTT100720812, author = {武元宏泰 and 西山伸宏}, title = {ジブロックコポリマーを基盤とする高分子ミセル型制がん剤送達キャリア}, publisher = {}, year = 2015, } @book{CTT100720783, author = {Nobuhiro Nishiyama and Hiroyasu Takemoto}, title = {Polymeric Micelles}, publisher = {}, year = 2014, } @book{CTT100720814, author = {武元宏泰 and 西山伸宏 and 片岡一則}, title = {凍結濃縮現象によるClick反応加速}, publisher = {}, year = 2014, } @book{CTT100720778, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Bioresponsive Polymer-Based Nucleic Acid Carriers}, publisher = {}, year = 2014, } @article{CTT100900229, author = {西山伸宏}, title = {高分子の精密設計に基づくがん診断・治療用ナノマシンの創製}, journal = {薬学雑誌}, year = 2023, } @article{CTT100900226, author = {Haochen Guo and Xu Wen and Takahiro Nomoto and Kaito Kanamori and Yan Ming Voon and Yuto Honda and Naoki Yamada and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Polymeric ligands comprising sulfur-containing amino acids for targeting tumor-associated amino acid transporters.}, journal = {Biomaterials}, year = 2022, } @article{CTT100900223, author = {Takahiro Nomoto and Kana Komoto and Tomoya Nagano and Takuya Ishii and Haochen Guo and Yuto Honda and Shun-ichiro OGURA and Masahiro Ishizuka and Nobuhiro Nishiyama}, title = {Polymeric iron chelators for enhancing 5-aminolevulinic acid-induced photodynamic therapy}, journal = {}, year = 2022, } @article{CTT100900217, author = {Yuto Honda and Sayaka Onodera and Hiroyasu Takemoto and Faizah Noor and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Yudi Sun and Yutaka Miura and Nobuhiro Nishiyama}, title = {Thermo-responsive polymer-siRNA conjugates enabling artificial control of gene silencing around body temperature}, journal = {Pharmaceutical Research}, year = 2022, } @article{CTT100900205, author = {Yijung Sung and Haochen Guo and Aria Ghasemizadeh and Xin Shen and Wanphiwat Chintrakulchai and Motoaki Kobayashi and Masahiro Toyoda and Koichi Ogi and Junya Michinishi and Tokoyuki Ohtake and Makoto Matsui and Yuto Honda and Takahiro Nomoto and Hiroyasu Takemoto and Yutaka Miura and Nobuhiro Nishiyama}, title = {Cancerous pH-responsive polycarboxybetaine-coated lipid nanoparticle for smart delivery of siRNA against subcutaneous tumor model}, journal = {Cancer Science}, year = 2022, } @article{CTT100884274, author = {Xue Xie and Yuta Kurashina and Makoto Matsui and Takahiro Nomoto and Munenari Itoh and Hirotaka J Okano and Kentaro Nakamura and Nobuhiro Nishiyama and Yoshitaka Kitamoto}, title = {Transdermal delivery of bFGF with sonophoresis facilitated by chitosan nanocarriers}, journal = {Elsevier}, year = 2022, } @article{CTT100876895, author = {Aziz Awaad and Hiroyasu Takemoto and Muneaki Iizuka and Koichi Ogi and Yuki Mochida and Abdul-Hackam Ranneh and Masahiro Toyoda and Makoto Matsui and Takahiro Nomoto and Yuto Honda and Kotaro Hayashi and Keishiro Tomoda and Tomoyuki Ohtake and Yutaka Miura and Nobuhiro Nishiyama}, title = {Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration}, journal = {Journal of Controlled Release}, year = 2022, } @article{CTT100867334, author = {Yuta Kurashina and Risa Asano and Makoto Matsui and Takahiro Nomoto and Keita Ando and Kentaro Nakamura and Nobuhiro Nishiyama and Yoshitaka Kitamoto}, title = {Quantitative analysis of acoustic pressure for sonophoresis and its effect on transdermal penetration}, journal = {}, year = 2022, } @article{CTT100875965, author = {Guo H. and Nomoto T. and Muttaqien S.E. and Sun X. and Komoto K. and Matsui M. and Miura Y. and Nishiyama N.}, title = {A polymeric iron chelator enhancing pro-oxidant antitumor efficacy of vitamin C by inhibiting extracellular Fenton reaction}, journal = {Molecular Pharmaceutics}, year = 2021, } @article{CTT100863940, author = {Yuto Honda* and Takahiro Nomoto and Makoto Matsui and Hiroyasu Takemoto and Yutaka Miura and Nobuhiro Nishiyama*}, title = {Sequentially Self-Assembled Nanoreactor Comprising Tannic Acid and Phenylboronic Acid-Conjugated Polymers Inducing Tumor-Selective Enzymatic Activity}, journal = {ACS Applied Materials and Interfaces}, year = 2021, } @article{CTT100877316, author = {Yuma Ikeda and Mariko Orioka and Takahiro Nomoto and Yuki Hiruma and Nobuhiro Nishiyama and Daniel Citterio}, title = {Differentialeffect of azetidine substitution in firefly luciferin analogues}, journal = {ChemBioChem}, year = 2021, } @article{CTT100877325, author = {Jing Liu and Cabral Horacio and Bing Song and Ichio Aoki and Zhouyun Chen and Nobuhiro Nishiyama and Yuan Huang and Kazunori Kataoka and Peng Mi}, title = {Nanoprobe-based magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors}, journal = {ACS Nano}, year = 2021, } @article{CTT100863939, author = {Yuto Honda* and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Kaori Taniwaki and Haochen Guo and Yutaka Miura and Nobuhiro Nishiyama*}, title = {Systemically Applicable Glutamine-Functionalized Polymer Exerting Multivalent Interaction with Tumors Overexpressing ASCT2.}, journal = {ACS Applied Bio Materials}, year = 2021, } @article{CTT100855598, author = {Masayoshi Tanaka and Mirei Hayashi and Roach Lucien and Yuka Kiriki and Tetsuya Kadonosono and Takahiro Nomoto and Nobuhiro Nishiyama and Choi Jonghoon and Critchley Kevin and D. Evans Stephen and Mina Okochi}, title = {Synthesis of near-infrared absorbing triangular Au nanoplates using biomineralisation peptides}, journal = {ACTA Biomaterialia}, year = 2021, } @article{CTT100853182, author = {Takahiro Nomoto and Ying Yao and Yukiya Inoue and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy}, journal = {Journal of Controlled Release}, year = 2021, } @article{CTT100853184, author = {Komoto Kana and Takahiro Nomoto and Muttaqien S. and Takemoto Hiroyasu and Matsui Makoto and Miura Yutaka and Nishiyama Nobuhiro}, title = {Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine}, journal = {Cancer Science}, year = 2021, } @article{CTT100835412, author = {S Muttaqien and Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Photodynamic therapy using LCST polymers exerting pH-responsive isothermal phase transition}, journal = {Journal of Controlled Release}, year = 2020, } @article{CTT100835414, author = {Yuto Honda and Takahiro Nomoto and Makoto Matsui and Hiroyasu Takemoto and Yuka Kaihara and Yutaka Miura and Nobuhiro Nishiyama}, title = {Sequential Self-Assembly Using Tannic Acid and Phenylboronic Acid-Modified Copolymers for Potential Protein Delivery}, journal = {Biomacromolecules}, year = 2020, } @article{CTT100835413, author = {Xiaohang Sun and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Haochen Guo and Yudi Sun and Yutaka Miura and Nobuhiro Nishiyama}, title = {Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives}, journal = {Journal of Controlled Release}, year = 2020, } @article{CTT100836394, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and M Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism}, journal = {Science Advances}, year = 2020, } @article{CTT100827010, author = {Yuma Ikeda and Takahiro Nomoto and Yuki Hiruta and Nobuhiro Nishiyama and Daniel Citterio}, title = {Ring-Fused Firefly Luciferins: Expanded Palette of Near-Infrared Emitting Bioluminescent Substrates}, journal = {Analytical Chemistry}, year = 2020, } @article{CTT100827009, author = {Hiroyasu Takemoto and Takanori Inaba and Takahiro Nomoto and Makoto Matsui and Gyomon Ryu and Masahiro Toyoda and Yuto Honda and Kaori Taniwaki and Naoki Yamada and Junhyun Kim and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects}, journal = {Biomaterials}, year = 2020, } @article{CTT100813306, author = {Y Horise and M Maeda and Y Konishi and J Okamoto and S Ikuta and Y Okamoto and H Ishii and S Umemura and T Ueyama and S Tamano and A Sofuni and K Takemae and K Masamune and H Iseki and Nobuhiro Nishiyama and K Kataoka and Y Muragaki}, title = {Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer}, journal = {Frontiers in Pharmacology}, year = 2019, } @article{CTT100813287, author = {Hiroyasu Takemoto and Wang, Chih-Ling and Takahiro Nomoto and Matsui, Makoto and Tomoda, Keishiro and Nobuhiro Nishiyama}, title = {Pyruvate responsiveness based on α-oxohydrazone formation for intracellular siRNA release from polyion complex-based carriers}, journal = {Biomacromolecules}, year = 2019, } @article{CTT100813276, author = {Watanabe, Sumiyo and Hayashi, Kotaro and Toh, Kazuko and Kim Hyun Jin and Liu, Xueying and Chaya, Hiroyuki and Fukushima, Shigeto and Katsushima, Keisuke and Kondo, Yutaka and Uchida, Satoshi and Ogura, Satomi and Takahiro Nomoto and Hiroyasu Takemoto and Cabral, Horacio and Kinoh, Hiroaki and Tanaka, Hiroyoshi