@article{CTT100773956, author = {H. Takemoto and N. Nishiyama}, title = {Functional polymer-based siRNA delivery carrier that recognizes site- specific biosignals}, journal = {Journal of Controlled Release}, year = 2017, } @article{CTT100773950, author = {Y. Anraku and H. Kuwahara and Y. Fukusato and A. Mizoguchi and T. Ishii and K. Nitta and Y. Matsumoto and K. Toh and K. Miyata and S. Uchida and K. Nishina and K. Osada and K. Itaka and N. Nishiyama and H. Mizusawa and T. Yamasoba and T. Yokota and K. Kataoka}, title = {Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain}, journal = {Nature Communications}, year = 2017, } @article{CTT100752146, author = {M. Maeda and Y. Muragaki and J. Okamoto and S. Yoshizawa and N. Abe and H. Nakamoto and H. Ishii and K. Kawabata and S. Umemura and N. Nishiyama and K. Kataoka and H. Iseki}, title = {Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound}, journal = {Ultrasound Med. Biol.}, year = 2017, } @article{CTT100806047, author = {Mi, Peng and Cabral, Horacio and Aoki, Ichio and Nobuhiro Nishiyama and Kataoka, Kazunori}, title = {A nanoparticle with pH-triggered contrast amplification ability for tumor malignancy imaging}, journal = {JOURNAL OF CONTROLLED RELEASE}, year = 2017, } @article{CTT100811952, author = {N. Yamada and Y. Honda and H. Takemoto and T. Nomoto and M. Matsui and K. Tomoda and M. Konno and H. Ishii and M. Mori and N. Nishiyama}, title = {Engineering tumour cell-binding synthetic polymers with sensing dense transporters associated with aberrant glutamine metabolism}, journal = {Scientific Reports}, year = 2017, } @article{CTT100752115, author = {P. Mi and H. Yanagie and N. Dewi and H.-C. Yen and X. Liu and M. Suzuki and Y. Sakurai and K. Ono and H. Takahashi and H. Cabral and K. Kataoka and N. Nishiyama}, title = {Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors}, journal = {J. Control. Release}, year = 2017, } @article{CTT100752123, author = {H. Taniguchi and D. Hoshino and C. Moriya and H. Zembutsu and N. Nishiyama and H. Yamamoto and K. Kataoka and K. Imai}, title = {Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer}, journal = {Oncotarget}, year = 2017, } @article{CTT100752056, author = {Mitsuru Naito and Ryota Azuma and Hiroyasu Takemoto and Mao Hori and Naoto Yoshinaga and Shigehito Osawa and Rimpei Kamegawa and Hyun Jin Kim and Takehiko Ishii and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori}, title = {Multilayered Polyion Complexes with Dissolvable Silica Layer Covered by Controlling Densities of cRGD-conjugated PEG Chains for Cancer-targeted siRNA Delivery}, journal = {Journal of Biomaterials Science, Polymer Edition}, year = 2017, } @article{CTT100752048, author = {Chih-Hao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Utility of 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-conjugated Polymer System}, journal = {ChemMedChem}, year = 2017, } @article{CTT100752111, author = {C. Moriya and H. Taniguchi and K. Miyata and N. Nishiyama and K. Kataoka and K. Imai}, title = {Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice}, journal = {Carcinogenesis}, year = 2017, } @inproceedings{CTT100773988, author = {Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group that allows highly selective cleavage in intracellular redox system and the application for a construction of siRNA-polymer conjugate}, booktitle = {}, year = 2017, } @inproceedings{CTT100773989, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Glutamine-Functionalized Polymer for Tumor-Selective High Affinity by Sensing Dense Glutamine Transporters Associated with Aberrant Metabolism}, booktitle = {}, year = 2017, } @inproceedings{CTT100773986, author = {Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Construction of siRNA-polymer conjugate and its biological application}, booktitle = {}, year = 2017, } @inproceedings{CTT100773987, author = {山田直生 and 本田雄士 and 武元宏泰 and 野本貴大 and 松井 