@article{CTT100916683,
  author = {Dhimas Agung Kurniawan and Sylvia Leo and Mutsumi Inamatsu and Sohei Funaoka and Taichi Aihara and Mizuno Aiko and Inoue Rei and Takeshi Sakura and Hiroshi Arakawa and Yukio Kato and Tomoaki Matsugi and Katsuhiro Esashika and Nobuaki Shiraki and Shoen Kume and Kenta Shinha and Hiroshi Kimura and Masaki Nishikawa and Yasuyuki Sakai},
  title = {Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism},
  journal = {PNAS Nexus},
  year = 2024,
}

@article{CTT100916685,
  author = {Kenta Ouchi and Kaori Isono and Yuki Ohya and Nobuaki Shiraki and Masayoshi Tasaki and Yukihiro Inomata and Mitsuharu Ueda and Takumi Era and Shoen Kume and Yukio Ando and Hirofumi Jono},
  title = {Characterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced pluripotent stem cells},
  journal = {Heliyon},
  year = 2024,
}

@article{CTT100915694,
  author = {Hiyoshi N and Enomoto T and Uefune F and Kato Y and Wu Y and Araki K and Sakano D and Shiraki N and Kume S.},
  title = {A specific plasma amino acid profile in the Insulin2Q104del Kuma mice at the diabetic state and reversal from hyperglycemia.},
  journal = {Biochem. Biophys. Res. Commun.},
  year = 2023,
}

@article{CTT100915687,
  author = {Tokuma H and Sakano D and Shiraki N and Kume S},
  title = {Selective proteasome degradation of the C-terminally-truncated human WFS1 mutants in the pancreatic beta cells.},
  journal = {FEBS Open Bio.},
  year = 2023,
}

@article{CTT100915691,
  author = {Helena Aprilia Grace and Teruhiko Watanabe and Kato Y and Shiraki N and Kume S.},
  title = {Activation of cAMP(EPAC2) signaling pathway promotes hepatocyte attachment.},
  journal = {Scientific Reports},
  year = 2023,
}

@article{CTT100895352,
  author = {Sylvia Leo and Yusuke Kato and Yumeng Wu and Mutsumi Yokota and Masato Koike and Shiro Yui and Kiichiro Tsuchiya and Nobuaki Shiraki and Shoen Kume},
  title = {The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells.},
  journal = {Stem Cells},
  year = 2023,
}

@article{CTT100895354,
  author = {Zixuan Erinn Sim and Takayuki Enomoto and Nobuaki Shiraki and Shoen Kume},
  title = {Protocol to generate human PSC-derived pancreatic beta-cells through methionine and zinc deprivation.},
  journal = {STAR Protocols},
  year = 2023,
}

@article{CTT100895355,
  author = {Yukihiro Shimaya and Nobuaki Shiraki and Shoen Kume},
  title = {Promoting pancreatic β cell proliferation: a powerful key for realizing regenerative therapy for diabetes. hionine and zinc deprivation.},
  journal = {J Diabetes Investig},
  year = 2023,
}

@article{CTT100895351,
  author = {Marwa ALI Ahmed and Yusuke Kato and Nobuaki Shiraki and Shoen Kume},
  title = {Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium.},
  journal = {Biology Open},
  year = 2023,
}

@article{CTT100883011,
  author = {Zixuan Erinn Sim and Takayuki Enomoto and Nobuaki Shiraki and Nao Furuta and Azusa Kambe and Hiroki Ozawa and Masayuki Miura and Shoen Kume},
  title = {Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization.},
  journal = {Cell Reports},
  year = 2022,
}

@article{CTT100856406,
  author = {Nobuaki Shiraki},
  title = {Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system},
  journal = {Scientific Reports},
  year = 2021,
}

@article{CTT100856410,
  author = {Nobuaki Shiraki},
  title = {Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies},
  journal = {Stem Cell Reports},
  year = 2021,
}

@article{CTT100856409,
  author = {Nobuaki Shiraki},
  title = {Recent progress in pancreatic islet cell therapy},
  journal = {Inflammation and Regeneration},
  year = 2021,
}

@article{CTT100856411,
  author = {Nobuaki Shiraki},
  title = {VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress},
  journal = {Diabetes},
  year = 2020,
}

@article{CTT100856412,
  author = {Nobuaki Shiraki},
  title = {Detailed analysis at a single‐cell level of cells undergoing pancreatic differentiation},
  journal = {Journal of Diabetes Investigation},
  year = 2020,
}

@article{CTT100811484,
  author = {Nobuaki Shiraki},
  title = {Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis},
  journal = {Scientific Reports},
  year = 2019,
}

@article{CTT100811486,
  author = {Nobuaki Shiraki},
  title = {Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats.},
  journal = {American journal of physiology. Endocrinology and metabolism},
  year = 2019,
}

@article{CTT100811487,
  author = {Nobuaki Shiraki},
  title = {Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells.},
  journal = {Biology open},
  year = 2019,
}

