@book{CTT100917286, author = {Junichi Yamamoto and Tomoko Asatsuma-Okumura and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {History of IMiDs and Protein Degradation as a Pharmacological Modality}, publisher = {John Wiley & Sons}, year = 2022, } @book{CTT100806658, author = {山口 雄輝}, title = {転写反応の生化学}, publisher = {}, year = 2017, } @book{CTT100806660, author = {田村隆明 and 浦聖恵 and 山口雄輝}, title = {遺伝子発現制御機構 クロマチン,転写制御,エピジェネティクス}, publisher = {東京化学同人}, year = 2017, } @book{CTT100830019, author = {Kyota Ko and Simon Gillett and 近藤 科江 and 山口 雄輝}, title = {理系英会話アクティブラーニング1 テツヤ、国際学会いってらっしゃい}, publisher = {羊土社}, year = 2014, } @book{CTT100830018, author = {Kyota Ko and Simon Gillett and 近藤 科江 and 山口 雄輝}, title = {理系英会話アクティブラーニング2 テツヤ、ディスカッションしようか}, publisher = {羊土社}, year = 2014, } @book{CTT100830020, author = {山口雄輝 and 成田央}, title = {基礎からしっかり学ぶ生化学}, publisher = {羊土社}, year = 2014, } @book{CTT100830021, author = {半田宏 and 山口雄輝}, title = {新しい遺伝子工学 新版}, publisher = {朝倉書店}, year = 2014, } @book{CTT100832491, author = {山口雄輝 and 半田宏}, title = {転写制御とエピジェネティクス—ゲノムデコードに向けて}, publisher = {南山堂}, year = 2008, } @book{CTT100549903, author = {山口雄輝 and 半田宏 and 和田忠士}, title = {転写因子による生命現象解明の最前線:実験医学増刊 25}, publisher = {シュプリンガー・フェアラーク}, year = 2007, } @book{CTT100531731, author = {Handa, Y. and Yamaguchi, Y.}, title = {Hepatitis Delta Virus}, publisher = {Landes Bioscience / Springer Science+Business Media}, year = 2006, } @book{CTT100723517, author = {山口雄輝}, title = {ケミカルバイオロジー・ケミカルゲノミクス}, publisher = {シュプリンガー・フェアラーク}, year = 2005, } @book{CTT100391530, author = {山口雄輝}, title = {転写研究集中マスター}, publisher = {羊土社}, year = 2005, } @book{CTT100391531, author = {山口雄輝}, title = {科学英語論文の赤ペン添削講座}, publisher = {}, year = 2005, } @book{CTT100499663, author = {山口雄輝}, title = {キーワードで理解する転写イラストマップ}, publisher = {羊土社}, year = 2004, } @book{CTT100538840, author = {山口雄輝}, title = {わかる実験医学シリーズ 転写がわかる}, publisher = {羊土社}, year = 2002, } @book{CTT100485046, author = {山口雄輝}, title = {ゲノムからの情報発現 転写因子とその機能}, publisher = {シュプリンガー・フェアラーク}, year = 2000, } @book{CTT100833101, author = {山口雄輝}, title = {BioScience用語ライブラリー新版}, publisher = {}, year = 1999, } @book{CTT100538837, author = {Handa, H. and Yamaguchi, Y. and Wada, T.}, title = {Purification of DNA binding proteins. in High resolution chromatography: A practical approach}, publisher = {Oxford University Press}, year = 1999, } @book{CTT100833102, author = {山口雄輝}, title = {BioScience用語ライブラリー}, publisher = {羊土社}, year = 1995, } @article{CTT100917288, author = {Noriyuki Azuma and Tadashi Yokoi and Taku Tanaka and Emiko Matsuzaka and Yuki Saida and Sachiko Nishina and Miho Terao and Shuji Takada and Maki Fukami and Kohji Okamura and Kayoko Maehara and Tokiwa Yamasaki and Jun Hirayama and Hiroshi Nishina and Hiroshi Handa and Yuki Yamaguchi}, title = {Integrator complex subunit 15 controls mRNA splicing and is critical for eye development}, journal = {Hum. Mol. Genet.}, year = 2023, } @article{CTT100879618, author = {Hidefumi Suzuki and Ryota Abe and Miho Shimada and Tomonori Hirose and Hiroko Hirose and Keisuke Noguchi and Yoko Ike and Nanami Yasui and Kazuki Furugori and Yuki Yamaguchi and Atsushi Toyoda and Yutaka Suzuki and Tatsuro Yamamoto and Noriko Saitoh and Shigeo Sato and Chieri Tomomori-Sato and Ronald Conaway and Joan Conaway and Hidehisa Takahashi}, title = {The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies}, journal = {Nat. Commun.}, year = 2022, } @article{CTT100879616, author = {Masahiko Okuda and Tetsufumi Suwa and Hidefumi Suzuki and Yuki Yamaguchi and Yoshifumi Nishimura}, title = {Three human RNA polymerases interact with TFIIH via a common RPB6 subunit}, journal = {Nucleic Acids Res.}, year = 2022, } @article{CTT100879617, author = {Nobuyuki Shimizu and Tomoko Asatsuma-Okumura and Junichi Yamamoto and Yuki Yamaguchi and Hiroshi Handa and Takumi Ito}, title = {PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates}, journal = {Commun. Biol.}, year = 2021, } @article{CTT100832156, author = {Junichi Yamamoto and Tetsufumi Suwa and Yuki Murase and Shunpei Tateno and Hirotaka Mizutome and Tomoko Asatsuma-Okumura and Nobuyuki Shimizu and Tsutomu Kishi and Shuji Momose and Masahiro Kizaki and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells}, journal = {Nature Chemical Biology}, year = 2020, } @article{CTT100819548, author = {Shunpei Tateno and Midori Iida and Satoshi Fujii and Miki Katayama and Haruka Tokuyama and Junichi Yamamoto and Takumi Ito and Satoshi Sakamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide }, journal = {Scientific Reports}, year = 2020, } @article{CTT100819420, author = {Takahashi H and Ranjan A and Chen S and Suzuki H and Shibata M and Hirose T and Hirose H and Sasaki K and Abe R and Chen K and He Y and Zhang Y and Takigawa I and Tsukiyama T and Watanabe M and Fujii S and Iida M and Yamamoto J and Yamaguchi Y and Suzuki Y and Matsumoto M and Nakayama KI and Washburn MP and Saraf A and Florens L and Sato S and Tomomori-Sato C and Conaway RC and Conaway JW and Hatakeyama S}, title = {The role of Mediator and Little Elongation Complex in transcription termination}, journal = {Nat Commun.}, year = 2020, } @article{CTT100807675, author = {Asatsuma-Okumura T and Ando H and De Simone M and Yamamoto J and Sato T and Shimizu N and Asakawa K and Yamaguchi Y and Takumi Ito and Guerrini L and Hiroshi Handa}, title = {p63 is a cereblon substrate involved in thalidomide teratogenicity}, journal = {Nature Chemical Biology}, year = 2019, } @article{CTT100798250, author = {Ando, H. and Sato, T. and Ito, T. and Yamamoto, J. and Sakamoto, S. and Nitta, N. and Asatsuma-Okumura, T. and Shimizu, N. and Mizushima, R. and Aoki, I. and Imai, T. and Yamaguchi, Y. and Berk, A.J. and Hiroshi Handa}, title = {Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation}, journal = {iScience}, year = 2019, } @article{CTT100792588, author = {Hidefumi Suzuki and Mayumi Okamoto-Katsuyama and Tetsufumi Suwa and Ryo Maeda and Taka-aki Tamura and Yuki Yamaguchi}, title = {TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis}, journal = {Scientific Reports}, year = 2019, } @article{CTT100778476, author = {Yasuaki kabe and Satoshi Sakamoto and Mamoru Hatakeyama and Yuki Yamaguchi and Makoto Suematsu and Makoto Itonaga and Hiroshi Handa}, title = {Application of high-performance magnetic nano-beads to biological sensing devices}, journal = {Anal. Bioanal. Chem.