誠 and 友田敬士郎 and 西山伸宏}, title = {がん選択的に相互作用するグルタミン担持高分子の創製と機能評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100773963, author = {Nobuhiro Nishiyama}, title = {Design of Functional Polymers for Smart Nanomedicine}, booktitle = {}, year = 2017, } @inproceedings{CTT100773984, author = {Dou Xuebo and 野本 貴大 and 武元 宏泰 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {光増感剤結合型高分子における多岐環状RGDペプチドの腫瘍集積性と腫瘍内分布への効果の検討}, booktitle = {}, year = 2017, } @inproceedings{CTT100773985, author = {武元宏泰 and 稲葉 高徳 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {糖骨格を有する制がん剤のポリアミノ酸への可逆的担持と薬効向上及び消化器毒性低減}, booktitle = {}, year = 2017, } @inproceedings{CTT100773983, author = {左久間隼矢 and Abdul-Hackam RANNEH and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {腫瘍指向性ステルス高分子の開発とDDSへの応 用-ベタイン構造内アニオン性基の影響-}, booktitle = {}, year = 2017, } @inproceedings{CTT100773982, author = {真貝 太規 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん代謝に着想した表層にグルタミンを有する高分子ミセル型薬物送達システムの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752170, author = {西山伸宏}, title = {革新的オリゴ核酸送達システムの実現に向けた材料設計}, booktitle = {}, year = 2017, } @inproceedings{CTT100752117, author = {武元 宏泰 and 稲葉 高徳 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {ゲムシタビンのポリアミノ酸への可逆的担持に基づく消化器毒性低減及び制がん効果向上}, booktitle = {}, year = 2017, } @inproceedings{CTT100752165, author = {Hiroyasu Takemoto and Huang Chih-Hao and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-Nitrobenzenesulfonamide Group that Responds to Intracellular Redox Potential with Enhanced Photostability for a Construction of Polymer-siRNA Conjugate System}, booktitle = {}, year = 2017, } @inproceedings{CTT100752091, author = {真貝太規 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん特異的代謝に着想した外殻にグルタミンを有する高分子ミセルの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752095, author = {左久間隼矢 and RannehA-Hackam and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {腫瘍内pHに応答する双性イオン型ポリマーの設計とDDS応用-ベタイン内アニオン性基の影響-}, booktitle = {}, year = 2017, } @inproceedings{CTT100752096, author = {Hiroyasu Takemoto and Chih Hao Huang and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group as a redox-sensitive linker for a construction of polymer-siRNA conjugate system}, booktitle = {}, year = 2017, } @inproceedings{CTT100752097, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Design of synthetic polymer toward achieving a selective high affinity to tumor cells by interacting with dense glutaminolysis-related transporters}, booktitle = {}, year = 2017, } @inproceedings{CTT100752093, author = {劉暁夢 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {ミトコンドリア呼吸鎖阻害剤を腫瘍組織に送達するための高分子ミセルの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752159, author = {Hiroyasu Takemoto and Huang Chih-Hao and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-Nitrobenzenesulfonamide group as a chemical linker with highly selective cleavability in response to intracellular redox system for a construction of siRNA-polymer conjugate.}, booktitle = {}, year = 2017, } @inproceedings{CTT100752161, author = {Yuto Honda and Naoki Yamada and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel design of glutamine-derived polymer with a high affinity to cancer cells based on aberrant glutamine metabolism.}, booktitle = {}, year = 2017, } @inproceedings{CTT100752152, author = {Takanori Inaba and Hiroyasu Takemoto and Makoto Matsui and Takahiro Nomoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Enhanced antitumor activity and reduced gastrointestinal toxicity of gemcitabine based on conjugation with biocompatible polymer via acetal linker}, booktitle = {}, year = 2017, } @inproceedings{CTT100752154, author = {武元宏泰 and キム ヒュンジン and 宮田完二郎 and 西山伸宏 and 片岡一則}, title = {単分子siRNA内包型小会合体を要素とするsiRNAキャリアの構築と全身投与による腫瘍組織への送達}, booktitle = {}, year = 2017, } @inproceedings{CTT100752155, author = {Ranneh Hackam and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of stealth shell based on