@article{CTT100811488,
  author = {Nobuaki Shiraki},
  title = {A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells.},
  journal = {Biomedical materials (Bristol, England)},
  year = 2019,
}

@article{CTT100811483,
  author = {Nobuaki Shiraki},
  title = {Induced Pluripotent Stem Cell Elimination in a Cell Sheet by Methionine-Free and 42°C Condition for Tumor Prevention.},
  journal = {Tissue engineering. Part C, Methods},
  year = 2018,
}

@article{CTT100779646,
  author = {Nobuaki Shiraki},
  title = {ヒトES細胞の維持・分化におけるメチオニン代謝の役割の解明},
  journal = {生化学},
  year = 2017,
}

@article{CTT100811489,
  author = {Nobuaki Shiraki},
  title = {Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.},
  journal = {American journal of physiology. Endocrinology and metabolism},
  year = 2017,
}

@article{CTT100753137,
  author = {Nobuaki Shiraki},
  title = {Erythropoietin facilitates definitive endodermal differentiation of mouse embryonic stem cells via activation of ERK signaling.},
  journal = {American Journal of Physiology - Cell Physiology},
  year = 2017,
}

@article{CTT100753138,
  author = {Nobuaki Shiraki},
  title = {Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm.},
  journal = {BMC biotechnology},
  year = 2017,
}

@article{CTT100724016,
  author = {Daisuke Sakano and Choi S and Kataoka M and Shiraki N and Uesugi M and Kume K and Shoen Kume},
  title = {Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.},
  journal = {Stem cell reports},
  year = 2016,
}

@article{CTT100744749,
  author = {Sakano D and Choi S and Kataoka M and Shiraki N and Uesugi M and Kume K and Kume S},
  title = {Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.},
  journal = {},
  year = 2016,
}

@article{CTT100712052,
  author = {Nobuaki Shiraki},
  title = {ヒトiPS細胞膵臓分化系を用いた生活習慣病胎児期起源説の検証},
  journal = {BIO Clinica},
  year = 2016,
}

@article{CTT100723369,
  author = {Soichiro Ogaki and Hisayoshi Omori and Mayu Morooka and Nobuaki Shiraki and Seiichi Ishida and Shoen Kume},
  title = {Late stage definitive endodermal differentiation can be defined by Daf1 expression},
  journal = {BMC Developmental Biology},
  year = 2016,
}

@article{CTT100744750,
  author = {Ogaki S and Omori H and Morooka M and Shiraki N and Ishida S and Kume S},
  title = {Late stage definitive endodermal differentiation can be defined by Daf1 expression.},
  journal = {},
  year = 2016,
}

@article{CTT100780724,
  author = {Nakashima R and Shiraki N and Daisuke Sakano and Ogaki S and Kume K and Shoen Kume},
  title = {Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.},
  journal = {Genes to Cells},
  year = 2015,
}

@article{CTT100704221,
  author = {Shahjalal HM and Shiraki N and Daisuke Sakano and Kikawa K and Ogaki S and Baba H and Kume K and Shoen Kume},
  title = {Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system.},
  journal = {Journal of Molecular Cellular and Biology},
  year = 2014,
}

@article{CTT100713325,
  author = {Kaitsuka, Taku and Noguchi, Hirofumi and Nobuaki Shiraki and Kubo, Takuya and Wei, Fan-Yan and Hakim, Farzana and Shoen Kume and Kazuhito Tomizawa},
  title = {Generation of Functional Insulin-Producing Cells From Mouse Embryonic Stem Cells Through 804G Cell-Derived Extracellular Matrix and Protein Transduction of Transcription Factors},
  journal = {Stem Cells Translational Medicine},
  year = 2014,
}

@article{CTT100713323,
  author = {Hakim, Farzana and Kaitsuka, Taku and Raeed, Jamiruddin Mohd and Wei, Fan-Yan and Nobuaki Shiraki and Akagi, Tadayuki and Yokota, Takashi and Shoen Kume and Kazuhito Tomizawa},
  title = {High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells*},
  journal = {Journal of Biological Chemistry},
  year = 2014,
}

@article{CTT100713322,
  author = {Nobuaki Shiraki and Yasuko Shiraki and Tomonori Tsuyama and Fumiaki Obata and Masayuki Miura and Genta Nagae and Hiroyuki Aburatani and Kazuhiko Kume and Fumio Endo and Shoen Kume},
  title = {Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells},
  journal = {Cell Metabolism},
  year = 2014,
}

@article{CTT100713321,
  author = {Nobuaki Shiraki and Soichiro Ogaki and Shoen Kume},
  title = {Profiling of embryonic stem cell differentiation.},
  journal = {The review of diabetic studies : RDS},
  year = 2014,
}

@article{CTT100724018,
  author = {Kazuhide Kikawa and Daisuke Sakano and Nobuaki Shiraki and Tomonori Tsuyama and Kazuhiko Kume and Fumio Endo and Shoen Kume},
  title = {Beneficial Effect of Insulin Treatment on Islet Transplantation Outcomes in Akita Mice},
  journal = {Plos One},
  year = 2014,
}

