@article{CTT100837910, author = {Tsukasa Chida and Yutaka Miura and Cabral Horacio and Takahiro Nomoto and Kazunori Kataoka and Nobuhiro Nishiyama}, title = {Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release}, journal = {J. Control. Release}, year = 2018, } @article{CTT100836396, author = {Muttaqien and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(N-isopropylacrylamide)-based polymer inducing isothermal hydrophilic-to-hydrophobic phase transition via detachment of hydrophilic acid-labile moiety}, journal = {BIOMACROMOLECULES}, year = 2018, } @article{CTT100773954, author = {R. Toshiyama R and M. Konno and H. Eguchi and H. Takemoto and T. Noda and A. Asai and J. Koseki and N. Haraguchi and Y. Ueda and K. Matsushita and K. Asukai and T. Ohashi and Y. Iwagami and D. Yamada and D. Sakai and T. Asaoka and T. Kudo and K. Kawamoto and K. Gotoh and S. Kobayashi and T. Satoh and Y. Doki and N. Nishiyama and M. Mori and H. Ishii}, title = {Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells}, journal = {Oncogene}, year = 2018, } @article{CTT100773952, author = {X. Dou and T. Nomoto and H. Takemoto and M. Matsui and K. Tomoda and N. Nishiyama}, title = {Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers}, journal = {Scientific Reports}, year = 2018, } @article{CTT100773951, author = {A.-H. Ranneh and H. Takemoto and S. Sakuma and A. Awaad and T. Nomoto and Y. Mochida and M. Matsui and K. Tomoda and M. Naito and N. Nishiyama}, title = {An ethylenediamine-based switch to control the polyzwitterion charge at tumorous pH for effective tumor accumulation of coated nanomaterials}, journal = {Angewandte Chemie International Edition}, year = 2018, } @inproceedings{CTT100811939, author = {Yuto Honda and Naoki Yamada and Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Tumor cell-targeting glutamine-derived polymer that can interact with high density glutamine transporter based on aberrant glutamine metabolism.}, booktitle = {}, year = 2018, } @inproceedings{CTT100783096, author = {西山 伸宏}, title = {機能性高分子の精密設計に基づくナノメディシンの創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100783089, author = {Sun Xiaohang and Taknaori Inaba and Kazuki Ohsakama and Mika Shishido and Hiroki Yoshioka and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {Development of degradable poly(ethylene glycol)(PEG) derivatives for suppressing cellular vacuolations}, booktitle = {}, year = 2018, } @inproceedings{CTT100783088, author = {Gyomon Ryu and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of poly(amino acid)-based carrier that loads gemcitabine via reversible linkage and its evaluation using pancreatic cancer model}, booktitle = {}, year = 2018, } @inproceedings{CTT100783087, author = {Sayaka Onodera and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Conjugation of siRNA and a polymer with coil-globule transition property for control of siRNA activity around body temperature}, booktitle = {}, year = 2018, } @inproceedings{CTT100783086, author = {Yuka Kaihara and Makoto Matsui and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of novel drug delivery system for enhancing bone regeneration in bone fracture model mouse}, booktitle = {}, year = 2018, } @inproceedings{CTT100783091, author = {Hiroyasu Takemoto and Abdul-Hackam Ranneh and Takahiro Nomoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Ethylenediamine-based polyzwitterion that becomes cationic at tumorous pH for effective tumor accumulation of the coated nanomaterials}, booktitle = {}, year = 2018, } @inproceedings{CTT100783090, author = {Sjaikhurrizal El Muttaqien and 松井 誠 and 武元 宏泰 and 野本 貴 大 and 友田 敬士郎 and 西山 伸宏}, title = {Poly(N-isopropylacrylamide) derivatives exering remarkable LCST shift in response to slight pH chnge via detachment of hydrophilic acid-labile moiety}, booktitle = {}, year = 2018, } @inproceedings{CTT100783095, author = {Nobuhiro Nishiyama}, title = {Smart nanomedicines based on the design of functional polymer}, booktitle = {}, year = 2018, } @inproceedings{CTT100783094, author = {西山 伸宏}, title = {機能性高分子の設計に基づくがん診断・治療システムの開発}, booktitle = {}, year = 2018, } @inproceedings{CTT100783082, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Metabolism-controlled