@book{CTT100811738, author = {Yoshiaki Masaki and Akihiro Ohkubo and Kohji Seio and Mitsuo Sekine}, title = {Effects of 2'-O-Modifications on RNA Duplex Stability}, publisher = {Springer}, year = 2018, } @book{CTT100786536, author = {清尾康志 and 大窪章寛}, title = {塩基部無保護ホスホロアミダイト法による核酸合成}, publisher = {シーエムシー出版}, year = 2018, } @book{CTT100722761, author = {KOHJI SEIO and Takashi Kanamori and Akihiro Ohkubo and MITSUO SEKINE}, title = {Synthesis and Fluorescence Properties of Nucleosides with Pyrimimidine-Type Base Moieties}, publisher = {}, year = 2016, } @book{CTT100786537, author = {清尾康志}, title = {新規蛍光核酸}, publisher = {光学図書株式会社}, year = 2009, } @book{CTT100785543, author = {Ohkubo Akihiro and Okamoto Itaru and Kasuya Rintaro and Sakamoto Kazushi and Sasami Takeshi and Odawara Yoko and Masaki Yoshiaki and Sakaue Toshiyuki and Nagasawa Hiroshi and Tsukahara Toshifumi and Seio Kohji and Sekine Mitsuo}, title = {Protected DNA probes (PDP): A new strategy for gene detection}, publisher = {}, year = 2008, } @book{CTT100786538, author = {清尾康志}, title = {蛍光色素の開発動向}, publisher = {講談社サイエンティフィク}, year = 2007, } @book{CTT100786539, author = {清尾康志 and 関根光雄}, title = {RNAの基礎知識}, publisher = {講談社サイエンティフィク}, year = 2005, } @book{CTT100786541, author = {清尾康志}, title = {人工核酸を用いる新しい遺伝子診断技術}, publisher = {}, year = 2003, } @article{CTT100472871, author = {Kosuke Sato and Kohji Seio and Mitsuo Sekine}, title = {Squaryl Group as a New Mimic of Phosphate Group in Modified Oligodeoxynucleotides: Synthesis and Properties of New Oligodeoxynucleotide Analogues Containing an Internucleotidic Squaryldiamide Linkage}, journal = {J. Am. Chem. Soc}, year = 2002, } @article{CTT100472892, author = {Tomohisa Moriguchi and Norio Asai and Kazuisa Okada and Kohji Seio and Takuma Sasaki and Mitsuo Sekine}, title = {First Synthesis and Anti-Cancer Activity of Phosmidosine and Its Related Compounds}, journal = {J. Org. Chem}, year = 2002, } @article{CTT100472894, author = {Akio Kobori and Ken-ichi Miyata and Masatoshi Ushioda and Kohji Seio and Mitsuo Sekine}, title = {A New Method for the Synthesis of Oligodeoxynucleotides Containing 4-N-Alkoxycarbonyldeoxycytidine Derivatives and Their Hybridization Property}, journal = {J. Org. Chem}, year = 2002, } @article{CTT100472898, author = {Yu-ichi Sato and Gosuke Tateno and Kohji Seio and Mitsuo Sekine}, title = {Substituent and Solvent Effects of TMS-triflate mediated C1'-Epimerization of alpha-Thymidine to beta-Thymidine}, journal = {Eur. J. Org. Chem}, year = 2002, } @article{CTT100917135, author = {Takayuki Kanagawa and Shigetoshi Tachibana and Yoshiaki Masaki and Kohji Seio}, title = {Synthesis and Conformational Analyses of Cyclonucleoside Having 13-Membered Ring Bridging Nucleobase and 5′-Position via a Linker Containing Sulfonamide}, journal = {Org. Lett.}, year = 2023, } @article{CTT100895475, author = {Kanagawa T and Koyoma A and Masaki Y and Seio K}, title = {Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2- N-carbamoyl- or (2-pyridyl)guanine}, journal = {Org Biomol Chem .}, year = 2023, } @article{CTT100895476, author = {Tomori T and Uekusa K and Koyama A and Kanagawa T and Masaki Y and Seio K}, title = {Synthesis of 2'-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2'-modified nucleoside for antisense oligonucleotides}, journal = {Bioorg Med Chem .}, year = 2022, } @article{CTT100895472, author = {Masaki Y and Tabira A and Hattori S and Wakatsuki S and Seio K}, title = {Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H}, journal = {Org. Biomol Chem.}, year = 2022, } @article{CTT100895471, author = {Masaki Y and Onishi Y and Seio K}, title = {Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides}, journal = {Sci Rep.}, year = 2022, } @article{CTT100878703, author = {Okamura H and Trinh GH and Dong Z and Masaki Y and Seio K and Nagatsugi F.}, title = {Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface}, journal = {Nucleic Acids Res.}, year = 2022, } @article{CTT100878704, author = {Masaki Y and Maruyama A and Yoshida K and Tomori T and Kishimura T and Seio K.}, title = {Oligodeoxynucleotides Modified with 2'- O-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions}, journal = {Bioconjug. Chem.}, year = 2022, } @article{CTT100877691, author = {Kishimura T and Tomori T and Masaki Y and Seio K.}, title = {Synthesis of 2′-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA}, journal = {Bioorg Med Chem Lett.}, year = 2021, } @article{CTT100839578, author = {Yuko Hara and Yoshitaka Mizobe and Yukiko U. Inoue and Yasumasa Hashimoto and Norio Motohashi and Yoshiaki Masaki and Kohji Seio and Shin’ichi Takeda and Tetsuya Nagata and Matthew J. A. Wood and Takayoshi Inoue and Yoshitsugu Aoki}, title = {Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping}, journal = {}, year = 2020, } @article{CTT100836273, author = {Seio K and Yamaguchi K and Yamazaki A and Kanamori T and Masaki Y.}, title = {Transcription of DNA duplex containing deoxypseudouridine and deoxypseudoisocytidine, and inhibition of transcription by triplex forming oligonucleotide that recognizes the modified duplex}, journal = {Nucleosides, Nucleotides & Nucleic Acids}, year = 2020, } @article{CTT100836271, author = {Takeshita L and Yamada Y and Masaki Y and Seio K.}, title = {Synthesis of Deoxypseudouridine 5′-Triphosphate Bearing the Photoremovable Protecting Group at the N1 Position Capable of Enzymatic Incorporation to DNA}, journal = {J. ORG. CHEM.}, year = 2020, } @article{CTT100811721, author = {Masaki Y and Yamamoto K and Yoshida K and Maruyama A and Tomori T and Iriyama Y and Nakajima H and Kanaki T and Seio K.}, title = {Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity}, journal = {Org. Biomol Chem.}, year = 2019, } @article{CTT100811719, author = {Seio K and Shiozawa T and Sugiyama D and Ohno K and Tomori T and Masaki Y.}, title = {31P NMR Study on the Reactions of Amino Acids and Sugar Derivatives with Pyrophosphorous Acid as a Possible Prebiotic Phosphonylating Agent}, journal = {Bull. Chem. Soc. Jpn.}, year = 2019, } @article{CTT100785147, author = {Kaori Ando and Hisao Saneyoshi and Kohji Seio and Mitsuo Sekine}, title = {A theoretical study on the elimination reaction of acrylonitrile from 2′-O-cyanoethylated nucleosides by Bu4NF}, journal = {Tetrahedron}, year = 2019, } @article{CTT100812079, author = {Takashi Kanamori and Masaki Y and Oda Y and Ohzeki H and Ohkubo A and Sekine M and Seio K.}, title = {DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine}, journal = {Org. Biomol Chem.}, year = 2019, } @article{CTT100811709, author = {Masaki Y and Inde T and Maruyama A and Seio K.}, title = {Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex}, journal = {Org. Biomol Chem.}, year = 2019, } @article{CTT100784916, author = {Yoshiaki Masaki and Keishi Yamamoto and Takeshi Inde and Keita Yoshida and Atsuya Maruyama and Tetsuya Nagata and Jun Tanihata and Shin'ichi Takeda and Mitsuo Sekine and Kohji Seio}, title = {Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides}, journal = {Bioorganic & Medicinal Chemistry Letters}, year = 2018, } @article{CTT100784914, author = {Yoshiaki Masaki and Yusuke Iriyama and Hiroyuki Nakajima and Yusuke Kuroda and Tatsuro Kanaki and Satoshi Furukawa and Mitsuo Sekine and Kohji Seio}, title = {Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides}, journal = {Nucleic Acid Ther.}, year = 2018, } @article{CTT100785064, author = {K. Seio and T. Kanamori and Y. Masaki}, title = {Synthesis of Fluorescent Nucleic Acids bearing Nucleobases Modified with Heteroaryl Group and Fluorophores}, journal = {JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN}, year = 2018, } @article{CTT100781220, author = {Takeshi Inde and Shuhei Nishizawa and Yuusaku Hattori and Takashi Kanamori and Hideya Yuasa and Kohji Seio and Mitsuo Sekine and Akihiro Ohkubo}, title = {Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine}, journal = {}, year = 2018, } @article{CTT100784913, author = {Takahito Tomori and Kento Nagaoka and Leo Takeshita and Takashi Shiozawa and Yuya Miyatake and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Deoxynucleoside Triphosphate Containing Pyridazin-3-one Aglycon as a Thymidine Triphosphate Substitute for Primer Extension and Chain Elongation by Klenow fragments}, journal = {J. Org. Chem.}, year = 2018, } @article{CTT100784912, author = {Kohji Seio and Takashi Kanamori and Yoshiaki Masaki}, title = {Solvent- and environment-dependent fluorescence of modified nucleobases}, journal = {Tetrahedron Lett.}, year = 2018, } @article{CTT100786561, author = {Inde, Takeshi and Nishizawa, Shuhei and Hattori, Yuusaku and Kanamori, Takashi and Yuasa, Hideya and Seio, Kohji and Sekine, Mitsuo and Ohkubo, Akihiro and KOHJI SEIO}, title = {Synthesis of and triplex formation in oligonucleotides containing 2 '-deoxy-6-thioxanthosine}, journal = {Bioorganic & Medicinal Chemistry}, year = 2018, } @article{CTT100785004, author = {K. Ohno and D. Sugiyama and L. Takeshita and T. Kanamori and Y. Masaki and M. Sekine and K. Seio}, title = {Synthesis of photocaged 6-O-(2-nitrobenzyl) guanosine and 4-O-(2-nitrobenzyl)uridine triphosphates for photocontrol of the RNA transcription reaction}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2017, } @article{CTT100785010, author = {T. Inde and Y. Masaki and A. Maruyama and Y. Ito and N. Makio and Y. Miyatake and T. Tomori and M. Sekine and K. Seio}, title = {Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2017, } @article{CTT100785011, author = {K. Seio and M. Tokugawa and K. Kaneko and T. Shiozawa and Y. Masaki}, title = {A systematic study of the synthesis of 2'-deoxynucleosides by Mitsunobu reaction}, journal = {SYNLETT}, year = 2017, } @article{CTT100748623, author = {Takashi Kanamori and Akihiro Takamura and Nobuhiro Tago and Yoshiaki Masaki and Akihiro Ohkubo and Mitsuo Sekine and Kohji Seio}, title = {Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation.}, journal = {Org. Biomol. Chem.}, year = 2017, } @article{CTT100785546, author = {Masaki Yoshiaki and Sekine Mitsuo and Seio Kohji}, title = {Deformability Calculation for Estimation of the Relative Stability of Chemically Modified RNA Duplexes.}, journal = {Current protocols in nucleic acid chemistry}, year = 2017, } @article{CTT100724906, author = {Kohji Seio and Yurie Ohno and Kentaro Ohno and Leo Takeshita and Takashi Kanamori and Yoshiaki Masaki and Mitsuo Sekine}, title = {Photo-controlled binding of MutS to photo-caged DNA duplexes incorporating 4-O-(2-nitrobenzyl) or 4-O-[2-(2-nitrophenyl)propyl]thymidine}, journal = {Bioorganic & Medicinal Chemistry Letters}, year = 2016, } @article{CTT100722448, author = {Yoshiaki Masaki and Hugo Itou and Yuki Oda and Kazufumi Yamazaki and Nobuhiro Tago and Kentaro Ohno and Nozomi Ishii and Hirosuke Tsunoda and Takashi Kanamori and Akihiro Ohkubo and Mitsuo Sekine and Kohji Seio}, title = {Enzymatic synthesis and reverse transcription of RNAs incorporating 2'-O-carbamoyl uridine triphosphate}, journal = {Chemical Communications}, year = 2016, } @article{CTT100722454, author = {Munefumi Tokugawa and Yoshiaki Masaki and Jan Christian Canggadibrata and Kazuhei Kaneko and Takashi Shiozawa and Takashi Kanamori and Morten Grøtli and L. Marcus Wilhelmsson and Mitsuo Sekine and Kohji Seio}, title = {7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein}, journal = {Chemical Communications}, year = 2016, } @article{CTT100716346, author = {Yu Ito and Yoshiaki Masaki and Takashi Kanamori and Akihiro Ohkubo and KOHJI SEIO and MITSUO SEKINE}, title = {Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA}, journal = {Bioorg. Med. Chem. Lett.}, year = 2016, } @article{CTT100716352, author = {Nobuhiro Tago and Yoshiaki Masaki and Takashi Kanamori and Akihiro Ohkubo and KOHJI SEIO and MITSUO SEKINE}, title = {A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3 Protection of Uridine Derivatives}, journal = {SYNLETT}, year = 2015, } @article{CTT100785012, author = {N. Tago and A. Katolik and N. E. Clark and E. J. Montemayor and K. Seio and M. Sekine and P. J. Hart and M. J. Damha}, title = {Design, synthesis, and properties of phosphoramidate 2 ',5 '-linked branched RNA: Toward the rational design of inhibitors of the RNA lariat debranching enzyme}, journal = {OURNAL OF ORGANIC CHEMISTRY}, year = 2015, } @article{CTT100714786, author = {Ohkubo and Kenji Yamada and Yu Ito and Kiichi Yoshimura and Koichiro Miyauchi and Takashi Kanamori and Yoshiaki Masaki and KOHJI SEIO and HIDEYA YUASA and Mitsuo}, title = {Synthesis and Triplex-forming Properties of Oligonucleotides Capable of Recognizing Corresponding DNA Duplexes Containing Four Base Pairs}, journal = {Nucleic Acids Res.}, year = 2015, } @article{CTT100716358, author = {Takahito Tomori and Yuya Miyatake and Takashi Kanamori and Yoshiaki Masaki and Akihiro Ohkubo and KOHJI SEIO and MITSUO SEKINE}, title = {Synthesis of peptide nucleic acids containing pyridazine derivatives as cytosine and thymine analogs, and their duplexes with complementary oligodeoxynucleotides}, journal = {ORG. LETT.}, year = 2015, } @article{CTT100716360, author = {munefumi tokugawa and Kazuhei Kaneko and Masanori Saito and Takashi Kanamori and Yoshiaki Masaki and Akihiro Ohkubo and KOHJI SEIO and MITSUO SEKINE}, title = {Synthesis of responsive fluorescent Nucleobases 7-(Benzofuran-2-yl)-7- deazahypoxanthine and 7-(benzofuran-2-yl)-7-deazaguanine using cross-coupling reaction}, journal = {CHEM. LETT.}, year = 2015, } @article{CTT100716361, author = {Takashi Kanamori and Hiroki Ohzeki and Yoshiaki Masaki and Akihiro Ohkubo and MITSUO SEKINE and KOHJI SEIO}, title = {Controlling the fluorescence of benzofuran-modified uracil residues in oligonucleotides by triple-helix formation}, journal = {Chembiochem}, year = 2015, } @article{CTT100724912, author = {Yoshiaki Masaki and Takeshi Inde and Tetsuya Nagata and Jun Tanihata and Takashi Kanamori and Kohji Seio and Shin'ichi Takeda and Mitsuo Sekine}, title = {Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides}, journal = {Med. Chem. Commun.}, year = 2014, } @article{CTT100785547, author = {Masaki Yoshiaki and Yamada Takeshi and Saneyoshi Hisao and Ohkubo Akihiro and Seio Kohji and Sekine Mitsuo}, title = {Synthesis and Exon-Skipping Activity of Chemically Modified RNAs}, journal = {Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications}, year = 2014, } @article{CTT100791115, author = {KOHJI SEIO and Takashi Kanamori and Sekine, M.}, title = {Synthesis of branched DNA using oxidatively cleavable tritylsulfenyl as a hydroxy protecting group}, journal = {Current Protocols in Nucleic Acid Chemistry}, year = 2014, } @article{CTT100785013, author = {T. Yamada and Y. Masaki and N. Okaniwa and T. Kanamori and A. Ohkubo and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis and properties of oligonucleotides modified with 2 '-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2014, } @article{CTT100785023, author = {K. Yamada and Y. Masaki and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2014, } @article{CTT100785027, author = {Y. Masaki and R. Miyasaka and K. Hirai and T. Kanamori and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Properties of 5- and/or 2-modified 2 '-O-cyanoethyl uridine residue: 2 '-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2014, } @article{CTT100786562, author = {Ohkubo, Akihiro and Seio, Kohji and Sekine, Mitsuo and KOHJI SEIO}, title = {Development of New Methods for Synthesis of Artificial Nucleic Acids having Various Functional Groups}, journal = {Journal of Synthetic Organic Chemistry Japan}, year = 2014, } @article{CTT100785035, author = {Y. Iijima and S. Kojima and E. Kodama and S. Kurohagi and T. Kanamori and Y. Masaki and A. Ohkubo and M. Sekine and K. Seio}, title = {Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3 '-terminus}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2013, } @article{CTT100785032, author = {K. Seio and M. Tokugawa and H. Tsunoda and A. Ohkubo and F. Arisaka and M. Sekine}, title = {Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2013, } @article{CTT100785034, author = {A. Ohkubo and Y. Kondo and M. Suzuki and H. Kobayashi and T. Kanamori and Y. Masaki and K. Seio and K. Nagai and M. Sekine}, title = {Chemical synthesis of U1 snRNA derivatives}, journal = {ORGANIC LETTERS}, year = 2013, } @article{CTT100785029, author = {K. Yamada and A. Ohkubo and Y. Esaka and T. Kanamori and Y. Masaki and K. Seio and M. Sekine}, title = {Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2013, } @article{CTT100785033, author = {K. Seio and T. Kanamori and M. Tokugawa and H. Ohzeki and Y. Masaki and H. Tsunoda and A. Ohkubo and M. Sekine}, title = {Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2013, } @article{CTT100785031, author = {K. Yamada and Y. Hattori and T. Inde and T. Kanamori and A. Ohkubo and K. Seio and M. Sekine}, title = {Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2013, } @article{CTT100653747, author = {Satoshi Hara and T. Nojima and KOHJI SEIO and MASASUKE YOSHIDA and TORU HISABORI}, title = {DNA-maleimide: An improved maleimide compound for electrophoresis-based titration of reactive thiols in a specific protein}, journal = {Biochimica Et Biophysica Acta-General Subjects}, year = 2013, } @article{CTT100653749, author = {T. Nojima and Hiroki Konno and N. Kodera and KOHJI SEIO and HIDEKI TAGUCHI and MASASUKE YOSHIDA}, title = {Nano-Scale Alignment of Proteins on a Flexible DNA Backbone}, journal = {Plos One}, year = 2012, } @article{CTT100785037, author = {K. Seio and M. Tokugawa and T. Kanamori and H. Tsunoda and A. Ohkubo and M. Sekine}, title = {Synthesis and properties of cationic 2 '-O- N-(4-aminobutyl)carbamoyl modified oligonucleotides}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2012, } @article{CTT100785043, author = {T. Harakawa and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts}, journal = {Bioorganic & Medicinal Chemistry Letters}, year = 2012, } @article{CTT100785039, author = {A. Ohkubo and N. Tago and A. Yokouchi and ; Y. Nishino and K. Yamada and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis of 5 '-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives}, journal = {ORGANIC LETTERS}, year = 2012, } @article{CTT100785038, author = {K. Seio and S. Kurohagi and E. Kodama and Y. Masaki and H. Tsunoda and A. Ohkubo and M. Sekine}, title = {Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexyl phosphates as substituents}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2012, } @article{CTT100785042, author = {T. Kanamori and Y. Masaki and M. Mizuta and H. Tsunoda and A. Ohkubo and M. Sekine and K. Seio}, title = {DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2012, } @article{CTT100785041, author = {Y. Masaki and R. Miyasaka and K. Hirai and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Prediction of the stability of modified RNA duplexes based on deformability analysis: Oligoribonucleotide derivatives modified with 2 '-o-cyanoethyl-5-propynyl-2-thiouridine as a promising component}, journal = {CHEMICAL COMMUNICATIONS}, year = 2012, } @article{CTT100785040, author = {A. Ohkubo and Y. Nishino and Y. Ito