@article{CTT100713326,
  author = {Isono, Kaori and Jono, Hirofumi and Ohya, Yuki and Nobuaki Shiraki and Taiji Yamazoe and Sugasaki, Ayaka and Era, Takumi and Fusaki, Noemi and Tasaki, Masayoshi and Ueda, Mitsuharu and Shinriki, Satoru and Inomata, Yukihiro and Shoen Kume and Ando, Yukio},
  title = {Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells},
  journal = {Stem Cell Research},
  year = 2014,
}

@article{CTT100780621,
  author = {Daisuke Sakano and Shiraki N and Kikawa K and Yamazoe T and Kataoka M and Umeda K and Araki K and Mao D and Matsumoto S and Nakagata N and Andersson O and Stainier D and Endo F and Kume K and Uesugi M and Shoen Kume},
  title = {VMAT2 identified as a regulator of late-stage β-cell differentiation.},
  journal = {Nature Chemical Biology},
  year = 2014,
}

@article{CTT100704230,
  author = {Ogaki S and Shiraki N and Kume K and Shoen Kume},
  title = {Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages.},
  journal = {Stem Cells},
  year = 2013,
}

@article{CTT100713329,
  author = {Iwashita, Hidefumi and Nobuaki Shiraki and Daisuke Sakano and Ikegami, Takashi and Shiga, Masanobu and Kazuhiko Kume and Shoen Kume},
  title = {Secreted Cerberus1 as a Marker for Quantification of Definitive Endoderm Differentiation of the Pluripotent Stem Cells},
  journal = {Plos One},
  year = 2013,
}

@article{CTT100713331,
  author = {Taiji Yamazoe and Nobuaki Shiraki and Toyoda, Masashi and Kiyokawa, Nobutaka and Okita, Hajime and Miyagawa, Yoshitaka and Akutsu, Hidenori and Umezawa, Akihiro and Sasaki, Yutaka and Kazuhiko Kume and Shoen Kume},
  title = {A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells},
  journal = {Journal of Cell Science},
  year = 2013,
}

@article{CTT100713330,
  author = {Kahoko Umeda and Suzuki, Keiichiro and Taiji Yamazoe and Nobuaki Shiraki and Higuchi, Yuichiro and Tokieda, Kumiko and Kazuhiko Kume and Mitani, Kohnosuke and Shoen Kume},
  title = {Albumin gene targeting in human embryonic stem cells and induced pluripotent stem cells with helper-dependent adenoviral vector to monitor hepatic differentiation},
  journal = {Stem Cell Research},
  year = 2013,
}

@article{CTT100704232,
  author = {Kataoka M and Kawamuro Y and Shiraki N and Miki R and Daisuke Sakano and Yoshida T and Yasukawa T and Kume K and Shoen Kume},
  title = {Recovery from diabetes in neonatal mice after a low-dose streptozotocin treatment.},
  journal = {},
  year = 2013,
}

@article{CTT100704234,
  author = {Nagae G and Isagawa T and Shiraki N and Fujita T and Yamamoto S and Tsutsumi S and Nonaka A and Yoshiba S and Matsusaka K and Midorikawa Y and Ishikawa S and Soejima H and Fukayama M and Suemori H and Nakatsuji N and Shoen Kume and Aburatani H},
  title = {Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.},
  journal = {Human Molecular Genetics},
  year = 2011,
}

@article{CTT100704235,
  author = {Higuchi Y and Shiraki N and Shoen Kume},
  title = {In vitro models of pancreatic differentiation using embryonic stem or induced pluripotent stem cells.},
  journal = {Congenital Anomalies},
  year = 2011,
}

@article{CTT100704236,
  author = {Shiraki N and Yamazoe T and Qin Z and Ohgomori K and Mochitate K and Kume K and Shoen Kume},
  title = {Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.},
  journal = {Plos One},
  year = 2011,
}

@article{CTT100704238,
  author = {Ogaki S and Harada S and Shiraki N and Kume K and Shoen Kume},
  title = {An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.},
  journal = {BMC Developmental Biology},
  year = 2011,
}

@article{CTT100704237,
  author = {Isagawa T and Nagae G and Shiraki N and Fujita T and Sato N and Ishikawa S and Shoen Kume and Aburatani H},
  title = {DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.},
  journal = {PLoS ONE},
  year = 2011,
}

@article{CTT100704239,
  author = {Higuchi Y and Shiraki N and Yamane K and Qin Z and Mochitate K and Araki K and Senokuchi T and Yamagata K and Hara M and Kume K and Shoen Kume},
  title = {Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages.},
  journal = {Journal of Cell Sciences},
  year = 2010,
}

@article{CTT100704240,
  author = {Katsumoto K and Shiraki N and Miki R and Shoen Kume},
  title = {Embryonic and adult stem cell systems in mammals: ontology and regulation.},
  journal = {Development Growth Differentiation},
  year = 2010,
}