polycarboxybetaine structure tuned to selectively interact with cells in tumor extracellular acidic pH}, booktitle = {}, year = 2017, } @inproceedings{CTT100752150, author = { Tsukasa Nishimori and Naoki Yamada and Hiroyasu Takemoto and Kentaro Suina and Juntaro Yamasaki and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Osamu Nagano and Hideyuki Saya and Nobuhiro Nishiyama}, title = {Development of intravenously injectable sulfasalazine derivatives to treat stem-like cancer cells}, booktitle = {}, year = 2017, } @inproceedings{CTT100752168, author = {西山伸宏}, title = {革新的医薬品の実現に向けた機能性高分子およびナノデバイスの設計}, booktitle = {}, year = 2017, } @inproceedings{CTT100752149, author = {Chi-Hao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group as a new chemical linker with redox sensitivity for siRNA-conjugated polymer system}, booktitle = {}, year = 2017, } @inproceedings{CTT100752172, author = {Nobuhiro Nishiyama}, title = {Development of polymer-based nanodevices for innovative medicine}, booktitle = {}, year = 2017, } @inproceedings{CTT100752171, author = {Nobuhiro Nishiyama}, title = {Development of smart nanomachines for cancer imaging and minimally invasive treatment}, booktitle = {}, year = 2017, } @inproceedings{CTT100752173, author = {Nobuhiro Nishiyama}, title = {Development of smart polymers and nanodevices for innovative medicine}, booktitle = {}, year = 2017, } @inproceedings{CTT100752169, author = {西山伸宏}, title = {精密合成高分子材料を基盤とするナノメディシンの創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100752167, author = {西山伸宏}, title = {DDSによる核酸医薬の有効性向上・毒性低減に向けて}, booktitle = {}, year = 2017, } @misc{CTT100805576, author = {西山伸宏}, title = {ペプチドリガンドを搭載したドラッグデリバリーシステム(DDS)の創製 (特集 生体機能性ペプチドを応用した次世代ナノメディシンの展開)}, year = 2017, } @misc{CTT100815579, author = {西山伸宏 and 武元宏泰 and Abdul-Hackam RANNEH and 友田敬士郎 and 野本貴大 and 松井誠}, title = {pH応答性ポリマー及び薬物送達システム}, howpublished = {登録特許}, year = 2021, month = {}, note = {特願2018-556597(2017/12/05), 再表2018/110366(2019/10/24), 特許第6995375号(2021/12/17)} } @misc{CTT100806614, author = {西山伸宏 and El Muttaqien SJAIKHURRIZAL and 野本貴大 and 武元宏泰 and 松井誠 and 友田敬士郎}, title = {温度応答性ポリマー及びそれを含む組成物}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2017-211893(2017/11/01), 特開2019-085438(2019/06/06)} } @misc{CTT100806622, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 山田直生 and 本田雄士 and 森 正樹 and 石井 秀始 and 今野 雅允}, title = {グルタミントランスポーターと多価結合することができるリガンド、及び当該リガンドを含む組成物}, howpublished = {登録特許}, year = 2022, month = {}, note = {特願2018-535630(2017/08/17), 特開(再表)2018-037996(2019/06/20), 特許第7076104号(2022/05/19)} } @misc{CTT100808501, author = {西山伸宏 and 中村浩之 and 武元宏泰 and 野本貴大 and 片岡 一則  and Mi Peng  and Horacio Cabral  and 柳衛 宏宣 and Novriana Dewi  and 黒澤 渉 and 姥貝 吏紗 and 北原 吉朗  and 須賀 泰世 }, title = {ホウ素クラスター結合ペプチド化合物}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2018-507416(2017/03/23), 再表2017/164334(2019/02/28)} } @misc{CTT100830142, author = {西山伸宏 and 武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 友田敬士郎}, title = {薬物送達用担体及び薬物送達システム}, howpublished = {公開特許}, year = 2020, month = {}, note = {特願2017-029264(2017/02/20), 特開2020-063191(2020/04/23)} } @misc{CTT100789761, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 山田直生 and 西森司 and 佐谷 秀行 and 永野 修  and 土橋 賢司 and 推名 健太郎}, title = {抗腫瘍剤}, howpublished = {登録特許}, year = 2020, month = {}, note = {特願2017-560416(2017/01/05), 再表2017/119462(2018/11/01), 特許第6803589号(2020/12/03)} } @misc{CTT100761475, author = {西山伸宏 and 武元宏泰 and Chih-Hao HUANG  and 野本貴大 and 友田敬士郎 and 松井誠}, title = {結合体}, howpublished = {公開特許}, year = 2017, month = {}, note = {特願2016-113664(2016/06/07), 特開2017-218408(2017/12/14)} } @misc{CTT100748975, author = {西山伸宏 and 喜納 宏昭 and 片岡 一則 and Horacio Cabral and 三浦 裕 and 福島 重人 and 千田 司}, title = {エピルビシン複合化ブロック共重合体と、抗癌剤とを含むミセル、及び当該ミセルを含む癌又は耐性癌、転移癌の治療に適用可能な医薬組成物}, howpublished = {登録特許}, year = 2017, month = {}, note = {特願2016-542591(2015/08/11), 再表2016/024595(2017/05/25), 特許第6229865号(2017/10/27)} }