"辻本 泰貴,山本 直希,Toshiaki Fukushima,Masayuki Komada,大町 侑香,本村 悠馬,大井 佑夏,佐々木 百合子,鈴木正暉,浦井 伸,坂東 弘教,山本 雅昭,井口 元三,西岡 宏,山田 正三,小川 渉,福岡 秀規","ACTH産生下垂体腫瘍におけるWW-like領域を含めたUSP8体細胞変異の解析","第97回日本内分泌学会総会",,,,,,2024,June
"Lestari B,Fukushima T,Utomo RY,Wahyuningsih MSH","Apoptotic and non-apoptotic roles of caspases in placenta physiology and pathology.",,"Placenta",,"Vol. 151",,"Page 37-47",2024,June
"Toshiaki Fukushima","Deubiquitinating enzyme USP8 controls proliferative signals and cell division, and its constitutive activation causes neoplastic diseases","International Symposium on “Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions”",,,,,,2024,Mar.
"Akinori Endo,Toshiaki Fukushima,高橋ちかげ,土屋光,大竹史明,Sayaka Ono,Ly Tony,吉田雪子,田中啓二,佐伯泰,Masayuki Komada","USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes.",,"Journal of Cell Biology",,"Vol. 223","No. 3","Page e202306013",2024,Mar.
"Marsya Nurrachma,Beni Lestari,Masayuki Komada,Toshiaki Fukushima","Development of a new method for identifying ubiquitin-binding proteins based on the Split-TurboID technology","第46回日本分子生物学会年会",,,,,,2023,Dec.
"Gai Ando,森次 圭,木寺 詔紀,Keijun Kakihara,Masayuki Komada,Toshiaki Fukushima","脱ユビキチン化酵素USP48の活性制御機構とクッシング病関連変異による制御異常","第46回日本分子生物学会年会",,,,,,2023,Dec.
"Kenta Hagiuda,Yuya Himi,Keijun Kakihara,Masayuki Komada,Toshiaki Fukushima","ユビキチン化依存的なGagとALIXの相互作用によってレンチウイルスRNAのウイルス粒子への取り込みが促進される","第46回日本分子生物学会年会",,,,,,2023,Dec.
"Yuzuka Nishioka,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","SNAREタンパク質VAMP8・STX17のユビキチン化がオートファジーの進行に果たす役割","第46回日本分子生物学会年会",,,,,,2023,Dec.
"KIMITOSHI DENDA,Masaya Kiyota,Sing Ying Wong,Kai Fushimi,Akira Kato,Beni Lestari,Toshiaki Fukushima,Masayuki Komada,nobuhiro hayashi","卵巣プロテオミクスによるプロテインキナーゼ NRKの機能解明","第46回日本分子生物学会年会",,,,,,2023,Dec.
"Keijun Kakihara,Masayuki Komada,Toshiaki Fukushima","Caspase-dependent STAMBPL1 cleavage promotes cell death through its C-terminal fragment with hyperactive deubiquitinating activity","The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “from Neo-Biology to Target Protein Degradation”",,,,,,2023,Dec.
"Nanami Kuramochi,Masayuki Komada,Toshiaki Fukushima","活性型ユビキチンプローブを用いたプロファイリングによる細胞老化関連DUBの同定","第46回日本分子生物学会年会",,,,,,2023,Dec.
"吉村 玲奈,Beni Lestari,Toshiaki Fukushima,森次 圭","NRKによるCK2活性制御の構造モデリングと解析","第61回日本生物物理学会",,,,,,2023,Nov.
"Junya Adachi,Toshiaki Fukushima,Haruka Oda,Hiroka Sugai,Kohei Sato,Hiroshi Kimura,Kazushi Kinbara","粘度応答性蛍光プローブの開発と生細胞内における応答性","第17回バイオ関連化学シンポジウム",,,,,,2023,Sept.
"Junya Adachi,Haruka Oda,Toshiaki Fukushima,Hiroka Sugai,Kohei Sato,Hiroshi Kimura,Kazushi Kinbara","水溶性蛍光プローブの生細胞内における粘度応答性とメラノソームの可視化","日本化学会第103春季年会",,,,,,2023,Mar.
"Keijun Kakihara,Masayuki Komada,Toshiaki Fukushima","Cis-activity regulation of USP8 and STAMBPL1, two endosomal deubiquitinating enzymes, and role of dysregulation in disease onset","TMiMS国際シンポジウム「New Frontiers in Ubiquitin Proteasome System」",,,,,,2022,Dec.
