@book{CTT100691752, author = {坂本聡 and 半田宏}, title = {技術予測レポート2023 上巻 「健康寿命の延伸を目指す」日本の技術編}, publisher = {日本能率協会総合研究所, ソレカラ社}, year = 2013, } @book{CTT100691755, author = {西尾広介 and 坂本聡 and 宇賀均 and 倉森見典 and 半田宏}, title = {磁性ビーズのバイオ・環境技術への応用展開(普及版)}, publisher = {シーエムシー出版}, year = 2012, } @book{CTT100614921, author = {Yasuaki Kabe and Mamoru Hatakeyama and Satoshi Sakamoto and KOSUKE NISHIO and Hiroshi Handa}, title = {Novel Applications of Affinity Beads}, publisher = {Jhon Wiley & Sons. Inc.}, year = 2009, } @book{CTT100614928, author = {半田宏 and 和田忠士 and 坂本聡}, title = {診断学、1.MEMSと診断 他}, publisher = {株式会社テクノシステム}, year = 2009, } @article{CTT100832458, author = {Cho, J. and Hiramoto, M. and Masaike, Y. and Satoshi Sakamoto and Imai, Y. and Imai, Y. and Hiroshi Handa and Imai, T.}, title = {UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner}, journal = {Biochem. Biophys. Res. Commun.}, year = 2020, } @article{CTT100819548, author = {Shunpei Tateno and Midori Iida and Satoshi Fujii and Miki Katayama and Haruka Tokuyama and Junichi Yamamoto and Takumi Ito and Satoshi Sakamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide }, journal = {Scientific Reports}, year = 2020, } @article{CTT100832459, author = {Sekino, M. and Kuwahata, A. and Fujita, S. and Matsuda, S. and Kaneko, M. and Chikaki, S. and Sakamoto, S. and Saito, I. and Hiroshi Handa and Kusakabe, M.}, title = {Development of an optimized dome-shaped magnet for rapid magnetic immunostaining}, journal = {Development of an optimized dome-shaped magnet for rapid magnetic immunostaining}, year = 2020, } @article{CTT100832460, author = {Sekino, M. and Kuwahata, A. and Yoshibe, A. and Imai, K. and Kaneko, M. and Chikaki, S. and Saito, I. and Tsuruma, A. and Sakamoto, S. and Handa, H. and Matsuda, A. and Kusakabe, M.}, title = {Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis}, journal = {Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis}, year = 2020, } @article{CTT100798250, author = {Ando, H. and Sato, T. and Ito, T. and Yamamoto, J. and Sakamoto, S. and Nitta, N. and Asatsuma-Okumura, T. and Shimizu, N. and Mizushima, R. and Aoki, I. and Imai, T. and Yamaguchi, Y. and Berk, A.J. and Hiroshi Handa}, title = {Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation}, journal = {iScience}, year = 2019, } @article{CTT100811795, author = {Tatsuya Onishi and Sachiko Matsuda and Yuki Nakamura and Junko Kuramoto and Akinori Tsuruma and Satoshi Sakamoto and Shunichi Suzuki and Daiichiro Fuchimoto and Akira Onishi and Shinichi Chikaki and Miki Kaneko and Akihiro Kuwahata and Masaki Sekino and Hiroshi Yasuno and Naohiro Hanyu and Tomoko Kurita and Hiroyuki Takei and Takashi Sakatani and Kanae Taruno and Seigo NakamuraTetsu Hayashida and Hiromitsu Jinno and Moriaki Kusakabe and Hiroshi Handa and Kaori Kameyama and Yuukou Kitagawa}, title = {Magnetically-promoted rapid immunofluorescence staining for frozen tissue sections.}, journal = {J. Histochem. Cytochem.