@article{CTT100704241,
  author = {Shiraki N and Harada S and Ogaki S and Kume K and Shoen Kume},
  title = {Identification of DAF1/CD55, a novel definitive endoderm marker.},
  journal = {Cell Structure Function},
  year = 2010,
}

@article{CTT100704242,
  author = {Yoshida T and Murata K and Shiraki N and Kume K and Shoen Kume},
  title = {Analysis of gene expressions of embryonic stem-derived Pdx1-expressing cells: implications of genes involved in pancreas differentiation.},
  journal = {Development Growth Differentiation},
  year = 2009,
}

@article{CTT100704243,
  author = {Shiraki N and Higuchi Y and Harada S and Umeda K and Isagawa T and Aburatani H and Kume K and Shoen Kume},
  title = {Differentiation and characterization of embryonic stem cells into three germ layers.},
  journal = {Biochemical and Biophysical Research Communications},
  year = 2009,
}

@article{CTT100704244,
  author = {Yoshida T and Shiraki N and Baba H and Goto M and Fujiwara S and Kume K and Shoen Kume},
  title = {Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.},
  journal = {Genes to Cells},
  year = 2008,
}

@article{CTT100704245,
  author = {Shiraki N and Umeda K and Sakashita N and Takeya M and Kume K and Shoen Kume},
  title = {Differentiation of mouse and human embryonic stem cells into hepatic lineages.},
  journal = {Genes to Cells},
  year = 2008,
}

@article{CTT100704246,
  author = {Shiraki N and Yoshida T and Araki K and Umezawa A and Higuchi Y and Goto H and Kume K and Shoen Kume},
  title = {Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.},
  journal = {Stem Cells},
  year = 2008,
}

@article{CTT100704249,
  author = {Shiraki N and Okamura K and Tokunaga J and Ohmura T and Yasuda K and Kawaguchi T and Hamada A and Nakano M},
  title = {Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells.},
  journal = {},
  year = 2002,
}

@article{CTT100704250,
  author = {Shiraki N and Hamada A and Ohmura T and Tokunaga J and Oyama N and Nakano M},
  title = {Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.},
  journal = {},
  year = 2001,
}

@inproceedings{CTT100916686,
  author = {Nobuaki Shiraki},
  title = {Methionine and Zinc: Key Regulators of Pluripotent Stem Cell Fate},
  booktitle = {},
  year = 2024,
}