"Yomogita H,Ito H,Hashimoto K,Kudo A,Fukushima T,Endo T,Hirate Y,Akimoto Y,Komada M,Kanai Y,Miyasaka N,Kanai-Azuma M","A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas",,"J Reprod Dev Mol",,"Vol. 69","No. 1","Page 32-40",2022,Dec.
"Gai Ando,Keijun Kakihara,Masayuki Komada,Toshiaki Fukushima","Molecular mechanisms underlying the over-activation of USP8 and USP48 by Cushing’s disease-associated mutations","The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “from Neo-Biology to Target Protein Degradation”",,,,,,2022,Dec.
"Marsya Yonna Nurrachma,Beni Lestari,Masayuki Komada,Toshiaki Fukushima","Ubiquitination-mediated activation of AKT and its cancer-associated mutants","第45回 日本分子生物学会年会",,,,,,2022,Nov.
"Toshiaki Fukushima,Keijun Kakihara,Kengo Asamizu,森次 圭,Tetsuya Kitaguchi,Masayuki Komada","クッシング病を引き起こすUSP8の過剰活性化機構","第95回 日本生化学会大会シンポジウム「ユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性」","第95回日本生化学会大会要旨集",,,,,2022,Nov.
"Yuzuka Nishioka,Keijun Kakihara,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","脱ユビキチン化酵素USP8によるVAMP8の制御とその細胞質分裂における意義の解明","第45回 日本分子生物学会年会",,,,,,2022,Nov.
"Junya Adachi,Toshiaki Fukushima,Haruka Oda,Hiroka Sugai,Kohei Sato,Hiroshi Kimura,Kazushi Kinbara","非TICT型粘度応答性蛍光プローブの開発と生細胞イメージングへの適用","2022年光化学討論会",,,,,,2022,Sept.
"Keijun Kakihara,Kei Moritsugu,Tetsuya Kitaguchi,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","Autoinhibition of USP8 by WW-like domain and the dysregulation in Cushing’s disease","EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”","EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”",,,,,2022,Sept.
"Toshiaki Fukushima,Keijun Kakihara,Masayuki Komada","脱ユビキチン化酵素USP8の遺伝子変異を介したクッシング病の発症メカニズム","第27回 日本病態プロテアーゼ学会学術集会",,,,,,2022,Aug.
"Junya Adachi,Toshiaki Fukushima,Haruka Oda,Hiroka Sugai,Kohei Sato,Hiroshi Kimura,Kazushi Kinbara","Development of Anthracene-Based Fluorescent Probes for Application in Cellular Systems","The 19th International Symposium on Novel Aromatic Compounds",,,,,,2022,July
"Toshiaki Fukushima","USP8 の機能異常は様々な疾患の発症・増悪に関与する","新学術領域「ケモユビキチン」第6回班会議（オンライン）",,,,,,2022,Feb.
"Beni Lestari,Satomi Naito,Akinori Endo,Hidenori Nishihara,Akira Kato,Erika Watanabe,Kimitoshi Denda,Masayuki Komada,Toshiaki Fukushima","Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2?PTEN?AKT Pathway and Placental Cell Proliferation",,"Molecular Biology and Evolution",,"Vol. 39","No. 2","p. msab371",2022,Feb.
"Keijun Kakihara,Kengo Asamizu,森次圭,Tetsuya Kitaguchi,Akinori Endo,木寺詔記,池口満徳,Masayuki Komada,Toshiaki Fukushima","脱ユビキチン化酵素USP8の自己阻害機構とクッシング病関連変異によるその解除","第44回日本分子生物学会年会","第44回日本分子生物学会年会要旨集",,,,,2021,Dec.
"蓬田裕,高峰愛幸,伊藤日加瑠,平手良和,Toshiaki Fukushima,Masayuki Komada,金井克晃,宮坂尚幸,金井正美","マウス、ヒト胎盤におけるNrk下流遺伝子群と分娩遅延の関連について","日本分子生物学会年会",,,,,,2021,Dec.
"Beni Lestari,Satomi Naito,Akinori Endo,Hidenori Nishihara,Akira Kato,Erika Watanabe,Kimitoshi Denda,Masayuki Komada,Toshiaki Fukushima","Comparative Phylogenetic Analysis and Molecular Characterization Reveal Eutherian-Specific Role of NRK in Regulating Placenta Development","日本分子生物学会年会",,,,,,2021,Dec.
"Yuya Himi,Keijun Kakihara,Akira Kato,Masayuki Komada,Toshiaki Fukushima","脱ユビキチン酵素USP8はレンチウイルス粒子へのウイルスRNAの動員を阻害することによってウイルスの増殖を防ぐ","日本分子生物学会年会",,,,,,2021,Dec.