}, year = 2019, } @article{CTT100778476, author = {Yasuaki kabe and Satoshi Sakamoto and Mamoru Hatakeyama and Yuki Yamaguchi and Makoto Suematsu and Makoto Itonaga and Hiroshi Handa}, title = {Application of high-performance magnetic nano-beads to biological sensing devices}, journal = {Anal. Bioanal. Chem.}, year = 2019, } @article{CTT100778477, author = {Yasuaki Kabe and Makoto Suematsu and Satoshi Sakamoto and Miwa Hirai and Ikko Koike and Takako Hishiki and Atsushi Matsuda and Yuichi Hasegawa and Koji Tsujita and Masayuki Ono and Naoko Minegishi and Atsushi Hozawa and Yoshinori Murakami and Michiaki Kubo and Makoto Itonaga and Hiroshi Handa}, title = {Development of a highly-sensitive device for counting the number of disease-specific exosomes in human sera}, journal = {Clin. Chem.}, year = 2018, } @article{CTT100782291, author = {Kimura A. and Kitajima, M. and Nishida, K. and Serada, S. and Fujimoto, M. and Naka, T. and Fujii-Kuriyama, Y. and Satoshi Sakamoto and Takumi Ito and HIROSHI HANDA and Tanaka, T. and Yoshimura, A and Suzuki, H.}, title = {NQO1 inhibits TLR-dependent production of selective cytokines by promoting PDLIM2-mediated degradation of IkB-z}, journal = {J. Exp. Med.}, year = 2018, } @article{CTT100782311, author = {Kaneko, M. and Chikaki, S. and Matsuda, S. and Kuwahata, A. and Namita, M. and Saito, I. and Sakamoto, S. and Kusakabe, M. and Sekino, M.}, title = {Development of magnet configurations for magnetic immunostaining}, journal = {AIP ADVANCES}, year = 2018, } @article{CTT100779857, author = {Tomoyuki Mori and Takumi Ito and Shujie Liu and Hideki Ando and Satoshi Sakamoto and Yuki Yamaguchi and Etsuko Tokunaga and Norio Shibata and Hiroshi Handa}, title = {Structural basis of thalidomide enantiomer binding to cereblon}, journal = {Scientific Reports}, year = 2018, } @article{CTT100782326, author = {Boccitto, M. and Lee, N. and Satoshi Sakamoto and Spruce, L. A. and Handa, H. and Clardy, J. and Seeholzer, S. H. and Kalb R. G.}, title = {The Neuroprotective Marine Compound Psammaplysene A Binds the RNA Binding Protein HNRNPK}, journal = {Mar. Drugs}, year = 2017, } @article{CTT100744530, author = {S. Mukai and S. Moriya and M. Hiramoto and H. Kazama and H. Kokuba and X.-F. Che and T. Yokoyama and S. Sakamoto and A. Sugawara and T. Sunazuka and S. Ōmura and H. Handa and T. Itoi and K. Miyazawa}, title = {Macrolides sensitize EGFR-​TKI-​induced non-​apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines}, journal = {Int. J. Oncol.}, year = 2016, } @article{CTT100782329, author = {Pérez-Perarnau, A. and Preciado, S. and Palmeri, C. M. and Moncunill-Massaguer, C. and Iglesias-Serret, D. and González-Gironès, D. M. and Miguel, M. and Satoki Karasawa and Sakamoto, S and Cosialls, A. M. and Rubio-Patiño, C. and Saura-Esteller, J. and Ramón, R. and Caja, L. and Fabregat, I. and Pons, G. and HIROSHI HANDA and Albericio, F. and Gil, J. and Lavilla, R.}, title = {A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins}, journal = {Angew. Chem. Int. Ed.