and Kano, Mitsunobu and Matsumoto, Yu and Fukuhama, Hiroshi and Uchida, Shyunya and Nagaku, Masaomi and Osada, Kensuke and Nobuhiro Nishiyama and Miyata, Kanjiro and Kataoka, Kazunori}, title = {In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers}, journal = {Nature Communications}, year = 2019, } @article{CTT100836396, author = {Muttaqien and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(N-isopropylacrylamide)-based polymer inducing isothermal hydrophilic-to-hydrophobic phase transition via detachment of hydrophilic acid-labile moiety}, journal = {BIOMACROMOLECULES}, year = 2018, } @article{CTT100837910, author = {Tsukasa Chida and Yutaka Miura and Cabral Horacio and Takahiro Nomoto and Kazunori Kataoka and Nobuhiro Nishiyama}, title = {Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release}, journal = {J. Control. Release}, year = 2018, } @article{CTT100773954, author = {R. Toshiyama R and M. Konno and H. Eguchi and H. Takemoto and T. Noda and A. Asai and J. Koseki and N. Haraguchi and Y. Ueda and K. Matsushita and K. Asukai and T. Ohashi and Y. Iwagami and D. Yamada and D. Sakai and T. Asaoka and T. Kudo and K. Kawamoto and K. Gotoh and S. Kobayashi and T. Satoh and Y. Doki and N. Nishiyama and M. Mori and H. Ishii}, title = {Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells}, journal = {Oncogene}, year = 2018, } @article{CTT100773952, author = {X. Dou and T. Nomoto and H. Takemoto and M. Matsui and K. Tomoda and N. Nishiyama}, title = {Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers}, journal = {Scientific Reports}, year = 2018, } @article{CTT100773951, author = {A.-H. Ranneh and H. Takemoto and S. Sakuma and A. Awaad and T. Nomoto and Y. Mochida and M. Matsui and K. Tomoda and M. Naito and N. Nishiyama}, title = {An ethylenediamine-based switch to control the polyzwitterion charge at tumorous pH for effective tumor accumulation of coated nanomaterials}, journal = {Angewandte Chemie International Edition}, year = 2018, } @article{CTT100773956, author = {H. Takemoto and N. Nishiyama}, title = {Functional polymer-based siRNA delivery carrier that recognizes site- specific biosignals}, journal = {Journal of Controlled Release}, year = 2017, } @article{CTT100752146, author = {M. Maeda and Y. Muragaki and J. Okamoto and S. Yoshizawa and N. Abe and H. Nakamoto and H. Ishii and K. Kawabata and S. Umemura and N. Nishiyama and K. Kataoka and H. Iseki}, title = {Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound}, journal = {Ultrasound Med. Biol.}, year = 2017, } @article{CTT100773950, author = {Y. Anraku and H. Kuwahara and Y. Fukusato and A. Mizoguchi and T. Ishii and K. Nitta and Y. Matsumoto and K. Toh and K. Miyata and S. Uchida and K. Nishina and K. Osada and K. Itaka and N. Nishiyama and H. Mizusawa and T. Yamasoba and T. Yokota and K. Kataoka}, title = {Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain}, journal = {Nature Communications}, year = 2017, } @article{CTT100806047, author = {Mi, Peng and Cabral, Horacio and Aoki, Ichio and Nobuhiro Nishiyama and Kataoka, Kazunori}, title = {A nanoparticle with pH-triggered contrast amplification ability for tumor malignancy imaging}, journal = {JOURNAL OF CONTROLLED RELEASE}, year = 2017, } @article{CTT100811952, author = {N. Yamada and Y. Honda and H. Takemoto and T. Nomoto and M. Matsui and K. Tomoda and M. Konno and H. Ishii and M. Mori and N. Nishiyama}, title = {Engineering tumour cell-binding synthetic polymers with sensing dense transporters associated with aberrant glutamine metabolism}, journal = {Scientific Reports}, year = 2017, } @article{CTT100752115, author = {P. Mi and H. Yanagie and N. Dewi and H.-C. Yen and X. Liu and M. Suzuki and Y. Sakurai and K. Ono and H. Takahashi and H. Cabral and K. Kataoka and N. Nishiyama}, title = {Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors}, journal = {J. Control. Release}, year = 2017, } @article{CTT100752123, author = {H. Taniguchi and D. Hoshino and C. Moriya and H. Zembutsu and N. Nishiyama and H. Yamamoto and K. Kataoka and K. Imai}, title = {Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer}, journal = {Oncotarget}, year = 2017, } @article{CTT100752056, author = {Mitsuru Naito and Ryota Azuma and Hiroyasu Takemoto and Mao Hori and Naoto Yoshinaga and Shigehito Osawa and Rimpei Kamegawa and Hyun Jin Kim and Takehiko Ishii and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori}, title = {Multilayered Polyion Complexes with Dissolvable Silica Layer Covered by Controlling Densities of cRGD-conjugated PEG Chains for Cancer-targeted siRNA Delivery}, journal = {Journal of Biomaterials Science, Polymer Edition}, year = 2017, } @article{CTT100752048, author = {Chih-Hao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Utility of 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-conjugated Polymer System}, journal = {ChemMedChem}, year = 2017, } @article{CTT100752111, author = {C. Moriya and H. Taniguchi and K. Miyata and N. Nishiyama and K. Kataoka and K. Imai}, title = {Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice}, journal = {Carcinogenesis}, year = 2017, } @article{CTT100714121, author = {Faizah Noor and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Artificial Control of Gene Silencing Activity Based on siRNA Conjugation with Polymeric Molecule Having Coil–Globule Transition Behavior}, journal = {Bioconjugate Chemistry}, year = 2016, } @article{CTT100714252, author = {Nobuhiro Nishiyama and Yasuhiro Matsumura and Kazunori Kataoka}, title = {Development of polymeric micelles for targeting intractable cancers.}, journal = {Cancer science}, year = 2016, } @article{CTT100752062, author = {H. Hino and M. Kamiya and K. Kitano and K. Mizuno and S. Tanaka and N. Nishiyama and K. Kataoka and Y. Urano and J. Nakajima}, title = {Rapid cancer fluorescence imaging using a γ-glutamyltranspeptidase-specific probe for primary lung cancer}, journal = {Translational Oncology}, year = 2016, } @article{CTT100752053, author = {M. Iijima and D. Ulkoski and S. Sakuma and D. Matsukuma and N. Nishiyama and H. Otsuka and C. Scholz}, title = {Synthesis of PEGylated poly(amino acid) pentablock copolymers and their self-assembly}, journal = {Polymer International}, year = 2016, } @article{CTT100714250, author = {Peng Mi and Daisuke Kokuryo and Cabral Horacio and Hailiang Wu and Yasuko Terada and Tsuneo Saga and Ichio Aoki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy}, journal = {Nature Nanotechnology}, year = 2016, } @article{CTT100714253, author = {Yoko Matsumoto and Miyamoto Yuichiro and Cabral Horacio and Yu Mastumoto and Kazunori Nagasawa and Shunsuke Nakagawa and Tetsu Yano and Daichi Maeda and Katsutoshi Oda and Kei Kawana and Nobuhiro Nishiyama and Kazunori Kataoka and Tomoyuki Fujii}, title = {Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132}, journal = {Cancer Science}, year = 2016, } @article{CTT100723937, author = {Takahiro Nomoto and Shigeto Fukushima and Michiaki Kumagai and Kozo Miyazaki and Aki Inoue and Peng Mi and Yoshinori Maeda and Kazuko Toh and Yu Mastumoto and Yuji Morimoto and Akihiro Kishimura and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy.}, journal = {Biomaterials science}, year = 2016, } @article{CTT100714260, author = {Haruka Nishida and Yoko Matsumoto and Kei Kawana and Christie James and Mitsuru Naito and Kim Beob Soo and Kazuko Toh and Hyun Su Min and Yi Yu and Yu Mastumoto and Hyun Jin Kim and Kanjiro Miyata and Ayumi Taguchi and Kensuke Tomio and Aki Yamashita and Tomoko Inoue and Hiroe Nakamura and Asaha Fujimoto and Masakazu Sato and Mitsuyo Yoshida and Katsuyuki Adachi and Takahide Arimoto and Osamu Wada-Hiraike and Katsutoshi Oda and Takeshi Nagamatsu and Nobuhiro Nishiyama and Kazunori Kataoka and Yutaka Osuga and Tomoyuki Fujii}, title = {Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes}, journal = {Journal of Controlled Release}, year = 2016, } @article{CTT100720774, author = {Kotaro Hayashi and Hiroyuki Chaya and Shigeto Fukushima and Sumiyo Watanabe and Hiroyasu Takemoto and Kensuke Osada and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Macromol. Rapid Commun. 6/2016.