and H. Tsunoda and K. Seio and M. Sekine}, title = {Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2012, } @article{CTT100785047, author = {A. Ohkubo and A. Yokouchi and K. Yamada and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis and properties of oligonucleotides having 5 '-terminal 2,2,7-trimethylguanosine cap analogues}, journal = {NUCLEIC ACID THERAPEUTICS}, year = 2011, } @article{CTT100785044, author = {T. Yamada and N. Okaniwa and H. Saneyoshi and A. Ohkubo and K. Seio and T. Nagata and Y. Aoki and S. Takeda and M. Sekine}, title = {Synthesis of 2 '-O- 2-(N-methylcarbamoyl)ethyl ribonucleosides using oxa-michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2011, } @article{CTT100785045, author = {H. Tsunoda and T. Kudo and Y. Masaki and A. Ohkubo and K. Seio and M. Sekine}, title = {Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions}, journal = {NUCLEIC ACIDS RESEARCH}, year = 2011, } @article{CTT100785049, author = {S. Q. Cao and I. Okamoto and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine}, journal = {TETRAHEDRON LETTERS}, year = 2011, } @article{CTT100785048, author = {A. Ohkubo and Y. Nishino and A. Yokouchi and Y. Ito and Y. Noma and Y. Kakishima and Y. Masaki and H. Tsunoda and K. Seio and M. Sekine}, title = {Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties}, journal = {CHEMICAL COMMUNICATIONS}, year = 2011, } @article{CTT100785046, author = {M. Sekine and Y. Oeda and Y. Iijima and H. Taguchi and A. Ohkubo and K. Seio}, title = {Synthesis and hybridization properties of 2 '-O-methylated oligoribonucleotides incorporating 2 '-O-naphthyluridines}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2011, } @article{CTT100785053, author = {H. Tsunoda and T. Kudo and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3 '-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N-3-cyano-ethylthymine}, journal = {MOLECULES}, year = 2010, } @article{CTT100785050, author = {K. Yamada and H. Taguchi and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and biochemical properties of oligodeoxynucleotides acylated by the chemically stable 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5 ' or 3 ' terminus}, journal = {Tetrahedron letters}, year = 2010, } @article{CTT100785058, author = {A. Ohkubo and T. Sakaue and H. Tsunoda and K. Seio and M. Sekine}, title = {Synthesis and hybridization properties of oligonucleotides incorporating bi- and tricyclic cytosine derivatives}, journal = {Chemistry letters}, year = 2010, } @article{CTT100785060, author = {A. Ohkubo and Y. Kuwayama and Y. Nishino and H. Tsunoda and K. Seio and M. Sekine}, title = {Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions}, journal = {ORGANIC LETTERS}, year = 2010, } @article{CTT100785062, author = {Y. Masaki and R. Miyasaka and A. Ohkubo and K. Seio and M. Sekine}, title = {Linear relationship between deformability and thermal stability of 2 '-O-modified RNA hetero duplexes}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, year = 2010, } @article{CTT100785061, author = {Y. Masaki and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis of 6-N-(benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2010, } @article{CTT100785055, author = {K. Seio and M. Shiraishi and E. Utagawa and A. Ohkubo and M. Sekine}, title = {Synthesis of oligodeoxynucleotides using the oxidatively cleavable 4-methoxytritylthio (MMTrS) group for protection of the 5 '-hydroxyl group}, journal = {NEW JOURNAL OF CHEMISTRY}, year = 2010, } @article{CTT100785515, author = {Y. Oeda and Y. Iijima and H. Taguchi and A. Ohkubo and K. Seio and M. Sekine}, title = {Microwave-Assisted Synthesis of 2 '-O-Aryluridine Derivatives}, journal = {ORGANIC LETTERS}, year = 2009, } @article{CTT100785506, author = {K. Seio and R. Tawarada and T. Sasami and M. Serizawa and M. Ise and A. Ohkubo and M. Sekine}, title = {Synthesis and hybridization of 2 '-O-methyl-RNAs incorporating 2 '-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2009, } @article{CTT100785549, author = {Seio Kohji and Miyazaki Kazuya and Kurohagi Sayako and Masaki Yoshiaki and Tsunoda Hirosuke and Ohkubo Akihiro and Sekine Mitsuo}, title = {Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization.}, journal = {Nucleic acids symposium series (2004)}, year = 2009, } @article{CTT100785504, author = {K. Yamada and H. Taguchi and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and properties of nucleoside derivatives acylated by chemically stable 2-(trimethylsilyl)benzoyl group}, journal = {Bioorganic & Medicinal Chemistry}, year = 2009, } @article{CTT100785512, author = {A. Ohkubo and K. Sasaki and Y. Noma and H. Tsunoda and K. Seio and M. Sekine}, title = {Efficient solid-phase synthesis of oligodeoxynucleotides having a 5 '-terminal 2,2,7-trimethylguanosine pyrophosphate linkage}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2009, } @article{CTT100785516, author = {M. Mizuta and K. Seio and A. Ohkubo and M. Sekine}, title = {Fluorescence Properties of Pyrimidopyrimidoindole Nucleoside dC(PPI) Incorporated into Oligodeoxynucleotides}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, year = 2009, } @article{CTT100785509, author = {T. Sasami and R. Tawarada and A. Ohkubo and M. Sekine and K. Seio}, title = {Computational evaluation of the stability of 2 '-O-methyl-RNA/RNA duplexes incorporating 3-deazaguanine derivatives by ab initio calculations and a molecular dynamics simulation}, journal = {JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM}, year = 2009, } @article{CTT100785513, author = {A. Ohkubo and Y. Noma and K. Aoki and H. Tsunoda and K. Seio and M. Sekine}, title = {Introduction of 3 '-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base Protection}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2009, } @article{CTT100785517, author = {K. Miyata and R. Tamamushi and H. Tsunoda and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and Triplex Formation of Oligonucleotides Containing 8-Thioxodeoxyadenosine}, journal = {Organic Letters}, year = 2009, } @article{CTT100785510, author = {T. Sasami and Y. Odawara and A. Ohkubo and M. Sekine and K. Seio}, title = {Synthesis of oligodeoxynucleotides incorporating 2-N-carbamoylguanine and evaluation of the hybridization properties}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2009, } @article{CTT100785511, author = {I. Okamoto and S. Q. Cao and H. Tanaka and K. Seio and M. Sekine}, title = {Synthesis of 4-Thiopseudoisocytidine and 4-Thiopseudouridine as Components of Triplex-forming Oligonucleotides}, journal = {CHEMISTRY LETTERS}, year = 2009, } @article{CTT100785505, author = {R. Tawarada and K. Seio and M. Sekine}, title = {Mechanistic studies on oxidative condensation of a thymidine 3 '-H-phosphonate derivative with 3 '-O-acetylthymidine}, journal = {Arkivoc}, year = 2009, } @article{CTT100785514, author = {A. Ohkubo and R. Kasuya and K. Miyata and H. Tsunoda and K. Seio and M. Sekine}, title = {New thermolytic carbamoyl groups for the protection of nucleobases}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2009, } @article{CTT100785507, author = {K. Seio and Y. Takaku and K. Miyazaki and S. Kurohagi and Y. Masaki and A. Ohkubo and M. Sekine}, title = {Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, year = 2009, } @article{CTT100785524, author = {K. Seio and M. Mizuta and K. Tasaki and K. Tamaki and A. Ohkubo and M. Sekine}, title = {Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2008, } @article{CTT100785553, author = {M. Mizuta and J. I. Banba and T. Kanamori and R. Tawarada and A. Ohkubo and M. Sekine and K. Seio}, title = {New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, year = 2008, } @article{CTT100785527, author = {A. Ohkubo and Y. Kuwayama and T. Kudo and H. Tsunoda and K. Seio and M. Sekine}, title = {O-selective condensation using P-N bond cleavage in RNA synthesis without base protection}, journal = {Organic letters}, year = 2008, } @article{CTT100785526, author = {I. Okamoto and K. Seio and M. Sekine}, title = {Study of the base discrimination ability of DNA and 2 '-O-methylated RNA oligomers containing 2-thiouracil bases towards complementary RNA or DNA strands and their application to single base mismatch detection}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2008, } @article{CTT100785525, author = {H. Saneyoshi and K. Tamaki and A. Ohkubo and K. Seio and M. Sekine}, title = {Synthesis and hybridization properties of 2 '-O-(tetrazol-5-yl)ethyl-modified oligonucleotides}, journal = {TETRAHEDRON}, year = 2008, } @article{CTT100785552, author = {A. Ohkubo and R. Kasuya and K. Aoki and A. Kobori and H. Taguchi and K. Seio and M. Sekine}, title = {Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, year = 2008, } @article{CTT100785528, author = {A. Ohkubo and R. Kasuya and K. Sakamoto and K. Miyata and H. Taguchi and H. Nagasawa and T. Tsukahara and T. Watanobe and Y. Maki and K. Seio and M. Sekine}, title = {'Protected DNA Probes' capable of strong hybridization without removal of base protecting groups}, journal = {NUCLEIC ACIDS RESEARCH}, year = 2008, } @article{CTT100785522, author = {K. Taira and S. Nakamura and K. Nakano and D. Maehara and K. Okamoto and S. Arimoto and D. Loakes and L. Worth and R. M. Schaaper and K. Seio and M. Sekine and K. Negishi and T. Negishi}, title = {Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency}, journal = {MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS}, year = 2008, } @article{CTT100785518, author = {H. Tsunoda and A. Ohkubo and H. Taguchi and K. Seio and M. Sekine}, title = {Synthesis and properties of DNA oligomers containing 2 '-deoxynucleoside N-oxide derivatives}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2008, } @article{CTT100785523, author = {M. Sumino and A. Ohkubo and H. Taguchi and K. Seio and M. Sekine}, title = {Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2'-deoxycytidines}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2008, } @article{CTT100785519, author = {R. Tawarada and K. Seio and M. Sekine}, title = {Synthesis and properties of oligonucleotides with iodo-substituted aromatic aglycons: Investigation of possible halogen bonding base pairs}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2008, } @article{CTT100785544, author = {Saneyoshi Hisao and Okamoto Itaru and Masaki Yoshiaki and Ohkubo Akihiro and Seio Kohji and Mitsuo}, title = {Facile synthesis of 2 '-O-cyanoethyluridine by ring-opening reaction of 2,2 '-anhydrouridine with cyanoethyl trimethylsilyl ether in the presence of BF3 center dot Et2O}, journal = {Tetrahedron Letters}, year = 2007, } @article{CTT100785558, author = {H. Saneyoshi and K. Ando and K. Seio and M. Sekine}, title = {Chemical synthesis of RNA via 2 '-O-cyanoethylated intermediates}, journal = {TETRAHEDRON}, year = 2007, } @article{CTT100785559, author = {A. Ohkubo and K. Tanaka and H. Taguchi and K. Seio and H. Nagasawa and T. Tsukahara and M. Sekine}, title = {An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2007, } @article{CTT100785554, author = {E. Utagawa and A. Ohkubo and M. Sekine and K. Seio}, title = {Synthesis of branched Oligonucleotides with three different sequences using an oxidatively removable tritylthio group}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2007, } @article{CTT100785560, author = {A. Ohkubo and H. Taguchi and K. Seio and H. Nagasawa and T. Tsukahara and M. Sekine}, title = {A new hydrophobic linker effective for the in situ synthesis of DNA-CPG conjugates as tools for SNP analysis}, journal = {TETRAHEDRON LETTERS}, year = 2007, } @article{CTT100785557, author = {T. Sasami and Y. Odawara and A. Ohkubo and M. Sekine and K. Seio}, title = {Synthesis and hybridization properties of oligodeoxynucleotides incorporating 2-N-carbamoylguanine derivatives as guanine analogs}, journal = {TETRAHEDRON LETTERS}, year = 2007, } @article{CTT100785561, author = {M. Mizuta and K. Seio and K. Miyata and M. Sekine}, title = {Fluorescent pyrimidopyrimidoindole nucleosides: Control of photophysical characterizations by substituent effects}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2007, } @article{CTT100785566, author = {B. Karwowski and K. Seio and M. Sekine}, title = {Chemical properties of 4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl (DECDO) as a hydroxyl protecting group of the 2 '-hydroxyl function in ribonucleosides}, journal = {JOURNAL OF HETEROCYCLIC CHEMISTRY}, year = 2007, } @article{CTT100785556, author = {K. Seio and T. Sasami and A. Ohkubo and K. Ando and M. Sekine}, title = {Highly selective recognition of cytosine over uracil and adenine by a guanine analogue, 2-N-Acetyl-3-deazaguanine, in 2 '-O-Methyl-RNA/RNA and DNA duplexes}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, year = 2007, } @article{CTT100785565, author = {K. Miyata and R. Mineo and R. Tamamushi and M. Mizuta and A. Ohkubo and H. Taguchi and K. Seio and T. Santa and M. Sekine}, title = {Synthesis and fluorescent properties of bi- and tricyclic 4-N-carbamoyldeoxycytidine derivatives}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2007, } @article{CTT100785555, author = {K. Seio and T. Terada and M. Mizuta and A. Ohkubo and H. Taguchi and M. Sekine}, title = {Synthesis and hybridization properties of oligodeoxynucleotides with long-chain linkers}, journal = {HELVETICA CHIMICA ACTA}, year = 2007, } @article{CTT100785563, author = {M. Mizuta and K. Seio and K. Miyata and A. Ohkubo and H. Taguchi and M. Sekine}, title = {A pyrimidopyrimidoindole nucleoside (dC(PPI)): Photophysical properties and thermal stability of the modified DNA duplexes}, journal = {NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS}, year = 2007, } @article{CTT100785567, author = {E. Utagawa and M. Sekine and K. Seio}, title = {cis-tetrahydrofuran-3,4-diol structure as a key skeleton of new protecting groups removable by self-cyclization under oxidative conditions}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2006, } @article{CTT100785572, author = {K. Miyata and R. Tamamushi and A. Ohkubo and H. Taguchi and K. Seio and T. Santa and M. Sekine}, title = {Synthesis and properties of a new fluorescent bicyclic 4-N-carbamoyldeoxycytidine derivative}, journal = {ORGANIC LETTERS}, year = 2006, } @article{CTT100785570, author = {I. Okamoto and K. Shohda and K. Seio and M. Sekine}, title = {Incorporation of 2 '-O-methyl-2-thiouridine into oligoribonucleotides induced stable A-form structure}, journal = {CHEMISTRY LETTERS}, year = 2006, } @article{CTT100785601, author = {H. Taguchi and A. Ohkubo and M. Sekine and K. Seio and H. Kakeya and H. Osada and T. Sasaki}, title = {Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage}, journal = {NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS}, year = 2006, } @article{CTT100785582, author = {K. Seio and T. Miyashita and K. Sato and M. Sekine}, title = {Synthesis and properties of new nucleotide analogues possessing squaramide moieties as new phosphate isosters}, journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, year = 2005, } @article{CTT100785578, author = {M. Sekine and M. Aoyagi and M. Ushioda and A. Ohkubo and K. Seio}, title = {Chemically stabilized phenylboranylidene groups having a dimethoxytrityl group as a colorimetrically detectable protecting group designed for cis-1,2-diol functions of ribonucleosides in the solid-phase synthesis of m(2)(2,2)G5 ' ppT}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, year = 2005, } @article{CTT100785579, author = {K. Seio and H. Ukawa and K. Shohda and M. Sekine}, title = {Computational evaluation of intermolecular interactions of a universal base 3-nitropyrrole in stacked dimers and DNA duplexes}, journal = {JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS}, year = 2005, } @article{CTT100785581, author = {K. Seio and T. Negishi and K. Negishi and M. Sekine}, title = {Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine}, journal = {LETTERS IN ORGANIC CHEMISTRY}, year = 2005, } @article{CTT100786563, author = {Ohkubo, A and Taguchi, H and Seio, K and Sekine, M and KOHJI SEIO}, title = {O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method.}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2005, } @article{CTT100786564, author = {Miyata, K and Tamamushi, R and Ohkubo, A and Taguchi, H and Seio, K and Sekine, M and KOHJI SEIO}, title = {Synthesis and conformational analysis of 4-N-carbamoyldeoxycytidine derivatives.}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2005, } @article{CTT100785585, author = {K. Seio and T. Sasaki and K. Yanagida and M. Baba and M. Sekine}, title = {Synthesis of benzodithiol-2-yl-substituted nucleoside derivatives as lead compounds having anti-bovine viral diarrhea virus activity}, journal = {JOURNAL OF MEDICINAL CHEMISTRY}, year = 2004, } @article{CTT100785586, author = {A. Ohkubo and Y. Ezawa and K. Seio and M. Sekine}, title = {O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, year = 2004, } @article{CTT100785583, author = {R. Tatsumi and K. Seio and M. Fujio and J. Katayama and T. Horikawa and K. Hashimoto and H. Tanaka}, title = {(+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane, as potent agonists for the alpha 7 nicotinic acetylcholine receptor}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, year = 2004, } @article{CTT100785587, author = {N. Hino and T. Suzuki and T. Yasukawa and K. Seio and K. Watanabe and T. Ueda}, title = {The pathogenic A4269G mutation in human mitochondrial tRNA(Ile) alters the T-stem structure and decreases the binding affinity for elongation factor Tu}, journal = {GENES TO CELLS}, year = 2004, } @article{CTT100785584, author = {K. Seio and E. Utagawa and M. Sekine}, title = {New protected protecting groups for the 5 '-hydroxy group of deoxynucleosides by use of 2-(hydroxymethyl)- and 2-[(methylamino)methyl]benzoyl skeletons and oxidatively cleavable tritylthio and (4-methoxytrityl)thio groups}, journal = {HELVETICA CHIMICA ACTA}, year = 2004, } @article{CTT100489345, author = {Kohji Seio and Hisashi Ukawa and Koh-ichiro Shohda and Mitsuo Sekine}, title = {Important factors stabilizing stacking interaction between 3-nitropyrrole and natural nucleobases revealed by ab intio calculations}, journal = {Nucleic Acids Res. Suppl. }, year = 2003, } @article{CTT100489341, author = {kohji Seio and Koh Kumura and Mitsuo Sekine}, title = {Enhanced stereoselectivity in internucleotidic bond formation by the use of the chiral ribose moiety of thymidine}, journal = {J. Org. Chem}, year = 2003, } @article{CTT100489342, author = {Mitsuo Sekine and Akihiro Ohkubo and Kohji Seui}, title = {Proton-block strategy for the synthesis of oligodeoxynucleotides without base protection, capping, and P-N bond cleavage reaction}, journal = {J. Org. Chem.