}, year = 2014, } @article{CTT100723501, author = {Satoshi Sakamoto and Kenshi Omagari and Yoshinori Kita and Yusuke Mochizuki and Yasuyuki Naito and Shintaro Kawata and Sachiko Matsuda and Osamu Itano and Hiromitsu Jinno and Hiroya Takeuchi and Yuki Yamaguchi and Yuko Kitagawa and Hiroshi Handa}, title = {Magnetically Promoted Rapid Immunoreactions Using Functionalized Fluorescent Magnetic Beads: A Proof of Principle}, journal = {Clinical Chemistry}, year = 2014, } @article{CTT100691776, author = {Shuji Iida and Kensuke Imai and Sachiko Matsuda and Osamu Itano and Mamoru Hatakeyama and Satoshi Sakamoto and Daisuke Kokuryo and Koji Okabayashi and Takashi Endo and Yoshiyuki Ishii and Hirotoshi Hasegawa and Ichio Aoki and Hiroshi Handa and Yuko Kitagawa}, title = {In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles}, journal = {Journal of Magnetic Resonance Imaging}, year = 2013, } @article{CTT100691772, author = {Vipul Gupta and Shujie Liu and Hideki Ando and Ryohei Ishii and Shumpei Tateno and Yuki Kaneko and Masato Yugami and Satoshi Sakamoto and Yuki Yamaguchi and Osamu Nureki and Hiroshi Handa}, title = {Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity}, journal = {Mol. Pharmacol.}, year = 2013, } @article{CTT100723504, author = {Teruya Enomoto and Masa-aki Kawano and Hajime Fukuda and Wataru Sawada and Takamasa Inoue and Kok Chee Haw and Yoshinori Kita and Satoshi Sakamoto and Yuki Yamaguchi and Takeshi Imai and Mamoru Hatakeyama and Shigeyoshi Saito and Adarsh Sandhu and Masanori Matsui and Ichio Aoki and Hiroshi Handa}, title = {Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1}, journal = {J. Biotechnol.}, year = 2013, } @article{CTT100691778, author = {Teruya Enomoto and Masaaki Kawano and Hajime Fukuda and Wataru Sawada and Takamasa Inoue and Kok Chee Haw and Yoshinori Kita and Satoshi Sakamoto and Takeshi Imai and Mamoru Hatakeyama and Shigeyoshi Saito and Adarsh Sandhu and Masanori Matsui and Ichio Aoki and Hiroshi Handa}, title = {Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1}, journal = {Journal of Biotechnology}, year = 2013, } @article{CTT100691780, author = {Kentaro Hotta and Akihiro Nashimoto and Eiji Yasumura and Masafumi Suzuki and Motoki Azuma and Yosuke Iizumi and Daisuke Shima and Ryusuke Nabeshima and Masaki Hiramoto and Akira Okada and Kumiko Sakata-Sogawa and Makio Tokunaga and Takumi Ito and Hideki Ando and Satoshi Sakamoto and Yasuaki Kabe and Shinichi Aizawa and Takeshi Imai and Yuki Yamaguchi and Hajime Watanabe and Hiroshi Handa}, title = {Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein}, journal = {Mol. Pharmacol.