@article{CTT100888672, author = {Junya Adachi and Haruka Oda and Toshiaki Fukushima and Beni Lestari and Hiroshi Kimura and Hiroka Sugai and Kentaro Shiraki and Rei Hamaguchi and Kohei Sato and Kazushi Kinbara}, title = {Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection}, journal = {Analytical Chemistry 2023}, year = 2023, } @article{CTT100898144, author = {Yomogita H and Ito H and Hashimoto K and Kudo A and Fukushima T and Endo T and Hirate Y and Akimoto Y and Komada M and Kanai Y and Miyasaka N and Kanai-Azuma M}, title = {A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas}, journal = {J Reprod Dev Mol}, year = 2022, } @article{CTT100874480, author = {Beni Lestari and Satomi Naito and Akinori Endo and Hidenori Nishihara and Akira Kato and Erika Watanabe and Kimitoshi Denda and Masayuki Komada and Toshiaki Fukushima}, title = {Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2–PTEN–AKT Pathway and Placental Cell Proliferation}, journal = {Molecular Biology and Evolution}, year = 2022, } @article{CTT100875112, author = {Keijun Kakihara and Kengo Asamizu and Kei Moritsugu and Masahide Kubo and Tetsuya Kitaguchi and Akinori Endo and Akinori Kidera and Mitsunori Ikeguchi and Akira Kato and Masayuki Komada and Toshiaki Fukushima.}, title = {Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.}, journal = {Commun Biol}, year = 2021, } @article{CTT100875537, author = {Béziat V and Rapaport F and Hu J and Titeux M and Bonnet des Claustres M and Bourgey M and Griffin H and Bandet É and Ma CS and Sherkat R and Rokni-Zadeh H and Louis DM and Changi-Ashtiani M and Delmonte OM and Fukushima T and Guennoun A and Khan T and Bender N and Rahman M and About F and Yang R and Rao G and Rouzaud C and Li J and Shearer D and Balogh K and Al Ali F and Ata M and Dabiri S and Momenilandi M and Nammour J and Alyanakian MA and Leruez-Ville M and Guenat D and Materna M and Marcot L and Vladikine N and Soret C and Vahidnezhad H and Youssefian L and Saeidian AH and Uitto J and Catherinot É and Navabi SS and Zarhrate M and Woodley DT and Jeljeli M and Abraham T and Belkaya S and Lorenzo L and Rosain J and Bayat M and Lanternier F and Lortholary O and Zakavi F and Gros P and Orth G and Abel L and Prétet JL and Fraitag S and Jouanguy E and Davis MM and Tangye SG and Notarangelo LD and Marr N and Waterboer T and Langlais D and Doorbar J and Hovnanian A and Christensen N and Bossuyt X and Shahrooei M and Casanova JL.}, title = {Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.}, journal = {Cell}, year = 2021, } @article{CTT100837022, author = {Satomi Naito and Toshiaki Fukushima and Akinori Endo and Kimitoshi Denda and Masayuki Komada}, title = {Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP}, journal = {FEBS Letters}, year = 2020, } @article{CTT100813373, author = {WH. Chan and M. Komada and T. Fukushima and EM. Southard-Smith and CR. Anderson. MJ. Wakefield}, title = {RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development}, journal = {Scientific Reports}, year = 2019, } @article{CTT100853339, author = {Ryohei Sakai and Ryosuke Fukuda and Shin Unida and Misaki Aki and Yuji Ono and Akinori Endo and Satoshi Kusumi and Daisuke Koga and Toshiaki Fukushima and Masayuki Komada and Tsukasa Okiyoneda}, title = {The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors}, journal = {Journal of cell science}, year = 2019, } @article{CTT100853340, author = {Ryohei Sakai and Ryosuke Fukuda and Shin Unida and Misaki Aki and Yuji Ono and Akinori Endo and Satoshi Kusumi and Daisuke Koga and Toshiaki Fukushima and Masayuki Komada and Tsukasa Okiyoneda}, title = {The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors}, journal = {Journal of cell science}, year = 2019, } @article{CTT100786915, author = {R. Sakai and R. Fukuda and S. Unida and M. Aki and Y. Ono and A. Endo and S. Kusumi and D. Koga and T. Fukushima and M. Komada and T. Okiyoneda}, title = {The integral function of endocytic recycling compartment is regulated by RFFL-mediated ubiquitination of Rab11 effectors}, journal = {J Cell Sci}, year = 2019, } @article{CTT100813374, author = {H. Furuta and H. Yoshihara and T. Fukushima and Y. Yoneyama and A. Ito and C. Worrall and A. Girnita and L. Girnita and M. Yoshida and T. Asano and M. Komada and N. Kataoka and K. Chida and F. Hakuno and SI. Takahashi}, title = {IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line}, journal = {Oncotarget}, year = 2018, } @article{CTT100786917, author = {K. Kawaguchi and A. Endo and T. Fukushima and Y. Madoka and T. Tanaka and M. Komada}, title = {Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion}, journal = {Biochem Biophys Res Commun}, year = 2018, } @article{CTT100786916, author = {X. Xie and S. Matsumoto and A. Endo and T. Fukushima and H. Kawahara and Y. Saeki and M. Komada}, title = {Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities}, journal = {J Cell Sci}, year = 2018, } @article{CTT100786920, author = {M. Ariga and Y. Yoneyama and T. Fukushima and Y. Ishiuchi and T. Ishii and H. Sato and F. Hakuno and T. Nedachi and S. I. Takahashi}, title = {Glucose deprivation attenuates sortilin levels in skeletal muscle cells}, journal = {Endocr J}, year = 2017, } @article{CTT100786956, author = {T. Fukushima and H. Yoshihara and H. Furuta and F. Hakuno and S. I. Iemura and T. Natsume and Y. Nakatsu and H. Kamata and T. Asano and M. Komada and S. I. Takahashi}, title = {USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination}, journal = {Biochem Biophys Res Commun}, year = 2017, } @article{CTT100786918, author = {T. Yamamotoya and Y. Nakatsu and Y. Matsunaga and T. Fukushima and H. Yamazaki and S. Kaneko and M. Fujishiro and T. Kikuchi and A. Kushiyama and F. Tokunaga and T. Asano and H. Sakoda}, title = {Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice}, journal = {Int J Mol Sci}, year = 2017, } @article{CTT100786958, author = {T. Yanagawa and K. Denda and T. Inatani and T. Fukushima and T. Tanaka and N. Kumaki and Y. Inagaki and M. Komada}, title = {Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice}, journal = {Am J Pathol}, year = 2016, } @article{CTT100786957, author = {L. Girnita and S. I. Takahashi and C. Crudden and T. Fukushima and C. Worrall and H. Furuta and H. Yoshihara and F. Hakuno and A. Girnita}, title = {Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling}, journal = {Prog Mol Biol Transl Sci}, year = 2016, } @article{CTT100786922, author = {H. Okubo and A. Kushiyama and H. Sakoda and Y. Nakatsu and M. Iizuka and N. Taki and M. Fujishiro and T. Fukushima and H. Kamata and A. Nagamachi and T. Inaba and F. Nishimura and H. Katagiri and T. Asahara and Y. Yoshida and O. Chonan and J. Encinas and T. Asano}, title = {Involvement of resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice}, journal = {Sci Rep}, year = 2016, } @article{CTT100786926, author = {Y. Nakatsu and M. Iwashita and H. Sakoda and H. Ono and K. Nagata and Y. Matsunaga and T. Fukushima and M. Fujishiro and A. Kushiyama and H. Kamata and S. Takahashi and H. Katagiri and H. Honda and H. Kiyonari and T. Uchida and T. Asano}, title = {Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the gamma subunit}, journal = {J Biol Chem}, year = 2015, } @article{CTT100786924, author = {T. Shinjo and Y. Nakatsu and M. Iwashita and T. Sano and H. Sakoda and H. Ishihara and A. Kushiyama and M. Fujishiro and