}, year = 2019, } @article{CTT100779857, author = {Tomoyuki Mori and Takumi Ito and Shujie Liu and Hideki Ando and Satoshi Sakamoto and Yuki Yamaguchi and Etsuko Tokunaga and Norio Shibata and Hiroshi Handa}, title = {Structural basis of thalidomide enantiomer binding to cereblon}, journal = {Scientific Reports}, year = 2018, } @article{CTT100723495, author = {Yasuaki Kabe and Takanori Nakane and Ikko Koike and Tatsuya Yamamoto and Yuki Sugiura and Erisa Harada and Kenji Sugase and Tatsuro Shimamura and Mitsuyo Ohmura and Kazumi Muraoka and Ayumi Yamamoto and Takeshi Uchida and So Iwata and Yuki Yamaguchi and Elena Krayukhina and Masanori Noda and Hiroshi Handa and Koichiro Ishimori and Susumu Uchiyama and Takuya Kobayashi and Makoto Suematsu}, title = {Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance}, journal = {Nat. Commun.}, year = 2016, } @article{CTT100723497, author = {Qing-Fu Cao and Junichi Yamamoto and Tomoyasu Isobe and Shunpei Tateno and Yuki Murase and Yexi Chen and Hiroshi Handa and Yuki Yamaguchi}, title = {Characterization of the human transcription elongation factor Rtf1: evidence for non-overlapping functions of Rtf1 and the Paf1 complex}, journal = {Mol. Cell. Biol.}, year = 2015, } @article{CTT100723496, author = {Clelia Laitem and Justyna Zaborowska and Michael Tellier and Yuki Yamaguchi and Seifuku Sou and Sylvain Egloff and Hiroshi Handa and Shona Murphy}, title = {CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription}, journal = {Transcription}, year = 2015, } @article{CTT100723498, author = {Masa-aki Kawano and Koji Doi and Hajime Fukuda and Yoshinori Kita and Imai Kensuke and Takamasa Inoue and Teruya Enomoto and Masanori Matsui and Mamoru Hatakeyama and Yuki Yamaguchi and Hiroshi Handa}, title = {SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes}, journal = {Biotechnol. Rep.}, year = 2015, } @article{CTT100723499, author = {Junichi Yamamoto and Yuri Hagiwara and Kunitoshi Chiba and Tomoyasu Isobe and Takashi Narita and Hiroshi Handa and Yuki Yamaguchi}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.}, journal = {Nat. Commun.}, year = 2014, } @article{CTT100723500, author = {Misao Takemoto and Yumi Kawamura and Mikako Hirohama and Yuki Yamaguchi and Hiroshi Handa and Hisato Saitoh and Yoichi Nakao and Manabu Kawada and Khan Khalid and Hiroyuki Koshino and Ken-ichi Kimura and Akihiro Ito and Minoru Yoshida}, title = {Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata}, journal = {J. Antibiot.}, year = 2014, } @article{CTT100723501, author = {Satoshi Sakamoto and Kenshi Omagari and Yoshinori Kita and Yusuke Mochizuki and Yasuyuki Naito and Shintaro Kawata and Sachiko Matsuda and Osamu Itano and Hiromitsu Jinno and Hiroya Takeuchi and Yuki Yamaguchi and Yuko Kitagawa and Hiroshi Handa}, title = {Magnetically Promoted Rapid Immunoreactions Using Functionalized Fluorescent Magnetic Beads: A Proof of Principle}, journal = {Clinical Chemistry}, year = 2014, } @article{CTT100691772, author = {Vipul Gupta and Shujie Liu and Hideki Ando and Ryohei Ishii and Shumpei Tateno and Yuki Kaneko and Masato Yugami and Satoshi Sakamoto and Yuki Yamaguchi and Osamu Nureki and Hiroshi Handa}, title = {Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity}, journal = {Mol. Pharmacol.}, year = 2013, } @article{CTT100723504, author = {Teruya Enomoto and Masa-aki Kawano and Hajime Fukuda and Wataru Sawada and Takamasa Inoue and Kok Chee Haw and Yoshinori Kita and Satoshi Sakamoto and Yuki Yamaguchi and Takeshi Imai and Mamoru Hatakeyama and Shigeyoshi Saito and Adarsh Sandhu and Masanori Matsui and Ichio Aoki and Hiroshi Handa}, title = {Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1}, journal = {J. Biotechnol.}, year = 2013, } @article{CTT100723502, author = {Efrat Shema-Yaacoby and Miroslav Nikolov and Mahmood Haj-Yahya and Peter Siman and Eric Allemand and Yuki Yamaguchi and Christian Muchardt and Henning Urlaub and Ashraf Brik and Moshe Oren and Wolfgang Fischle}, title = {Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription}, journal = {Cell Rep.}, year = 2013, } @article{CTT100723503, author = {Tomoyasu Isobe and Soken-Nakazawa J. Song and Prabha Tiwari and Hiroki Ito and Yuki Yamaguchi and Kazuyuki Yoshizaki}, title = {Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression}, journal = {FEBS Letters}, year = 2013, } @article{CTT100691780, author = {Kentaro Hotta and Akihiro Nashimoto and Eiji Yasumura and Masafumi Suzuki and Motoki Azuma and Yosuke Iizumi and Daisuke Shima and Ryusuke Nabeshima and Masaki Hiramoto and Akira Okada and Kumiko Sakata-Sogawa and Makio Tokunaga and Takumi Ito and Hideki Ando and Satoshi Sakamoto and Yasuaki Kabe and Shinichi Aizawa and Takeshi Imai and Yuki Yamaguchi and Hajime Watanabe and Hiroshi Handa}, title = {Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein}, journal = {Mol. Pharmacol.}, year = 2013, } @article{CTT100691782, author = {Jeff Kershaw and Christoph Leuze and Ichio Aoki and Takayuki Obata and Iwao Kanno and Hiroshi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence}, journal = {Neuroimage}, year = 2013, } @article{CTT100691783, author = {Satoki Karasawa and Motoki Azuma and Takeshi Kasama and Satoshi Sakamoto and Yasuaki Kabe and Takeshi Imai and Yuki Yamaguchi and Keisuke Miyazawa and Hiroshi Handa}, title = {Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis}, journal = {Molecular Pharmacology}, year = 2013, } @article{CTT100691784, author = {Yuki Yamaguchi and Hirotaka Shibata and Hiroshi Handa}, title = {Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond}, journal = {Biochimica et Biophysica Acta. Gene Regulatory Mechanisms}, year = 2013, } @article{CTT100748892, author = {Yuki Ito and Takumi Ito and Satoki Karasawa and Teruya Enomoto and Nashimoto, Akihiro and Hase, Yasuyoshi and Sakamoto, Satoshi and Mimori, Tsuneyo and Yoshihisa Matsumoto and Yuki Yamaguchi and HIROSHI HANDA}, title = {Identification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) as a Novel Target of Bisphenol A}, journal = {Plos One}, year = 2012, } @article{CTT100691786, author = {Gil Diamant and Liat Amir-Zilberstein and Yuki Yamaguchi and Hiroshi Handa and Rivka Dikstein}, title = {DSIF Restricts NF-κB Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes}, journal = {Cell Reports}, year = 2012, } @article{CTT100691793, author = {Teruya Enomoto and Iwao Kukimoto and Masa-aki Kawano and Yuki Yamaguchi and Arnold J. Berk and Hiroshi Handa}, title = {In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer}, journal = {Virology}, year = 2011, } @article{CTT100691792, author = {Ayumi Kawano and Yohei Hayashi and Shuhei Noguchi and Hiroshi Handa and Masami Horikoshi and Yuki Yamaguchi}, title = {Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library}, journal = {Genes Cells}, year = 2011, } @article{CTT100691803, author = {Takuya Taneda and Wenyan Zhu and Qingfu Cao and Hajime Watanabe and Yuki Yamaguchi and Hiroshi Handa and Tadashi Wada}, title = {Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation}, journal = {Genes to Cells}, year = 2011, } @article{CTT100614755, author = {Kunitoshi Chiba and Junichi Yamamoto and Yuki Yamaguchi and Hiroshi Handa}, title = {Promoter-proximal pausing and its release: molecular mechanisms and physiological functions}, journal = {Exp. Cell Res.