"Keijun Kakihara,Kengo Asamizu,Kei Moritsugu,Masahide Kubo,Tetsuya Kitaguchi,Akinori Endo,Akinori Kidera,Mitsunori Ikeguchi,Akira Kato,Masayuki Komada,Toshiaki Fukushima.","Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.",,"Commun Biol",,"  4",,"  1272",2021,Nov.
"B?ziat V,Rapaport F,Hu J,Titeux M,Bonnet des Claustres M,Bourgey M,Griffin H,Bandet ?,Ma CS,Sherkat R,Rokni-Zadeh H,Louis DM,Changi-Ashtiani M,Delmonte OM,Fukushima T,Guennoun A,Khan T,Bender N,Rahman M,About F,Yang R,Rao G,Rouzaud C,Li J,Shearer D,Balogh K,Al Ali F,Ata M,Dabiri S,Momenilandi M,Nammour J,Alyanakian MA,Leruez-Ville M,Guenat D,Materna M,Marcot L,Vladikine N,Soret C,Vahidnezhad H,Youssefian L,Saeidian AH,Uitto J,Catherinot ?,Navabi SS,Zarhrate M,Woodley DT,Jeljeli M,Abraham T,Belkaya S,Lorenzo L,Rosain J,Bayat M,Lanternier F,Lortholary O,Zakavi F,Gros P,Orth G,Abel L,Pr?tet JL,Fraitag S,Jouanguy E,Davis MM,Tangye SG,Notarangelo LD,Marr N,Waterboer T,Langlais D,Doorbar J,Hovnanian A,Christensen N,Bossuyt X,Shahrooei M,Casanova JL.","Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.",,"Cell",,"Vol. 184","No. 14","pp. 3812-3828",2021,July
"Toshiaki Fukushima","USP8の自己阻害機構の理解に基づく阻害剤開発とクッシング病治療への応用","新学術領域「ケモユビキチン」第5回領域班会議",,,,,,2021,June
"Keijun Kakihara,Kengo Asamizu,Kei Moritsugu,Masahide Kubo,Tetsuya Kitaguchi,Akinori Endo,Akinori Kidera,Mitsunori Ikeguchi,Akira Kato,Masayuki Komada,Toshiaki Fukushima","The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain",,"bioRxiv",,,,,2021,May
"Toshiaki Fukushima,Akinori Endo,Kohei Kawaguchi,円由香,Masayuki Komada","クッシング病の治療薬開発を目指したUSP8-STAM1複合体を作用点とするACTH分泌制御物質の開発","第6回橋渡し研究戦略的推進プログラムシンポジウム",,,,,,2021,Mar.
"Toshiaki Fukushima","ケモテクノロジーによって明らかとなった脱ユビキチン化酵素USP8の作用機構","新学術領域研究「ケモユビキチン」第4回領域班会議",,,,,,2021,Feb.
"Toshiaki Fukushima,Kohei Kawaguchi","コラーゲンの細胞内輸送の分子機構 -脱ユビキチン化酵素 USP8 による輸送制御-",,"FRAGRANCE JOURNAL","フレグランスジャーナル社",,,,2020,Aug.
"Satomi Naito,Toshiaki Fukushima,Akinori Endo,Kimitoshi Denda,Masayuki Komada","Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP",,"FEBS Letters",,"  594","  11","  1778-1786",2020,Mar.
"Keijun Kakihara,Kengo Asamizu,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction","The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)",,,,,,2019,Dec.
"Toshiaki Fukushima","The mechanism of action of wild-type and Cushing's disease-associated mutant USP8","新学術領域「ケモユビキチン」第3回班会議",,,,,,2019,Dec.
"Satomi Naito,Akinori Endo,Kimitoshi Denda,Akira Kato,Masayuki Komada,Toshiaki Fukushima","Nik-related kinase is regulated by quality control ubiquitin ligase CHIP","新学術領域「ケモユビキチン」第3回班会議",,,,,,2019,Dec.
"Keijun Kakihara,Kengo Asamizu,Akinori Endo,Kei Moritsugu,Akira Kato,Masayuki Komada,Toshiaki Fukushima","The enzyme activity of USP8 is regulated by the intramolecular interaction of the USP domain and the WW domain","新学術領域「ケモユビキチン」第3回班会議",,,,,,2019,Dec.
"Arakaki Saki,Toshiaki Fukushima","14-3-3 protein regulates USP8-STAM1 complex formation and the subcellular localization","新学術領域「ケモユビキチン」第3回班会議",,,,,,2019,Dec.