T. Fukushima and Y. Tsuchiya and H. Kamata and F. Nishimura and T. Asano}, title = {DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappaB activation}, journal = {Am J Physiol Endocrinol Metab}, year = 2015, } @article{CTT100786930, author = {T. Fukushima and H. Yoshihara and H. Furuta and H. Kamei and F. Hakuno and J. Luan and C. Duan and Y. Saeki and K. Tanaka and S. Iemura and T. Natsume and K. Chida and Y. Nakatsu and H. Kamata and T. Asano and S. Takahashi}, title = {Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity}, journal = {Nat Commun}, year = 2015, } @article{CTT100786925, author = {H. Okubo and Y. Nakatsu and H. Sakoda and A. Kushiyama and M. Fujishiro and T. Fukushima and Y. Matsunaga and H. Ohno and M. Yoneda and H. Kamata and T. Shinjo and M. Iwashita and F. Nishimura and T. Asano}, title = {Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model}, journal = {Am J Physiol Gastrointest Liver Physiol}, year = 2015, } @article{CTT100786927, author = {Y. Matsunaga and Y. Nakatsu and T. Fukushima and H. Okubo and M. Iwashita and H. Sakoda and M. Fujishiro and T. Yamamotoya and A. Kushiyama and S. Takahashi and Y. Tsuchiya and H. Kamata and F. Tokunaga and K. Iwai and T. Asano}, title = {LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis}, journal = {Mediators Inflamm}, year = 2015, } @article{CTT100786929, author = {F. Hakuno and T. Fukushima and Y. Yoneyama and H. Kamei and A. Ozoe and H. Yoshihara and D. Yamanaka and T. Shibano and M. Sone-Yonezawa and B. C. Yu and K. Chida and S. Takahashi}, title = {The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins}, journal = {Front Endocrinol (Lausanne)}, year = 2015, } @article{CTT100786928, author = {R. Kanaoka and A. Kushiyama and Y. Seno and Y. Nakatsu and Y. Matsunaga and T. Fukushima and Y. Tsuchiya and H. Sakoda and M. Fujishiro and T. Yamamotoya and H. Kamata and A. Matsubara and T. Asano}, title = {Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines}, journal = {PLoS One}, year = 2015, } @article{CTT100786932, author = {Y. Kawashima and F. Hakuno and S. Okada and T. Hotsubo and T. Kinoshita and M. Fujimoto and R. Nishimura and T. Fukushima and K. Hanaki and S. Takahashi and S. Kanzaki}, title = {Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation}, journal = {Clin Endocrinol (Oxf)}, year = 2014, } @article{CTT100786931, author = {A. Ozoe and M. Sone and T. Fukushima and N. Kataoka and K. Chida and T. Asano and F. Hakuno and S. Takahashi}, title = {Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis}, journal = {Front Endocrinol (Lausanne)}, year = 2014, } @article{CTT100786938, author = {M. Iwashita and Y. Nakatsu and H. Sakoda and M. Fujishiro and A. Kushiyama and T. Fukushima and S. Kumamoto and T. Shinjo and H. Kamata and F. Nishimura and T. Asano}, title = {Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice}, journal = {Adipocyte}, year = 2014, } @article{CTT100786936, author = {H. Okubo and H. Sakoda and A. Kushiyama and M. Fujishiro and Y. Nakatsu and T. Fukushima and Y. Matsunaga and H. Kamata and T. Asahara and Y. Yoshida and O. Chonan and M. Iwashita and F. Nishimura and T. Asano}, title = {Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model}, journal = {Am J Physiol Gastrointest Liver Physiol}, year = 2013, } @article{CTT100786934, author = {A. Ozoe and M. Sone and T. Fukushima and N. Kataoka and T. Arai and K. Chida and T. Asano and F. Hakuno and S. Takahashi}, title = {Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes}, journal = {FEBS Lett}, year = 2013, } @article{CTT100786937, author = {A. Kushiyama and H. Sakoda and N. Oue and M. Okubo and Y. Nakatsu and H. Ono and T. Fukushima and H. Kamata