}, year = 2010, } @article{CTT100614756, author = {Sol Kim and Junichi Yamamoto and Yexi Chen and Masatoshi Aida and Tadashi Wada and Hiroshi Handa and Yuki Yamaguchi}, title = {Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation}, journal = {Genes Cells}, year = 2010, } @article{CTT100614754, author = {Kanako Kume and Yosuke Iizumi and Masashi Shimada and Yuki Ito and Tsutomu Kishi and Yuki Yamaguchi and Hiroshi Handa}, title = {Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway}, journal = {Genes Cells}, year = 2010, } @article{CTT100614753, author = {Takumi Ito and Hideki Ando and Takayuki Suzuki and Toshihiko Ogura and Kentaro Hotta and Yoshimasa Imamura and Yuki Yamaguchi and Hiroshi Handa}, title = {Identification of a primary target of thalidomide teratogenicity}, journal = {Science}, year = 2010, } @article{CTT100691810, author = {Yuka Masaike and Takeshi Takagi and Masataka Hirota and Joe Yamada and Satoru Ishihara and Tetsu M. C. Yung and Takamasa Inoue and Chika Sawa and Hiroshi Sagara and Satoshi Sakamoto and Yasuyuki Takahashi and Yuki Yamaguchi and Hiroshi Handa and Yasuaki Kabe}, title = {Identification of Dynamin-2-Mediated Endocytosis as a New Target of Osteoporosis Drugs, Bisphosphonates}, journal = {Molecular Pharmacology}, year = 2010, } @article{CTT100597661, author = {Yexi Chen and Yuki Yamaguchi and Yuta Tsugeno and Junichi Yamamoto and Tomoko Yamada and Mitsuhiro Nakamura and Koji Hisatake and Hiroshi Handa}, title = {DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation}, journal = {Genes Dev.}, year = 2009, } @article{CTT100614750, author = {Hui Chen and Xavier Contreras and Yuki Yamaguchi and Hiroshi Handa and B. Matija Peterlin and Su Guo}, title = {Repression of RNA Polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5}, journal = {PLoS ONE}, year = 2009, } @article{CTT100597658, author = {Hiroyuki Kamiya and Akihiro Suzuki and Yuki Yamaguchi and Hiroshi Handa and Hideyoshi Harashima}, title = {Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases}, journal = {Free Radic. Biol. Med.}, year = 2009, } @article{CTT100597657, author = {Tetsu M. C. Yung and Takashi Narita and Toshiharu Komori and Yuki Yamaguchi and Hiroshi Handa}, title = {Cellular dynamics of the negative transcription elongation factor NELF}, journal = {Exp. Cell Res.}, year = 2009, } @article{CTT100597655, author = {Chikanori Kuramori and Yasuyoshi Hase and Koichi Hoshikawa and Keiko Watanabe and Takeyuki Nishi and Takako Hishiki and Tomoyoshi Soga and Akihiro Nashimoto and Yasuaki Kabe and Yuki Yamaguchi and Hajime Watanabe and Kohsuke Kataoka and Makoto Suematsu and Hiroshi Handa}, title = {Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis}, journal = {Toxicol. Sci.}, year = 2009, } @article{CTT100597654, author = {Toshiharu Komori and Naoto Inukai and Tomoko Yamada and Yuki Yamaguchi and Hiroshi Handa}, title = {Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis}, journal = {Genes Cells}, year = 2009, } @article{CTT100597653, author = {Chikanori Kuramori and Motoki Azuma and Kanako Kume and Yuki Kaneko and Atsushi Inoue and Yuki Yamaguchi and Yasuaki Kabe and Takamitsu Hosoya and Masahiro Kizaki and Makoto Suematsu and Hiroshi Handa}, title = {Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus}, journal = {Biochem. Biophys. Res. Commun.}, year = 2009, } @article{CTT100597656, author = {Satoshi Sakamoto and Yasuaki Kabe and Mamoru Hatakeyama and Yuki Yamaguchi and Hiroshi Handa}, title = {Development and application of high-performance affinity beads: toward chemical biology and drug discovery}, journal = {Chem. Rec.}, year = 2009, } @article{CTT100597650, author = {Kozue Ando and Satoshi Hirao and Yasuaki Kabe and Yuji Ogura and Iwao Sato and Yuki Yamaguchi and Tadashi Wada and Hiroshi Handa}, title = {A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity}, journal = {Nucleic Acids Res.}, year = 2008, } @article{CTT100597652, author = {Motoki Azuma and Yasuaki Kabe and Chikanori Kuramori and Masao Kondo and Yuki Yamaguchi and Hiroshi Handa}, title = {Adenine nucleotide translocator transports haem precursors into mitochondria}, journal = {PLoS One}, year = 2008, } @article{CTT100597651, author = {Ryou-u Takahashi and Shin-nosuke Kanesashi and Takamasa Inoue and Teruya Enomoto and Masa-aki Kawano and Hiroko Tsukamoto and Fumitaka Takeshita and Takeshi Imai and Takahiro Ochiya and Kohsuke Kataoka and Yuki Yamaguchi and Hiroshi Handa}, title = {Presentation of functional foreign peptides on the surface of SV40 virus-like particles}, journal = {J. Biotechnol.}, year = 2008, } @article{CTT100597649, author = {Masafumi Suzuki and Shoichiro Furukawa and Chikanori Kuramori and Chika Sawa and Yasuaki Kabe and Mitsuhiro Nakamura and Jun-ichi Sawada and Yuki Yamaguchi and Satoshi Sakamoto and Satoshi Inouye and Hiroshi Handa}, title = {Development of a chemical screening system using aqueorin-fused protein}, journal = {Biochem. Biophys. Res. Commun.}, year = 2008, } @article{CTT100549890, author = {Hase, Y. and Tatsuno, M. and Nishi, T. and Kataoka, K. and Kabe, Y. and Yamaguchi, Y. and Ozawa, N. and Natori, M. and Handa, H. and Watanabe, H.}, title = {Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm}, journal = {Biochem. Biophys. Res. Commun.}, year = 2008, } @article{CTT100549905, author = {山口雄輝 and 半田宏}, title = {細胞周期依存的なヒストンの発現機構}, journal = {蛋白質核酸酵素}, year = 2007, } @article{CTT100549887, author = {Tsukamoto, H. and Kawano, M. and Inoue, T. and Enomoto, T. and Takahashi, R. and Yokoyama, N. and Yamamoto, N. and Imai, T. and Kataoka, K. and Yamaguchi, Y. and Handa, H.