@inproceedings{CTT100916691,
  author = {Ritoru Kimura and Takumi Saito and Teruhiko Watanabe and Yuna Osada and Nobuaki Shiraki and Shoen Kume},
  title = {共培養系を用いた iPS-小腸細胞と肝細胞との相互作用の解析},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916690,
  author = {Shigemi Tominaga and Fumiya Uefune and Airi Inoue and Yuki Itatani and Hiraku Tokuma and Nobuaki Shiraki and Daisuke Sakano and Shoen Kume},
  title = {膵臓β細胞における不均⼀なドーパミン合成能の⽣理学的役割の解明},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916692,
  author = {岸本恵理子 and 徳間啓 and 井上愛里 and 白木伸明 and 坂野大介 and 粂昭苑},
  title = {HSVTK-GCV スイッチを利用した iPS 細胞由来β細胞における造腫瘍抑制},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916688,
  author = {Yoshinori Suzuki and Shun-ichiro OGURA and Nobuaki Shiraki and Shoen Kume},
  title = {5-アミノレブリン酸を用いた光線力学療法のヒト iPS 膵臓分化誘導への応用},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100917218,
  author = {Nanami Zushi and Megumi Takuma and Yumeng Wu and Atena Endo and Shoen Kume and Nobuaki Shiraki and Toshinori Fujie},
  title = {多孔質高分子ナノシートの積層によるタンパク質透過性の制御},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916689,
  author = {Nobuaki Shiraki and Erinn Zixuan Sim and Takayuki Enomoto and Nao Furuta and Soshiro Kashio and Taiho Kambe and Tomonori Tsuyama and Akihiro Arakawa and Hiroki Ozawa and Mizuho Yokoyama and Masayuki Miura and Shoen Kume},
  title = {Methionine metabolism regulates pluripotent stem cell through zinc mobilization},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916687,
  author = {Nobuaki Shiraki},
  title = {幹細胞制御におけるメチオニンと亜鉛のクロストーク},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895362,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {ヒト多能性幹細胞由来膵β細胞の成熟化},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895366,
  author = {Tamano Kadokura and 荒川哲大 and 山崎淳子 and Zixuan Erinn Sim and Nobuaki Shiraki and Shoen Kume},
  title = {多能性幹細胞の未分化および分化状態における細胞内亜鉛動態解析},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895363,
  author = {渡邊輝彦 and Grace Aprilia Helena and Nobuaki Shiraki and Shoen Kume},
  title = {浮遊型初代ヒト肝細胞を培養容器に接着させる培地の開発とそのアプリケーション},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895360,
  author = {Marwa Ali and Yusuke Kato and Nobuaki Shiraki and Shoen Kume},
  title = {Generation of induced pluripotent stem cell-derived Beta cells in blood amino acids-like medium},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895359,
  author = {Dwina Juliana Warman and Takami Watanabe and Nobuaki Shiraki and Shoen Kume and Huijuan Jia and Hisanori Kato},
  title = {Effects of two-day prenatal methionine deficiency on pancreatic development in newborn rats},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895368,
  author = {Naoya Hiyoshi and Takayuki Enomoto and Airi Inoue and Yusuke Kato and Daisuke Sakano and Kimi Araki and Nobuaki Shiraki and Shoen Kume},
  title = {Investigation of metabolite profile in plasma from Kuma mice using LC-MS/MS},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895367,
  author = {Leo Sylvia and Kato Yusuke and Wu Yumeng and Shiraki Nobuaki and Kume Shoen},
  title = {The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895364,
  author = {渡邊輝彦 and Nobuaki Shiraki and Shoen Kume},
  title = {ad-MEDビトリゲル2とciKIC IEC MMを用いて構築したヒトiPS細胞由来腸管上皮モデルの消化管吸収評価モデルとしての有用性},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895365,
  author = {Tomoyo Kaneko and Takayuki Enomoto and Erika Kojima and Nobuaki Shiraki and Shoen Kume},
  title = {メチオニン制限を組み込んだ新規iPS細胞膵臓分化方法の開発},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883018,
  author = {Nobuaki Shiraki and Hiroki Ozawa and Azusa Kambe and Shoen Kume},
  title = {メチオニンは亜鉛代謝を介して多能性幹細胞を制御する},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883016,
  author = {Shiraki Nobuaki and Shoen Kume},
  title = {Characterization of heterozygous ATTR Y114C amyloidosis-specific iPS cells},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883017,
  author = {Shiraki Nobuaki and Shoen Kume},
  title = {Characterization of heterozygous ATTR Y114C amyloidosis-specific iPS cells},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883014,
  author = {Kato Yusuke and Shiraki Nobuaki and Shoen Kume},
  title = {Generation of functional pancreatic beta cells derived from human induced pluripotent Stem Cell-with physiological cell culture medium},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895361,
  author = {Nobuaki Shiraki},
  title = {メチオニン代謝制御による分化誘導の安定化},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100878695,
  author = {Grace Aprilia Helena and Nobuaki Shiraki and Shoen Kume},
  title = {Improvement of Primary Human Hepatocyte Cell Attachment},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878693,
  author = {Hiroki Ozawa and Azusa Kambe and Kohdai Hibi and Hiroshi Kimura and Nobuaki Shiraki and Shoen Kume},
  title = {メチオニン除去培養によるエピジェネティック変化を伴うヒトiPS細胞分化促進},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852311,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {コラーゲンビトリゲル膜と新規培地で培養したヒトiPS細胞由来小腸細胞の有用性},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852310,
  author = {Ryunosuke Hagimoto and Sylvia Han Yun Leo and Nobuaki Shiraki and Shoen Kume},
  title = {吸収腸上皮細胞への分化を促進する低分子化合物のスクリーニング},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852309,
  author = {Nataku Takinami and Takayuki Enomoto and Nobuaki Shiraki and Shoen Kume},
  title = {ヒ膵島移植に用いるための免疫隔離カプセルの評価},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100856388,
  author = {Nobuaki Shiraki},
  title = {細胞の分化と栄養 (特集 食・栄養から健康を拓く生化学)},
  booktitle = {生化学},
  year = 2021,
}

@inproceedings{CTT100856690,
  author = {Nobuaki Shiraki},
  title = {ヒト肝細胞の接着性向上とMPSへの応用},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852313,
  author = {Shinpei Yoshida and Takayuki Honjo and Nobuaki Shiraki and Shoen Kume},
  title = {薬物動態評価モデルとしてのヒトiPS細胞由来小腸上皮細胞の開発},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100856419,
  author = {Nobuaki Shiraki and 粂 昭苑},
  title = {臓器チップに要求される細胞組織ソースと細胞共用培地 (特集 創薬におけるMPS技術の開発)},
  booktitle = {細胞},
  year = 2020,
}

@inproceedings{CTT100811426,
  author = {五日市 実侑 and Nobuaki Shiraki and 伊東 宏晃 and 粂 昭苑},
  title = {iPS細胞肝臓分化誘導系を用いたDOHaDの検証},
  booktitle = {DOHaD研究},
  year = 2019,
}

@inproceedings{CTT100811428,
  author = {Nobuaki Shiraki},
  title = {多能性幹細胞の未分化維持や分化におけるアミノ酸の役割の解明 (第12回学術大会(JSAAS2018)) -- (日本アミノ酸学会 科学・技術賞受賞講演)},
  booktitle = {アミノ酸研究 = Amino acid research},
  year = 2019,
}