and F. Nishimura and T. Kikuchi and M. Fujishiro and K. Nishiyama and H. Aburatani and S. Kushiyama and M. Iizuka and N. Taki and J. Encinas and K. Sentani and N. Ogonuki and A. Ogura and S. Kawazu and W. Yasui and Y. Higashi and H. Kurihara and H. Katagiri and T. Asano}, title = {Resistin-like molecule beta is abundantly expressed in foam cells and is involved in atherosclerosis development}, journal = {Arterioscler Thromb Vasc Biol}, year = 2013, } @article{CTT100786933, author = {J. Zhang and Y. Nakatsu and T. Shinjo and Y. Guo and H. Sakoda and T. Yamamotoya and Y. Otani and H. Okubo and A. Kushiyama and M. Fujishiro and T. Fukushima and Y. Tsuchiya and H. Kamata and M. Iwashita and F. Nishimura and H. Katagiri and S. Takahashi and H. Kurihara and T. Uchida and T. Asano}, title = {Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions}, journal = {J Biol Chem}, year = 2013, } @article{CTT100786935, author = {Y. Otani and Y. Nakatsu and H. Sakoda and T. Fukushima and M. Fujishiro and A. Kushiyama and H. Okubo and Y. Tsuchiya and H. Ohno and S. Takahashi and F. Nishimura and H. Kamata and H. Katagiri and T. Asano}, title = {Integrator complex plays an essential role in adipose differentiation}, journal = {Biochem Biophys Res Commun}, year = 2013, } @article{CTT100786941, author = {Y. Nakatsu and Y. Otani and H. Sakoda and J. Zhang and Y. Guo and H. Okubo and A. Kushiyama and M. Fujishiro and T. Kikuch and T. Fukushima and H. Ohno and Y. Tsuchiya and H. Kamata and A. Nagamachi and T. Inaba and F. Nishimura and H. Katagiri and S. Takahashi and H. Kurihara and T. Uchida and T. Asano}, title = {Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model}, journal = {J Biol Chem}, year = 2012, } @article{CTT100786945, author = {T. Fukushima and Y. Nakamura and D. Yamanaka and T. Shibano and K. Chida and S. Minami and T. Asano and F. Hakuno and S. Takahashi}, title = {Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation}, journal = {J Biol Chem}, year = 2012, } @article{CTT100786943, author = {Y. Kawashima and K. Higaki and T. Fukushima and F. Hakuno and J. Nagaishi and K. Hanaki and E. Nanba and S. Takahashi and S. Kanzaki}, title = {Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation}, journal = {Clin Endocrinol (Oxf)}, year = 2012, } @article{CTT100786939, author = {H. Yoshihara and T. Fukushima and F. Hakuno and Y. Saeki and K. Tanaka and A. Ito and M. Yoshida and S. Iemura and T. Natsume and T. Asano and K. Chida and L. Girnita and S. Takahashi}, title = {Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs}, journal = {Biochem Biophys Res Commun}, year = 2012, } @article{CTT100786940, author = {D. Yamanaka and T. Akama and T. Fukushima and T. Nedachi and C. Kawasaki and K. Chida and S. Minami and K. Suzuki and F. Hakuno and S. Takahashi}, title = {Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells}, journal = {Mol Endocrinol}, year = 2012, } @article{CTT100786944, author = {M. Iwashita and H. Sakoda and A. Kushiyama and M. Fujishiro and H. Ohno and Y. Nakatsu and T. Fukushima and S. Kumamoto and Y. Tsuchiya and T. Kikuchi and H. Kurihara and H. Akazawa and I. Komuro and H. Kamata and F. Nishimura and T. Asano}, title = {Valsartan, independently of AT1 receptor or PPARgamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes}, journal = {Am J Physiol Endocrinol Metab}, year = 2012, } @article{CTT100786942, author = {A. Kushiyama and H. Okubo and H. Sakoda and T. Kikuchi and M. Fujishiro and H. Sato and S. Kushiyama and M. Iwashita and F. Nishimura and T. Fukushima and Y. Nakatsu and H. Kamata and S. Kawazu and Y. Higashi and H. Kurihara and T. Asano}, title = {Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development}, journal = {Arterioscler Thromb Vasc Biol}, year = 2012, } @article{CTT100786948, author = {T. Fukushima and H. Okajima and D. Yamanaka and M. Ariga and S. Nagata and A. Ito and M. Yoshida and T. Asano and K. Chida and F. Hakuno and S. Takahashi}, title = {HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells}, journal = {Mol Cell Endocrinol}, year = 2011, } @article{CTT100786947, author = {Y. Nakatsu and H. Sakoda and A. Kushiyama and J. Zhang and H. Ono and M. Fujishiro and T. Kikuchi and T. Fukushima and M. Yoneda and H. Ohno and N. Horike and M. Kanna and Y. Tsuchiya and H. Kamata and F. Nishimura and T. Isobe and T. Ogihara and H. Katagiri and Y. Oka and S. Takahashi and H. Kurihara and T. Uchida and T. Asano}, title = {Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis}, journal = {J Biol Chem}, year = 2011, } @article{CTT100786946, author = {H. Ohno and Y. Nakatsu and H. Sakoda and A. Kushiyama and H. Ono and M. Fujishiro and Y. Otani and H. Okubo and M. Yoneda and T. Fukushima and Y. Tsuchiya and H. Kamata and F. Nishimura and H. Kurihara and H. Katagiri and Y. Oka and T. Asano}, title = {4F2hc stabilizes GLUT1 protein and increases glucose transport activity}, journal = {Am J Physiol Cell Physiol}, year = 2011, } @article{CTT100786949, author = {T. Fukushima and T. Arai and M. Ariga-Nedachi and H. Okajima and Y. Ooi and Y. Iijima and M. Sone and Y. Cho and Y. Ando and K. Kasahara and A. Ozoe and H. Yoshihara and K. Chida and S. Okada and J. J. Kopchick and T. Asano and F. Hakuno and S. Takahashi}, title = {Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases}, journal = {Biochem Biophys Res Commun}, year = 2011, } @article{CTT100786951, author = {Y. Nakatsu and H. Sakoda and A. Kushiyama and H. Ono and M. Fujishiro and N. Horike and M. Yoneda and H. Ohno and Y. Tsuchiya and H. Kamata and H. Tahara and T. Isobe and F. Nishimura and H. Katagiri and Y. Oka and T. Fukushima and S. Takahashi and H. Kurihara and T. Uchida and T. Asano}, title = {Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity}, journal = {J Biol Chem}, year = 2010, } @article{CTT100786950, author = {M. Shibata and F. Hakuno and D. Yamanaka and H. Okajima and T. Fukushima and T. Hasegawa and T. Ogata and Y. Toyoshima and K. Chida and K. Kimura and H. Sakoda and A. Takenaka and T. Asano and S. Takahashi}, title = {Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes}, journal = {J Biol Chem}, year = 2010, } @article{CTT100786952, author = {T. Fukushima and T. Nedachi and H. Akizawa and M. Akahori and F. Hakuno and S. Takahashi}, title = {Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells}, journal = {Endocrinology}, year = 2008, } @article{CTT100786953, author = {Y. Kawashima and S. Kanzaki and F. Yang and T. Kinoshita and K. Hanaki and J. Nagaishi and Y. Ohtsuka and I. Hisatome and H. Ninomoya and E. Nanba and T. Fukushima and S. Takahashi}, title = {Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation}, journal = {J Clin Endocrinol Metab}, year = 2005, } @article{CTT100786954, author = {Y. Okubo and K. Siddle and H. Firth and S. O'Rahilly and L. C. Wilson and L. Willatt and T. Fukushima and S. Takahashi and C. J. Petry and T. Saukkonen and R. Stanhope and D. B. Dunger}, title = {Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene}, journal = {J Clin Endocrinol Metab}, year = 2003, } @article{CTT100786955, author = {S. I. Takahashi and T. Nedachi and T. Fukushima and K. Umesaki and Y. Ito and F. Hakuno and J. J. Van Wyk and M. Conti}, title = {Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells}, journal = {Biochim Biophys Acta}, year = 2001, } @inproceedings{CTT100898133, author = {Keijun Kakihara