}, title = {Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles}, journal = {Genes Cells}, year = 2007, } @article{CTT100549878, author = {Yamaguchi, Y. and Mura, T. and Chanarat, T. and Okamoto, S. and Handa, H.}, title = {Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity}, journal = {Genes Cells}, year = 2007, } @article{CTT100549881, author = {Amir-Zilberstein, L. and Ainbinder, E. and Taube, L. and Yamaguchi, Y. and Handa, H. and Dikstein, R.}, title = {Differential regulation of NF-kB by elongation factors is determined by core promoter type}, journal = {Mol. Cell. Biol.}, year = 2007, } @article{CTT100549882, author = {Zhu, W. and Wada, T. and Okabe, S. and Taneda, T. and Yamaguchi, Y. and Handa, H.}, title = {DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation}, journal = {Nucleic Acids Res.}, year = 2007, } @article{CTT100549875, author = {Takashi Narita and Yung, T.M.C. and Junichi Yamamoto and Tsuboi, Y. and Tanabe, H. and Tanaka, K. and Yamaguchi, Y. and HIROSHI HANDA and and }, title = {NELF interacts with CBC and participates in 3'-end processing of replication-dependent histone mRNAs}, journal = {Mol. Cell}, year = 2007, } @article{CTT100531738, author = {Nishio, K. and Gokon, N. and Hasegawa, M. and Ogura, Y. and Ikeda, M. and Narimatsu, H. and Tada, M. and Yamaguchi, Y. and Sakamoto, S. and Abe, M. and Handa, H.}, title = {Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP)}, journal = {Colloids Surf. B. Biointerfaces.}, year = 2007, } @article{CTT100531744, author = {Yamamoto, N. and Suzuki, M. and Kawano, M. and Inoue, T. and Takahashi, R. and Tsukamoto, H. and Enomoto, T. and Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {Adeno-associated virus site-specific integration is regulated by TRP-185}, journal = {J. Virol.}, year = 2007, } @article{CTT100531740, author = {Yugami, M. and Kabe, Y. and Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {hnRNP-U enhances the expression of specific genes by stabilizing mRNA.}, journal = {FEBS Lett.}, year = 2007, } @article{CTT100531736, author = {Kubo, T. and Wada, T. and Yamaguchi, Y. and Shimizu, A. and Handa, H.}, title = {Knock-down of 25-kDa subunit of cleavage factor Im in HeLa cells alters alternative polyadenylation within 3' UTRs}, journal = {Nucleic Acid Res.}, year = 2006, } @article{CTT100524642, author = {Aida, M. and Chen, Y. and Nakajima, K. and Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene}, journal = {Mol. Cell. Biol.}, year = 2006, } @article{CTT100561138, author = {Hitoshi Uga and Chikanori Kuramori and Akiko Ohta and Yasunori Tsuboi and Hiroshi Tanaka and Mamoru Hatakeyama and Yuki Yamaguchi and Masahiro Kizaki and Takashi Takahashi and Hiroshi Handa}, title = {A new mechanism of methotrexate action revealed by target screening with affinity beads}, journal = {Mol. Pharmacol.}, year = 2006, } @article{CTT100524640, author = {Ogura, Y. and Azuma, M. and Tsuboi, Y. and Kabe, Y. and Yamaguchi, Y. and Wada, T. and Watanabe, H. and Handa, H.}, title = {TFII-I down-regulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor α}, journal = {Genes Cell}, year = 2006, } @article{CTT100723516, author = {Yamada, T. and Yamaguchi, Y. and Inukai, N. and Kamijo, S. and Mura, T. and Handa, H.}, title = {P-TEFb-mediated phosphorylation of the hSpt5 C-terminal repeats is critical to processive transcription elongation}, journal = {Mol. Cell}, year = 2006, } @article{CTT100723518, author = {Delehouzee, S. and Yoshikawa, T. and Sawa, C. and Sawada, J. and Ito, T. and Omori, M. and Wada, T. and Yamaguchi, Y. and Kabe, Y. and Handa, H.}, title = {GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis}, journal = {Genes Cells}, year = 2005, } @article{CTT100540495, author = {Azuma, N. and Tadokoro, K. and Asaka, A. and Yamada, M. and Yamaguchi, Y. and Handa, H. and Matsushima, S. and Watanabe, T. and Kida, Y. and Ogura, T. and Shimamura, K. and Nakafuku, M.}, title = {Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor}, journal = {Hum. Mol. Genet.}, year = 2005, } @article{CTT100540494, author = {Wu and C.-H. and Lee, C. and Fan, R. and Smith, M.J. and Yamaguchi, Y. and Handa, H. and Gilmour, D.S.}, title = {Molecular characterization of Drosophila NELF}, journal = {Nucleic Acids Res.}, year = 2005, } @article{CTT100540493, author = {Ohtsu, Y. and Ohba, R. and Imamura, Y. and Kobayashi, M. and Hatori, H. and Zenkoh, T. and Hatakeyama, M. and Manabe, T. and Hino, M. and Yamaguchi, Y. and Kataoka, K. and Kawaguchi, H. and Watanabe, H. and Handa, H.}, title = {Selective ligand purification using high-performance affinity beads}, journal = {Anal. Biochem.}, year = 2005, } @article{CTT100540492, author = {Wang, G. and Balamotis, M.A. and Stevens, J.L. and Yamaguchi, Y. and Handa, H. and Berk, A.}, title = {Mediator requirement for both recruitment and post-recruitment steps in transcription initiation}, journal = {Mol. Cell}, year = 2005, } @article{CTT100723519, author = {Azuma, N. and Tadokoro, K. and Asaka, A. and Yamada, M. and Yamaguchi, Y. and Handa, H. and Matsushima, S. and Watanabe, T. and Kohsaka, S. and Kida, Y. and Shiraishi, T. and Ogura, T. and Shimamura, K. and Nakafuku, M.}, title = {The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure}, journal = {Hum. Mol. Genet.}, year = 2005, } @article{CTT100723512, author = {Kabe, Y. and Yamada, J. and Uga, H. and Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes}, journal = {Mol. Cell. Biol.}, year = 2005, } @article{CTT100539441, author = {Jennings, B.H. and Shah, S. and Yamaguchi, Y. and Seki, M. and Phillips, R.G. and Handa, H. and Ish-Horowicz, D.}, title = {Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila}, journal = {Curr. Biol.}, year = 2004, } @article{CTT100723513, author = {Aiyar, S.E. and Sun and J.-L. and Blair, A.L. and Moskaluk, C.A. and Lv, Y. and Ye and Q.-N. and Yamaguchi, Y. and Mukherjee, A. and Ren and D.-M. and Handa, H. and Li, R.}, title = {Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor}, journal = {Genes Dev.}, year = 2004, } @article{CTT100723514, author = {Oshima, S. and Nakamura, T. and Namiki, S. and Okada, E. and Tsuchiya, K. and Okamoto, R. and Yamazaki, M. and Yokota, T. and Aida, M. and Yamaguchi, Y. and Kanai, T. and Handa, H. and Watanab}, title = {Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells}, journal = {Mol. Cell. Biol.