"Satomi Naito,Akinori Endo,Kimitoshi Denda,Yuka Madoka,Akira Kato,Masayuki Komada,Toshiaki Fukushima","Nrk prevents hyperplasia by modulating CK2-PTEN-Akt signaling pathway","The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)",,,,,,2019,Dec.
"Toshiaki Fukushima,Yuka Madoka,Akinori Endo,Kohei Kawaguchi,Saki Arakaki,Masayuki Komada","Constitutive formation of USP8-STAM1 complex plays an important role in the onset of Cushing’s disease","The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)",,,,,,2019,Dec.
"Keijun Kakihara,Kengo Asamizu,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction","The 92nd Annual Meeting of the Japanease Biochemical Society",,,,,,2019,Sept.
"Toshiaki Fukushima","USP8-STAM1 deubiquitinating enzyme complex is a novel drug target for Cushing's disease","Targeted Protein Degradation Forum in Japan",,,,,,2019,Aug.
"Keijun Kakihara,Kengo Asamizu,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","脱ユヒ?キチン化酵素 USP8 の自己活性抑制機構","2019年度日本生化学会関東支部例会",,,,,,2019,June
"Toshiaki Fukushima","The mechanism of action of deubiquitinating enzyme USP8 revealed by chemo-technologies","新学術領域「ケモユビキチン」第２回班会議",,,,,,2019,June
"WH. Chan,M. Komada,T. Fukushima,EM. Southard-Smith,CR. Anderson. MJ. Wakefield","RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development",,"Scientific Reports",,"Vol. 9","No. 1","Page 3929",2019,Mar.
"Ryohei Sakai,Ryosuke Fukuda,Shin Unida,Misaki Aki,Yuji Ono,Akinori Endo,Satoshi Kusumi,Daisuke Koga,Toshiaki Fukushima,Masayuki Komada,Tsukasa Okiyoneda","The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors",,"Journal of cell science",,"Vol. 132","No. 3","pp. 228007",2019,Feb.
"Ryohei Sakai,Ryosuke Fukuda,Shin Unida,Misaki Aki,Yuji Ono,Akinori Endo,Satoshi Kusumi,Daisuke Koga,Toshiaki Fukushima,Masayuki Komada,Tsukasa Okiyoneda","The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors",,"Journal of cell science",,"Vol. 132","No. 3","pp. 228007",2019,Feb.
"Toshiaki Fukushima","USP8遺伝子変異によるクッシング病発症機構解明の新展開","第2回ユビキチン研究会",,,,,,2019,Jan.
"R. Sakai,R. Fukuda,S. Unida,M. Aki,Y. Ono,A. Endo,S. Kusumi,D. Koga,T. Fukushima,M. Komada,T. Okiyoneda","The integral function of endocytic recycling compartment is regulated by RFFL-mediated ubiquitination of Rab11 effectors",,"J Cell Sci",,,,,2019,Jan.
"Keijun Kakihara,Kengo Asamizu,Akinori Endo,Masayuki Komada,Toshiaki Fukushima","脱ユビキチン化酵素USP8の自己活性抑制機構","第2回ユビキチン研究会",,,,,,2019,Jan.
"Akinori Endo,Toshiaki Fukushima,Masayuki Komada","A deubiquitinase USP8, a master regulator of endosome-centered membrane traffic, controls inter-cellular signal transduction.","Annual Meeting of the Molecular Biology Society of Japan",,,,,,2018,Nov.
"Takahiro Sawada,Kazuya Inoko,Kohei Kawaguchi,Akinori Endo,Yasushi Saeki,Keiji Tanaka,Toshiaki Fukushima,Masayuki Komada","Nuclear localization mechanism of deubiquitinating enzyme USP8 in Cushing’s disease","Annual Meeting of the Molecular Biology Society of Japan",,,,,,2018,Nov.
"Satomi Naito,Akinori Endo,Toshiaki Fukushima,Kimitoshi Denda,Akira Kato,Masayuki Komada","Molecular mechanisms underlying the control of Nrk protein levels and Nrk-mediated anti-proliferation effects","Annual Meeting of the Molecular Biology Society of Japan",,,,,,2018,Nov.
"Toshiaki Fukushima,Takahiro Sawada,Kazuya Inoko,Suguru Machidori,Akinori Endo,Masayuki Komada","脱ユビキチン化酵素USP8の遺伝子変異に起因するACTH過剰産生の分子機構","第２回 ＰＯＭＣ研究者の集い",,,,,,2018,Sept.