and Masayuki Komada and Toshiaki Fukushima}, title = {Caspase-dependent STAMBPL1 cleavage promotes cell death through its C-terminal fragment with hyperactive deubiquitinating activity}, booktitle = {}, year = 2023, } @inproceedings{CTT100902387, author = {Junya Adachi and Toshiaki Fukushima and Haruka Oda and Hiroka Sugai and Kohei Sato and Hiroshi Kimura and Kazushi Kinbara}, title = {粘度応答性蛍光プローブの開発と生細胞内における応答性}, booktitle = {}, year = 2023, } @inproceedings{CTT100891137, author = {Junya Adachi and Haruka Oda and Toshiaki Fukushima and Hiroka Sugai and Kohei Sato and Hiroshi Kimura and Kazushi Kinbara}, title = {水溶性蛍光プローブの生細胞内における粘度応答性とメラノソームの可視化}, booktitle = {}, year = 2023, } @inproceedings{CTT100898131, author = {Gai Ando and Keijun Kakihara and Masayuki Komada and Toshiaki Fukushima}, title = {Molecular mechanisms underlying the over-activation of USP8 and USP48 by Cushing’s disease-associated mutations}, booktitle = {}, year = 2022, } @inproceedings{CTT100898129, author = {Keijun Kakihara and Masayuki Komada and Toshiaki Fukushima}, title = {Cis-activity regulation of USP8 and STAMBPL1, two endosomal deubiquitinating enzymes, and role of dysregulation in disease onset}, booktitle = {}, year = 2022, } @inproceedings{CTT100898138, author = {Toshiaki Fukushima and Keijun Kakihara and Kengo Asamizu and 森次 圭 and Tetsuya Kitaguchi and Masayuki Komada}, title = {クッシング病を引き起こすUSP8の過剰活性化機構}, booktitle = {第95回日本生化学会大会要旨集}, year = 2022, } @inproceedings{CTT100898135, author = {Marsya Yonna Nurrachma and Beni Lestari and Masayuki Komada and Toshiaki Fukushima}, title = {Ubiquitination-mediated activation of AKT and its cancer-associated mutants}, booktitle = {}, year = 2022, } @inproceedings{CTT100898134, author = {Yuzuka Nishioka and Keijun Kakihara and Akinori Endo and Masayuki Komada and Toshiaki Fukushima}, title = {脱ユビキチン化酵素USP8によるVAMP8の制御とその細胞質分裂における意義の解明}, booktitle = {}, year = 2022, } @inproceedings{CTT100886408, author = {Junya Adachi and Toshiaki Fukushima and Haruka Oda and Hiroka Sugai and Kohei Sato and Hiroshi Kimura and Kazushi Kinbara}, title = {非TICT型粘度応答性蛍光プローブの開発と生細胞イメージングへの適用}, booktitle = {}, year = 2022, } @inproceedings{CTT100898141, author = {Keijun Kakihara and Kei Moritsugu and Tetsuya Kitaguchi and Akinori Endo and Masayuki Komada and Toshiaki Fukushima}, title = {Autoinhibition of USP8 by WW-like domain and the dysregulation in Cushing’s disease}, booktitle = {EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”}, year = 2022, } @inproceedings{CTT100898140, author = {Toshiaki Fukushima and Keijun Kakihara and Masayuki Komada}, title = {脱ユビキチン化酵素USP8の遺伝子変異を介したクッシング病の発症メカニズム}, booktitle = {}, year = 2022, } @inproceedings{CTT100879301, author = {Junya Adachi and Toshiaki Fukushima and Haruka Oda and Hiroka Sugai and Kohei Sato and Hiroshi Kimura and Kazushi Kinbara}, title = {Development of Anthracene-Based Fluorescent Probes for Application in Cellular Systems}, booktitle = {}, year = 2022, } @inproceedings{CTT100875550, author = {Toshiaki Fukushima}, title = {USP8 の機能異常は様々な疾患の発症・増悪に関与する}, booktitle = {}, year = 2022, } @inproceedings{CTT100875548, author = {Beni Lestari and Satomi Naito and Akinori Endo and Hidenori Nishihara and Akira Kato and Erika Watanabe and Kimitoshi Denda and Masayuki Komada and Toshiaki Fukushima}, title = {Comparative Phylogenetic Analysis and Molecular Characterization Reveal Eutherian-Specific Role of NRK in Regulating Placenta Development}, booktitle = {}, year = 2021, } @inproceedings{CTT100875549, author = {蓬田裕 and 高峰愛幸 and 伊藤日加瑠 and 平手良和 and Toshiaki Fukushima and Masayuki Komada and 金井克晃 and 宮坂尚幸 and 金井正美}, title = {マウス、ヒト胎盤におけるNrk下流遺伝子群と分娩遅延の関連について}, booktitle = {}, year = 2021, } @inproceedings{CTT100875547, author = {Yuya Himi and Keijun Kakihara and Akira Kato and Masayuki Komada and Toshiaki Fukushima}, title = {脱ユビキチン酵素USP8はレンチウイルス粒子へのウイルスRNAの動員を阻害することによってウイルスの増殖を防ぐ}, booktitle = {}, year = 2021, } @inproceedings{CTT100875225, author = {Keijun Kakihara and Kengo Asamizu and 森次圭 and Tetsuya Kitaguchi and Akinori Endo and 木寺詔記 and 池口満徳 and Masayuki Komada and Toshiaki Fukushima}, title = {脱ユビキチン化酵素USP8の自己阻害機構とクッシング病関連変異によるその解除}, booktitle = {第44回日本分子生物学会年会要旨集}, year = 2021, } @inproceedings{CTT100853021, author = {Toshiaki Fukushima}, title = {USP8の自己阻害機構の理解に基づく阻害剤開発とクッシング病治療への応用}, booktitle = {}, year = 2021, } @inproceedings{CTT100853019, author = {Toshiaki Fukushima and Akinori Endo and Kohei Kawaguchi and 円由香 and Masayuki Komada}, title = {クッシング病の治療薬開発を目指したUSP8-STAM1複合体を作用点とするACTH分泌制御物質の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853020, author = {Toshiaki Fukushima}, title = {ケモテクノロジーによって明らかとなった脱ユビキチン化酵素USP8の作用機構}, booktitle = {}, year = 2021, } @inproceedings{CTT100813520, author = {Toshiaki Fukushima and Yuka Madoka and Akinori Endo and Kohei Kawaguchi and Saki Arakaki and Masayuki Komada}, title = {Constitutive formation of USP8-STAM1 complex plays an important role in the onset of Cushing’s disease}, booktitle = {}, year = 2019, } @inproceedings{CTT100813514, author = {Satomi Naito and Akinori Endo and Kimitoshi Denda and Akira Kato and Masayuki Komada and Toshiaki Fukushima}, title = {Nik-related kinase is regulated by quality control ubiquitin ligase CHIP}, booktitle = {}, year = 2019, } @inproceedings{CTT100813513, author = {Toshiaki Fukushima}, title = {The mechanism of action of wild-type and Cushing's disease-associated mutant USP8}, booktitle = {}, year = 2019, } @inproceedings{CTT100813515, author = {Keijun Kakihara and Kengo Asamizu and Akinori Endo and Kei Moritsugu and Akira Kato and Masayuki Komada and Toshiaki Fukushima}, title = {The enzyme activity of USP8 is regulated by the intramolecular interaction of the USP domain and the WW domain}, booktitle = {}, year = 2019, } @inproceedings{CTT100813517, author = {Arakaki Saki and Toshiaki Fukushima}, title = {14-3-3 protein regulates USP8-STAM1 complex formation and the subcellular localization}, booktitle = {}, year = 2019, } @inproceedings{CTT100813518, author = {Satomi Naito and Akinori Endo and Kimitoshi Denda and Yuka Madoka and Akira Kato and Masayuki Komada and Toshiaki Fukushima}, title = {Nrk prevents hyperplasia by modulating CK2-PTEN-Akt signaling pathway}, booktitle = {}, year = 2019, } @inproceedings{CTT100813519, author = {Keijun Kakihara and Kengo Asamizu and Akinori Endo and Masayuki Komada and Toshiaki Fukushima}, title = {A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction}, booktitle = {}, year = 2019, } @inproceedings{CTT100813525, author = {Keijun Kakihara and Kengo Asamizu and Akinori Endo and Masayuki Komada and Toshiaki Fukushima}, title = {A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction}, booktitle = {}, year = 2019, } @inproceedings{CTT100813522, author = {Toshiaki Fukushima}, title = {USP8-STAM1 deubiquitinating enzyme complex is a novel drug target for Cushing's disease}, booktitle = {}, year = 2019, } @inproceedings{CTT100813526, author = {Keijun Kakihara and Kengo Asamizu and Akinori Endo and Masayuki Komada and Toshiaki Fukushima}, title = {脱ユビキチン化酵素 USP8 の自己活性抑制機構}, booktitle = {}, year = 2019, } @inproceedings{CTT100813523, author = {Toshiaki Fukushima}, title = {The mechanism of action of deubiquitinating enzyme USP8 revealed by chemo-technologies}, booktitle = {}, year = 2019, } @inproceedings{CTT100813528, author = {Toshiaki Fukushima}, title = {USP8遺伝子変異によるクッシング病発症機構解明の新展開}, booktitle = {}, year = 2019, } @inproceedings{CTT100813529, author = {Keijun Kakihara and Kengo Asamizu and Akinori Endo and Masayuki Komada and Toshiaki Fukushima}, title = {脱ユビキチン化酵素USP8の自己活性抑制機構}, booktitle = {}, year = 2019, } @inproceedings{CTT100813533, author = {Akinori Endo and Toshiaki Fukushima and Masayuki Komada}, title = {A deubiquitinase USP8, a master regulator of endosome-centered membrane traffic, controls inter-cellular signal transduction.