}, year = 2004, } @article{CTT100723515, author = {Endou, M. and Zhu, W. and Hasegawa, J. and Watanabe, H. and Kim and D.-K. and Aida, M. and Inukai, N. and Narita, T. and Yamada, T. and Furuya, A. and Sato, H. and Yamaguchi, Y. and Mandal, S.S. and Rei}, title = {Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro}, journal = {Mol. Cell. Biol.}, year = 2004, } @article{CTT100539438, author = {Ainbinder, E. and Amir-Zilberstein, L. and Yamaguchi, Y. and Handa, H. and Dikstein, R.}, title = {Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-κB}, journal = {Mol. Cell. Biol.}, year = 2004, } @article{CTT100539437, author = {Inukai, N. and Yamaguchi, Y. and Kuraoka, I. and Yamada, T. and Kamijo, S. and Kato, J. and Tanaka, K. and Handa, H.}, title = {A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis}, journal = {J. Biol. Chem.}, year = 2004, } @article{CTT100723509, author = {Wu and C.-H. and Yamaguchi, Y. and Benjamin, L.R. and Horvat-Gordon, M. and Washinski, J. and Enerly, E. and Larsson, J. and Lambertsson, A. and Handa, H. and Gilmour, D.S.}, title = {NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila}, journal = {Genes Dev.}, year = 2003, } @article{CTT100723510, author = {Azuma, N. and Yamaguchi, Y. and Handa, H. and Tadokoro, K. and Asaka, A. and Kawase, E. and Yamada, M.}, title = {Mutations of the PAX6 gene detected in patients with a variety of optic nerve malformations}, journal = {Am. J. Hum. Genet.}, year = 2003, } @article{CTT100723508, author = {Nedialkov, Y.A. and Gong, X.Q. and Hovde, S.L. and Yamaguchi, Y. and Handa, H. and Geiger, J.H. and Yan, H. and Burton, Z.F.}, title = {NTP-driven translocation by human RNA polymerase II}, journal = {J. Biol. Chem.}, year = 2003, } @article{CTT100531750, author = {Kim, D. and Inukai, N. and Yamada, T. and Furuya, A. and Sato, H. and Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex}, journal = {Genes Cells}, year = 2003, } @article{CTT100538834, author = {Shima, D. and Yugami, M. and Tatsuno, M. and Wada, T. and Yamaguchi, Y. and Handa, H.}, title = {Mechanism of H-8 inhibition of Cyclin-dependent kinase 9: study using inhibitor-immobilized matrices}, journal = {Genes Cells}, year = 2003, } @article{CTT100538833, author = {Narita, T. and Yamaguchi, Y. and Yano, K. and Sugimoto, S. and Chanarat, S. and Wada, T. and Kim, D. and Hasegawa, J. and Omori, M. and Inukai, N. and Endoh, M. and Yamada, T. and Handa and H..}, title = {Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex}, journal = {Mol. Cell. Biol.}, year = 2003, } @article{CTT100538835, author = {Kuraoka, I. and Endou, M. and Yamaguchi, Y. and Wada, T. and Handa, H. and Tanaka, K.}, title = {Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II: Implications for transcription-coupled DNA repair and transcriptional mutagenesis}, journal = {J. Biol. Chem.}, year = 2003, } @article{CTT100539436, author = {Hasegawa, J. and Endou, M. and Narita, T. and Yamada, T. and Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {A rapid purification method for human RNA polymerase II by two-step affinity chromatography}, journal = {J. Biochem.}, year = 2003, } @article{CTT100466634, author = {Yamaguchi, Y. and Inukai, N. and Narita, T. and Wada, T. and Handa, H.}, title = {Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA}, journal = {Mol. Cell. Biol.}, year = 2002, } @article{CTT100485019, author = {Nishi, T. and Shimizu, N. and Hiramoto, M. and Sato, I. and Yamaguchi, Y. and Hasegawa, M. and Aizawa, S. and Tanaka, H. and Kataoka, K. and Watanabe, H. and Handa, H.}, title = {Spatial redox regulation of a critical cysteine residue of NF-kB in vivo}, journal = {J. Biol. Chem.}, year = 2002, } @article{CTT100466637, author = {Shiba, K. and Hamaguchi, T. and Kataoka, K. and Yamaguchi, Y. and Handa, H. and Adachi, K.}, title = {Cloning of the hamstar androgen receptor gene}, journal = {J. Dermatol. Sci.}, year = 2001, } @article{CTT100465117, author = {Yamaguchi, Y. and Filipovska, J. and Yano, K. and Furuya, A. and Inukai, N. and Narita, T. and Wada, T. and Sugimoto, S. and Konarska, M.M. and Handa, H.}, title = {Stimulation of RNA polymerase II elongation by hepatitis delta antigen}, journal = {Science}, year = 2001, } @article{CTT100466635, author = {Renner, D.B. and Yamaguchi, Y. and Wada, T. and Handa, H. and Price, D.H.}, title = {A highly purified RNA polymerase II elongation control system}, journal = {J. Biol. Chem}, year = 2001, } @article{CTT100466639, author = {Wada, T. and Orphanides, G. and Hasegawa, J. and Kim and D.-K. and Shima, D. and Yamaguchi, Y. and Fukuda, A. and Hisatake, K. and Oh, S. and Reinberg, D. and Handa, H.}, title = {FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH}, journal = {Mol. Cell}, year = 2000, } @article{CTT100465118, author = {Guo, S. and Yamaguchi, Y. and Schilbach, S. and Wada, T. and Lee, J. and Goddard, A. and French, D. and Handa, H. and Rosenthal, A.}, title = {A regulator of transcriptional elongation controls vertebrate neuronal development}, journal = {Nature}, year = 2000, } @article{CTT100466641, author = {Azuma, N. and Yamaguchi, Y. and Handa, H. and Hayakawa, M. and Kanai, A. and Yamada, M.}, title = {Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies.}, journal = {Am. J. Hum. Genet.}, year = 1999, } @article{CTT100466640, author = {Kim, J.B. and Yamaguchi, Y. and Wada, T. and Handa, H. and Sharp, P.A.}, title = {Tat-SF1 protein associates with RAP30 and human SPT5 proteins}, journal = {Mol. Cell. Biol.}, year = 1999, } @article{CTT100466643, author = {Yamaguchi, Y. and Wada, T. and Watanabe, D. and Takagi, T. and Hasegawa, J. and Handa, H.}, title = {Structure and function of the human transcription elongation factor DSIF.}, journal = {J. Biol. Chem.}, year = 1999, } @article{CTT100465119, author = {Yamaguchi, Y. and Takagi, T. and Wada, T. and Yano, K. and Furuya, A. and Sugimoto, S. and Hasegawa, J. and Handa, H.}, title = {NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation}, journal = {Cell}, year = 1999, } @article{CTT100466645, author = {Yamaguchi, Y. and Wada, T. and Suzuki, F. and Takagi, T. and Hasegawa, J. and Handa, H.}, title = {Casein kinase II interacts with the bZIP domains of several transcription factors}, journal = {Nucleic Acids Res.