"H. Furuta,H. Yoshihara,T. Fukushima,Y. Yoneyama,A. Ito,C. Worrall,A. Girnita,L. Girnita,M. Yoshida,T. Asano,M. Komada,N. Kataoka,K. Chida,F. Hakuno,SI. Takahashi","IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line",,"Oncotarget",,"Vol. 9","No. 74","Page 33871-33883",2018,Sept.
"Suguru Machidori,Kazuya Inoko,Kohei Kawaguchi,Akinori Endo,Toshiaki Fukushima,Masayuki Komada","USP8 遺伝子のゲノム編集によるCushing 病モデル細胞の作製と解析","第３３回日本下垂体研究会学術集会",,,,,,2018,Aug.
"Toshiaki Fukushima","USP8, a deubiquitinating enzyme in the endocytic pathway, plays roles in proteostasis in the secretory pathway.","Tokyo Tech WRHI-Cell Biology Center Mini-Symposium on Proteostasis in the Cell",,,,,,2018,Aug.
"Kohei Kawaguchi,Akinori Endo,Toshiaki Fukushima,Masayuki Komada","Ubiquitin-specific protease 8 suppresses collagen secretion by deubiquitinating Sec31","Cell and Developmental Biology Meeting",,,,,,2018,June
"K. Kawaguchi,A. Endo,T. Fukushima,Y. Madoka,T. Tanaka,M. Komada","Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion",,"Biochem Biophys Res Commun",,"Vol. 499","No. 3","pp. 635-641",2018,May
"Xie Xuan,Shunsuke Matsumoto,Akinori Endo,Toshiaki Fukushima,Hiroyuki Kawahara,Yasushi Saeki,Masayuki Komada","Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities.","Cold Spring Harbor Asia Conferences, Ubiquitin Family, Autophagy and Diseases",,,,,,2018,Apr.
"X. Xie,S. Matsumoto,A. Endo,T. Fukushima,H. Kawahara,Y. Saeki,M. Komada","Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities",,"J Cell Sci",,,,,2018,Mar.
"Kimitoshi Denda,二口  充,丹野  正隆,Toshiaki Fukushima,Yoko Tanabe,nobuhiro hayashi","胎盤特異的な新規プロテインキナーゼNRKは乳腺組織における細胞増殖制御を司る",,,,,,,2018,Jan.
"M. Ariga,Y. Yoneyama,T. Fukushima,Y. Ishiuchi,T. Ishii,H. Sato,F. Hakuno,T. Nedachi,S. I. Takahashi","Glucose deprivation attenuates sortilin levels in skeletal muscle cells",,"Endocr J",,"Vol. 64","No. 3","pp. 255-268",2017,Mar.
"T. Fukushima,H. Yoshihara,H. Furuta,F. Hakuno,S. I. Iemura,T. Natsume,Y. Nakatsu,H. Kamata,T. Asano,M. Komada,S. I. Takahashi","USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination",,"Biochem Biophys Res Commun",,"Vol. 484","No. 3","pp. 522-528",2017,Mar.
"T. Yamamotoya,Y. Nakatsu,Y. Matsunaga,T. Fukushima,H. Yamazaki,S. Kaneko,M. Fujishiro,T. Kikuchi,A. Kushiyama,F. Tokunaga,T. Asano,H. Sakoda","Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice",,"Int J Mol Sci",,"Vol. 18","No. 2",,2017,Feb.
"T. Yanagawa,K. Denda,T. Inatani,T. Fukushima,T. Tanaka,N. Kumaki,Y. Inagaki,M. Komada","Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice",,"Am J Pathol",,"Vol. 186","No. 10","pp. 2751-60",2016,Oct.
"Takayo Yanagawa,Kimitoshi Denda,Takuya Inatani,Toshiaki Tanaka,Toshiaki Fukushima,Nobue Kumaki,Yutaka Inagaki,Masayuki Komada","乳がんを抑制する新たな遺伝子を発見",,"大学ジャーナル",,,,,2016,Sept.
"Takayo Yanagawa,Kimitoshi Denda,Takuya Inatani,Toshiaki Tanaka,Toshiaki Fukushima,Nobue Kumaki,Yutaka Inagaki,Masayuki Komada.","乳がんを抑制する新たな遺伝子を発見―ヒト乳がんの診断・治療への応用に期待―",,,"東工大ニュース",,,,2016,Sept.