}, year = 2013, } @article{CTT100691783, author = {Satoki Karasawa and Motoki Azuma and Takeshi Kasama and Satoshi Sakamoto and Yasuaki Kabe and Takeshi Imai and Yuki Yamaguchi and Keisuke Miyazawa and Hiroshi Handa}, title = {Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis}, journal = {Molecular Pharmacology}, year = 2013, } @article{CTT100691791, author = {Satoshi Sakamoto and Mamoru Hatakeyama and Takumi Ito and Hiroshi Handa}, title = {Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound}, journal = {Bioorganic & Medicinal Chemistry}, year = 2012, } @article{CTT100691805, author = {Naoya Maekawa and Masaki Hiramoto and Satoshi Sakamoto and Motoki Azuma and Takumi Ito and Marie Ikeda and Michitaka Naitou and Hukum P. Acharya and Yuichi Kobayashi and Makoto Suematsu and Hiroshi Handa and Takeshi Imai}, title = {High-performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads}, journal = {Biomedical Chromatography}, year = 2011, } @article{CTT100691797, author = {Mamoru Hatakeyama and Hiroshi Kishi and Yoshinori Kita and Kensuke Imai and Kosuke Nishio and Satoki Karasawa and Yuka Masaike and Satoshi Sakamoto and Adarsh Sandhu and Akihiro Tanimoto and Tatsuya Gomi and Eiichi Kohda and Masanori Abe and Hiroshi Handa}, title = {A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications}, journal = {Journal of Materials Chemistry}, year = 2011, } @article{CTT100691806, author = {Yoshitaka Morimoto and Tsukasa Takamura and Sang Yoon Park and Satoshi Sakamoto and Shintaro Kawata and Hiroshi Handa and Adarsh Sandhu}, title = {Detection of 8 nm Diameter Superparamagnetic Beads by Magnetically-Induced Manipulation of Micrometer-Sized Magnetic Beads: A Novel Protocol for Magnetically-Labeled Biosensing}, journal = {Japanese Journal of Applied Physics}, year = 2010, } @article{CTT100691810, author = {Yuka Masaike and Takeshi Takagi and Masataka Hirota and Joe Yamada and Satoru Ishihara and Tetsu M. C. Yung and Takamasa Inoue and Chika Sawa and Hiroshi Sagara and Satoshi Sakamoto and Yasuyuki Takahashi and Yuki Yamaguchi and Hiroshi Handa and Yasuaki Kabe}, title = {Identification of Dynamin-2-Mediated Endocytosis as a New Target of Osteoporosis Drugs, Bisphosphonates}, journal = {Molecular Pharmacology}, year = 2010, } @article{CTT100597656, author = {Satoshi Sakamoto and Yasuaki Kabe and Mamoru Hatakeyama and Yuki Yamaguchi and Hiroshi Handa}, title = {Development and application of high-performance affinity beads: toward chemical biology and drug discovery}, journal = {Chem. Rec.}, year = 2009, } @article{CTT100597649, author = {Masafumi Suzuki and Shoichiro Furukawa and Chikanori Kuramori and Chika Sawa and Yasuaki Kabe and Mitsuhiro Nakamura and Jun-ichi Sawada and Yuki Yamaguchi and Satoshi Sakamoto and Satoshi Inouye and Hiroshi Handa}, title = {Development of a chemical screening system using aqueorin-fused protein}, journal = {Biochem. Biophys. Res. Commun.}, year = 2008, } @article{CTT100543743, author = {K. Nishio and M. Ikeda and N. Gokon and S. Tsubouchi and H. Narimatsu and Y. Mochizuki and S. Sakamoto and A. Sandhu and M. Abe and H. Handa}, title = {Preparation of size-controlled (30-100nm) magnetite nanoparticles for biomedical applications.}, journal = {J. Magn. Magn. Mater.