}, journal = {Macromolecular rapid communications}, year = 2016, } @article{CTT100720773, author = {Kotaro Hayashi and Hiroyuki Chaya and Shigeto Fukushima and Sumiyo Watanabe and Hiroyasu Takemoto and Kensuke Osada and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers}, journal = {Macromolecular Rapid Communications}, year = 2016, } @article{CTT100714258, author = {Hirokuni Uchida and Keiji Itaka and Satoshi Uchida and Takehiko Ishii and Tomoya Suma and Kanjiro Miyata and Makoto Oba and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure}, journal = {Journal of the American Chemical Society}, year = 2016, } @article{CTT100714255, author = {Novriana Dewi and Peng Mi and Hironobu Yanagie and Yuriko Sakurai and Yasuyuki Morishita and Masashi Yanagawa and Takayuki Nakagawa and Atsuko Shinohara and Takehisa Mastukawa and Kazuhito Yokoyama and Cabral Horacio and Minoru Suzuki and Yoshinori Sakurai and Hiroki Tanaka and Koji Ono and Nobuhiro Nishiyama and Kazunori Kataoka and Hiroyuki Takahashi}, title = {In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent}, journal = {Journal of Cancer Research and Clinical Oncology}, year = 2015, } @article{CTT100714351, author = {Masahiro Murakami and Kazutaka Nishina and Chie Watanabe and Kie Yoshida-Tanaka and Wenying Piao and Hiroya Kuwahara and Yuji Horikiri and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka and Masayuki Yoshida and Hidehiro Mizusawa and Takanori Yokota}, title = {Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route}, journal = {Scientific Reports}, year = 2015, } @article{CTT100806050, author = {Hino, Haruaki and Kawashima, Mitsuaki and Murayama, Tomonori and Ichinose, Junji and Kitano, Kentaro and Nagayama, Kazuhiro and Nitadori, Jun-ichi and Anraku, Masaki and Murakawa, Tomohiro and Mizuno, Kasue and Tanaka, Sayaka and Kamiya, Mako and Nobuhiro Nishiyama and Kataoka, Kazunori and Miyazono, Kohei and Urano, Yasuteru and Nakajima, Jun}, title = {Rapid Cancer Imaging By GGT-targeted Fluorescence Probe For Primary Lung Cancer}, journal = {CANCER RESEARCH}, year = 2015, } @article{CTT100714350, author = {Kumiko Sakai-Kato and Kunie Nanjo and Hiroyuki Kusuhara and Nobuhiro Nishiyama and Kazunori Kataoka and Toru Kawanishi and Haruhiko Okuda and Yukihiro Goda}, title = {Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice}, journal = {Molecular Pharmaceutics}, year = 2015, } @article{CTT100714352, author = {Kumiko Sakai-Kato and Nobuhiro Nishiyama and Masato Kozaki and Takeshi Nakanishi and Yoshihiro Matsuda and Mai Hirano and Hiroyuki Hanada and Shigeru HIsada and Hiroshi Onodera and Hideyoshi Harashima and Yasuhiro Matsumura and Kazunori Kataoka and Yukihiro Goda and Haruhiko Okuda and Toru Kawanishi}, title = {General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100714353, author = {Peng Mi and Novriana Dewi and Hironobu Yanagie and Daisuke Kokuryo and Minoru Suzuki and Yoshinori Sakurai and Yanmin Li and Ichio Aoki and Koji Ono and Hiroyuki Takahashi and Cabral Horacio and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy}, journal = {Acs Nano}, year = 2015, } @article{CTT100714348, author = {Peng Mi and Hironobu Yanagie and Daisuke Kokuryo and Novriana Dewi and Ichio Aoki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Block copolymer hybrid calcium phosphate micelles for cancer diagnosis and neutron capture therapy}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100804893, author = {Ogawa, H. and Wu, X. and Kawamoto, K. and Nishida, N. and Konno, M. and Koseki, J. and Matsui, H. and Noguchi, K. and Gotoh, N. and Yamamoto, T. and Miyata, K. and Nobuhiro Nishiyama and Nagano, H. and Yamamoto, H. and Obika, S. and Kataoka, K. and Doki, Y. and Mori, M. and Ishii, H.}, title = {MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells}, journal = {PLoS ONE}, year = 2015, } @article{CTT100806078, author = {Osada, Kensuke and Cabral, Horacio and Mochida, Yuki and Anraku, Yasutaka and Kishimura, Akihiro and Nobuhiro Nishiyama and Kataoka, Kazunori}, title = {Metallosomes as bioactive polymersomes formed by supramolecular assembly of block copolymer-metal complexation}, journal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY}, year = 2014, } @article{CTT100804377, author = {Sakai-Kato, K. and Un, K. and Nanjo, K. and Nobuhiro Nishiyama and Kusuhara, H. and Kataoka, K. and Kawanishi, T. and Goda, Y. and Okuda, H.}, title = {Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components}, journal = {Biomaterials}, year = 2014, } @article{CTT100723941, author = {Yoshinori Maeda and Frederico Pittella and Takahiro Nomoto and Hiroyasu Takemoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles}, journal = {Macromolecular Rapid Communications}, year = 2014, } @article{CTT100804473, author = {Kim, H.J. and Ishii, T. and Zheng, M. and Watanabe, S. and Toh, K. and Matsumoto, Y. and Nobuhiro Nishiyama and Miyata, K. and Kataoka, K.}, title = {Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer}, journal = {Drug Delivery and Translational Research}, year = 2014, } @article{CTT100720785, author = {Frederico Pittella and Cabral Horacio and Yoshinori Maeda and Peng Mi and Sumiyo Watanabe and Hiroyasu Takemoto and Hyun Jin Kim and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles}, journal = {Journal of Controlled Release}, year = 2014, } @article{CTT100720784, author = {Hyun Jin Kim and Hiroyasu Takemoto and Yi Yu and Meng Zheng and Yoshinori Maeda and Hiroyuki Chaya and Kotaro Hayashi and Peng Mi and Frederico Pittella and Christie James and Kazuko Toh and Yu Mastumoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles}, journal = {Acs Nano}, year = 2014, } @article{CTT100720779, author = {Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Design of Functional Polymers for Intracellular Nucleic Acids Delivery}, journal = {Intracellular Delivery Ii: Fundamentals and Applications}, year = 2014, } @article{CTT100806039, author = {Wang, M. and Miura, Y. and Cabral, H. and Nobuhiro Nishiyama and Kataoka, K.}, title = {Targeting cancer stem cells with platinum anti-cancer drug-incorporated polymeric micelles}, journal = {EUROPEAN JOURNAL OF CANCER}, year = 2013, } @article{CTT100720786, author = {Hiroyasu Takemoto and Kanjiro Miyata and Shota Hattori and Takehiko Ishii and Tomoya Suma and Satoshi Uchida and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Acidic pH-Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFN alpha-Associated Immune Response}, journal = {Angewandte Chemie-International Edition}, year = 2013, } @article{CTT100804685, author = {Cabral, H. and Murakami, M. and Hojo, H. and Terada, Y. and Kano, M.R. and Chung and U.-I. and Nobuhiro Nishiyama and Kataoka, K.}, title = {Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = 2013, } @article{CTT100804981, author = {Kokuryo, D. and Anraku, Y. and Kishimura, A. and Tanaka, S. and Kano, M.R. and Kershaw, J. and Nobuhiro Nishiyama and Saga, T. and Aoki, I. and Kataoka, K.}, title = {SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)}, journal = {Journal of Controlled Release}, year = 2013, } @article{CTT100720789, author = {Kanjiro Miyata and Christie James and Tomoya Suma and Hiroyasu Takemoto and Hirokuni Uchida and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Fine-Tuning of Repeating Aminoethyelene Units in Poly(aspartamide) Side Chains for Enhanced siRNA Delivery}, journal = {Tailored Polymer Architectures For Pharmaceutical and Biomedical Applications}, year = 2013, } @article{CTT100720793, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {siRNA-grafted polymer for efficient siRNA delivery system}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2012, } @article{CTT100720790, author = {Hiroyasu Takemoto and Kanjiro Miyata and Takehiko Ishii and Shota Hattori and Shigehito Osawa and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Accelerated Polymer-Polymer Click Conjugation by Freeze-Thaw Treatment}, journal = {Bioconjugate Chemistry}, year = 2012, } @article{CTT100720791, author = {Tomoya Suma and Kanjiro Miyata and Yasutaka Anraku and Sumiyo Watanabe and Christie James and Hiroyasu Takemoto and Momoko Shioyama and Noha Gouda and Takehiko Ishii and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG}, journal = {Acs Nano}, year = 2012, } @article{CTT100720796, author = {Kanjiro Miyata and Takahiro Nomoto and Hiroyasu Takemoto and Hyun Jin Kim and Yu Matsumoto and Makoto Oba and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Development of advanced polymer-based nanodevices for nucleic acids delivery}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2010, } @article{CTT100720798, author = {Kanjiro Miyata and Noha Gouda and Hiroyasu Takemoto and Makoto Oba and Yan Lee and Hiroyuki Koyama and Yuichi Yamasaki and Keiji Itaka and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Enhanced transfection with silica-coated polyplexes loading plasmid DNA}, journal = {Biomaterials}, year = 2010, } @article{CTT100720799, author = {Hiroyasu Takemoto and Atsushi Ishii and Kanjiro Miyata and Masataka Nakanishi and Makoto Oba and Takehiko Ishii and Yuichi Yamasaki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system}, journal = {Biomaterials}, year = 2010, } @article{CTT100712733, author = {Han M. and Oba M and Nishiyama N and Kano MR and Kizaka-Kondoh S and Kataoka K.