"L. Girnita,S. I. Takahashi,C. Crudden,T. Fukushima,C. Worrall,H. Furuta,H. Yoshihara,F. Hakuno,A. Girnita","Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling",,"Prog Mol Biol Transl Sci",,"Vol. 141",,"pp. 277-311",2016,Apr.
"H. Okubo,A. Kushiyama,H. Sakoda,Y. Nakatsu,M. Iizuka,N. Taki,M. Fujishiro,T. Fukushima,H. Kamata,A. Nagamachi,T. Inaba,F. Nishimura,H. Katagiri,T. Asahara,Y. Yoshida,O. Chonan,J. Encinas,T. Asano","Involvement of resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice",,"Sci Rep",,"Vol. 6",,"pp. 20157",2016,
"Y. Nakatsu,M. Iwashita,H. Sakoda,H. Ono,K. Nagata,Y. Matsunaga,T. Fukushima,M. Fujishiro,A. Kushiyama,H. Kamata,S. Takahashi,H. Katagiri,H. Honda,H. Kiyonari,T. Uchida,T. Asano","Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the gamma subunit",,"J Biol Chem",,"Vol. 290","No. 40","pp. 24255-66",2015,Oct.
"T. Shinjo,Y. Nakatsu,M. Iwashita,T. Sano,H. Sakoda,H. Ishihara,A. Kushiyama,M. Fujishiro,T. Fukushima,Y. Tsuchiya,H. Kamata,F. Nishimura,T. Asano","DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappaB activation",,"Am J Physiol Endocrinol Metab",,"Vol. 309","No. 3","pp. E214-23",2015,Aug.
"T. Fukushima,H. Yoshihara,H. Furuta,H. Kamei,F. Hakuno,J. Luan,C. Duan,Y. Saeki,K. Tanaka,S. Iemura,T. Natsume,K. Chida,Y. Nakatsu,H. Kamata,T. Asano,S. Takahashi","Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity",,"Nat Commun",,"Vol. 6",,"pp. 6780",2015,Apr.
"H. Okubo,Y. Nakatsu,H. Sakoda,A. Kushiyama,M. Fujishiro,T. Fukushima,Y. Matsunaga,H. Ohno,M. Yoneda,H. Kamata,T. Shinjo,M. Iwashita,F. Nishimura,T. Asano","Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model",,"Am J Physiol Gastrointest Liver Physiol",,"Vol. 308","No. 2","pp. G151-8",2015,Jan.
"R. Kanaoka,A. Kushiyama,Y. Seno,Y. Nakatsu,Y. Matsunaga,T. Fukushima,Y. Tsuchiya,H. Sakoda,M. Fujishiro,T. Yamamotoya,H. Kamata,A. Matsubara,T. Asano","Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines",,"PLoS One",,"Vol. 10","No. 6","pp. e0127467",2015,
"F. Hakuno,T. Fukushima,Y. Yoneyama,H. Kamei,A. Ozoe,H. Yoshihara,D. Yamanaka,T. Shibano,M. Sone-Yonezawa,B. C. Yu,K. Chida,S. Takahashi","The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins",,"Front Endocrinol (Lausanne)",,"Vol. 6",,"pp. 73",2015,
"Y. Matsunaga,Y. Nakatsu,T. Fukushima,H. Okubo,M. Iwashita,H. Sakoda,M. Fujishiro,T. Yamamotoya,A. Kushiyama,S. Takahashi,Y. Tsuchiya,H. Kamata,F. Tokunaga,K. Iwai,T. Asano","LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis",,"Mediators Inflamm",,"Vol. 2015",,"pp. 125380",2015,
"Y. Kawashima,F. Hakuno,S. Okada,T. Hotsubo,T. Kinoshita,M. Fujimoto,R. Nishimura,T. Fukushima,K. Hanaki,S. Takahashi,S. Kanzaki","Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation",,"Clin Endocrinol (Oxf)",,"Vol. 81","No. 2","pp. 312-4",2014,Aug.
"A. Ozoe,M. Sone,T. Fukushima,N. Kataoka,K. Chida,T. Asano,F. Hakuno,S. Takahashi","Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis",,"Front Endocrinol (Lausanne)",,"Vol. 5",,"pp. 24",2014,Mar.
"M. Iwashita,Y. Nakatsu,H. Sakoda,M. Fujishiro,A. Kushiyama,T. Fukushima,S. Kumamoto,T. Shinjo,H. Kamata,F. Nishimura,T. Asano","Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice",,"Adipocyte",,"Vol. 2","No. 1","pp. 28-32",2014,Jan.