}, year = 2007, } @article{CTT100543640, author = {Adarsh Sandhu and Yoshimich Kumagai and Adam Lapicki and Satoshi Sakamoto and Masanori Abe and Hiroshi Handa}, title = {High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules}, journal = {Biosensors & Bioelectronics}, year = 2007, } @article{CTT100832461, author = {Sakamoto, S. and Sakazaki, H. and Hagiwara, K. and Kamada, K. and Ishii, K. and Noda, T. and Inoue, M. and Hirama, M.}, title = {A Formal Total Synthesis of (+)-Pinnatoxin A}, journal = {Angew. Chem. Int. Ed.}, year = 2004, } @inproceedings{CTT100917279, author = {荒川 翼 and 山口 雄輝 and 坂本 聡}, title = {神経変性疾患の原因であるタンパク質凝集体を選択的に分解誘導するPROTACの開発を目指した研究}, booktitle = {}, year = 2023, } @inproceedings{CTT100884047, author = {原口大和 and 坂本聡 and 山口雄輝}, title = {二次元的スクリーニング解析を駆使した既存抗がん剤の新規作用機序の解明を目指した研究}, booktitle = {}, year = 2022, } @inproceedings{CTT100879612, author = {原口大和 and 坂本聡 and 山口雄輝}, title = {ナノ磁性ビーズ精製とCRISPRライブラリースクリーニングによる薬剤標的分子の網羅的同定を目指した研究}, booktitle = {}, year = 2021, } @inproceedings{CTT100790002, author = {小泉 純玲 and 坂本 聡 and 山口 雄輝}, title = {抗がん作用を有するカンナビノイドの作用機序の解析}, booktitle = {}, year = 2019, } @inproceedings{CTT100777899, author = {坂本 聡 and Gupta Vipul and 劉 舒捷 and 安藤秀樹 and 舘野峻平 and 金子裕生 and 湯上真人 and 石井亮平 and 濡木 理 and 山口雄輝 and 半田 宏}, title = {抗炎症薬サリチル酸が示す生体内作用メカニズムの解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777377, author = {坂本 聡 and 山口 雄輝 and 半田宏}, title = {ターゲット因子の解析を基盤とする生物活性物質が示す作用機構の解明}, booktitle = {}, year = 2017, } @inproceedings{CTT100779844, author = {坂本 聡 and 伊藤 拓水 and 森 智行 and 安藤 秀樹 and 山口 雄輝 and 箱嶋 敏雄 and 半田 宏}, title = {CRBNに対するサリドマイド光学異性体の結合基盤解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100777832, author = {Satoshi Sakamoto and Takumi Ito and Yuki Yamaguchi and Hideki Ando and Hiroshi Handa}, title = {Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs)}, booktitle = {}, year = 2015, } @inproceedings{CTT100777831, author = {Satoshi Sakamoto and Yuki Yamaguchi and Takumi Ito and Hiroshi Handa}, title = {Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads}, booktitle = {}, year = 2015, } @inproceedings{CTT100777828, author = {坂本 聡 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {IMiDs標的タンパク質CRBNの生化学的解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100777827, author = {坂本 聡 and 山口雄輝 and 半田 宏}, title = {アフィニティビーズを利用した生物活性物質標的タンパク質の単離・同定・評価}, booktitle = {}, year = 2015, } @inproceedings{CTT100777380, author = {坂本 聡 and Vipul Gupta and 劉 舒捷 and 安藤 秀樹 and 舘野 峻平 and 金子 裕生 and 湯上 真人 and 石井 亮平 and 濡木 理 and 山口 雄輝 and 半田 宏}, title = {抗炎症薬サリチル酸の生体内作用機構の解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100777379, author = {坂本 聡 and 唐澤 慧記 and 東 基記 and 笠間 健嗣 and 宮澤 啓介 and 山口 雄輝 and 半田 宏}, title = {ビタミンK2が引き起こすがん細胞のアポトーシス誘導機構の解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100802326, author = {Nakagomi, Madoka and Shudo, Koichi and Satoshi Sakamoto and Handa, Hiroshi and Iwamoto, Takeo and Matsuura, Tomokazu}, title = {A Novel Aromatic Carboxylic Acid Inhibits Luciferase Enzymatic Activity in Mammalian Cells by Acylation of an Active Regulatory Lysine Residue}, booktitle = {BIOPHYSICAL JOURNAL}, year = 2014, } @inproceedings{CTT100801443, author = {Tsujita, K. and Hasegawa, Y. and Ono, M. and Itonaga, M. and Kabe, Y. and Satoshi Sakamoto and Handa, H.