}, title = {Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles.}, journal = {Molecular Therapy}, year = 2009, } @inproceedings{CTT100900269, author = {本田雄士 and 長尾周平 and 喜納宏昭 and 松平望 and Xueying Liu and 野本貴大 and Anjaneyulu Dirisala and 三浦裕 and 片岡一則 and 西山伸宏}, title = {集束超音波と高分子複合体を組み合わせた脳選択的AAV送達システムの構築}, booktitle = {}, year = 2023, } @inproceedings{CTT100900265, author = {西山伸宏}, title = {精密高分子合成を基盤とするスマートナノマシンの創製}, booktitle = {}, year = 2023, } @inproceedings{CTT100900264, author = {西山伸宏}, title = {精密合成ポリマー技術を基盤としたナノメディシンの研究開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100900273, author = {Anudari Batbayar and Haochen Guo and Takahiro Nomoto and Yan Ming Voon and Nobuhiro Nishiyama}, title = {Developing of Ovalbumin-Loaded Ternary Complexes Utilizing Tannic Acid and Phenylboronic Acid Conjugated Polymers for Cancer Immunotherapy}, booktitle = {}, year = 2022, } @inproceedings{CTT100900272, author = {松平望 and 本田雄士 and 長尾周平 and 喜納宏昭 and 野本貴大 and Xueying Liu and Anjaneyulu Dirisala and 三浦裕 and 片岡一則 and 西山伸宏}, title = {腫瘍細胞標的機能を備えた全身投与型アデノ随伴ウイルス(AAV)三元系複合体の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100900271, author = {Nobuhiro Nishiyama}, title = {Development of polymer conjugates for drug delivery system targeting tumor-associated amino acid transporters}, booktitle = {}, year = 2022, } @inproceedings{CTT100900270, author = {Nobuhiro Nishiyama}, title = {Sequential self-assembly bio-building blocks based on polyphenol materials for efficient biomolecules delivery}, booktitle = {}, year = 2022, } @inproceedings{CTT100900262, author = {Nobuhiro Nishiyama}, title = {Novel core-shell design for smart polymeric micelles}, booktitle = {}, year = 2022, } @inproceedings{CTT100900261, author = {西山伸宏}, title = {高分子ミセルによる核酸・ペプチド・タンパク質医薬品の送達技術に関する研究}, booktitle = {}, year = 2022, } @inproceedings{CTT100900267, author = {Haochen Guo and Takahiro Nomoto and Hiroaki Kinoh and Jun Ishihara and Nobuhiro Nishiyama}, title = {Polymeric Iron Chelator Modulating Tumor Immune Microenvironment}, booktitle = {}, year = 2022, } @inproceedings{CTT100900263, author = {西山伸宏}, title = {バイオ医薬品送達システムを指向した高分子ミセルのコア-シェル設計}, booktitle = {}, year = 2022, } @inproceedings{CTT100900260, author = {西山伸宏}, title = {精密高分子設計に基づくナノDDSの設計と光治療への応用}, booktitle = {}, year = 2022, } @inproceedings{CTT100877338, author = {西山伸宏}, title = {高分子の精密設計に基づくがん診断・治療用ナノマシンの創製}, booktitle = {}, year = 2022, } @inproceedings{CTT100876898, author = {松尾拓海 and 本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸導入高分子で構築されたCas9 RNPデリバリーシステムの開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100876897, author = {本田雄士 and 長尾周平 and 喜納宏昭 and 野本貴大 and Liu Xueying and Dirisala Anjaneyulu and 松井誠 and 三浦裕 and 片岡一則 and 西山伸宏}, title = {アデノ随伴ウイルス(AAV)の中和抗体回避および活性を向上させるAAV内包三元系複合体}, booktitle = {}, year = 2022, } @inproceedings{CTT100877337, author = {西山伸宏}, title = {精密高分子設計を基盤とする中分子バイオ医薬品のDDS開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100877336, author = {Nobuhiro Nishiyama}, title = {Novel core-shell design for smart polymeric micelles}, booktitle = {}, year = 2021, } @inproceedings{CTT100863943, author = {本田雄士 and 山田直生 and 野本貴大 and 松井誠 and 西山伸宏}, title = {グルタミントランスポーターを高密度で発現しているがん細胞を認識する機能性高分子の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863942, author = {長尾周平 and 本田雄士 and 喜納宏昭 and 野本貴大 and Liu Xueying and Dirisala Anjaneyulu and 松井誠 and 三浦裕 and 片岡一則 and 西山伸宏}, title = {アデノ随伴ウイルス(AAV)中和抗体回避を可能にする全身投与型AAV搭載三元系複合体の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863941, author = {松尾拓海 and 本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸導入高分子の自己会合によって構成されたCas9 RNPデリバリーシステムの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100862986, author = {Yuta Kurashina and Risa Asano and Makoto Matsui and Takahiro Nomoto and Kentaro Nakamura and Nobuhiro Nishiyama and Yoshitaka Kitamoto}, title = {Measurement and calculation of acoustic pressure on the effect of transdermal penetration by sonophoresis}, booktitle = {}, year = 2021, } @inproceedings{CTT100861662, author = {本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {効率的なタンパク質送達を指向したタンニン酸とフェニルボロン酸導入高分子で構成されたタンパク質内包三元系複合体の構築}, booktitle = {}, year = 2021, } @inproceedings{CTT100877335, author = {Guo Haochen and 野本貴大 and 松井誠 and VOONYAN MING and SUNGYi-Jung and 三浦裕 and 西山伸宏}, title = {高分子鉄キレート剤を利用した腫瘍免疫逃避環境の克服}, booktitle = {}, year = 2021, } @inproceedings{CTT100876010, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Kaito Kanamori and Minoru Suzuki and Kakeru Konarita and Makoto Matsui and Nobuhiro Nishiyama}, title = {Synthesis of functional polymers boosting therapeutic potential of p-boronophenylalanine and analysis of the effect of their physicochemical properties on pharmacokinetics}, booktitle = {}, year = 2021, } @inproceedings{CTT100861664, author = {臼倉幸一 and 本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {官能基が異なるボロン酸導入高分子とタンニン酸で構成されたタンパク質三元系複合体の安定性評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100861663, author = {松尾拓海 and 本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸導入高分子で構築された自己会合型Cas9 RNP送達システムの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100861606, author = {Yuto Honda and Takahiro Nomoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Construction of sequential self-assembled protein ternary complex utilizing boronic acid conjugated-polymer and tannic acid for protein delivery}, booktitle = {}, year = 2021, } @inproceedings{CTT100862978, author = {Yuta Kurashina and Risa Asano and Makoto Matsui and Takahiro Nomoto and Kentaro Nakamura and Nobuhiro Nishiyama and Yoshitaka Kitamoto}, title = {Effect of sonophoresis with various nanoparticles on transdermal drug delivery}, booktitle = {}, year = 2021, } @inproceedings{CTT100876011, author = {野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 鈴木実 and 小成田翔 and 松井誠 and 西山伸宏}, title = {側鎖に糖構造を有する高分子とボロノフェニルアラニンから構成される薬物送達システムの設計}, booktitle = {}, year = 2021, } @inproceedings{CTT100857505, author = {大橋遼太郎 and 本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸導入高分子で構成されるオボアルブミン封入三元系複合体の構築とがん免疫療法への応用}, booktitle = {}, year = 2021, } @inproceedings{CTT100876012, author = {野本貴大 and 小成田翔 and 鈴木実 and 松井誠 and 西山伸宏}, title = {ポリビニルアルコールを利用したボロノフェニルアラニンの中性子捕捉療法における治療効果向上}, booktitle = {}, year = 2021, } @inproceedings{CTT100877334, author = {Guo Haochen and 野本貴大 and 松井誠 and 河本花奈 and ElMuttaqien S. and 三浦裕 and 西山伸宏}, title = {高分子鉄キレート剤を用いた腫瘍内鉄イオン制御とそのアスコルビン酸の抗腫瘍効果への影響に関する検討}, booktitle = {}, year = 2021, } @inproceedings{CTT100857506, author = {長尾周平 and 本田雄士 and 喜納宏昭 and 野本貴大 and Liu Xueying and Dirisala Anjaneyulu and 松井誠 and 三浦裕 and 片岡一則 and 西山伸宏}, title = {アデノ随伴ウイルス(AAV)ベクターの中和抗体および副作用を克服するAAV/タンニン酸/ボロン酸導入高分子三元系複合体の構築}, booktitle = {}, year = 2021, } @inproceedings{CTT100857504, author = {松尾拓海 and 本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸修飾高分子からなるCRISPR/Casタンパク質デリバリーシステムの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100857503, author = {本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸導入高分子の自己会合によって形成されたナノリアクターの酵素プロドラッグ療法への応用}, booktitle = {}, year = 2021, } @inproceedings{CTT100857508, author = {本田雄士 and 福原菜摘 and 浮田菜央 and 松井誠 and 大野哲史 and 野本貴大 and 西山伸宏 and 保科克行 and 三浦裕}, title = {ボロン酸エステルを介したスタチン内包高分子型ミセルの構築および薬理効果}, booktitle = {}, year = 2021, } @inproceedings{CTT100857507, author = {本田雄士 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {タンニン酸とフェニルボロン酸導入高分子から成る自己会合型ナノリアクターの構築および酵素プロドラッグ療法への応用}, booktitle = {}, year = 2021, } @inproceedings{CTT100877329, author = {小成田翔 and 野本貴大 and 金盛開人 and 鈴木実 and 松井誠 and 三浦裕 and 西山伸宏}, title = {Poly(vinyl alcohol)と D-4-boronophenylalanine から構成される 薬物送達システムによるホウ素中性子捕捉療法の検討}, booktitle = {}, year = 2021, } @inproceedings{CTT100856031, author = {西山伸宏}, title = {機能性ポリマーの精密設計に基づく ナノメディシンの開発}, booktitle = {}, year = 2020, } @inproceedings{CTT100856030, author = {Nobuhiro Nishiyama}, title = {Shell and core design of polymeric micelles for delivery of biopharmaceuticals}, booktitle = {}, year = 2020, } @inproceedings{CTT100856032, author = {西山伸宏}, title = {pH反応性ポリマーとナノ粒子}, booktitle = {}, year = 2020, } @inproceedings{CTT100835423, author = {野本貴大 and Dou Xuebo and 武元宏泰 and 西山伸宏}, title = {多価環状RGDペプチド担持高分子型光増感剤によるphotochemical internalizationの検討}, booktitle = {}, year = 2020, } @inproceedings{CTT100856036, author = {西山伸宏}, title = {高分子の精密設計に基づくナノDDSの開発}, booktitle = {}, year = 2020, } @inproceedings{CTT100856040, author = {西山伸宏}, title = {高分子の精密設計に基づくホウ素薬剤送達システムの開発}, booktitle = {}, year = 2020, } @inproceedings{CTT100836393, author = {武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {高分子修飾によるsiRNA周囲の空間支配と薬理機構制御}, booktitle = {}, year = 2020, } @inproceedings{CTT100836392, author = {豊田真広 and 武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {腫瘍内pH応答性の獲得を目指した高分子ベタイン内の両イオン性基の種類・間隔の検討}, booktitle = {}, year = 2020, } @inproceedings{CTT100836391, author = {SUNYudi and 武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {ASO-分岐PEG結合体を内包する小分子キャリアの開発および機能評価}, booktitle = {}, year = 2020, } @inproceedings{CTT100836390, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Kakeru Konarita and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Development of functional polymers to boost therapeutic potential of boronophenylalanine in neutron capture therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100836389, author = {河本花奈 and 野本貴大 and Sjaikhurrizal El Muttaqien and 武元宏泰 and 松井誠 and 三浦裕 and 西山伸宏}, title = {がん鉄キレート療法のための効率的な除鉄を実現する機能性高分子の開発}, booktitle = {}, year = 2020, } @inproceedings{CTT100836388, author = {I Dewa Agung Panji Dwipayana and Yuto Honda and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Development of a versatile drug delivery system using tannic acid and boronic acid-conjugated polymer}, booktitle = {}, year = 2020, } @inproceedings{CTT100836387, author = {ムツタキンシャイクリザルエル and Yutaka Miura and Haochen Guo and Takahiro Nomoto and Kana Komoto and S Muttaqien and Xiaohang Sun and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Polymeric iron-chelators for improving high- dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100832687, author = {Yuta Kurashina and Risa Asano and Makoto Matsui and Takahiro Nomoto and Kentaro Nakamura and Nobuhiro Nishiyama and Yoshitaka Kitamoto}, title = {Transdermal Delivery of Large Nanoparticles via Ultrasonic Irradiation in Low-Frequency Range}, booktitle = {Proceedings of IUS 2020}, year = 2020, } @inproceedings{CTT100835432, author = {武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {"環状アセタール構造に基づくゲムシタビン担持型高分子の開発とその機能評価 および副作用低減"}, booktitle = {}, year = 2020, } @inproceedings{CTT100835429, author = {Guo Haochen and 野本貴大 and 河本花奈 and ElMuttaqien S. and Sun Xiaohang and 武元宏泰 and 松井誠 and 三浦裕 and 西山伸宏}, title = {Effect of polymeric iron-chelators on high-dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835424, author = {野本貴大 and 本田雄士 and 海原悠可 and 喜納宏昭 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {タンニン酸とボロン酸ケミストリーを利用した高分子複合体の簡便調製法}, booktitle = {}, year = 2020, } @inproceedings{CTT100835426, author = {Guo Haochen and Takahiro Nomoto and Kana Komoto and Sun Xiaohang and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Development of polymeric iron-chelators for enhancing high-dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835419, author = {Takahiro Nomoto and Sjaikhurrizal El Muttaqien and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Photodynamic therapy utilizing functional polymers that exert pH-responsive isothermal phase transition}, booktitle = {}, year = 2020, } @inproceedings{CTT100835427, author = {豊田真広 and 武元 宏泰 and 野本 貴大 and 松井 誠 and 三浦 裕 and 西山 伸宏}, title = {高分子ベタイン内のイオン性基の種類・間隔の制御と腫瘍内pH応答性への展開}, booktitle = {}, year = 2020, } @inproceedings{CTT100856041, author = {西山伸宏}, title = {機能性高分子の精密設計に基づく医療ナノマシンの創製}, booktitle = {}, year = 2020, } @inproceedings{CTT100835428, author = {武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {"環状アセタール構造を介したゲムシタビンのポリアミノ酸への導入と薬効増大 および副作用低減"}, booktitle = {}, year = 2020, } @inproceedings{CTT100835418, author = {Kana Komoto and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Iron chelation cancer therapy using functional polymers targeting tumors}, booktitle = {}, year = 2020, } @inproceedings{CTT100835417, author = {Yuto Honda and Takahiro NOMOTO and Makoto MATSUI and Hiroyasu TAKEMOTO and Yuka KAIHARA and Yutaka MIURA and Nobuhiro NISHIYAMA}, title = {Development of intracellular pH- responsive protein delivery system utilizing boronic acid-conjugated polymer and tannic acid}, booktitle = {}, year = 2020, } @inproceedings{CTT100835416, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(vinyl alcohol) for enhancing therapeutic effects of p-boronophenylalanine in neutron capture therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100813362, author = {Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Photosensitizer delivery to tumor cells and tumor-associated vasculature using functional polymers}, booktitle = {}, year = 2019, } @inproceedings{CTT100813335, author = {西山伸宏}, title = {Development of Smart Nanomachines for Minimally Invasive Cancer Treatment}, booktitle = {}, year = 2019, } @inproceedings{CTT100813360, author = {河本花奈 and 野本貴大 and 武元宏泰 and 松井誠 and 三浦裕 and 西山伸宏}, title = {がん治療のための効率的な生体内の除鉄を実現する機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813624, author = {武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {環状アセタール構造に基づくゲムシタビンの高分子修飾と制がん効果増大及び副作用低減}, booktitle = {}, year = 2019, } @inproceedings{CTT100813361, author = {野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 鈴木実 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {生体適合性高分子とボロノフェニルアラニンから構成される中性子捕捉療法用代謝制御型ホウ素送達システム}, booktitle = {}, year = 2019, } @inproceedings{CTT100813359, author = {野本貴大 and 松井誠 and 武元宏泰 and 海原悠可 and 三浦裕 and 西山伸宏}, title = {ボロン酸導入高分子とタンニン酸を用いた細胞内環境応答タンパク質送達システムの構築}, booktitle = {}, year = 2019, } @inproceedings{CTT100813333, author = {西山伸宏}, title = {機能性高分子の精密設計に基づく医療ナノマシンの創製}, booktitle = {}, year = 2019, } @inproceedings{CTT100813358, author = {Kaito Kanamori and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {BPA delivery system utilizing sugar-modified polymers forming stable boronate esters}, booktitle = {The 10th Young Member’s Boron Neutron Capture Therapy (10th YBNCT)}, year = 2019, } @inproceedings{CTT100813357, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Makoto Matsui and Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Boosting Therapeutic Potential of p-Boronophenylalanine Using Biocompatible Polymers}, booktitle = {}, year = 2019, } @inproceedings{CTT100813332, author = {西山伸宏}, title = {精密高分子設計に基づくDDSとPDT応用}, booktitle = {}, year = 2019, } @inproceedings{CTT100813329, author = {Nobuhiro Nishiyama}, title = {Design of functional polymers for smart nanomedicine}, booktitle = {}, year = 2019, } @inproceedings{CTT100813352, author = {野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 鈴木実 and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {生体適合性高分子とp-boronophenylalanineから構成されるホウ素送達システムの開発と構成高分子の物性が体内動態と治療効果に与える影響に関する考察}, booktitle = {}, year = 2019, } @inproceedings{CTT100813353, author = {本田雄士 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん細胞の高密度グルタミントランスポーターと選 択的な相互作用を示す機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813354, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {温度応答性高分子-siRNA結合体の合成と外部刺激によるsiRNAの生物活性制御}, booktitle = {}, year = 2019, } @inproceedings{CTT100813355, author = {武元宏泰 and AZIZMUHAMMAD and RannehA-Hackam and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {腫瘍内pH応答性高分子ベタインの設計と被覆ナノ粒子への展開}, booktitle = {}, year = 2019, } @inproceedings{CTT100813356, author = {野本貴大 and ElMuttaqien S. and 武元宏泰 and 松井誠 and 西山伸宏}, title = {腫瘍内低pH環境に応答して親水-疎水相転移挙動を示す高分子コンジュゲート型光増感剤}, booktitle = {}, year = 2019, } @inproceedings{CTT100813348, author = {河本花奈 and 野本貴大 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {がん治療を指向した生体内鉄イオンをキレートする機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813346, author = {松井誠 and 海原悠可 and 武元宏泰 and 野本貴大 and 西山伸宏}, title = {薬物送達技術を応用した新規骨折治療法の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813351, author = {Nobuhiro Nishiyama and Kana Komoto and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui}, title = {Development of polymeric iron chelator for cancer therapy}, booktitle = {}, year = 2019, } @inproceedings{CTT100813347, author = {金盛開人 and 野本貴大 and 鈴木実 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {ボロン酸エステルを利用したホウ素薬物送達キャリアの開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813349, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {温度応答性高分子-siRNA結合体とのポリイオンコンプレックス形成と外部刺激によるsiRNA の薬効制御}, booktitle = {}, year = 2019, } @inproceedings{CTT100813345, author = {武元宏泰 and AZIZMUHAMMAD and 野本貴大 and 松井誠 and 西山伸宏}, title = {腫瘍 pH 応答性高分子ベタインの開発とナノ粒子のがん送達への展開}, booktitle = {}, year = 2019, } @inproceedings{CTT100811104, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Shinichi