@inproceedings{CTT100811496,
  author = {小田 雄一 and 篠原 満利恵 and Keita Iino and 新谷 華梨 and 進 和美 and 佐藤 琢 and 荒川 大 and Nobuaki Shiraki and 立野 知世 and 杉浦 慎治 and Shoen Kume and 加藤 将 夫 and 金森 敏幸 and 木村 啓志 and やすゆき さかい},
  title = {二臓器連結モデル型 Microphysiological System を用いた新鮮ヒト肝細胞とヒト iPS 細胞由来腸管上皮細胞の灌流共培養},
  booktitle = {},
  year = 2019,
}

@inproceedings{CTT100811491,
  author = {Ima Shibata and Takahiro Shitamichi and 渡邊 輝彦 and 山口 宏之 and Nobuaki Shiraki and Shoen Kume},
  title = {メチオニン除去培地とコラーゲンビトリゲル薄膜を用いて分化誘導したヒト iPS 細胞由来肝臓細胞を利用した薬物毒性試験系の構築},
  booktitle = {},
  year = 2019,
}

@inproceedings{CTT100811493,
  author = {nobuaki shiraki},
  title = {Methionine metabolism regulates ESCs/iPSCs Differentiation},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811536,
  author = {小田 雄一 and 篠原 満利恵 and Keita Iino and 新谷 華梨 and 進 和美 and 佐藤 琢 and 荒川 大 and Nobuaki Shiraki and 立野 知世 and 杉浦 慎治 and Shoen Kume and 加藤 将 夫 and 金森 敏幸 and 木村 啓志 and やすゆき さかい},
  title = {二臓器連結－圧力駆動型Microphysiological Systemを用いたヒト肝細胞とヒトiPS細胞由来腸管上皮細胞のリアルタイム灌流共培養},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811499,
  author = {Kohdai Hibi and 秋山 智彦 and 洪実 and Nobuaki Shiraki and Shoen Kume},
  title = {メチオニン除去培養によるヒトiPS細胞分化促進の機序解明},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811501,
  author = {Takayuki Honjo and Keita Iino and 前田 和哉 and 渡邊 輝彦 and 石川 晶也 and Hiroyuki Kusuhara and Nobuaki Shiraki and Shoen Kume},
  title = {ヒトiPS細胞から機能的な小腸吸収上皮細胞への新規分化誘導系の構築},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811494,
  author = {Nobuaki Shiraki},
  title = {多能性幹細胞の未分化維持や分化におけるアミノ酸の役割の解明},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811519,
  author = {Zixuan Erinn Sim and Nobuaki Shiraki and Shoen Kume},
  title = {Insulin supplement is essential in differentiating human induced pluripotent stem cells into pancreatic beta cells},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811427,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {ES/iPS細胞から膵β細胞への分化制御と糖尿病再生医療の現状と展開 (特集 代謝関連疾患と合併症の再生医療の最前線)},
  booktitle = {内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism},
  year = 2018,
}

@inproceedings{CTT100784998,
  author = {Nobuaki Shiraki},
  title = {ヒト多能性幹細胞の分化および未分化維持におけるメチオニン代謝の役割},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100784999,
  author = {Nobuaki Shiraki},
  title = {Methionine metabolism regulates stem cell pluripotency},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744755,
  author = {Erinn Sim Zixuan and Saeko Momma and Nobuaki Shiraki and Shoen Kume},
  title = {A NOVEL 3D SPHEROID CULTURE SYSTEM FOR GENERATING FUNCTIONAL PANCREATIC beta CELLS DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744663,
  author = {Hiraku Tokuma and Zixuan Erinn Sim and Fumiya Uefune and Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {Establishment and analysis of hiPSC that visualize the INSULIN producing cells},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744753,
  author = {Saeko Momma and Nobuaki Shiraki and Shoen Kume},
  title = {多能性幹細胞から膵臓β細胞への分化誘導過程におけるアミノ酸要求性},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744670,
  author = {Hiraku Tokuma and Erinn Sim Zixuan and Fumiya Uefune and Daisuke Sakano and Nobuaki Shiraki and Shoen Kume.},
  title = {Generation and Characterization of an INSULIN promoter driven mCherry Reporter Human iPS Cell Lines Using CRISPR/Cas9 system},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744754,
  author = {nobuaki shiraki},
  title = {Amino acids regulate  pancreatic differentiation of  human pluripotent stem cells},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744752,
  author = {Nobuaki Shiraki},
  title = {多能性幹細胞から膵臓β細胞への分化誘導},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100791778,
  author = {Nobuaki Shiraki},
  title = {METHIONINE METABOLISM REGULATES THE FUNCTIONS OF HUMAN PLURIPOTENT STEM CELLS},
  booktitle = {ANNALS OF NUTRITION AND METABOLISM},
  year = 2017,
}