}, year = 1998, } @article{CTT100466647, author = {Wada, T. and Takagi, T. and Yamaguchi, Y. and Ferdous, A. and Imai, T. and Hirose, S. and Sugimoto, S. and Yano, K. and Hartzog, G.A. and Winston, F. and Buratowski, S. and Handa, H.}, title = {DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.}, journal = {Genes Dev.}, year = 1998, } @article{CTT100466644, author = {Wada, T. and Takagi, T. and Yamaguchi, Y. and Watanabe, D. and Handa, H.}, title = {Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro}, journal = {EMBO J.}, year = 1998, } @article{CTT100466648, author = {Yamaguchi, Y. and Sawada, J. and Yamada, M. and Handa, H. and Azuma, N.}, title = {Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain}, journal = {Genes Cells}, year = 1997, } @article{CTT100466649, author = {Wada, T. and Takagi, T. and Yamaguchi, Y. and Kawase, H. and Hiramoto, M. and Ferdous, A. and Takamiya, M. and Lee, K.A. and Hurst, H.C. and Handa, H.}, title = {Copurification of casein kinase II with transcription factor ATF/E4TF3}, journal = {Nucleic Acids Res.}, year = 1996, } @inproceedings{CTT100917277, author = {Nutchaya Muksombat and Yuki Yamaguchi}, title = {A focused study of uncharacterized human genes containing putative nucleic acid-interacting motifs: toward a comprehensive understanding of the human genome}, booktitle = {}, year = 2023, } @inproceedings{CTT100917279, author = {荒川 翼 and 山口 雄輝 and 坂本 聡}, title = {神経変性疾患の原因であるタンパク質凝集体を選択的に分解誘導するPROTACの開発を目指した研究}, booktitle = {}, year = 2023, } @inproceedings{CTT100884047, author = {原口大和 and 坂本聡 and 山口雄輝}, title = {二次元的スクリーニング解析を駆使した既存抗がん剤の新規作用機序の解明を目指した研究}, booktitle = {}, year = 2022, } @inproceedings{CTT100884045, author = {奥田昌彦 and 諏訪哲史 and 鈴木秀文 and 山口雄輝 and 西村善文}, title = {ヒトRNAポリメラーゼと基本転写/修復因子TFIIHの新たな相互作用の構造生物学的研究}, booktitle = {}, year = 2022, } @inproceedings{CTT100884046, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {レナリドマイド耐性多発性骨髄腫細胞の生存に重要なポマリドマイド依存性CRL4CRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100884044, author = {高橋秀尚 and 鈴木秀文 and 阿部竜太 and 嶋田美穂 and 廣瀬智威 and 廣瀬博子 and 野口慶介 and 池陽子 and 安井七海 and 古郡華月 and 山口雄輝 and 豊田敦 and 鈴木穣 and 山本達郎 and 斉藤典子 and Sato Shigeo and Tomomori-Sato Chieri and Conaway Joan and Canaway Ronald}, title = {Pol IIの一時停止および核体凝集体の制御におけるメディエーター複合体の役割}, booktitle = {}, year = 2022, } @inproceedings{CTT100884043, author = {野口慶介 and 鈴木秀文 and 阿部竜太 and 池陽子 and 井野洋子 and 木村弥生 and 梁明秀 and 土井宏 and 田中章景 and 山口雄輝 and 高橋秀尚}, title = {新規ビオチン標識法を用いたマルチオミクス解析によるCajal body構成因子の網羅的解析とCajal body形成メカニズムの解明}, booktitle = {}, year = 2022, } @inproceedings{CTT100884042, author = {鈴木秀文 and 阿部竜太 and 嶋田美穂 and 廣瀬智威 and 廣瀬博子 and 野口慶介 and 池陽子 and 安井七海 and 古郡華月 and 山口雄輝 and 豊田敦 and 鈴木穣 and 山本達郎 and 斉藤典子 and Sato Shigeo and Tomomori-Sato Chieri and Conaway Ronald and Conaway Joan and 高橋秀尚}, title = {メディエーター複合体による新規の転写スピード調節機構の解明}, booktitle = {}, year = 2022, } @inproceedings{CTT100879603, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {ポマリドミド依存的な CRBN のネオ基質 ARID2 の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100879609, author = {野口慶介 and 鈴木秀文 and 阿部竜太 and 池陽子 and 井野洋子 and 木村弥生 and 梁明秀 and 土井宏 and 田中章景 and 山口雄輝 and 高橋秀尚}, title = {新規ビオチン標識法を用いたマルチオミックス解析によるCajal body形成メカニズムの解明}, booktitle = {}, year = 2021, } @inproceedings{CTT100879608, author = {鈴木秀文 and 阿部竜太 and 嶋田美穂 and 廣瀬智威 and 廣瀬博子 and 野口慶介 and 古郡華月 and 池陽子 and 安井七海 and 豊田敦 and 鈴木穣 and 山本達郎 and 斉藤典子 and Ronald Conaway and Joan Conaway and 山口雄輝 and 高橋秀尚}, title = {メディエーター複合体による新規の3' Pol IIポージング制御機構の解明}, booktitle = {}, year = 2021, } @inproceedings{CTT100879614, author = {奥田昌彦 and 諏訪哲史 and 鈴木秀文 and 山口雄輝 and 西村善文}, title = {RNAポリメラーゼと基本転写/修復因子TFIIHの新たな相互作用}, booktitle = {}, year = 2021, } @inproceedings{CTT100879613, author = {諏訪哲史 and 奥田昌彦 and 鈴木秀文 and 西村善文 and 山口雄輝}, title = {共通サブユニットRPB6を介したヒトRNAポリメラーゼと基本転写因子TFIIHの相互作用}, booktitle = {}, year = 2021, } @inproceedings{CTT100879612, author = {原口大和 and 坂本聡 and 山口雄輝}, title = {ナノ磁性ビーズ精製とCRISPRライブラリースクリーニングによる薬剤標的分子の網羅的同定を目指した研究}, booktitle = {}, year = 2021, } @inproceedings{CTT100879611, author = {古屋智基 and 山口雄輝}, title = {In situ ビオチン化によるコヒーシン近傍因子の探索}, booktitle = {}, year = 2021, } @inproceedings{CTT100879610, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {ポマリドミド依存的なCRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100879606, author = {山口雄輝}, title = {RNAポリメラーゼとTFIIHの相互作用部位の細胞機能解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100808942, author = {高橋秀尚 and Amol Ranjan and 鈴木 秀文 and 阿部 竜太 and 廣瀬 智威 and 佐々木 和教 and 山口 雄輝 and 中山 敬一 and Joan Conaway and Ronald Conaway and 畠山 鎮次}, title = {メディエーター複合体による転写終結制御機構の解明}, booktitle = {}, year = 2019, } @inproceedings{CTT100814295, author = {高森 朝浩 and Fajar Muhamad and 山口 雄輝}, title = {タンパク質コード遺伝子の3'末端プロセシングにおけるポリ(A)付加サイト選択の作用機序の解明}, booktitle = {}, year = 2019, } @inproceedings{CTT100808939, author = {山口 雄輝 and 瑞慶覧 安里 and Muhamad Fajar and 舘野 峻平 and 高森 朝浩}, title = {Pol IIの転写終結部位を制御する分子機構}, booktitle = {}, year = 2019, } @inproceedings{CTT100808938, author = {山口 雄輝}, title = {E3ユビキチンリガーゼを標的とした創薬の新展開}, booktitle = {}, year = 2019, } @inproceedings{CTT100806293, author = {Yuki Yamaguchi}, title = {Comprehensive identification of proximal proteins by in situ biotinylation through a specific antibody: toward proteomic analysis of liquid droplets}, booktitle = {}, year = 2019, } @inproceedings{CTT100790002, author = {小泉 純玲 and 坂本 聡 and 山口 雄輝}, title = {抗がん作用を有するカンナビノイドの作用機序の解析}, booktitle = {}, year = 2019, } @inproceedings{CTT100779830, author = {諏訪 哲史 and 鈴木 秀文 and 奥田 昌彦 and 西村 善文 and 山口 雄輝}, title = {TFIIH の多機能性を司るPleckstrin homology ドメインと新規標的因子の機能構造解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100779806, author = {水止 洋孝 and 新垣 貴之 and 山口 雄輝}, title = {In situでのビオチン化反応を利用したタンパク質間相互作用の解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100779835, author = {Yuki Yamaguchi}, title = {Molecular mechanisms controlling pathways and sites for Pol Ⅱ transcription termination}, booktitle = {}, year = 2018, } @inproceedings{CTT100777902, author = {鈴木 秀文 and 前田 亮 and 木村 宏 and 浦 聖恵 and 田村 隆明 and 山口 雄輝}, title = {DNA損傷応答における転写抑制メカニズムとその生理的意義の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777906, author = {舘野 峻平 and Thiengtrong Benjarat and 山口 雄輝}, title = {snRNAプロセシング因子Integrator複合体の分子構造解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777907, author = {山本 淳一 and Fajar Muhamad and 瑞慶覧 安里 and 舘野 峻平 and 半田宏 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位の選択機構の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777904, author = {Fajar