Sato and Takahiro Nomoto and Kyra See and Hiroyuki Nakamura and Nobuhiro Nishiyama and Shinae Kizaka-Kondoh}, title = {Development of photoimmunotherapy probe using a small antibody mimetic with structurally constrained anti-HER2 CDR peptides}, booktitle = {}, year = 2019, } @inproceedings{CTT100813338, author = {金盛開人 and 野本貴大 and 鈴木実 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {糖修飾高分子とホウ素薬物から構成される薬物送達システムの開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813339, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {ポリイオンコンプレックスを利用した温度応答性高分子-siRNA結合体の細胞内導入と外部刺激によるsiRNAの生物活性制御}, booktitle = {}, year = 2019, } @inproceedings{CTT100813342, author = {豊田真広 and 武元宏泰 and 野本貴大 and 松井誠 and 西山伸宏}, title = {腫瘍内pH応答性高分子ベタイン内のイオン性基間距離の検討}, booktitle = {}, year = 2019, } @inproceedings{CTT100813344, author = {本田雄士 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん細胞の高密度グルタミントランスポーターを標的として選択的な相互作用を示す機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813350, author = {Kaito Kanamori and Takahiro Nomoto and Minoru Suzuki and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Boron Delivery Using Sugar-Modified Polymers for Neutron Capture Therapy}, booktitle = {}, year = 2019, } @inproceedings{CTT100813337, author = {野本貴大 and 井上透矢 and YAOYing and 鈴木実 and 金盛開人 and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {Metabolism-controlled boron delivery systems composed of biocompatible polymers and boronophenylalanine for neutron capture therapy}, booktitle = {Abstracts of Papers of the American Chemical Society}, year = 2019, } @inproceedings{CTT100783096, author = {西山 伸宏}, title = {機能性高分子の精密設計に基づくナノメディシンの創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100783086, author = {Yuka Kaihara and Makoto Matsui and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of novel drug delivery system for enhancing bone regeneration in bone fracture model mouse}, booktitle = {}, year = 2018, } @inproceedings{CTT100783087, author = {Sayaka Onodera and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Conjugation of siRNA and a polymer with coil-globule transition property for control of siRNA activity around body temperature}, booktitle = {}, year = 2018, } @inproceedings{CTT100783088, author = {Gyomon Ryu and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of poly(amino acid)-based carrier that loads gemcitabine via reversible linkage and its evaluation using pancreatic cancer model}, booktitle = {}, year = 2018, } @inproceedings{CTT100783089, author = {Sun Xiaohang and Taknaori Inaba and Kazuki Ohsakama and Mika Shishido and Hiroki Yoshioka and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {Development of degradable poly(ethylene glycol)(PEG) derivatives for suppressing cellular vacuolations}, booktitle = {}, year = 2018, } @inproceedings{CTT100783090, author = {Sjaikhurrizal El Muttaqien and 松井 誠 and 武元 宏泰 and 野本 貴 大 and 友田 敬士郎 and 西山 伸宏}, title = {Poly(N-isopropylacrylamide) derivatives exering remarkable LCST shift in response to slight pH chnge via detachment of hydrophilic acid-labile moiety}, booktitle = {}, year = 2018, } @inproceedings{CTT100783091, author = {Hiroyasu Takemoto and Abdul-Hackam Ranneh and Takahiro Nomoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Ethylenediamine-based polyzwitterion that becomes cationic at tumorous pH for effective tumor accumulation of the coated nanomaterials}, booktitle = {}, year = 2018, } @inproceedings{CTT100811939, author = {Yuto Honda and Naoki Yamada and Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Tumor cell-targeting glutamine-derived polymer that can interact with high density glutamine transporter based on aberrant glutamine metabolism.}, booktitle = {}, year = 2018, } @inproceedings{CTT100783094, author = {西山 伸宏}, title = {機能性高分子の設計に基づくがん診断・治療システムの開発}, booktitle = {}, year = 2018, } @inproceedings{CTT100783095, author = {Nobuhiro Nishiyama}, title = {Smart nanomedicines based on the design of functional polymer}, booktitle = {}, year = 2018, } @inproceedings{CTT100783093, author = {西山 伸宏}, title = {機能性ポリマーの精密設計に基づく スマート機能型ナノメディシンの創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100783083, author = {Ying Yao and Takahiro Nomoto and Yukiya Inoue and Minoru Suzuki and Makoto Matsui and Hiroyasu Takemoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Enhanced tumor-targeted delivery of p-boronophenylalanine using fructose-functionalized polymers for boron neutron capture therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100783082, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Metabolism-controlled boron delivery systems composed of p-boronophenylalanine and poly(vinyl alcohol)}, booktitle = {}, year = 2018, } @inproceedings{CTT100773999, author = {野本 貴大 and 井上 透矢 and Yao Ying and 鈴木 実 and 金盛 開人 and 武元 宏泰 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {生体適合性機能性高分子によるボロノフェニルアラニンの代謝制御と治療効果の向上}, booktitle = {}, year = 2018, } @inproceedings{CTT100774000, author = {本田雄士 and 山田 直生 and 武元 宏泰 and 野本 貴 大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {グルタミン代謝が亢進したがん細胞の高密度グルタ ミントランスポーターを認識してアフィニティを示す機能性高 分子}, booktitle = {}, year = 2018, } @inproceedings{CTT100774003, author = {Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Multiple cyclic RGD-conjugated functional polymers controlling intratumoral distribution of IRDye 700DX}, booktitle = {}, year = 2018, } @inproceedings{CTT100774002, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue}, booktitle = {}, year = 2018, } @inproceedings{CTT100774001, author = {Gyomon Ryu and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of gemcitabine-conjugated poly(amino acid) and its evaluation using pancreatic tumor model}, booktitle = {}, year = 2018, } @inproceedings{CTT100773998, author = {Sjaikhurrizal El Muttaqien and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel design of pH-responsive polymer for targeting acidic microenvironment of tumor}, booktitle = {}, year = 2018, } @inproceedings{CTT100773997, author = {Hiroyasu Takemoto and Abduhl Hackam Ranneh and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Ethylenediamine-based betaine structure switches the neutral net charge of polyzwitterion into cationic at tumorous pH toward effective tumor accumulation of the coated nanomaterials}, booktitle = {}, year = 2018, } @inproceedings{CTT100773995, author = {野本貴大 and Dou Xuebo and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {IRDye 700DXの腫瘍内分布を制御する環状RGD担持高分子コンジュゲートによる光線力学効果の検討}, booktitle = {}, year = 2018, } @inproceedings{CTT100773994, author = {yao ying and 野本貴大 and 井上透矢 and 鈴木実 and 松井誠 and 武元宏泰 and 友田敬士郎 and 西山伸宏}, title = {Tumor-targeted delivery of BPA using functional polymers for boron neutron capture therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100783092, author = {西山伸宏}, title = {機能性ポリマーによるナノDDS設計:高分子ミセルからナノマシンへ}, booktitle = {}, year = 2018, } @inproceedings{CTT100773993, author = {武元宏泰 and Ranneh Abdul-Hackam and 野本貴大 and 松井誠 and 友田敬士郎 and 持田祐希 and 内藤瑞 and 西山伸宏}, title = {腫瘍内環境を認識する高分子ベタインの開発とナノ粒子の効率的な腫瘍集積への展開}, booktitle = {}, year = 2018, } @inproceedings{CTT100773990, author = {劉暁夢 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {可逆的にゲムシタビンを担持するポリアミノ酸型キャリアの開発とすい臓がんモデルでの機能評価}, booktitle = {}, year = 2018, } @inproceedings{CTT100773992, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {siRNAへのCoil-globule挙動を有する高分子の結合と生体温度付近での遺伝子発現抑制能の精密制御}, booktitle = {}, year = 2018, } @inproceedings{CTT100768254, author = {1. 