}, year = 2003, } @article{CTT100785594, author = {T. Kohara and H. Tanaka and K. Kimura and H. Horiuchi and K. Seio and M. Arita and T. Fujimoto and I. Yamamoto}, title = {Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives}, journal = {JOURNAL OF HETEROCYCLIC CHEMISTRY}, year = 2002, } @article{CTT100785595, author = {A. Kobori and K. Miyata and M. Ushioda and K. Seio and M. Sekine}, title = {A new silyl ether-type linker useful for the automated synthesis of oligonucleotides having base-labile protective groups}, journal = {CHEMISTRY LETTERS}, year = 2002, } @article{CTT100460676, author = {A. Kobori and K. Miyata and M. Ushioda and K. Seio and M. Sekine}, title = {A New Silyl Ether-Type Linker Useful for the Automated Synthesis of Oligonucleotides Having Base-Labile Protecting Groups}, journal = {Chem. Lett.}, year = 2002, } @article{CTT100479497, author = {Kohji Seio and Eri Utagawa and Mitsuo Sekine}, title = {A new protecting group for 5'-hydroxyl function of nucleitides in oligonucleotide snthesis without acid treatment utilizing unique properties of tritylthio group}, journal = {Nucleic Acid Research Supplement}, year = 2002, } @article{CTT100480442, author = {Masatoshi Ushioda and Michinori Kadokura and Tomohisa Moriguchi and Akio Kobori and Morihiro Aoyagi and Kohji Seio and Mitsuo Sekine}, title = {Unique pqrticupation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of the Si-O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5'-terminal guanylated oligodeoxynucleotides}, journal = {Helvetica Chimica Acta}, year = 2002, } @article{CTT100480441, author = {Akihiro Ohkubo and Kohji Seio and Mitsuo Sekine}, title = {A new strategy for the synthesis of oligodeoxynucleotides in the phosphoramidite method without base protection via phosphite intermediates}, journal = {Nucleic Acids Research Supplement}, year = 2002, } @article{CTT100480440, author = {Kohji Seio and Eri Utagawa and Mitsuo Sekine}, title = {A new protecting group for 5'-hydroxyl function of nucleotides in oligonucleotide synthesis without acid treatment utilizing unique properties of tritylthio group}, journal = {Nucleic Acids Research Supplement}, year = 2002, } @article{CTT100786565, author = {Sato, Y and Tateno, G and Seio, K and Sekine, M and KOHJI SEIO}, title = {Substituent and solvent effects of TMS triflate mediated C1 ' epimerization of beta-thymidine to alpha-thymidine}, journal = {European Journal of Organic Chemistry}, year = 2002, } @article{CTT100460680, author = {Kousuke Sato and Kohji Seio and Mitsuo Sekine}, title = {Synthesis and Properties of a New Nucleotide Analogue Containing Squaryl Group}, journal = {Nuceic Acids Research Supplement No1}, year = 2001, } @article{CTT100460678, author = {M. Sekine and T. Moriguchi and T. Wada and K. Seio}, title = {Total Synthesis of Agrocin 84 and Phosmidosine as Naturally Occurring Nucleotidic Antibiotics Having P-N Bond Linkages}, journal = {J. Org. Synth. Chem. Jpn}, year = 2001, } @article{CTT100460677, author = {M. Kadokura and T. Wada and K. Seio and T. Moriguchi and J. Huber and R. Luhrmann and M. Sekine}, title = {Solid-Phase Synthesis of a 5-Terminal TMG-Capped Trinucleotide Block of U1 snRNA}, journal = {Tetrahedron Lett.}, year = 2001, } @article{CTT100460679, author = {K. Negishi and D. Maehara and S. Nakamura and D. Loakes and l. Worth and Jr. R. M. Schaaper and K. Seio and M. Sekine and T. Negishi}, title = {Binding Specificities of the Mismatch Binding Protein, MutS, to Oligonucleotides Containing Modified bases}, journal = {Nuceic Acids Research Supplement No1}, year = 2001, } @article{CTT100460683, author = {M. Sekine and O. Kurasawa and K. Shohda and K. Seio and T. Wada}, title = {Essential factors for stabilization of the predominant C3'-endo conformation in dinucleoties phosphotriester derivatives with cyclonucleotide bridge structures at the downstream 3'-position}, journal = {Eur. J. Org.}, year = 2001, } @article{CTT100460652, author = {Kohji Seio and Mitsuo Sekine}, title = {Synthesis of pentathymidylate using a 4-monomethoxytritylthio (MMTrS) group as a 5'-hydroxyl protecting group: toward oligonucleotide synthesis without acid treatment}, journal = {Tetrahedron Letters}, year = 2001, } @article{CTT100460681, author = {A. Ohkubo and K. Seio and M. Sekine}, title = {A New Coupling Method for the Synthesis of Oligodeoxyribonucleotides Based on Protection by Protonation of Nnucleoside Bbases}, journal = {Nuceic Acids Research Supplement No1}, year = 2001, } @article{CTT100786566, author = {Takahashi, K and Seio, K and Sekine, M and Hino, O and Esashi, M and KOHJI SEIO}, title = {Fabrication of directly synthesized DNA chip using photolithography for rapid and parallel gene analysis}, journal = {Transducers '01: Eurosensors Xv, Digest of Technical Papers, Vols 1 and 2}, year = 2001, } @article{CTT100442808, author = {KOHJI SEIO}, title = {Synthesis and properties of oligonucleotides having a phosphorous chiral center by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives}, journal = {J. Org. Chem.}, year = 2000, } @article{CTT100442807, author = {KOHJI SEIO}, title = {Solid-phase synthesis of deoxyribonucleotides having a cap structure analog}, journal = {Nucleic Acids Symp. Ser.}, year = 2000, } @article{CTT100460682, author = {H. Narita and T. Moriguchi and K. Seio and M. Sekine and H. Miyaguchi and K. Sakamoto and S. Yokoyama}, title = {Synthesis of N-labeled peptidyl AMP}, journal = {Nucleosides Nucleotides }, year = 2000, } @article{CTT100443521, author = {KOHJI SEIO}, title = {Chemical synthesis of hydroxymethylphosophnate α-DNA}, journal = {Nucleic Acids Sym. Ser.}, year = 2000, } @article{CTT100443520, author = {KOHJI SEIO}, title = {synthesis and properties of 2'-O-methyl-2-thiouridine and oligoribonucleotides containing 2'-O-methyl-2-thiouridine}, journal = {Bioorg. Med. chem. Lett.}, year = 2000, } @article{CTT100443519, author = {KOHJI SEIO}, title = {Synthesis and antitumor activities fo phomidosine A and its N-acylated derivatives}, journal = {Tetrahedron Lett.}, year = 2000, } @article{CTT100442811, author = {KOHJI SEIO}, title = {Synthesis and properties of oligothymidilates incorporating an artificial bend motif}, journal = {Helvetica Chimica Acta}, year = 2000, } @article{CTT100442810, author = {KOHJI SEIO}, title = {Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5'-terminal site}, journal = {J. Org. Chem.}, year = 2000, } @article{CTT100442809, author = {KOHJI SEIO}, title = {Synthesis of 4-thiouridine, 6-thiuridine and 6-thioguanosine 3', 5'-bisphosphates as donor molecule for RNA ligation and their application to the synthesis of photoactivatable TMG-capped U1 snRNA fragments}, journal = {J. Org. Chem.}, year = 2000, } @article{CTT100431640, author = {Mitsuo Sekine and Osamu Kurasawa and Kohji Seio and Koh-ichiro Shohda and Takeshi Wada}, title = {Synthesis of artificially bent oligonucleotides by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives}, journal = {Nucleosides & Nucleotides}, year = 1999, } @article{CTT100442813, author = {KOHJI SEIO}, title = {Chemical synthesis and properties of conformationaly fixed diuridine monophosphatesas building blocks of the RNA turn motif}, journal = {J. Org. Chem.}, year = 1998, } @article{CTT100442814, author = {KOHJI SEIO}, title = {Synthesis and properties of conformationally rigid cyclicuridylic acids having covalent bonding linkers between the uracil 5-position and the 5'-phosphate group}, journal = {Nucleosides Nucleotides}, year = 1997, } @article{CTT100442816, author = {KOHJI SEIO}, title = {chemical synthesis and conformational properties of a new cyclouridylic acid having an ethylene bridge between the uracil 6-position and 5'-phosphate group}, journal = {J. Org. Chem}, year = 1996, } @article{CTT100442815, author = {KOHJI SEIO}, title = {chemical synthesis of a 5'-terminal TMG-capped triribonucleotide m3 2,2,7G5'pppAmUmA of U1 RNA}, journal = {J. Org. Chem.}, year = 1996, } @article{CTT100442824, author = {KOHJI SEIO}, title = {Synthesis of oligonucleotide having a bent structure by incorporation of an interresidually cyclized uridylyl(3'-5')uridine unit}, journal = {Nucleic Acids Symp. Ser.}, year = 1995, } @article{CTT100786567, author = {Seio, K and Wada, T and Sakamoto, K and Yokoyama, S and Sekine, M and KOHJI SEIO}, title = {Synthesis and properties of conformationally rigid cyclouridylic acid having a covalent bonding linker between the uracil 5-position and the 5'-phosphate group}, journal = {Tetrahedron Letters}, year = 1995, } @article{CTT100442823, author = {KOHJI SEIO}, title = {Synthesis and properties of conformationally rigid cycliuridylic acid having a covalent bonding linker between the uracil 5-position and the 5'-phosphate group}, journal = {Tetrahedron Lett.}, year = 1994, } @article{CTT100443522, author = {KOHJI SEIO}, title = {Chemical synthesis of the 5'-terminal structure of U1 RNA}, journal = {Nucleic Acids Symp. Ser.