boron delivery systems composed of p-boronophenylalanine and poly(vinyl alcohol)}, booktitle = {}, year = 2018, } @inproceedings{CTT100783083, author = {Ying Yao and Takahiro Nomoto and Yukiya Inoue and Minoru Suzuki and Makoto Matsui and Hiroyasu Takemoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Enhanced tumor-targeted delivery of p-boronophenylalanine using fructose-functionalized polymers for boron neutron capture therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100783093, author = {西山 伸宏}, title = {機能性ポリマーの精密設計に基づく スマート機能型ナノメディシンの創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100774003, author = {Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Multiple cyclic RGD-conjugated functional polymers controlling intratumoral distribution of IRDye 700DX}, booktitle = {}, year = 2018, } @inproceedings{CTT100773999, author = {野本 貴大 and 井上 透矢 and Yao Ying and 鈴木 実 and 金盛 開人 and 武元 宏泰 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {生体適合性機能性高分子によるボロノフェニルアラニンの代謝制御と治療効果の向上}, booktitle = {}, year = 2018, } @inproceedings{CTT100774000, author = {本田雄士 and 山田 直生 and 武元 宏泰 and 野本 貴 大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {グルタミン代謝が亢進したがん細胞の高密度グルタ ミントランスポーターを認識してアフィニティを示す機能性高 分子}, booktitle = {}, year = 2018, } @inproceedings{CTT100774001, author = {Gyomon Ryu and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of gemcitabine-conjugated poly(amino acid) and its evaluation using pancreatic tumor model}, booktitle = {}, year = 2018, } @inproceedings{CTT100774002, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue}, booktitle = {}, year = 2018, } @inproceedings{CTT100773998, author = {Sjaikhurrizal El Muttaqien and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel design of pH-responsive polymer for targeting acidic microenvironment of tumor}, booktitle = {}, year = 2018, } @inproceedings{CTT100773997, author = {Hiroyasu Takemoto and Abduhl Hackam Ranneh and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Ethylenediamine-based betaine structure switches the neutral net charge of polyzwitterion into cationic at tumorous pH toward effective tumor accumulation of the coated nanomaterials}, booktitle = {}, year = 2018, } @inproceedings{CTT100773995, author = {野本貴大 and Dou Xuebo and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {IRDye 700DXの腫瘍内分布を制御する環状RGD担持高分子コンジュゲートによる光線力学効果の検討}, booktitle = {}, year = 2018, } @inproceedings{CTT100773994, author = {yao ying and 野本貴大 and 井上透矢 and 鈴木実 and 松井誠 and 武元宏泰 and 友田敬士郎 and 西山伸宏}, title = {Tumor-targeted delivery of BPA using functional polymers for boron neutron capture therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100783092, author = {西山伸宏}, title = {機能性ポリマーによるナノDDS設計:高分子ミセルからナノマシンへ}, booktitle = {}, year = 2018, } @inproceedings{CTT100773990, author = {劉暁夢 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {可逆的にゲムシタビンを担持するポリアミノ酸型キャリアの開発とすい臓がんモデルでの機能評価}, booktitle = {}, year = 2018, } @inproceedings{CTT100773993, author = {武元宏泰 and Ranneh Abdul-Hackam and 野本貴大 and 松井誠 and 友田敬士郎 and 持田祐希 and 内藤瑞 and 西山伸宏}, title = {腫瘍内環境を認識する高分子ベタインの開発とナノ粒子の効率的な腫瘍集積への展開}, booktitle = {}, year = 2018, } @inproceedings{CTT100773992, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {siRNAへのCoil-globule挙動を有する高分子の結合と生体温度付近での遺伝子発現抑制能の精密制御}, booktitle = {}, year = 2018, } @inproceedings{CTT100768254, author = {1. 野本貴大 and 福島重人 and 熊谷康顕 and 宮崎幸造 and 井上明季 and Mi Peng and 前田芳周 and 籐加珠子 and 松本有 and 守本祐司 and 岸村顕広 and 西山伸宏 and 片岡一則 and 野本貴大}, title = {効率的な光線力学療法を指向したハイブリッド型光増感剤送達システム}, booktitle = {}, year = 2018, } @inproceedings{CTT100773964, author = {Nobuhiro Nishiyama}, title = {Development of Smart Nanodiagnostics for Targeted Cancer Therapy}, booktitle = {}, year = 2018, } @misc{CTT100768248, author = {Takahiro Nomoto and Nobuhiro Nishiyama}, title = {Design of drug delivery systems for physical energy-induced chemical surgery}, year = 2018, } @misc{CTT100789761, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 山田直生 and 西森司 and 佐谷 秀行 and 永野 修  and 土橋 賢司 and 推名 健太郎}, title = {抗腫瘍剤}, howpublished = {登録特許}, year = 2020, month = {}, note = {特願2017-560416(2017/01/05), 再表2017/119462(2018/11/01), 特許第6803589号(2020/12/03)} }