野本貴大 and 福島重人 and 熊谷康顕 and 宮崎幸造 and 井上明季 and Mi Peng and 前田芳周 and 籐加珠子 and 松本有 and 守本祐司 and 岸村顕広 and 西山伸宏 and 片岡一則 and 野本貴大}, title = {効率的な光線力学療法を指向したハイブリッド型光増感剤送達システム}, booktitle = {}, year = 2018, } @inproceedings{CTT100773964, author = {Nobuhiro Nishiyama}, title = {Development of Smart Nanodiagnostics for Targeted Cancer Therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100773989, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Glutamine-Functionalized Polymer for Tumor-Selective High Affinity by Sensing Dense Glutamine Transporters Associated with Aberrant Metabolism}, booktitle = {}, year = 2017, } @inproceedings{CTT100773988, author = {Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group that allows highly selective cleavage in intracellular redox system and the application for a construction of siRNA-polymer conjugate}, booktitle = {}, year = 2017, } @inproceedings{CTT100773986, author = {Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Construction of siRNA-polymer conjugate and its biological application}, booktitle = {}, year = 2017, } @inproceedings{CTT100773987, author = {山田直生 and 本田雄士 and 武元宏泰 and 野本貴大 and 松井 誠 and 友田敬士郎 and 西山伸宏}, title = {がん選択的に相互作用するグルタミン担持高分子の創製と機能評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100773963, author = {Nobuhiro Nishiyama}, title = {Design of Functional Polymers for Smart Nanomedicine}, booktitle = {}, year = 2017, } @inproceedings{CTT100773983, author = {左久間隼矢 and Abdul-Hackam RANNEH and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {腫瘍指向性ステルス高分子の開発とDDSへの応 用-ベタイン構造内アニオン性基の影響-}, booktitle = {}, year = 2017, } @inproceedings{CTT100773982, author = {真貝 太規 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん代謝に着想した表層にグルタミンを有する高分子ミセル型薬物送達システムの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100773985, author = {武元宏泰 and 稲葉 高徳 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {糖骨格を有する制がん剤のポリアミノ酸への可逆的担持と薬効向上及び消化器毒性低減}, booktitle = {}, year = 2017, } @inproceedings{CTT100773984, author = {Dou Xuebo and 野本 貴大 and 武元 宏泰 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {光増感剤結合型高分子における多岐環状RGDペプチドの腫瘍集積性と腫瘍内分布への効果の検討}, booktitle = {}, year = 2017, } @inproceedings{CTT100752170, author = {西山伸宏}, title = {革新的オリゴ核酸送達システムの実現に向けた材料設計}, booktitle = {}, year = 2017, } @inproceedings{CTT100752117, author = {武元 宏泰 and 稲葉 高徳 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {ゲムシタビンのポリアミノ酸への可逆的担持に基づく消化器毒性低減及び制がん効果向上}, booktitle = {}, year = 2017, } @inproceedings{CTT100752165, author = {Hiroyasu Takemoto and Huang Chih-Hao and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-Nitrobenzenesulfonamide Group that Responds to Intracellular Redox Potential with Enhanced Photostability for a Construction of Polymer-siRNA Conjugate System}, booktitle = {}, year = 2017, } @inproceedings{CTT100752096, author = {Hiroyasu Takemoto and Chih Hao Huang and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group as a redox-sensitive linker for a construction of polymer-siRNA conjugate system}, booktitle = {}, year = 2017, } @inproceedings{CTT100752097, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Design of synthetic polymer toward achieving a selective high affinity to tumor cells by interacting with dense glutaminolysis-related transporters}, booktitle = {}, year = 2017, } @inproceedings{CTT100752095, author = {左久間隼矢 and RannehA-Hackam and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {腫瘍内pHに応答する双性イオン型ポリマーの設計とDDS応用-ベタイン内アニオン性基の影響-}, booktitle = {}, year = 2017, } @inproceedings{CTT100752091, author = {真貝太規 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん特異的代謝に着想した外殻にグルタミンを有する高分子ミセルの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752093, author = {劉暁夢 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {ミトコンドリア呼吸鎖阻害剤を腫瘍組織に送達するための高分子ミセルの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752159, author = {Hiroyasu Takemoto and Huang Chih-Hao and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-Nitrobenzenesulfonamide group as a chemical linker with highly selective cleavability in response to intracellular redox system for a construction of siRNA-polymer conjugate.}, booktitle = {}, year = 2017, } @inproceedings{CTT100752161, author = {Yuto Honda and Naoki Yamada and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel design of glutamine-derived polymer with a high affinity to cancer cells based on aberrant glutamine metabolism.}, booktitle = {}, year = 2017, } @inproceedings{CTT100752155, author = {Ranneh Hackam and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of stealth shell based on polycarboxybetaine structure tuned to selectively interact with cells in tumor extracellular acidic pH}, booktitle = {}, year = 2017, } @inproceedings{CTT100752150, author = { Tsukasa Nishimori and Naoki Yamada and Hiroyasu Takemoto and Kentaro Suina and Juntaro Yamasaki and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Osamu Nagano and Hideyuki Saya and Nobuhiro Nishiyama}, title = {Development of intravenously injectable sulfasalazine derivatives to treat stem-like cancer cells}, booktitle = {}, year = 2017, } @inproceedings{CTT100752152, author = {Takanori Inaba and Hiroyasu Takemoto and Makoto Matsui and Takahiro Nomoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Enhanced antitumor activity and reduced gastrointestinal toxicity of gemcitabine based on conjugation with biocompatible polymer via acetal linker}, booktitle = {}, year = 2017, } @inproceedings{CTT100752154, author = {武元宏泰 and キム ヒュンジン and 宮田完二郎 and 西山伸宏 and 片岡一則}, title = {単分子siRNA内包型小会合体を要素とするsiRNAキャリアの構築と全身投与による腫瘍組織への送達}, booktitle = {}, year = 2017, } @inproceedings{CTT100752149, author = {Chi-Hao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group as a new chemical linker with redox sensitivity for siRNA-conjugated polymer system}, booktitle = {}, year = 2017, } @inproceedings{CTT100752173, author = {Nobuhiro Nishiyama}, title = {Development of smart polymers and nanodevices for innovative medicine}, booktitle = {}, year = 2017, } @inproceedings{CTT100752172, author = {Nobuhiro Nishiyama}, title = {Development of polymer-based nanodevices for innovative medicine}, booktitle = {}, year = 2017, } @inproceedings{CTT100752171, author = {Nobuhiro Nishiyama}, title = {Development of smart nanomachines for cancer imaging and minimally invasive treatment}, booktitle = {}, year = 2017, } @inproceedings{CTT100752168, author = {西山伸宏}, title = {革新的医薬品の実現に向けた機能性高分子およびナノデバイスの設計}, booktitle = {}, year = 2017, } @inproceedings{CTT100752167, author = {西山伸宏}, title = {DDSによる核酸医薬の有効性向上・毒性低減に向けて}, booktitle = {}, year = 2017, } @inproceedings{CTT100752169, author = {西山伸宏}, title = {精密合成高分子材料を基盤とするナノメディシンの創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100752147, author = {Chihhao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzensulfonamide groups as a chemical linker with enhanced extracellular stability and redox-sensitive cleavability for siRNA-conjugated polymer system}, booktitle = {}, year = 2016, } @inproceedings{CTT100752174, author = {Nobuhiro Nishiyama}, title = {evelopment of supramolecular nanodevices for cancer diagnostics and therapy}, booktitle = {}, year = 2016, } @inproceedings{CTT100752148, author = {Faizah Noor and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Artificial control of siRNA bioactivity based on the phase transition behavior of the conjugated polymeric molecule}, booktitle = {}, year = 2016, } @inproceedings{CTT100752175, author = {Nobuhiro Nishiyama}, title = {Challenge to new generation micellar nanocarriers}, booktitle = {}, year = 2016, } @inproceedings{CTT100752141, author = {武元宏泰 and 宮田完二郎 and 林光太朗 and 持田祐希 and 片岡一則 and 西山伸宏}, title = {シロキサンネットワークにて形成されるsiRNA内包有機-無機ハイブリッドナノ粒子の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752143, author = {越後真梨那 and 武元 宏泰 and 林 光太朗 and 宮田 完二郎 and 金澤秀子 and 片岡 一則 and 西山 伸宏}, title = {がん細胞内にて特異的に切断される Linker を利用した siRNA 送達キャリアの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752166, author = {西山伸宏}, title = {精密合成高分子材料を基盤する がん診断・治療ナノマシンの創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100752144, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel glutamine-based polymeric ligand for transporter-mediated tumor targeting}, booktitle = {}, year = 2016, } @inproceedings{CTT100752163, author = {西山伸宏}, title = {高分子ナノテクノロジーを基盤とした革新的ナノ診断・治療システムの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752164, author = {西山伸宏}, title = {精密合成高分子材料を基盤するがん診断・治療ナノマシンの創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100752136, author = {KimJunhyun and 武元 宏 泰 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {高分子ミセルにおける内核構造の安定性の差異がもたらす腫瘍集積性に関する考察}, booktitle = {}, year = 2016, } @inproceedings{CTT100752139, author = {SunXiaohang and 武元 宏 泰 and 野本 貴大 and 友田 敬士郎 and 松井 誠 and 西山 伸宏}, title = {がんへの薬剤の集積状態をレポートするナノメディシンの開 発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752135, author = {Chih Ling Wang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {A Novel Design of Polyion Complex (PIC) with The Pyruvate-Reactive Function toward Enhanced Cytosolic Release of siRNA}, booktitle = {}, year = 2016, } @inproceedings{CTT100752131, author = {Faizah Noor and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Development of siRNA-conjugated polymer with coil-globule transition behavior for an artificially controlled gene silencing activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100752162, author = {西山伸宏}, title = {高分子ナノテクノロジーを基盤とした革新的DDSの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752160, author = {西山伸宏}, title = {がんの標的治療のための高分子ミセル型薬物送達システムの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752158, author = {西山伸宏}, title = {高分子ナノテクノロジーを基盤とする革新的がん診断・治療システムの創出}, booktitle = {}, year = 2016, } @inproceedings{CTT100752157, author = {西山伸宏}, title = {高分子ミセル型ナノ医薬品の開発-アカデミアからの取り組み-}, booktitle = {}, year = 2016, } @inproceedings{CTT100752153, author = {西山伸宏}, title = {高分子ミセル型ナノマシンが拓く未来医療}, booktitle = {}, year = 2016, } @inproceedings{CTT100752128, author = {Chih-Ling and Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Programmed siRNA Release based on α-Oxohydrazone Chemistry for Polyion complex-based siRNA Delivery System}, booktitle = {}, year = 2016, } @inproceedings{CTT100752156, author = {西山伸宏}, title = {高分子ナノテクノロジーを基盤とする革新的ナノメディシンの創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100752130, author = {NOOR and Hiroyasu Takemoto and Takahiro Nomoto and Nobuhiro Nishiyama}, title = {Development of thermoresponsive polymer-siRNA conjugates for controlled RNAi activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100752176, author = {Nobuhiro Nishiyama}, title = {Development of supramolecular nanodevices for cancer diagnosis and therapy}, booktitle = {}, year = 2016, } @inproceedings{CTT100752179, author = {Nobuhiro Nishiyama}, title = {Development of supramolecular nanodevices for cancer diagnosis and therapy}, booktitle = {}, year = 2016, } @inproceedings{CTT100752178, author = {Nobuhiro Nishiyama and Horacio Cabral}, title = {Development of supramolecular nanomedicines for cancer diagnosis and therapy}, booktitle = {}, year = 2016, } @inproceedings{CTT100752151, author = {西山伸宏}, title = {高分子ナノテクノロジーを基盤とした革新的核酸医薬シーズ送達システムの創出}, booktitle = {}, year = 2016, } @inproceedings{CTT100768256, author = {Takahiro Nomoto and Shigeto Fukushima and Michiaki Kumagai and Kaori Machitani and Kanjiro Miyata and Makoto Oba and Yu Matsumoto and Kensuke Osada and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Three-layered polyplex micelle for light-induced gene transfer}, booktitle = {}, year = 2015, } @inproceedings{CTT100705310, author = {K. Miura and T. Hirasawa and J. Kang and Y. Shoji and Y. Okada and H. Yokoi and N. Nishiyama and S. Arai and Tetsuya Mizumoto}, title = {Amorphous Silicon Waveguide Optical Isolator on Ce:YIG Substrate}, booktitle = {}, year = 2014, } @misc{CTT100853190, author = {野本貴大 and 西山伸宏}, title = {ポリビニルアルコールによるBNCT治療効果向上について}, year = 2020, } @misc{CTT100828163, author = {西山伸宏}, title = {核酸医薬のためのDDS}, year = 2019, } @misc{CTT100768248, author = {Takahiro Nomoto and Nobuhiro Nishiyama}, title = {Design of drug delivery systems for physical energy-induced chemical surgery}, year = 2018, } @misc{CTT100805576, author = {西山伸宏}, title = {ペプチドリガンドを搭載したドラッグデリバリーシステム(DDS)の創製 (特集 生体機能性ペプチドを応用した次世代ナノメディシンの展開)}, year = 2017, } @misc{CTT100752031, author = {P. Mi and F. Wang and N. Nishiyama and H. Cabral}, title = {Molecular cancer imaging with polymeric nanoassemblies: from tumor detection to theranostics}, year = 2016, } @misc{CTT100805572, author = {西山伸宏}, title = {[FOREWORD]アカデミアと企業の連携による医療イノベーションの実現に向けて}, year = 2015, } @misc{CTT100892274, author = {西山伸宏 and 武元宏泰 and 三浦裕 and 野本貴大 and 松井誠 and SUNG, Yi-Jung and 豊田真広 and GhasemizadehAria and 尾木 公一 and 道西 准也  and 飯塚 宗明   and 大嶽 知之 }, title = {高純度pH応答性ポリマー及びその製造方法}, howpublished = {公開特許}, year = 2023, month = {}, note = {PCT/JP2022/026864(2022/07/06), WO 2023/282297(2023/01/12)} } @misc{CTT100892275, author = {西山伸宏 and 武元宏泰 and 三浦裕 and 野本貴大 and 松井誠 and SUNG, Yi-Jung and 豊田真広 and GhasemizadehAria and 尾木 公一 and 道西 准也   and 大嶽 知之}, title = {pH応答性脂質誘導体}, howpublished = {公開特許}, year = 2023, month = {}, note = {PCT/JP2022/026863(2022/07/06), WO 2023/282296(2023/01/12)} } @misc{CTT100909661, author = {西山伸宏 and 野本貴大 and GUOHaochen and Voon Yan Ming and Wen Xu and 金盛開人 and 山田直生 and 松井誠 and 武元宏泰 and 萩山 朋子}, title = {L型アミノ酸トランスポーター1を標的とした高分子}, howpublished = {公開特許}, year = 2023, month = {}, note = {特願2022-075447(2022/04/28), 特開2023-164109(2023/11/10)} } @misc{CTT100860419, author = {西山伸宏 and 吉岡 宏樹  and 羽村 健  and 大坂間 順規 }, title = {マルチアーム型分解性ポリエチレングリコール誘導体}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-160391(2020/09/25), 特開2021-055079(2021/04/08)} } @misc{CTT100860424, author = {西山伸宏 and 吉岡 宏樹  and 羽村 健  and 大坂間 順規}, title = {非対称分岐型分解性ポリエチレングリコール誘導体}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-160392(2020/09/25), 特開2021-055080(2021/04/08)} } @misc{CTT100869592, author = {西山伸宏 and 本田雄士 and 野本貴大 and 武元宏泰 and 松井誠 and 喜納 宏昭 and 片岡 一則 and 劉 学蛍 and Dirisala, Anjaneyulu}, title = {複合体、医薬、癌治療剤、キット及び結合体}, howpublished = {公開特許}, year = 2020, month = {}, note = {PCT/JP2020/021301(2020/05/29), WO 2020/241819(2020/12/03)} } @misc{CTT100869610, author = {西山伸宏 and 野本貴大 and 河本花奈 and 武元宏泰 and 松井誠}, title = {結合体、及び癌治療剤}, howpublished = {公開特許}, year = 2020, month = {}, note = {PCT/JP2020/017421(2020/04/23), WO 2020/218390(2020/10/29)} } @misc{CTT100843278, author = {西山伸宏 and 松井誠 and 武元宏泰 and 野本貴大 and SunXiaohang and 吉岡 宏樹  and 大坂間 順規  and 羽村 美華 and 稲葉 高徳 }, title = {分岐型分解性ポリエチレングリコール誘導体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2020-055411(2020/03/26), 特開2020-164855(2020/10/08), 特許第7411188号(2023/12/27)} } @misc{CTT100843292, author = {西山伸宏 and 松井誠 and 武元宏泰 and 野本貴大 and SunXiaohang and 吉岡 宏樹  and 大坂間 順規  and 羽村 美華 and 稲葉 高徳 }, title = {分岐型分解性ポリエチレングリコール結合体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2020-055412(2020/03/26), 特開2020-164856(2020/10/08), 特許第7411189号(2023/12/27)} } @misc{CTT100815578, author = {西山伸宏 and 松井誠 and 武元宏泰 and 宮内和輝 and 野本貴大 and 友田敬士郎 and 吉岡 宏樹  and 神谷 昌樹 and 山本 裕二 and 平居 翠 and 佐々木 明子 }, title = {分解性ポリエチレングリコール結合体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-068351(2019/03/29), 特開2019-172673(2019/10/10), 特許第7249591号(2023/03/23)} } @misc{CTT100815581, author = {西山伸宏 and 松井誠 and 武元宏泰 and 宮内和輝 and 野本貴大 and 友田敬士郎 and 山本 裕二 and 吉岡 宏樹 and 神谷 昌樹 and 平居 翠  and 佐々木 明子}, title = {分解性ポリエチレングリコール誘導体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-068350(2019/03/29), 特開2019-173014(2019/10/10), 特許第7205827号(2023/01/06)} } @misc{CTT100845913, author = {西山伸宏 and 野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 武元宏泰 and 松井誠 and 友田敬士郎}, title = {p-ボロノフェニルアラニン誘導体及びそれを含む組成物、並びにそれらを製造するためのキット}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2020-500974(2019/02/19), 再表2019/163790(2021/02/12), 特許第7219925号(2023/02/01)} } @misc{CTT100845885, author = {西山伸宏 and 武元宏泰 and 森 正樹  and 石井 秀始 and 今野 雅允 and 江口 英利   and 原口 直紹 and 俊山 礼志 }, title = {抗がん剤}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-569175(2019/01/30), 再表2019/151320(2021/01/14), 特許第7267609号(2023/04/24)} } @misc{CTT100815579, author = {西山伸宏 and 武元宏泰 and Abdul-Hackam RANNEH and 友田敬士郎 and 野本貴大 and 松井誠}, title = {pH応答性ポリマー及び薬物送達システム}, howpublished = {登録特許}, year = 2021, month = {}, note = {特願2018-556597(2017/12/05), 再表2018/110366(2019/10/24), 特許第6995375号(2021/12/17)} } @misc{CTT100806614, author = {西山伸宏 and El Muttaqien SJAIKHURRIZAL and 野本貴大 and 武元宏泰 and 松井誠 and 友田敬士郎}, title = {温度応答性ポリマー及びそれを含む組成物}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2017-211893(2017/11/01), 特開2019-085438(2019/06/06)} } @misc{CTT100806622, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 山田直生 and 本田雄士 and 森 正樹 and 石井 秀始 and 今野 雅允}, title = {グルタミントランスポーターと多価結合することができるリガンド、及び当該リガンドを含む組成物}, howpublished = {登録特許}, year = 2022, month = {}, note = {特願2018-535630(2017/08/17), 特開(再表)2018-037996(2019/06/20), 特許第7076104号(2022/05/19)} } @misc{CTT100808501, author = {西山伸宏 and 中村浩之 and 武元宏泰 and 野本貴大 and 片岡 一則  and Mi Peng  and Horacio Cabral  and 柳衛 宏宣 and Novriana Dewi  and 黒澤 渉 and 姥貝 吏紗 and 北原 吉朗  and 須賀 泰世 }, title = {ホウ素クラスター結合ペプチド化合物}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2018-507416(2017/03/23), 再表2017/164334(2019/02/28)} } @misc{CTT100830142, author = {西山伸宏 and 武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 友田敬士郎}, title = {薬物送達用担体及び薬物送達システム}, howpublished = {公開特許}, year = 2020, month = {}, note = {特願2017-029264(2017/02/20), 特開2020-063191(2020/04/23)} } @misc{CTT100789761, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 山田直生 and 西森司 and 佐谷 秀行 and 永野 修  and 土橋 賢司 and 推名 健太郎}, title = {抗腫瘍剤}, howpublished = {登録特許}, year = 2020, month = {}, note = {特願2017-560416(2017/01/05), 再表2017/119462(2018/11/01), 特許第6803589号(2020/12/03)} } @misc{CTT100761475, author = {西山伸宏 and 武元宏泰 and Chih-Hao HUANG  and 野本貴大 and 友田敬士郎 and 松井誠}, title = {結合体}, howpublished = {公開特許}, year = 2017, month = {}, note = {特願2016-113664(2016/06/07), 特開2017-218408(2017/12/14)} } @misc{CTT100748975, author = {西山伸宏 and 喜納 宏昭 and 片岡 一則 and Horacio Cabral and 三浦 裕 and 福島 重人 and 千田 司}, title = {エピルビシン複合化ブロック共重合体と、抗癌剤とを含むミセル、及び当該ミセルを含む癌又は耐性癌、転移癌の治療に適用可能な医薬組成物}, howpublished = {登録特許}, year = 2017, month = {}, note = {特願2016-542591(2015/08/11), 再表2016/024595(2017/05/25), 特許第6229865号(2017/10/27)} }