}, year = 1994, } @article{CTT100443523, author = {KOHJI SEIO}, title = {Synthesis and properties of N-tritylthio nucleoside derivatives and reductive removal of the tritylthiogroup by use of tributyltin hydride and tris(trimethylsilyl)silane}, journal = {J. Chem. Soc. Perkin 1}, year = 1993, } @article{CTT100443524, author = {KOHJI SEIO}, title = {Synthesis of uridylyl(3'-5')uridine derivatives containing 5-(methylaminomethyl)uridine as a modified nucleoside found from E. Coli minor tRNA Arg}, journal = {Nucleosides Nucleotides}, year = 1993, } @article{CTT100786568, author = {SEKINE, M and SEIO, K and SATOH, T and SAKAMOTO, K and YOKOYAMA, S and KOHJI SEIO}, title = {SYNTHESIS OF URIDYLYL (3'-5') URIDINE DERIVATIVES CONTAINING 5-(METHYLAMINO-METHYL)URIDINE AS A MODIFIED NUCLEOSIDE FOUND FROM ESCHERICHIA-COLI MINOR TRANSFER RNA(ARG)}, journal = {Nucleosides & Nucleotides}, year = 1993, } @inproceedings{CTT100917126, author = {立花茂載 and 大西里絵 and 正木慶昭 and 清尾康志}, title = {5´位を増炭したスルホンアミド骨格を有するチミジンダイマーの合成と物性評価}, booktitle = {}, year = 2024, } @inproceedings{CTT100917133, author = {宮地健人 and 羽生愛深 and 清尾康志 and 正木慶昭}, title = {7位にピリジル基を導入した7-デアザデオキシグアノシンを含むオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2024, } @inproceedings{CTT100917132, author = {鈴木雄大 and 須田雪音 and 井分彩乃 and 正木慶昭 and 清尾 康志}, title = {光架橋ビオチンリンカーを有するグアノシンテトラリン酸類似体の合成}, booktitle = {}, year = 2024, } @inproceedings{CTT100917129, author = {瀧川駿太朗 and 友利貴人 and 植草宏哉 and 正木慶昭 and 清尾康志}, title = {2´水酸基にスルホンアミド修飾またはスルホネート修飾を有する5-メチルウリジン誘導体の合成および二重鎖形成能の評価}, booktitle = {}, year = 2024, } @inproceedings{CTT100917127, author = {田平彩乃 and 若月駿介 and 清尾 康志 and 正木 慶昭}, title = {置換基を導入した2´-O, 3´-C架橋アラビノフラノシルチミンを含むオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2024, } @inproceedings{CTT100917130, author = {島村大輝 and 有江嶺美 and 金山朱里 and 宮内彩 and 清尾康志 and 正木慶昭}, title = {細胞選択的送達を目指した糖リガンド修飾アンチセンス核酸の合成と性質}, booktitle = {}, year = 2024, } @inproceedings{CTT100917124, author = {Masaki Y and Onishi Y and Seio K}, title = {Estimation of synthetic errors toward long DNA chemical synthesis}, booktitle = {}, year = 2024, } @inproceedings{CTT100917125, author = {Tabira A and Httori S and Seio K and Masaki Y}, title = {Extended phosphate backbone of ASO reveals importance of deoxyribose recognition by RNase H}, booktitle = {}, year = 2024, } @inproceedings{CTT100917123, author = {田平彩乃 and 服部詩萌里 and 清尾康志 and 正木慶昭}, title = {メチレン基のリン酸バックボーンへの挿入がRNase Hによるミスマッチを含む二重差切断に与える影響}, booktitle = {}, year = 2023, } @inproceedings{CTT100917122, author = {清尾康志 and 大西里絵 and 立花茂載 and 正木慶昭}, title = {スルホンアミド型バックボーンを導入したギャップマーの合成およびアンチセンス核酸としての性質}, booktitle = {}, year = 2023, } @inproceedings{CTT100895468, author = {Tachibana S and Kanagawa T and Ohnishi R and Masaki Y and Seio K}, title = {Synthesis and the structural analysis of a cyclic sulfonamide thymidine derivative}, booktitle = {}, year = 2022, } @inproceedings{CTT100895466, author = {Uekusa K and Tomori T and Koyama A and Masaki Y and Seio K}, title = {Synthesis of nucleoside and oligonucleotide derivatives incorporating 2’-O-sulfamoylpropyl or 2’-O-sulfamoylbutyl modifications}, booktitle = {}, year = 2022, } @inproceedings{CTT100895465, author = {Ohnishi R and Sekiya S and Edamura W and Tachibana S and Masaki Y and Seio K}, title = {Synthesis and structural analysis of sulfonamide linkage-containing oligonucleotides for the development of antisense nucleic acids}, booktitle = {}, year = 2022, } @inproceedings{CTT100895467, author = {Yagata T and Masaki Y and Onishi Y and Seio K}, title = {Synthesis and property of alkoxytrityl type protecting group having reactive moiety}, booktitle = {}, year = 2022, } @inproceedings{CTT100895464, author = {Masaki Y and Onishi Y and Seio K}, title = {Systemic comparison of DNA chemical synthesis conditions by next-generation sequencing}, booktitle = {}, year = 2022, } @inproceedings{CTT100895469, author = {Tabira A and Masaki Y and Hattori S and Wakatsuki S and Seio K}, title = {Effects of inserting methylene group in the interaction of RNase H and ASO}, booktitle = {}, year = 2022, } @inproceedings{CTT100895463, author = {金川峻幸 and 立花茂載 and 大西里絵 and 正木慶昭 and 清尾康志}, title = {スルホンアミド構造を有する環状チミジン誘導体の合成とその構造解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100895461, author = {金川峻幸 and 小山彩 and 正木慶昭 and 清尾康志}, title = {塩基部修飾グアニン導入によるアンチセンス核酸の標的切断変化とオフターゲット抑制}, booktitle = {}, year = 2022, } @inproceedings{CTT100895460, author = {正木慶昭 and 田平彩乃 and 金川峻幸 and 若月駿介 and 服部詩萌里 and 小山彩 and 井上敦 and 清尾康志}, title = {RNase H依存型アンチセンス核酸の安全性向上に向けた化学修飾の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100895462, author = {植草宏哉 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2’-O-スルファモイルアルキル修飾を導入したオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2022, } @inproceedings{CTT100877684, author = {正木慶昭 and 矢形太一 and 清尾康志}, title = {次世代シーケンサーをもちいた化学合成DNAの副生成物解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100877687, author = {大西里絵 and 関谷彰太 and 枝村亘 and 正木慶昭 and 清尾康志}, title = {スルホンアミド骨格を含む人工核酸の合成とアンチセンス活性の評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100877686, author = {小山彩 and 友利貴人 and 江利川友紀 and 正木慶昭 and 清尾康志}, title = {2´カルバモイルエチルリンカーの脂溶性残基を導入したアンチセンスオリゴヌクレオチドの合成と特性評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100877685, author = {井分彩乃 and 赤井恒 and 友利貴人 and 清尾康志 and 正木慶昭}, title = {リンカーを介して2´-水酸基にビオチンを有するグアノシンテトラリン酸誘導体の合成}, booktitle = {}, year = 2022, } @inproceedings{CTT100877690, author = {正木慶昭 and 田平彩乃 and 服部詩萌里 and 清尾康志}, title = {5´-デオキシ-5´-ヒドロキシメチルチミジン及び3´-デオキシ-3´-ヒドロキシメチルチミジンを含むリン酸骨格を伸長したオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2022, } @inproceedings{CTT100877689, author = {金川峻幸 and 立花茂載 and 大西里絵 and 正木慶昭 and 清尾康志}, title = {塩基部と5´位をスルホンアミド結合で架橋したチミジン誘導体の合成法の検討}, booktitle = {}, year = 2022, } @inproceedings{CTT100877688, author = {矢形太一 and 正木慶昭 and 清尾康志}, title = {末端アルキンを有するアルコキシトリチル型保護基の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100877683, author = {Tomori, T. and Kishimura T. and Uekusa K. and Koyama A. and Erikawa Y. and Masaki Y. and Seio K}, title = {Synthesis of oligonucleotides with lipophilic residues via 2´-O-carbamoylethyl linker for providing 3´-exonuclease resistance and duplex stability}, booktitle = {}, year = 2021, } @inproceedings{CTT100877682, author = {清尾康志 and 岸村智太 and 友利貴人 and 正木慶昭}, title = {2'位に種々のカルバモイルエチル基を有する人工核酸の合成とアンチセンス核酸としての性質}, booktitle = {}, year = 2021, } @inproceedings{CTT100856693, author = {岸村智太 and 植草宏哉 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2 ́-O-アルキルカルバモイルエチル型修飾を持つ人工核酸の合成および性質}, booktitle = {}, year = 2021, } @inproceedings{CTT100856697, author = {清尾康志 and 大西里絵 and 関谷彰太 and 枝村亘 and 正木慶昭}, title = {スルホンアミド結合を含む人工核酸の合成と塩基対形成能}, booktitle = {}, year = 2021, } @inproceedings{CTT100856696, author = {若月駿介 and 井上敦 and 正木慶昭 and 清尾康志}, title = {2 ́-O,3 ́-C架橋型 [3.3.0]ビシクロアラビノフラノシルチミン誘導体を含むオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2021, } @inproceedings{CTT100856695, author = {赤井恒 and 杉山大樹 and 大野健太郎 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2'水酸基保護基にTBDMS基を用いた緊縮応答分子ppGppの化学合成法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100856694, author = {服部詩萌里 and 正木慶昭 and 清尾康志}, title = {リン酸骨格を伸長した5 ́-デオキシ-5 ́-ヒドロキシメチルチミジンを含むオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2021, } @inproceedings{CTT100856692, author = {正木慶昭 and 矢形太一 and 清尾康志}, title = {長鎖 DNA合成に向けたホスホロアミダイト法における副反応の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100836261, author = {赤井恒 and 杉山大樹 and 大野健太郎 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {ホスホロアミダイト化合物を用いた緊縮応答分子ppGppの効率的合成法}, booktitle = {}, year = 2020, } @inproceedings{CTT100836265, author = {宮崎翔 and 正木慶昭 and 清尾康志}, title = {高圧条件下での2 ́,5 ́-ヌクレオチド残機を含んだRNA二重鎖の分子シミュレーション}, booktitle = {}, year = 2020, } @inproceedings{CTT100836264, author = {山田悠司 and 竹下玲央 and 正木慶昭 and 清尾康志}, title = {光ケージされたデオキシシュードウリジンを含むDNA二重鎖および三重鎖構造の安定性の評価}, booktitle = {}, year = 2020, } @inproceedings{CTT100836263, author = {若月駿介 and 井上敦 and 正木慶昭 and 清尾康志}, title = {2 ́-O,3 ́-C架橋型 [3.3.0] ピシクロアラビノフラノシルミチン誘導体の合成}, booktitle = {}, year = 2020, } @inproceedings{CTT100836260, author = {岸村智太 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2´位に種々のアルキルカルバモイルエチル修飾を持つ核酸の合成と二重鎖形成能}, booktitle = {}, year = 2020, } @inproceedings{CTT100836266, author = {Edamura W and Sekiya S and Masaki Y and Seio K}, title = {Conformation and properties of oligonucleotide with sulfonamide skeleton}, booktitle = {}, year = 2020, } @inproceedings{CTT100836257, author = {Miyazaki S and Masaki Y and Seio K}, title = {The conformational property of RNA duplex including 2 ́,5 ́-linkage under high pressure conditions}, booktitle = {}, year = 2019, } @inproceedings{CTT100836258, author = {Yamada Y and Takeshita L and Masaki Y and Seio K}, title = {Enzymatic synthesis and photo-deprotection of DNA incorporating photo-caged deoxypseudouridine}, booktitle = {}, year = 2019, } @inproceedings{CTT100836259, author = {Takeshita L and Iwake A and Tomori T and Masaki Y and Seio K}, title = {Enzymatic incorporation of 2'-O-alkylcarbamoyl-UTP for development of RNA aptamer}, booktitle = {}, year = 2019, } @inproceedings{CTT100811700, author = {竹下玲央 and 井分彩乃 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2´-O-アルキルカルバモイル修飾UTPの合成と転写および逆転写反応への応用}, booktitle = {}, year = 2019, } @inproceedings{CTT100811699, author = {正木慶昭 and 井上敦 and 入山友輔 and 金木達朗 and 中嶋宏之 and 清尾康志}, title = {化学修飾によるアンチセンス核酸のRNase H依存オフターゲット効果の抑制}, booktitle = {}, year = 2019, } @inproceedings{CTT100811698, author = {Y. Masaki and T. Inde and A. Maruyama and K. Seio}, title = {Tolerance of N2-heteroaryl modifications on guanine bases in G-quadruplex structure}, booktitle = {}, year = 2019, } @inproceedings{CTT100811694, author = {竹下玲央 and 井分彩乃 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {アプタマー応用を志向した2´-O-カルバモイル型修飾を有するウリジン三リン酸の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100811693, author = {Y. Masaki and K. Yamamoto and Y. Yoshida and A. Maruyama and T. Tomori and Y. Iriyama and H. Nakajima and T. Kanaki and K. Seio}, title = {Synthesis and properties of 2'-O-modified oligonucleotides having carbamoylethyl linker}, booktitle = {}, year = 2019, } @inproceedings{CTT100811727, author = {Maruyama, A. and Yoshida, K. and Masaki, Y. and Seio, K.}, title = {Incorporation of peptide into 2 ́ position of oligonucleotide by Native Chemical Ligation}, booktitle = {}, year = 2019, } @inproceedings{CTT100811725, author = {Takeshita, L. and Masaki, Y. and Seio, K.}, title = {Synthesis and properties of photo-responsive DNA probes containing thioxanthone and nitrophenethyl group}, booktitle = {}, year = 2019, } @inproceedings{CTT100811726, author = {Kishimura, T. and Tomori, T. and Masaki, Y. and Seio, K.