@inproceedings{CTT100744745,
  author = {Azusa Kambe and Nobuaki Shiraki and Hiroshi Kimura and Shoen Kume},
  title = {ヒトiPS細胞におけるメチオニン代謝とヒストン修飾の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744748,
  author = {Nobuaki Shiraki},
  title = {幹細胞におけるアミノ酸代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744746,
  author = {Nao Furuta and 荒川哲大 and 岩畑大悟 and Nobuaki Shiraki and Shoen Kume},
  title = {未分化iPS細胞および分化過程おける亜鉛の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744751,
  author = {Nobuaki Shiraki},
  title = {多能性幹細胞から膵臓β細胞への分化誘導},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744747,
  author = {Nobuaki Shiraki},
  title = {幹細胞の維持および分化におけるメチオニン代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100712053,
  author = {Nobuaki Shiraki},
  title = {多能性幹細胞におけるメチオニン代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744744,
  author = {Saeko Momma and Nobuaki Shiraki and 及川彰 and Shoen Kume},
  title = {幹細胞の未分化維持及び分化におけるメチオニン代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100712054,
  author = {Nobuaki Shiraki},
  title = {アミノ酸代謝制御による 幹細胞の未分化性維持と分化促進},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100723357,
  author = {Nobuaki Shiraki and Saeko Momma and Shoen Kume},
  title = {幹細胞分化におけるアミノ酸代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100723355,
  author = {Nobuaki Shiraki},
  title = {幹細胞維持と分化におけるメチオニン代謝},
  booktitle = {},
  year = 2015,
}

@inproceedings{CTT100723346,
  author = {Nobuaki Shiraki},
  title = {ES/iPS細胞分化制御におけるアミノ酸代謝},
  booktitle = {},
  year = 2015,
}

@inproceedings{CTT100856390,
  author = {Nobuaki Shiraki and 粂 昭苑},
  title = {幹細胞維持と分化におけるメチオニン代謝 (特集 がん幹細胞 : 新しい医療を求めて)},
  booktitle = {日本臨床},
  year = 2015,
}

@inproceedings{CTT100712033,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {糖尿病の再生医療 (第5土曜特集 糖尿病のすべて) -- (糖尿病対策と将来の根治・予防)},
  booktitle = {医学のあゆみ},
  year = 2015,
}

@inproceedings{CTT100856391,
  author = {Nobuaki Shiraki and 粂 昭苑},
  title = {ES/iPS細胞から膵臓への分化誘導},
  booktitle = {ファルマシア},
  year = 2012,
}

@inproceedings{CTT100712038,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {ES/iPS細胞から膵臓への分化誘導(最前線,<特集>躍進する幹細胞研究)},
  booktitle = {ファルマシア},
  year = 2012,
}

@inproceedings{CTT100712042,
  author = {山添 太士 and Nobuaki Shiraki and Shoen Kume},
  title = {ES細胞由来分化肝細胞の創出 (AYUMI ヒト幹細胞による薬物代謝・トランスポート・副作用予測--iPS・ES細胞・間葉系細胞を用いた新たな創薬スクリーニング)},
  booktitle = {医学のあゆみ},
  year = 2010,
}

@inproceedings{CTT100712045,
  author = {樋口 裕一郎 and Nobuaki Shiraki and Shoen Kume},
  title = {iPS細胞を用いた膵臓細胞の作製と, その移植医療への応用},
  booktitle = {移植},
  year = 2009,
}

@inproceedings{CTT100712047,
  author = {Shoen Kume and Nobuaki Shiraki},
  title = {膵の発生分化と幹細胞系を用いた膵の再生医学},
  booktitle = {臨床病理 = THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE},
  year = 2006,
}

@inproceedings{CTT100712048,
  author = {Nobuaki Shiraki and 岡村 恵子 and 徳永 仁 and 濱田 哲暢 and 中野 眞汎},
  title = {Bromocriptineによる抗癌薬の多剤耐性克服},
  booktitle = {薬物動態 = Xenobiotic metabolism and disposition},
  year = 2001,
}

@inproceedings{CTT100712049,
  author = {徳永 仁 and 岡村 恵子 and 濱田 哲暢 and Nobuaki Shiraki and 宮本 晋治 and 藤井 淳子 and 有森 和彦 and 中野 眞汎},
  title = {マクロライド系抗生物質による消化管粘膜傷害の基礎的検討},
  booktitle = {医療薬学},
  year = 2001,
}

@misc{CTT100916684,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {メチオニンと亜鉛は多能性幹細胞の多能性および分化を制御する},
  year = 2023,
}

@misc{CTT100723363,
  author = {Tomonori Tsuyama and Nobuaki Shiraki and Shoen Kume},
  title = {Definitive Endoderm Differentiation of Human Embryonic Stem Cells Combined with Selective Elimination of Undifferentiated Cells by Methionine Deprivation.},
  year = 2016,
}

@misc{CTT100723312,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {アミノ酸代謝によるヒト多能性幹細胞の維持・分化誘導},
  year = 2016,
}

@misc{CTT100723316,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {iPS細胞と肝胆膵疾患ー膵臓・肝臓への分化ー},
  year = 2016,
}

@misc{CTT100723343,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {iPS細胞の内胚葉系への誘導},
  year = 2015,
}

@misc{CTT100723326,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {幹細胞維持と分化におけるメチオニン代謝},
  year = 2015,
}

@misc{CTT100723365,
  author = {Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {Pancreatic differentiation from murine embryonic stem cells},
  year = 2015,
}