"H. Okubo,H. Sakoda,A. Kushiyama,M. Fujishiro,Y. Nakatsu,T. Fukushima,Y. Matsunaga,H. Kamata,T. Asahara,Y. Yoshida,O. Chonan,M. Iwashita,F. Nishimura,T. Asano","Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model",,"Am J Physiol Gastrointest Liver Physiol",,"Vol. 305","No. 12","pp. G911-8",2013,Nov.
"A. Ozoe,M. Sone,T. Fukushima,N. Kataoka,T. Arai,K. Chida,T. Asano,F. Hakuno,S. Takahashi","Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes",,"FEBS Lett",,"Vol. 587","No. 15","pp. 2319-24",2013,Aug.
"A. Kushiyama,H. Sakoda,N. Oue,M. Okubo,Y. Nakatsu,H. Ono,T. Fukushima,H. Kamata,F. Nishimura,T. Kikuchi,M. Fujishiro,K. Nishiyama,H. Aburatani,S. Kushiyama,M. Iizuka,N. Taki,J. Encinas,K. Sentani,N. Ogonuki,A. Ogura,S. Kawazu,W. Yasui,Y. Higashi,H. Kurihara,H. Katagiri,T. Asano","Resistin-like molecule beta is abundantly expressed in foam cells and is involved in atherosclerosis development",,"Arterioscler Thromb Vasc Biol",,"Vol. 33","No. 8","pp. 1986-93",2013,Aug.
"J. Zhang,Y. Nakatsu,T. Shinjo,Y. Guo,H. Sakoda,T. Yamamotoya,Y. Otani,H. Okubo,A. Kushiyama,M. Fujishiro,T. Fukushima,Y. Tsuchiya,H. Kamata,M. Iwashita,F. Nishimura,H. Katagiri,S. Takahashi,H. Kurihara,T. Uchida,T. Asano","Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions",,"J Biol Chem",,"Vol. 288","No. 28","pp. 20692-701",2013,July
"Y. Otani,Y. Nakatsu,H. Sakoda,T. Fukushima,M. Fujishiro,A. Kushiyama,H. Okubo,Y. Tsuchiya,H. Ohno,S. Takahashi,F. Nishimura,H. Kamata,H. Katagiri,T. Asano","Integrator complex plays an essential role in adipose differentiation",,"Biochem Biophys Res Commun",,"Vol. 434","No. 2","pp. 197-202",2013,May
"Y. Nakatsu,Y. Otani,H. Sakoda,J. Zhang,Y. Guo,H. Okubo,A. Kushiyama,M. Fujishiro,T. Kikuch,T. Fukushima,H. Ohno,Y. Tsuchiya,H. Kamata,A. Nagamachi,T. Inaba,F. Nishimura,H. Katagiri,S. Takahashi,H. Kurihara,T. Uchida,T. Asano","Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model",,"J Biol Chem",,"Vol. 287","No. 53","pp. 44526-35",2012,Nov.
"T. Fukushima,Y. Nakamura,D. Yamanaka,T. Shibano,K. Chida,S. Minami,T. Asano,F. Hakuno,S. Takahashi","Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation",,"J Biol Chem",,"Vol. 287","No. 35","pp. 29713-21",2012,Aug.
"Y. Kawashima,K. Higaki,T. Fukushima,F. Hakuno,J. Nagaishi,K. Hanaki,E. Nanba,S. Takahashi,S. Kanzaki","Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation",,"Clin Endocrinol (Oxf)",,"Vol. 77","No. 2","pp. 246-54",2012,Aug.
"H. Yoshihara,T. Fukushima,F. Hakuno,Y. Saeki,K. Tanaka,A. Ito,M. Yoshida,S. Iemura,T. Natsume,T. Asano,K. Chida,L. Girnita,S. Takahashi","Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs",,"Biochem Biophys Res Commun",,"Vol. 423","No. 1","pp. 122-7",2012,June
"D. Yamanaka,T. Akama,T. Fukushima,T. Nedachi,C. Kawasaki,K. Chida,S. Minami,K. Suzuki,F. Hakuno,S. Takahashi","Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells",,"Mol Endocrinol",,"Vol. 26","No. 6","pp. 1043-55",2012,June
"A. Kushiyama,H. Okubo,H. Sakoda,T. Kikuchi,M. Fujishiro,H. Sato,S. Kushiyama,M. Iwashita,F. Nishimura,T. Fukushima,Y. Nakatsu,H. Kamata,S. Kawazu,Y. Higashi,H. Kurihara,T. Asano","Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development",,"Arterioscler Thromb Vasc Biol",,"Vol. 32","No. 2","pp. 291-8",2012,Feb.