Muhamad and Ari Zukeran and Shunpei Tateno and Junichi Yamamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Mechanisms that affect post-transcriptional fate of RNA polymerase II-transcribed genes}, booktitle = {}, year = 2017, } @inproceedings{CTT100777903, author = {鈴木 翔子 and 柴田 紘孝 and 山口 雄輝}, title = {マウスES細胞における2細胞期特異的遺伝子Zscan4の転写制御機構の解明}, booktitle = {}, year = 2017, } @inproceedings{CTT100779805, author = {高橋 秀尚 and 柴田 美音 and 瀧川 一学 and 渡部 昌 and 築山 忠維 and 山本 淳一 and 山口 雄輝 and 藤井聡 and 飯田緑 and Amol Ranjan and Shigeo Sato and Chieri Tomomori-Sato and Joan Conaway and Ronald Conaway and 畠山 鎮次}, title = {メディエーター複合体による転写終結制御機構}, booktitle = {}, year = 2017, } @inproceedings{CTT100777901, author = {Shunpei Tateno and Ari Zukeran and Junichi Yamamoto and Yuki Yamaguchi}, title = {Molecular mechanisms for polyadenylation site selection by NELF and related factors}, booktitle = {}, year = 2017, } @inproceedings{CTT100777900, author = {Hidefumi Suzuki and Ryo Maeda and Hiroshi Kimura and Kiyoe Ura and Taka-aki Tamura and Yuki Yamaguchi}, title = {Transcription silencing by TLP contributes to etoposide-induced apoptosis}, booktitle = {}, year = 2017, } @inproceedings{CTT100777899, author = {坂本 聡 and Gupta Vipul and 劉 舒捷 and 安藤秀樹 and 舘野峻平 and 金子裕生 and 湯上真人 and 石井亮平 and 濡木 理 and 山口雄輝 and 半田 宏}, title = {抗炎症薬サリチル酸が示す生体内作用メカニズムの解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777375, author = {瑞慶覧 安里 and 舘野 峻平 and 山本淳一 and 山口 雄輝}, title = {RNAポリメラーゼⅡ転写産物の長さを決める3’末端プロセシングの制御メカニズムの解明}, booktitle = {}, year = 2017, } @inproceedings{CTT100777376, author = {徳山 遥香 and 片山 美樹 and 山口 雄輝}, title = {E3ユビキチンリガーゼCRBNの細胞内局在が免疫調整薬IMiDsの薬効に及ぼす影響}, booktitle = {}, year = 2017, } @inproceedings{CTT100777377, author = {坂本 聡 and 山口 雄輝 and 半田宏}, title = {ターゲット因子の解析を基盤とする生物活性物質が示す作用機構の解明}, booktitle = {}, year = 2017, } @inproceedings{CTT100777378, author = {鈴木秀文 and 前田 亮 and 木村 宏 and 浦聖恵 and 山口 雄輝 and 田村隆明}, title = {DNA損傷時に誘導される転写制御の生理的意義とTLPの役割}, booktitle = {}, year = 2017, } @inproceedings{CTT100779849, author = {鈴木 翔子 and 柴田 紘孝 and 山口 雄輝}, title = {マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100779850, author = {舘野 峻平 and 飯田 緑 and 藤井 聡 and 佐倉 絵里 and 山口 雄輝}, title = {多発性骨髄腫における Pomalidomide 標的因子の網羅的探索}, booktitle = {}, year = 2017, } @inproceedings{CTT100779847, author = {瑞慶覧 安里 and 山本 淳一 and 山口 雄輝}, title = {How Pol II termination and 3' processing sites are precisely determined in higher eukaryotes.高等真核生物においてPol IIの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか}, booktitle = {}, year = 2016, } @inproceedings{CTT100779848, author = {瑞慶覧 安里 and 山本 淳一 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位選択のメカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100744295, author = {Shinnnosuke Kunimi and Yuma Ito and Yuki Yamaguchi and Kumiko Sakata-Sogawa and Makio Tokunaga}, title = {Quantitative image analysis of dynamics of promoter-proximal pausing related proteins}, booktitle = {}, year = 2016, } @inproceedings{CTT100777374, author = {瑞慶覧 安里 and 舘野 峻平 and 山本淳一 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位選択のメカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100777372, author = {鈴木秀文 and 前田 亮 and 浦聖恵 and 木村 宏 and 山口 雄輝 and 田村隆明}, title = {TBP類似因子TLPによるDNA損傷応答時の転写抑制と細胞死誘導機構の解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100777373, author = {瑞慶覧 安里 and 長谷川 冴妃子 and 舘野 峻平 and 山本淳一 and 山口 雄輝}, title = {高等真核生物においてPOL Ⅱの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか}, booktitle = {}, year = 2016, } @inproceedings{CTT100779846, author = {伊藤 拓水 and 朝妻 知子 and 山本 淳一 and 安藤 秀樹 and 佐藤 智美 and 山口 雄輝 and 半田 宏}, title = {リガンド依存的ユビキチンリガーゼCRBNの制御機構}, booktitle = {}, year = 2016, } @inproceedings{CTT100779844, author = {坂本 聡 and 伊藤 拓水 and 森 智行 and 安藤 秀樹 and 山口 雄輝 and 箱嶋 敏雄 and 半田 宏}, title = {CRBNに対するサリドマイド光学異性体の結合基盤解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100777362, author = {舘野 峻平 and 飯田緑 and 藤井聡 and 山口 雄輝}, title = {多発性骨髄腫におけるPomalidomide標的因子の網羅的探索}, booktitle = {}, year = 2016, } @inproceedings{CTT100777365, author = {新垣 貴之 and 徳山 遥香 and 山口 雄輝}, title = {PolⅡ複合体をモデルとしたタンパク質間相互作用の実験系の評価}, booktitle = {}, year = 2016, } @inproceedings{CTT100777366, author = {瑞慶覧 安里 and 山本 淳一 and 磯部 智康 and 山口 雄輝}, title = {NELFを中心としたRNAの品質管理のメカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100777367, author = {徳山 遥香 and 新垣 貴之 and 山口雄輝}, title = {サリドマイド標的タンパク質CRBNの相互作用因子の探索}, booktitle = {}, year = 2016, } @inproceedings{CTT100777369, author = {鈴木 翔子 and 柴田 紘孝 and 山口 雄輝}, title = {マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100777370, author = {山口 雄輝 and 伊藤拓水 and 山本淳一 and 半田宏}, title = {サリドマイドの多様な薬理作用の分子メカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100777371, author = {外山 黛 and 荻原 裕里 and Thiengtrong Benjarat and 山口 雄輝}, title = {snRNA3'末端プロセシング因子インテグレーターの構造・機能解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100777364, author = {佐倉 絵里 and 舘野 峻平 and 山口 雄輝}, title = {新規抗がん剤の作用機構の解明}, booktitle = {}, year = 2016, } @inproceedings{CTT100777831, author = {Satoshi Sakamoto and Yuki Yamaguchi and Takumi Ito and Hiroshi Handa}, title = {Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads}, booktitle = {}, year = 2015, } @inproceedings{CTT100779843, author = {舘野 峻平 and 飯田緑 and 藤井聡 and 山口 雄輝}, title = {多発性骨髄腫に対するポマリドマイドの標的因子の網羅的探索}, booktitle = {}, year = 2015, } @inproceedings{CTT100777832, author = {Satoshi Sakamoto and Takumi Ito and Yuki Yamaguchi and Hideki Ando and Hiroshi Handa}, title = {Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs)}, booktitle = {}, year = 2015, } @inproceedings{CTT100777830, author = {山口雄輝}, title = {PolⅡの転写伸長と運命決定制御のメカニズム}, booktitle = {}, year = 2015, } @inproceedings{CTT100777829, author = {Yuki Yamaguchi and Junichi Yamamoto}, title = {Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes}, booktitle = {}, year = 2015, } @inproceedings{CTT100777357, author = {山口 雄輝 and 磯部智康 and 曹 青福 and 山本 淳一}, title = {転写伸長段階の制御メカニズム:新たな制御因子の探索}, booktitle = {}, year = 2015, } @inproceedings{CTT100777360, author = {磯部智康 and 山口 雄輝}, title = {転写伸張因子DSIFのCTRを介した転写制御機構の解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100777361, author = {瑞慶覧 安里 and 山本 淳一 and 磯部智康 and 山口 雄輝}, title = {NELFを中心としたmRNAの品質管理のメカニズム}, booktitle = {}, year = 2015, } @inproceedings{CTT100777828, author = {坂本 聡 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {IMiDs標的タンパク質CRBNの生化学的解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100777827, author = {坂本 聡 and 山口雄輝 