@misc{CTT100723319,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {糖尿病の再生医学},
  year = 2015,
}

@misc{CTT100723331,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {ES/iPS細胞からの膵臓β細胞への分化誘導},
  year = 2015,
}

@misc{CTT100712034,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {iPS細胞研究最前線 : 疾患モデルから臓器再生まで(Vol.10)ES/iPS細胞を用いた内胚葉細胞(膵,肝,小腸)への分化誘導},
  year = 2014,
}

@misc{CTT100704216,
  author = {Yamazoe T and Shiraki N and Shoen Kume},
  title = {Hepatic Differentiation from Murine and Human iPS Cells Using Nanofiber Scaffolds.},
  year = 2014,
}

@misc{CTT100704217,
  author = {Umeda K and Shiraki N and Shoen Kume},
  title = {Hepatic Differentiation from Human Ips Cells Using M15 Cells.},
  year = 2014,
}

@misc{CTT100712035,
  author = {Nobuaki Shiraki},
  title = {ES/iPS細胞分化制御におけるアミノ酸代謝},
  year = 2014,
}

@misc{CTT100712036,
  author = {木川 和英 and Daisuke Sakano and Nobuaki Shiraki},
  title = {Akitaマウスに対するインスリン治療が膵島移植の成績に与える効果 (特集 小児内分泌学の進歩2014) -- (糖尿病・糖代謝異常)},
  year = 2013,
}

@misc{CTT100712039,
  author = {Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {多能性幹細胞から膵β細胞への分化 (特集 発生・分化・再生と代謝関連臓器)},
  year = 2013,
}

@misc{CTT100712037,
  author = {Nobuaki Shiraki and Nobuaki Shiraki and 佐々木 裕 and Shoen Kume},
  title = {肝臓の再生医療 (特集 再生医療)},
  year = 2013,
}

@misc{CTT100712041,
  author = {Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {１型糖尿病治療の新しい知見  ６．ｉＰＳ細胞による糖尿病医療研究のこれから},
  year = 2011,
}

@misc{CTT100712040,
  author = {Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {iPS細胞による糖尿病医療研究のこれから},
  year = 2011,
}

@misc{CTT100712044,
  author = {梅田 香穂子 and Nobuaki Shiraki and Shoen Kume},
  title = {最新医学講座 iPS細胞(9)ES細胞やiPS細胞からの膵臓分化誘導と臨床への応用},
  year = 2009,
}

@misc{CTT100712046,
  author = {Nobuaki Shiraki and Shoen Kume},
  title = {再生医療・遺伝子治療 ES細胞を用いた膵臓の再生医学 (新時代の糖尿病学(3)病因・診断・治療研究の進歩) -- (糖尿病治療学の進歩)},
  year = 2008,
}

@misc{CTT100882391,
  author = {Shoen Kume and Nobuaki Shiraki},
  title = {肝細胞の培養方法},
  howpublished = {PublishedPatent},
  year = 2022,
  month  = {},
  note   = {PCT/JP2021/048217(2021/12/24), WO 2022/138922(2022/06/30)}
}


@misc{CTT100869580,
  author = {Shoen Kume and Nobuaki Shiraki},
  title = {ジヒドロインドリジノン誘導体を用いたインスリン産生細胞の作製法},
  howpublished = {PublishedPatent},
  year = 2021,
  month  = {},
  note   = {PCT/JP2020/026543(2020/07/07), WO 2021/006268(2021/01/14)}
}


@misc{CTT100828293,
  author = {Shoen Kume and Nobuaki Shiraki},
  title = {多能性幹細胞から腸細胞の作製方法},
  howpublished = {RegisteredPatent},
  year = 2023,
  month  = {},
  note   = {特願2019-117748(2019/06/25), 特開2020-039337(2020/03/19), 特許第7377486号(2023/11/01)}
}


@misc{CTT100861476,
  author = {Shoen Kume and Nobuaki Shiraki and Takayuki Enomoto},
  title = {多能性幹細胞の分化促進方法},
  howpublished = {RegisteredPatent},
  year = 2024,
  month  = {},
  note   = {特願2020-515575(2019/04/25), WO 2019/208713(2019/10/31), 特許第7470342号(2024/04/10)}
}


@misc{CTT100845253,
  author = {Shoen Kume and Nobuaki Shiraki},
  title = {多能性幹細胞から肝細胞への分化誘導方法},
  howpublished = {RegisteredPatent},
  year = 2023,
  month  = {},
  note   = {特願2019-548186(2018/10/09), 再表2019/073951(2020/12/03), 特許第7315150号(2023/07/18)}
}


@misc{CTT100746395,
  author = {Shoen Kume and Nobuaki Shiraki},
  title = {インスリン産生細胞の分化誘導方法},
  howpublished = {RegisteredPatent},
  year = 2019,
  month  = {},
  note   = {特願2016-521118(2015/05/19), 再表2015/178397(2017/04/20), 特許第6596708号(2019/10/11)}
}