"M. Iwashita,H. Sakoda,A. Kushiyama,M. Fujishiro,H. Ohno,Y. Nakatsu,T. Fukushima,S. Kumamoto,Y. Tsuchiya,T. Kikuchi,H. Kurihara,H. Akazawa,I. Komuro,H. Kamata,F. Nishimura,T. Asano","Valsartan, independently of AT1 receptor or PPARgamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes",,"Am J Physiol Endocrinol Metab",,"Vol. 302","No. 3","pp. E286-96",2012,Feb.
"T. Fukushima,H. Okajima,D. Yamanaka,M. Ariga,S. Nagata,A. Ito,M. Yoshida,T. Asano,K. Chida,F. Hakuno,S. Takahashi","HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells",,"Mol Cell Endocrinol",,"Vol. 344","No. 1-2","pp. 81-9",2011,Sept.
"Y. Nakatsu,H. Sakoda,A. Kushiyama,J. Zhang,H. Ono,M. Fujishiro,T. Kikuchi,T. Fukushima,M. Yoneda,H. Ohno,N. Horike,M. Kanna,Y. Tsuchiya,H. Kamata,F. Nishimura,T. Isobe,T. Ogihara,H. Katagiri,Y. Oka,S. Takahashi,H. Kurihara,T. Uchida,T. Asano","Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis",,"J Biol Chem",,"Vol. 286","No. 23","pp. 20812-22",2011,June
"H. Ohno,Y. Nakatsu,H. Sakoda,A. Kushiyama,H. Ono,M. Fujishiro,Y. Otani,H. Okubo,M. Yoneda,T. Fukushima,Y. Tsuchiya,H. Kamata,F. Nishimura,H. Kurihara,H. Katagiri,Y. Oka,T. Asano","4F2hc stabilizes GLUT1 protein and increases glucose transport activity",,"Am J Physiol Cell Physiol",,"Vol. 300","No. 5","pp. C1047-54",2011,May
"T. Fukushima,T. Arai,M. Ariga-Nedachi,H. Okajima,Y. Ooi,Y. Iijima,M. Sone,Y. Cho,Y. Ando,K. Kasahara,A. Ozoe,H. Yoshihara,K. Chida,S. Okada,J. J. Kopchick,T. Asano,F. Hakuno,S. Takahashi","Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases",,"Biochem Biophys Res Commun",,"Vol. 404","No. 3","pp. 767-73",2011,Jan.
"Y. Nakatsu,H. Sakoda,A. Kushiyama,H. Ono,M. Fujishiro,N. Horike,M. Yoneda,H. Ohno,Y. Tsuchiya,H. Kamata,H. Tahara,T. Isobe,F. Nishimura,H. Katagiri,Y. Oka,T. Fukushima,S. Takahashi,H. Kurihara,T. Uchida,T. Asano","Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity",,"J Biol Chem",,"Vol. 285","No. 43","pp. 33018-27",2010,Oct.
"M. Shibata,F. Hakuno,D. Yamanaka,H. Okajima,T. Fukushima,T. Hasegawa,T. Ogata,Y. Toyoshima,K. Chida,K. Kimura,H. Sakoda,A. Takenaka,T. Asano,S. Takahashi","Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes",,"J Biol Chem",,"Vol. 285","No. 27","pp. 20915-25",2010,July
"T. Fukushima,T. Nedachi,H. Akizawa,M. Akahori,F. Hakuno,S. Takahashi","Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells",,"Endocrinology",,"Vol. 149","No. 7","pp. 3729-42",2008,July
"Y. Kawashima,S. Kanzaki,F. Yang,T. Kinoshita,K. Hanaki,J. Nagaishi,Y. Ohtsuka,I. Hisatome,H. Ninomoya,E. Nanba,T. Fukushima,S. Takahashi","Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation",,"J Clin Endocrinol Metab",,"Vol. 90","No. 8","pp. 4679-87",2005,Aug.
"Y. Okubo,K. Siddle,H. Firth,S. O'Rahilly,L. C. Wilson,L. Willatt,T. Fukushima,S. Takahashi,C. J. Petry,T. Saukkonen,R. Stanhope,D. B. Dunger","Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene",,"J Clin Endocrinol Metab",,"Vol. 88","No. 12","pp. 5981-8",2003,Nov.
"S. I. Takahashi,T. Nedachi,T. Fukushima,K. Umesaki,Y. Ito,F. Hakuno,J. J. Van Wyk,M. Conti","Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells",,"Biochim Biophys Acta",,"Vol. 1540","No. 1","pp. 68-81",2001,July