and 半田 宏}, title = {アフィニティビーズを利用した生物活性物質標的タンパク質の単離・同定・評価}, booktitle = {}, year = 2015, } @inproceedings{CTT100777356, author = {磯部智康 and 千葉 国俊 and 山口 雄輝}, title = {転写伸長因子DSIFのリン酸化の転写伸長反応への寄与の解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100779842, author = {山本淳一 and 半田宏 and 山口 雄輝}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes}, booktitle = {}, year = 2015, } @inproceedings{CTT100777355, author = {Yuki Yamaguchi and Junichi Yamamoto}, title = {Regulatory Mechanisms for Pol II Termination Sites and 3' Processing Pathways in Higher Eukaryotes}, booktitle = {}, year = 2014, } @inproceedings{CTT100777826, author = {片山 美樹 and 伊藤拓水 and 安藤 秀樹 and 山口 雄輝 and 半田宏}, title = {E3ユビキチンリガーゼの基質認識レセプター CRBNとポマリドマイド依存的な基質Aiolosの生化学的解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100777067, author = {曹 青福 and 陳 業熹 and 半田 宏 and 山口 雄輝}, title = {新規転写伸長因子ヒトRtf1が関与する転写制御の分子機構}, booktitle = {}, year = 2014, } @inproceedings{CTT100777063, author = {山口雄輝 and 山本淳一 and 半田宏}, title = {ヒトRNA ポリメラーゼII 転写産物のプロセシング経路の選択機構}, booktitle = {}, year = 2014, } @inproceedings{CTT100779838, author = {磯部智康 and 千葉 国俊 and 山口 雄輝}, title = {転写伸長因子DSIFにリン酸化依存的に相互作用する因子の機能解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100779840, author = {山本淳一 and 半田宏 and 山口雄輝}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes}, booktitle = {}, year = 2014, } @inproceedings{CTT100779841, author = {柴田 紘孝 and 半田宏 and 山口 雄輝}, title = {転写伸長因子DSIFおよびNELFがES細胞の多分化能維持に果たす役割}, booktitle = {}, year = 2014, } @inproceedings{CTT100777380, author = {坂本 聡 and Vipul Gupta and 劉 舒捷 and 安藤 秀樹 and 舘野 峻平 and 金子 裕生 and 湯上 真人 and 石井 亮平 and 濡木 理 and 山口 雄輝 and 半田 宏}, title = {抗炎症薬サリチル酸の生体内作用機構の解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100777379, author = {坂本 聡 and 唐澤 慧記 and 東 基記 and 笠間 健嗣 and 宮澤 啓介 and 山口 雄輝 and 半田 宏}, title = {ビタミンK2が引き起こすがん細胞のアポトーシス誘導機構の解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100777061, author = {中村 佳奈子 and 山口 雄輝}, title = {ゲノム上のRNAポリメラーゼ等の動的解析を目指した予備的な検討}, booktitle = {}, year = 2014, } @inproceedings{CTT100777056, author = {飯田緑 and 舘野 峻平 and 山口 雄輝 and 藤井聡}, title = {Cellecta社製プール型レンチウイルスshRNAライブラリーを用いたスクリーニングデータ解析法の検討}, booktitle = {}, year = 2014, } @inproceedings{CTT100777057, author = {柴田 紘孝 and 半田 宏 and 山口 雄輝}, title = {転写伸長因子DSIFおよびNELFがES細胞の多分化能維持に果たす役割}, booktitle = {}, year = 2014, } @inproceedings{CTT100777059, author = {曹 青福 and 陳 業熹 and 半田 宏 and 山口 雄輝}, title = {転写伸長因子ヒトPaf1複合体が関与する転写制御の分子機構}, booktitle = {}, year = 2014, } @inproceedings{CTT100777060, author = {舘野 峻平 and 山口 雄輝}, title = {多発性骨髄腫に対するポマリドマイドの標的因子の網羅的探索}, booktitle = {}, year = 2014, } @inproceedings{CTT100777062, author = {長谷川 冴妃子 and 千葉 国俊 and 磯部智康 and 山口 雄輝}, title = {転写伸長因子DSIFにリン酸化依存的に相互作用する因子の機能解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100799916, author = {中村 佳奈子 and 山口 雄輝}, title = {ゲノム上のRNA ポリメラーゼ等のカイネティクス解析を目指した予備的な検討}, booktitle = {}, year = 2013, } @inproceedings{CTT100799919, author = {舩造 正英 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {多発性骨髄腫におけるCRBN 結合因子の探索及び解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100799918, author = {舘野 峻平 and 山口 雄輝}, title = {多発性骨髄腫に対するポマリドマイドの標的因子の網羅的探索}, booktitle = {}, year = 2013, } @inproceedings{CTT100799917, author = {飯田 結 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {サリドマイドターゲット分子CRBN の生化学的解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100805135, author = {伊藤 拓水 and 安藤 秀樹 and 山口雄輝 and 半田 宏}, title = {S16-4 サリドマイドによる催奇性の分子機構 : ナノビーズ技術を用いたアプローチ(シンポジウムS16 薬物有害反応の発現機構と予測の新展開,臨床から学び臨床へと還元する医療薬学)}, booktitle = {日本医療薬学会年会講演要旨集}, year = 2010, } @misc{CTT100879615, author = {Junichi Yamamoto and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.}, year = 2022, } @misc{CTT100856883, author = {Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology}, year = 2021, } @misc{CTT100828258, author = {山口 雄輝}, title = {サリドマイド胎芽症診療ガイド 2020}, year = 2020, } @misc{CTT100805377, author = {山口雄輝}, title = {転写伸長研究の新展開}, year = 2010, } @misc{CTT100485015, author = {Nedialkov, Y.A. and Gong, X.Q. and Yamaguchi, Y. and Handa, H. and Burton, Z.F.}, title = {Assay of transient state kinetics of elongation by human RNA polymerase II}, year = 2003, } @misc{CTT100485020, author = {Yamaguchi, Y. and Delehouzee, S. and Handa, H.}, title = {HIV and HDV: evolution takes different paths to relieve blocks in transcriptional elongation}, year = 2002, } @misc{CTT100466636, author = {Kim, D. and Yamaguchi Y. and Wada, T. and Handa, H.}, title = {The regulation of elongation by eukaryotic RNA polymerase II: A recent view.}, year = 2001, } @misc{CTT100466638, author = {Yamaguchi, Y. and Narita, T. and Inukai, N. and Wada, T. and Handa, H.}, title = {SPT genes: Key players in the regulation of transcription, chromatin structure and other cellular processes}, year = 2001, } @misc{CTT100466646, author = {Yamaguchi, Y. and Wada, T. and Handa, H.}, title = {Interplay between positive and negative elongation factors: drawing a new view of DRB}, year = 1998, } @misc{CTT100594158, author = {山口雄輝}, title = {転写伸長反応を抑制する因子群の同定と解析}, year = 1999, } @misc{CTT100601946, author = {山口雄輝}, title = {転写伸長反応を抑制する因子群の同定と解析}, year = 1999, } @misc{CTT100877450, author = {山口雄輝 and 山本淳一 and 半田 宏  and 伊藤 拓水 }, title = {抗骨髄腫剤および抗骨髄腫剤のスクリーニング方法}, howpublished = {公開特許}, year = 2022, month = {}, note = {特願2020-141689(2020/08/25), 特開2022-037510(2022/03/09)} } @misc{CTT100845904, author = {山口雄輝 and 半田 宏  and 伊藤 拓水 and 朝妻 知子 and Luisa Guerrini}, title = {p63スプライシングバリアントの分解剤およびその用途}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2019-139820(2019/07/30), 特開2021-020879(2021/02/18)} } @misc{CTT100819394, author = {山口雄輝 and 舘野峻平 and 片山 美樹 and 半田 宏 }, title = {CRBNモジュレーターの薬効を高める補助薬のスクリーニング方法}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2018-093652(2018/05/15), 特開2019-198254(2019/11/21)} } @misc{CTT100666212, author = {今井剛 and 半田宏 and 山口雄輝}, title = {骨、関節又は歯異常症の治療物質のスクリーニング方法}, howpublished = {公開特許}, year = 2013, month = {}, note = {特願2012-140671(2012/06/22), 特開2013-188201(2013/09/26)} } @misc{CTT100667578, author = {今井剛 and 半田宏 and 山口雄輝}, title = {相乗的抗糖尿病治療剤}, howpublished = {登録特許}, year = 2016, month = {}, note = {特願2012-108729(2012/05/10), 特開2013-234159(2013/11/21), 特許第6015903号(2016/10/07)} } @phdthesis{CTT100594158, author = {山口雄輝}, title = {転写伸長反応を抑制する因子群の同定と解析}, school = {東京工業大学}, year = 1999, } @phdthesis{CTT100601946, author = {山口雄輝}, title = {転写伸長反応を抑制する因子群の同定と解析}, school = {東京工業大学}, year = 1999, }