}, title = {Synthesis and properties of oligonucleotides having alkyl carbamoylethyl groups at 2 ́ position}, booktitle = {}, year = 2019, } @inproceedings{CTT100811728, author = {杉山大樹 and 大野健太郎 and 正木慶昭 and 清尾康志}, title = {ホスホロアミダイト化合物を利用したグアノシンテトラリン酸の効率的合成法の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100811729, author = {井上敦 and 正木慶昭 and 清尾康志}, title = {2 ́,3 ́-糖部架橋型アラビノフラノシルチミン誘導体の効率的な合成研究}, booktitle = {}, year = 2019, } @inproceedings{CTT100811730, author = {山田悠司 and 竹下玲央 and 山田悠司 and 竹下玲央 and 正木慶昭 and 清尾康志}, title = {光ケージされた5-ヒドロキシメチルデオキシウリジンを含むDNAの酵素合成法}, booktitle = {}, year = 2019, } @inproceedings{CTT100811724, author = {Maruyama A. and Inde T. and Masaki Y. and Seio K.}, title = {Synthesis of oligodeoxyribonucleotides containing 2-N-heteroarylguanine residues and their effect on G-quadruplex structure and stability}, booktitle = {}, year = 2018, } @inproceedings{CTT100785115, author = {L. Takeshita and Y. Masaki and K. Seio}, title = {Synthesis and properties of photo-responsive DNA probes containing photo-cleavable protecting group and thioxanthone as a photo-sensitizer}, booktitle = {}, year = 2018, } @inproceedings{CTT100785114, author = {Y. Masaki and K. Yamamoto and K. Yoshida and Y. Iriyama and H. Nakajima and T. Kanaki and T. Tomori and K. Seio}, title = {Application of 2'-O-carbamoylethyl-type modifications in antisense oligonucleotide}, booktitle = {}, year = 2018, } @inproceedings{CTT100785113, author = {Y. Masaki and T. Inde and A. Maruyama and K. Seio}, title = {Synthesis of oligodeoxyribonucleotides containing N2-heteroarylguanine residues and their properties in G-quadruplex structures}, booktitle = {}, year = 2018, } @inproceedings{CTT100785112, author = {L. Takeshita and T. Shiozawa and D. Sugiyama and T. Tomori and Y. Masaki and K. Seio}, title = {A structure-activity relationship of incorporation of 2'-O-carbamoyl modified uridine triphosphate by RNA polymerase}, booktitle = {}, year = 2018, } @inproceedings{CTT100811722, author = {正木 慶昭 and 井上 敦 and 入山 友輔 and 金木 達朗 and 中嶋 宏之 and 清尾 康志}, title = {RNaseH依存型アンチセンス核酸への応用に向けた化学修飾核酸の開発}, booktitle = {}, year = 2018, } @inproceedings{CTT100811723, author = {岸村智太 and 吉田圭汰 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2´位にカルバモイルエチル型修飾を持つ核酸の合成と性質}, booktitle = {}, year = 2018, } @inproceedings{CTT100785104, author = {L. TAKESHITA and Y. MASAKI and K. SEIO}, title = {Synthesis of DNA probes containing photo-sensitizer and caged molecule}, booktitle = {}, year = 2018, } @inproceedings{CTT100785103, author = {印出健志 and 正木慶昭 and 宮武佑弥 and 関根光雄 and 清尾康志}, title = {α-デオキシヌクレオシドを含むオリゴヌクレオチドのアンチパラレル型三重鎖形成能と塩基識別能}, booktitle = {}, year = 2018, } @inproceedings{CTT100785105, author = {岸村智太 and 吉田圭汰 and 阿野晃大 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2'水酸基に種々のカルバモイルエチル型修飾を持つ核酸の効率的合成と性質}, booktitle = {}, year = 2018, } @inproceedings{CTT100785106, author = {塩澤貴史 and 杉山大樹 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {還元的リン化学種による生体小分子の亜リン酸化反応の検討}, booktitle = {}, year = 2018, } @inproceedings{CTT100785107, author = {関谷彰太 and 竹下玲央 and 正木慶昭 and 清尾康志}, title = {スルホンアミド骨格を有するオリゴヌクレオチドを鋳型に用いたDNAポリメラーゼ反応}, booktitle = {}, year = 2018, } @inproceedings{CTT100785108, author = {井上敦 and 正木慶昭 and 清尾康志}, title = {2',3'-糖部架橋型化学修飾核酸の合成}, booktitle = {}, year = 2018, } @inproceedings{CTT100785109, author = {杉山大樹 and 塩澤貴史 and 大野健太郎 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {ピロ亜リン酸による亜リン酸化反応を経由したヌクレオチド合成}, booktitle = {}, year = 2018, } @inproceedings{CTT100785110, author = {丸山敦也 and 印出健志 and 正木慶昭 and 清尾康志}, title = {グアニン塩基部2位にヘテロアリール環修飾を有するオリゴヌクレオチドの合成と高次構造形成}, booktitle = {}, year = 2018, } @inproceedings{CTT100785111, author = {竹下玲央 and 山田悠司 and 正木慶昭 and 清尾康志}, title = {光ケージされたデオキシシュードウリジンを含むDNAの酵素合成法}, booktitle = {}, year = 2018, } @inproceedings{CTT100785102, author = {D. Sugiyama and T. Shiozawa and K. Ohno and T. Tomori and Y. Masaki and K. Seio}, title = {Reaction of H-pyrophosphonic acid toward nucleosides, nucleotides and amino acids}, booktitle = {}, year = 2017, } @inproceedings{CTT100785101, author = {L. Takeshita and K. Ohno and K. Nagaoka and Y. Yamada and Y. Masaki and K. Seio}, title = {Photo-regulation of transcription by using enzymatically synthesized photo-caged DNA}, booktitle = {}, year = 2017, } @inproceedings{CTT100785100, author = {T. Inde and Y. Masaki and A. Maruyama and Y. Ito and N. Makio and Y. Miyatake and T. Tomori and M. Sekine and K. Seio}, title = {Synthesis of oligodeoxyribonucleotides containing 2-N-heteroarylguanine residues and their effect on higher-order structure stability}, booktitle = {}, year = 2017, } @inproceedings{CTT100785098, author = {竹下玲央 and 大野健太郎 and 長岡健斗 and 山田悠司 and 正木慶昭 and 清尾康志}, title = {光分解性保護基を導入したヌクレオシド三リン酸の合成と転写反応の光制御への応用}, booktitle = {}, year = 2017, } @inproceedings{CTT100785099, author = {印出健志 and 丸山敦也 and 伊藤 優 and 牧尾直明 and 友利貴人 and 正木慶昭 and 関根光雄 and 清尾康志}, title = {2 位のアミノ基にヘテロアリール環を導入したデオキシグアノシン誘導体の合成と オリゴヌクレオチド中での性質評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100785092, author = {Yoshiaki Masaki and Mitsuo Sekine and KOHJI SEIO}, title = {Relationship between deformability of sugar-modified RNA duplexes and their melting temperatures}, booktitle = {}, year = 2017, } @inproceedings{CTT100785093, author = {大野健太郎 and 竹下玲央 and 杉山大樹 and 正木慶昭 and 清尾康志}, title = {6-O-(2-ニトロベンジル)グアノシン三リン酸の合成と転写反応の光制御}, booktitle = {}, year = 2017, } @inproceedings{CTT100785095, author = {竹下玲央 and 大野健太郎 and 長岡健斗 and 山田悠司 and 正木昭慶 and 清尾康志}, title = {酵素合成可能な光ケージド DNA の開発と転写制御への応用}, booktitle = {}, year = 2017, } @inproceedings{CTT100785096, author = {塩澤貴史 and 友利貴人 and 杉山大樹 and 金和平 and 正木慶昭 and 清尾康志}, title = {還元的リン化学種と生体小分子との反応の検討}, booktitle = {}, year = 2017, } @inproceedings{CTT100785097, author = {関谷彰太 and 北川諒 and 竹下玲央 and 田胡信広 and 正木慶昭 and 清尾康志}, title = {スルホンアミド結合を有する人工核酸の新規合成と性質}, booktitle = {}, year = 2017, } @inproceedings{CTT100785091, author = {正木 慶昭 and 宮坂 隆太 and 山本 恵士 and 吉田 圭汰 and 関根 光雄 and 清尾 康志}, title = {糖部修飾オリゴヌクレオチドの変形能解析と二重鎖融解温度の関係}, booktitle = {}, year = 2017, } @inproceedings{CTT100785089, author = {清尾康志 and 正木慶昭 and 山本恵士 and 印出健志 and 入山友輔 and 中島宏之 and 金木達朗 and 黒田雄介 and 古川賢 and 谷端 淳 and 永田哲也 and 武田伸一 and 関根 光雄}, title = {2’-水酸基にカルバモイルエチル型修飾を有する人工核酸を用いたアンチセンス核酸の開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100722469, author = {正木 慶昭 and 吉田 圭汰 and 山本 恵士 and 関根 光雄 and 清尾 康志}, title = {糖部化学修飾RNA二重鎖の変形能と二重鎖融解温度の関係}, booktitle = {}, year = 2016, } @inproceedings{CTT100722445, author = {Yoshiaki Masaki and Ryuta Miyasaka and Keishi Yamamoto and Keita Yoshida and Akihiro Ohkubo and Mitsuo Sekine and Kohji Seio}, title = {Deformability analysis of chemically modified RNA and its applicability for estimation of RNA duplex stability}, booktitle = {}, year = 2016, } @inproceedings{CTT100723931, author = {塩澤 貴史 and 正木 慶昭 and 金子 和平 and チャンガディブラタ ヤン クリスティアン and 徳川 宗史 and 清尾 康志}, title = {一本鎖結合タンパク質とDNAの相互作用を検出するための(7-ベンゾフラン-2-イル)-7-デアザ-2´-デオキシグアノシンを有する蛍光プローブ}, booktitle = {}, year = 2016, } @inproceedings{CTT100723600, author = {Leo Takeshita and Kentaro Ohno and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Chemical and Enzymatic Synthesis of Photo-caged DNA containing N1-Nitrobenzyl-2´-deoxypseudouridine for UV Dependent Regulation of Transcription}, booktitle = {}, year = 2016, } @inproceedings{CTT100723585, author = {Takahito Tomori and Kento Nagaoka and Yuya Miyatake and Yoshiaki Masaki and Mitsuo Sekine and Kohji seio}, title = {Synthesis and Enzymatic Properties of C-nucleoside Triphosphate Containing Pyridazin-3-one As a Uracil Analog}, booktitle = {}, year = 2016, } @inproceedings{CTT100723580, author = {Takeshi Inde and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Base Pair Recognition of Alpha-deoxyribonucleosides with Unmodified Nucleobase and 8-Oxo-adenine in Antiparallel DNA Triplex}, booktitle = {}, year = 2016, } @inproceedings{CTT100724410, author = {宮村 大地 and 金森 功吏 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {塩基部5位に3-メチルベンゾフラン誘導体を導入した2'-デオキシウリジンの合成と蛍光特性}, booktitle = {}, year = 2016, } @inproceedings{CTT100724885, author = {小田雄貴 and 伊藤比佑吾 and 金森功吏 and 大窪章寛 and 正木慶昭 and 関根光雄 and 清尾康志}, title = {塩基性条件下不安定なヌクレオシド三リン酸の新規合成法の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100724396, author = {友利 貴人 and 長岡 健斗 and 宮武 佑弥 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {ピリダジン-3-オンを核酸塩基部に有する/C/ヌクレオシドの合成と性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724394, author = {山本 恵士 and 正木 慶昭 and 吉田圭汰 and 入山 友輔 and 中嶋 宏之 and 金木 達朗 and 関根 光雄 and 清尾 康志}, title = {2-(N-エチルカルバモイル)エチル構造を有する糖部修飾核酸の合成と性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724389, author = {北川 諒 and 田胡 信広 and 関谷 彰太 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {スルホンアミド骨格を有するヌクレオシド誘導体の合成と性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724887, author = {Hiroya Asami and Munefumi Tokugawa and Yoshiaki Masaki and Eric Gloaguen and Kohji Seio and Mitsuo Sekine and Michel Mons}, title = {An Effective Molecular Model for Nanosecond Laser Spectroscopy of Short-lived Nucleobase: Application to Anharmonic Vibrational Analysis in the Mid-IR Region}, booktitle = {}, year = 2016, } @inproceedings{CTT100724884, author = {岸村智太 and 印出健志 and 正木慶昭 and 関根光雄 and 清尾康志}, title = {アンチセンス核酸の5´末端に糖を修飾するためのリンカーの設計と合成}, booktitle = {}, year = 2016, } @inproceedings{CTT100724400, author = {竹下 玲央 and 大野 健太郎 and 正木 慶昭 and 関根 光雄 and 清尾 康志}, title = {DNA-タンパク質相互作用の光制御をめざした光ケージされたデオキシシュードウリジンを含む核酸の合成および性質}, booktitle = {}, year = 2016, } @inproceedings{CTT100724896, author = {Yoshiaki Masaki and Keishi Yamamoto and Takeshi Inde and Tetsuya Nagata and Jun Tanihata and Yusuke