}, booktitle = {}, year = 2018, } @inproceedings{CTT100813531, author = {Takahiro Sawada and Kazuya Inoko and Kohei Kawaguchi and Akinori Endo and Yasushi Saeki and Keiji Tanaka and Toshiaki Fukushima and Masayuki Komada}, title = {Nuclear localization mechanism of deubiquitinating enzyme USP8 in Cushing’s disease}, booktitle = {}, year = 2018, } @inproceedings{CTT100813532, author = {Satomi Naito and Akinori Endo and Toshiaki Fukushima and Kimitoshi Denda and Akira Kato and Masayuki Komada}, title = {Molecular mechanisms underlying the control of Nrk protein levels and Nrk-mediated anti-proliferation effects}, booktitle = {}, year = 2018, } @inproceedings{CTT100813535, author = {Toshiaki Fukushima and Takahiro Sawada and Kazuya Inoko and Suguru Machidori and Akinori Endo and Masayuki Komada}, title = {脱ユビキチン化酵素USP8の遺伝子変異に起因するACTH過剰産生の分子機構}, booktitle = {}, year = 2018, } @inproceedings{CTT100813538, author = {Suguru Machidori and Kazuya Inoko and Kohei Kawaguchi and Akinori Endo and Toshiaki Fukushima and Masayuki Komada}, title = {USP8 遺伝子のゲノム編集によるCushing 病モデル細胞の作製と解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100813536, author = {Toshiaki Fukushima}, title = {USP8, a deubiquitinating enzyme in the endocytic pathway, plays roles in proteostasis in the secretory pathway.}, booktitle = {}, year = 2018, } @inproceedings{CTT100813539, author = {Kohei Kawaguchi and Akinori Endo and Toshiaki Fukushima and Masayuki Komada}, title = {Ubiquitin-specific protease 8 suppresses collagen secretion by deubiquitinating Sec31}, booktitle = {}, year = 2018, } @inproceedings{CTT100813540, author = {Xie Xuan and Shunsuke Matsumoto and Akinori Endo and Toshiaki Fukushima and Hiroyuki Kawahara and Yasushi Saeki and Masayuki Komada}, title = {Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities.}, booktitle = {}, year = 2018, } @inproceedings{CTT100757624, author = {Kimitoshi Denda and 二口 充 and 丹野 正隆 and Toshiaki Fukushima and Yoko Tanabe and nobuhiro hayashi}, title = {胎盤特異的な新規プロテインキナーゼNRKは乳腺組織における細胞増殖制御を司る}, booktitle = {}, year = 2018, } @misc{CTT100853023, author = {Keijun Kakihara and Kengo Asamizu and Kei Moritsugu and Masahide Kubo and Tetsuya Kitaguchi and Akinori Endo and Akinori Kidera and Mitsunori Ikeguchi and Akira Kato and Masayuki Komada and Toshiaki Fukushima}, title = {The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain}, year = 2021, } @misc{CTT100837023, author = {Toshiaki Fukushima and Kohei Kawaguchi}, title = {コラーゲンの細胞内輸送の分子機構 -脱ユビキチン化酵素 USP8 による輸送制御-}, year = 2020, } @misc{CTT100745527, author = {Takayo Yanagawa and Kimitoshi Denda and Takuya Inatani and Toshiaki Tanaka and Toshiaki Fukushima and Nobue Kumaki and Yutaka Inagaki and Masayuki Komada.}, title = {乳がんを抑制する新たな遺伝子を発見―ヒト乳がんの診断・治療への応用に期待―}, year = 2016, } @misc{CTT100745528, author = {Takayo Yanagawa and Kimitoshi Denda and Takuya Inatani and Toshiaki Tanaka and Toshiaki Fukushima and Nobue Kumaki and Yutaka Inagaki and Masayuki Komada}, title = {乳がんを抑制する新たな遺伝子を発見}, year = 2016, } @misc{CTT100835041, author = {Toshiaki Fukushima}, title = {クッシング病治療剤のスクリーニング方法}, howpublished = {PublishedPatent}, year = 2020, month = {July}, note = {特願2018-244180(2018/12/27), 特開2020-106356(2020/07/09)} }