}, title = {Single nanobeads detection by scanning laser spot for immunosensing}, booktitle = {18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014}, year = 2014, } @inproceedings{CTT100801750, author = {Tsujita, K. and Hasegawa, Y. and Ono, M. and Itonaga, M. and Satoshi Sakamoto and Hatakeyama, M. and Handa, H.}, title = {Ultrahigh-sensitivity biomarker sensing system based on the combination of optical disc technologies and nanobead technologies}, booktitle = {Japanese Journal of Applied Physics}, year = 2013, } @misc{CTT100594416, author = {Satoshi Sakamoto}, title = {Synthetic Study of Pinnatoxin A}, year = 2003, } @misc{CTT100699750, author = {半田宏 and 坂本聡}, title = {蛍光性ポリマー微粒子及び蛍光標識セット}, howpublished = {公開特許}, year = 2015, month = {Aug.}, note = {特願2014-030228(2014/02/20), 特開2015-155813(2015/08/27)} } @misc{CTT100696687, author = {勝亦 優 and 半田宏 and 坂本聡}, title = {粒子の単分散状態維持方法及び分析対象物の検出方法}, howpublished = {公開特許}, year = 2015, month = {June}, note = {特願2013-240897(2013/11/21), 特開2015-102337(2015/06/04)} } @misc{CTT100713471, author = {平瀬 匠 and 中山 雅人 and 半田 宏 and 坂本 聡 and 内藤 靖之}, title = {被検物質の検出システム}, howpublished = {登録特許}, year = 2017, month = {Oct.}, note = {特願2014-523750(2013/07/02), 再表2014/007248(2016/06/02), 特許第6217936号(2017/10/06)} } @misc{CTT100682131, author = {半田宏 and 坂本聡 and 河田 慎太郎}, title = {ポリマー微粒子の製造方法}, howpublished = {登録特許}, year = 2017, month = {Apr.}, note = {特願2013-071029(2013/03/29), 特開2014-193972(2014/10/09), 特許第6123053号(2017/04/14)} } @misc{CTT100660988, author = {半田宏 and 畠山 士 and 坂本聡}, title = {機能性物質包含微粒子を用いたバイオセンシング方法}, howpublished = {登録特許}, year = 2016, month = {Apr.}, note = {特願2011-260624(2011/11/29), 特開2013-113735(2013/06/10), 特許第5924571号(2016/04/28)} } @misc{CTT100648166, author = {平瀬 匠 and 勝亦 優 and 土屋 真紀子 and 星野 昭裕 and 入江 新司 and 中山 雅人 and 半田宏 and 坂本聡 and 河田 慎太郎 and 内藤 靖之}, title = {標識磁性粒子を用いた被検物質の検出方法、及び被検物質の検出システム}, howpublished = {登録特許}, year = 2014, month = {Nov.}, note = {特願2011-053415(2011/03/10), 特開2012-189453(2012/10/04), 特許第5645020号(2014/11/14)} } @misc{CTT100658249, author = {半田宏 and 畠山 士 and 坂本聡 and 岸寛}, title = {ポリマー被覆フェライト微粒子および製造方法}, howpublished = {登録特許}, year = 2015, month = {Feb.}, note = {特願2011-538254(2010/10/28), 特開(再表)2011/052205(2013/03/14), 特許第5688807号(2015/02/06)} } @misc{CTT100677665, author = {半田宏 and 畠山 士 and 坂本聡 and 望月 勇輔 and 河田 慎太郎}, title = {蛍光分子を含有するポリマー粒子およびその製造方法}, howpublished = {登録特許}, year = 2014, month = {}, note = {特願2010-528640(2009/09/10), 特開(再表)2010/029739(2012/02/02), 特許第5574492号(2014/07/11)} } @misc{CTT100677662, author = {半田宏 and 畠山 士 and 坂本聡 and 政池 由佳 and 西尾 広介 and 北 善紀 and 阿部正紀 and 岸寛}, title = {表面被覆無機物粒子の製造方法}, howpublished = {登録特許}, year = 2014, month = {}, note = {特願2009-524516(2008/07/25), 特開(再表)2009/014201(2010/10/07), 特許第5569837号(2014/07/04)} } @phdthesis{CTT100594416, author = {Satoshi Sakamoto}, title = {Synthetic Study of Pinnatoxin A}, school = {東北大学}, year = 2003, }