Iriyama and Shinishi Takeda and Mitsuo Sekine and KOHJI SEIO}, title = {Enhancement of exon skipping efficiency by using antisense oligonucleotides containing 2-thiothymidine derivatives}, booktitle = {}, year = 2015, } @inproceedings{CTT100723567, author = {Yoshiaki Masaki and Keishi Yamamoto and Takeshi Inde and Tetsuya Nagata and Jun Tanihata and Yusuke Iriyama and Shin'ichi Takeda and Kohji Seio and Mitsuo Sekine}, title = {Enhancement of exon skipping by 2´-O-(N-methylcarbamoyl)ethyl (MCE) and/or nucleobase modified nucleosides incorporation into phosphorothioate oligonucleotides}, booktitle = {}, year = 2015, } @inproceedings{CTT100723956, author = {Yu Ito and Takashi Kanamori and Yoshiaki Masaki and Akihiro Ohkubo and Kohji Seio and Mitsuo Sekine}, title = {Synthesis of deoxyuridine derivatives modified with 2,4-diaminopyrimidine moiety for the development of high affinity triplex forming oligonucleotides}, booktitle = {}, year = 2015, } @inproceedings{CTT100723963, author = {Kentaro Ohno and Leo Takeshita and Yoshihiro Iijima and Takashi Kanamori and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Synthesis of oligonucleotides containing photo-caged 2´ -deoxypseudouridine for the regulation of DNA-protein interaction}, booktitle = {}, year = 2015, } @inproceedings{CTT100723961, author = {Ayano Yamazaki and Kei Yamaguchi and Takashi Kanamori and Yoshiaki Masaki and Mitsuo Sekine and Kohji Seio}, title = {Synthesis of oligodeoxynucleotides containing 2´-deoxy-pseudoisocytidine for the development of chemically modified DNA duplexes and triplexes}, booktitle = {}, year = 2015, } @inproceedings{CTT100724868, author = {大野 健太郎 and 正木 慶昭 and 金森 功吏 and 関根 光雄 and 清尾 康志}, title = {光ケージヌクレオシド三リン酸の合成と性質}, booktitle = {}, year = 2015, } @inproceedings{CTT100724858, author = {山本 恵士 and 正木 慶昭 and 石井 陽大 and 印出 健志 and 金森 功吏 and 関根 光雄 and 清尾 康志}, title = {2'-O-メチルカルバモイルエチル修飾2-チオリボチミジンを含むオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2015, } @inproceedings{CTT100724882, author = {田胡信広 and 北川諒 and Adam Kotolik and Nathaniel E. Clark and Eric J. Montemayor and P. John Hart and 正木 慶昭 and 金森 功吏 and 関根 光雄 and 清尾 康志 and Masad J. Damha}, title = {5'-アミノグアノシンを分岐部位に導入した2'-5'修飾分岐RNAの合成と性質}, booktitle = {}, year = 2015, } @misc{CTT100786540, author = {清尾康志 and 岡本到 and 関根光雄}, title = {2-チオウリジンを利用したアンチセンス核酸の化学合成と性質}, year = 2004, } @misc{CTT100596390, author = {KOHJI SEIO}, title = {環状構造によりコンホメーションを固定化した核酸の化学合成と高次構造制御に関する研究}, year = 1996, } @misc{CTT100907829, author = {清尾康志 and 正木慶昭 and 友利貴人 and 植草宏哉}, title = {2’位にアミノスルホニルアルコキシ基を有する新規人工核酸}, howpublished = {公開特許}, year = 2023, month = {}, note = {特願2022-031303(2022/03/01), 特開2023-127483(2023/09/13)} } @misc{CTT100907817, author = {清尾康志 and 正木慶昭 and 金川峻幸 and 小山彩}, title = {塩基部修飾ヌクレオシドを含む新規アンチセンス核酸}, howpublished = {公開特許}, year = 2023, month = {}, note = {特願2022-031307(2022/03/01), 特開2023-127484(2023/09/13)} } @misc{CTT100846525, author = {清尾康志 and 正木慶昭 and 山本恵士 and 吉田圭汰 and 入山 友輔 and 中嶋 宏之 and 金木 達朗}, title = {人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド}, howpublished = {登録特許}, year = 2022, month = {}, note = {特願2020-202186(2020/12/04), 特開2021-046433(2021/03/25), 特許第7085739号(2022/06/09)} } @misc{CTT100869598, author = {清尾康志 and 正木慶昭 and 友利貴人}, title = {アンチセンス核酸の毒性を軽減する方法}, howpublished = {公開特許}, year = 2021, month = {}, note = {PCT/JP2020/044370(2020/11/27), WO 2021/107143(2021/06/03)} } @misc{CTT100846537, author = {正木慶昭 and 清尾康志 and 井上敦 and 入山友輔 and 金木達朗 and 中嶋宏之}, title = {毒性が低減されたアンチセンスオリゴヌクレオチド}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-507884(2019/03/20), 再表/2019/182037(2021/03/11)} } @misc{CTT100845884, author = {清尾康志 and 正木慶昭 and 大野健太郎 and 友利貴人}, title = {グアノシン-3’,5’-ビスジホスフェートの製造方法及びその製造中間体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-571182(2019/02/08), 再表2019/156240(2021/01/28), 特許第7205914号(2023/01/06)} } @misc{CTT100845919, author = {清尾康志 and 正木慶昭}, title = {スルホンアミド骨格をもつオリゴヌクレオチドを鋳型として用いたDNA複製法}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2019-568531(2018/02/02), 再表2019/150564(2021/02/04)} } @misc{CTT100793185, author = {清尾康志 and 正木慶昭 and 山本恵士 and 吉田圭汰 and 入山 友輔  and 中嶋 宏之 and 金木 達朗 }, title = {人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド}, howpublished = {登録特許}, year = 2021, month = {}, note = {特願2018-500218(2017/02/17), 再表2017/142054(2018/12/06), 特許第6853537号(2021/03/16)} } @misc{CTT100758860, author = {清尾康志 and 正木慶昭 and 島崎 猛夫 and 山本 聡子}, title = {アンチセンスオリゴ核酸化合物およびその配列決定法}, howpublished = {公開特許}, year = 2017, month = {}, note = {特願2016-070202(2016/03/31), 特開2017-176074(2017/10/05)} } @misc{CTT100690777, author = {関根光雄 and 清尾康志 and 大窪章寛 and 角田浩佑 and 正木慶昭 and 金森功吏 and 山田 希 and 山崎一史 and 伊藤比祐吾}, title = {2'-0-カルバモイル修飾ヌクレオシド三リン酸}, howpublished = {登録特許}, year = 2017, month = {}, note = {特願2013-152578(2013/07/23), 特開2015-020994(2015/02/02), 特許第6261027号(2017/12/22)} } @misc{CTT100660981, author = {清尾康志 and 関根光雄 and 宮崎 一也 and 黒萩 早耶子 and 兒玉 恵里佳}, title = {オリゴヌクレオチド誘導体}, howpublished = {公開特許}, year = 2013, month = {}, note = {特願2012-500643(2011/02/17), 特開(再表)2011/102414(2013/06/17)} } @misc{CTT100626090, author = {清尾康志 and 関根光雄 and 角田 浩佑 and 伊勢 美沙子 and 八代 洵 and 中原 雄二}, title = {シリル化ヌクレオシド合成法}, howpublished = {公開特許}, year = 2011, month = {}, note = {特願2009-237339(2009/10/14), 特開2011-084495(2011/04/28)} } @misc{CTT100593886, author = {関根光雄 and 清尾康志 and 大窪章寛 and 角田 浩佑 and 工藤 智美}, title = {ヌクレオシドトリホスフェート誘導体}, howpublished = {公開特許}, year = 2009, month = {}, note = {特願2008-057295(2008/03/07), 特開2009-215171(2009/09/24)} } @misc{CTT100592292, author = {清尾康志 and 関根光雄 and 高久 悠介 and 宮崎 一也}, title = {オリゴヌクレオチド誘導体}, howpublished = {公開特許}, year = 2009, month = {}, note = {特願2008-030372(2008/02/12), 特開2009-190983(2009/08/27)} } @misc{CTT100591489, author = {関根光雄 and 山田 剛史 and 実吉 尚郎 and 清尾康志}, title = {2’水酸基修飾リボヌクレオシド誘導体}, howpublished = {登録特許}, year = 2013, month = {}, note = {特願2008-503910(2007/03/08), 特開(再表)2007/102581(2009/07/13), 特許第5194256号(2013/02/15)} } @misc{CTT100572863, author = {関根光雄 and 実吉 尚郎 and 宮田 健一 and 清尾康志}, title = {新規亜リン酸エステルの酸化方法}, howpublished = {公開特許}, year = 2008, month = {}, note = {特願2006-312193(2006/10/20), 特開2008-100976(2008/05/01)} } @misc{CTT100591483, author = {関根光雄 and 清尾康志 and 大窪章寛 and 田中 邦彦}, title = {オリゴヌクレオチド固定化固相担体}, howpublished = {公開特許}, year = 2009, month = {}, note = {特願2006-066396(2006/03/10), 特開2009-153381(2009/07/16)} } @misc{CTT100572990, author = {清尾康志 and 関根光雄 and 高久 悠介}, title = {オリゴヌクレオチド誘導体}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2006-066135(2006/03/10), 特開2007-238550(2007/09/20)} } @misc{CTT100572764, author = {関根光雄 and 田口 晴彦 and 山田 研 and 清尾康志}, title = {エステル結合を有するヌクレオシド誘導体}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2006-059370(2006/03/06), 特開2007-238462(2007/09/20)} } @misc{CTT100577192, author = {関根光雄 and 清尾康志 and 大窪章寛 and 坂本 一石 and 佐々見 武志}, title = {オリゴヌクレオチド誘導体、遺伝子検出用プローブ及びDNAチップ}, howpublished = {登録特許}, year = 2011, month = {}, note = {特願2007-505962(2006/02/28), 再表2006-093157(2008/08/07), 特許第4882074号(2011/12/16)} } @misc{CTT100572772, author = {関根光雄 and 清尾康志 and 大窪章寛}, title = {固体支持体及びDNAチップ}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-263722(2005/09/12), 特開2007-078399(2007/03/29)} } @misc{CTT100572997, author = {関根光雄 and 田口 晴彦 and 成田 岳史 and 清尾康志}, title = {ヌクレオシド誘導体及びその製造方法}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-270041(2005/09/16), 特開2007-077109(2007/03/29)} } @misc{CTT100572792, author = {関根光雄 and 宮下 拓平 and 清尾康志}, title = {ピロリン酸アナログ及びピロリン酸アナログ合成方法}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-264155(2005/09/12), 特開2007-077043(2007/03/29)} } @misc{CTT100572981, author = {関根光雄 and KARWOWSKI and 清尾康志 and 清尾 康志}, title = {RNA合成に有用な水酸基の新規保護基を有する化合物}, howpublished = {公開特許}, year = 2006, month = {}, note = {特願2005-260564(2005/09/08), 特開2006-077013(2006/03/23)} } @misc{CTT100572914, author = {関根光雄 and 寺田 武史 and 清尾康志}, title = {動的カチオン感受性部位を挿入した新規ヌクレオシド誘導体}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-261657(2005/09/09), 特開2007-070308(2007/03/22)} } @misc{CTT100572869, author = {関根光雄 and 宮田 健一 and 峯尾 良太 and 清尾康志}, title = {ヌクレオシド誘導体}, howpublished = {登録特許}, year = 2012, month = {}, note = {特願2005-196680(2005/07/05), 特開2007-015948(2007/01/25), 特許第5017639号(2012/06/22)} } @misc{CTT100572998, author = {関根光雄 and 清尾康志 and 岡本 到 and 尾島 晃司郎}, title = {ヌクレオシドホスホロアミダイト化合物}, howpublished = {公開特許}, year = 2006, month = {}, note = {特願2005-067121(2005/03/10), 特開2006-248975(2006/09/21)} } @misc{CTT100572975, author = {関根光雄 and 俵田 隆哉 and 清尾康志}, title = {ヌクレオシド、ヌクレオシド誘導体、オリゴヌクレオチド、及びオリゴヌクレオチド会合体}, howpublished = {公開特許}, year = 2006, month = {}, note = {特願2005-067805(2005/03/10), 特開2006-248987(2006/09/21)} } @misc{CTT100572816, author = {関根光雄 and 清尾康志 and 大窪章寛 and 粕谷 林太郎}, title = {トリチル型化合物}, howpublished = {公開特許}, year = 2006, month = {}, note = {特願2005-066555(2005/03/10), 特開2006-248956(2006/09/21)} } @misc{CTT100573343, author = {関根光雄 and 玉木 継吾 and 實吉 尚郎 and 清尾康志}, title = {2’-O-修飾ヌクレオシドの製造方法}, howpublished = {公開特許}, year = 2006, month = {}, note = {特願2005-064888(2005/03/09), 特開2006-248930(2006/09/21)} } @misc{CTT100573194, author = {関根光雄 and 實吉 尚郎 and 清尾康志}, title = {リボヌクレオシドの2’水酸基の脱保護方法}, howpublished = {登録特許}, year = 2011, month = {}, note = {特願2005-064883(2005/03/09), 特開2006-248929(2006/09/21), 特許第4797156号(2011/08/12)} } @misc{CTT100573042, author = {関根光雄 and 宮田 健一 and 玉虫 隆二 and 清尾康志}, title = {置換カルバモイル基を保護基とした核酸の合成方法}, howpublished = {公開特許}, year = 2006, month = {}, note = {特願2005-064892(2005/03/09), 特開2006-248931(2006/09/21)} } @phdthesis{CTT100596390, author = {KOHJI SEIO}, title = {環状構造によりコンホメーションを固定化した核酸の化学合成と高次構造制御に関する研究}, school = {東京工業大学}, year = 1996, }