@book{CTT100887278, author = {門之園 哲哉}, title = {シン・中分子ペプチド創薬への技術革新と進化}, publisher = {羊土社}, year = 2022, } @book{CTT100810129, author = {門之園 哲哉}, title = {構造計算を利用した高精度デザインペプチドライブラリー}, publisher = {情報機構}, year = 2019, } @book{CTT100810128, author = {門之園 哲哉 and 近藤 科江}, title = {CDRペプチドの構造ゆらぎ制御による抗体代替小型タンパク質デザイン}, publisher = {シーエムシー出版}, year = 2019, } @book{CTT100793140, author = {Tetsuya Kadonosono and Yumi Ota and Wanaporn Yimchuen and Kyra See and Tadaomi Furuta and Takahiro Kuchimaru and Shinae Kondoh}, title = {Creation of High Performance Antibody Drug Alternatives Harboring Constrained CDR Peptides}, publisher = {The Japanese Peptide Society, Osaka}, year = 2018, } @book{CTT100766718, author = {門之園 哲哉}, title = {化学合成可能な高性能抗体代替分子の開発技術}, publisher = {技術情報協会}, year = 2017, } @article{CTT100629722, author = {Tetsuya Kadonosono and Eri Chatani and Rikimaru Hayashi and Hideaki Moriyama and Tatzuo Ueki}, title = {Minimization of cavity size ensures protein stability and folding: structures of Phe46-replaced bovine pancreatic RNase A}, journal = {Biochemistry}, year = 2003, } @article{CTT100629725, author = {Seiji Shibasaki and Ai Kawabata and Jun Ishii and Shunsuke Yagi and Tetsuya Kadonosono and Michiko Kato and Nobuo Fukuda and Akihiko Kondo and Mitsuyoshi Ueda}, title = {Construction of a novel synergistic system for production and recovery of secreted recombinant proteins by the cell surface engineering}, journal = {Applied Microbiology and Biotechnology}, year = 2007, } @article{CTT100629728, author = {Tetsuya Kadonosono and Michiko Kato and Mitsuyoshi Ueda}, title = {Substrate specificity of rat brain neurolysin disclosed by molecular display system and putative substrates in rat tissues}, journal = {Applied Microbiology and Biotechnology}, year = 2007, } @article{CTT100629732, author = {Tetsuya Kadonosono and Michiko Kato and Mitsuyoshi Ueda}, title = {Metallopeptidase, neurolysin, as a novel molecular tool for analysis of properties of cancer-producing matrix metalloproteinases-2 and -9}, journal = {Applied Microbiology and Biotechnology}, year = 2007, } @article{CTT100629733, author = {Takeshi Fukuda and Michiko Kato-Murai and Tetsuya Kadonosono and Hiroshi Sahara and Yoji Hata and Shin-ichiro Suye and Mitsuyoshi Ueda}, title = {Enhancement of substrate recognition ability by combinatorial mutation of beta-glucosidase displayed on the yeast cell surface}, journal = {}, year = 2007, } @article{CTT100629735, author = {Norihiko Okochi and Michiko Kato-Murai and Tetsuya Kadonosono and Mitsuyoshi Ueda}, title = {Design of a serine protease-like catalytic triad on an antibody light chain displayed on the yeast cell surface}, journal = {Applied Microbiology and Biotechnology}, year = 2007, } @article{CTT100629736, author = {Tetsuya Kadonosono and Michiko Kato-Murai and Mitsuyoshi Ueda}, title = {Alteration of substrate specificity of rat neurolysin from matrix metalloproteinase-2/9-type to -3-type specificity by comprehensive mutation}, journal = {Protein Engineering Design and Selection}, year = 2008, } @article{CTT100629740, author = {Takahiro Kuchimaru and Tetsuya Kadonosono and Shotaro Tanaka and Takashi Ushiki and Masahiro Hiraoka and Shinae Kizaka-Kondoh}, title = {In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system}, journal = {PLoS One}, year = 2010, } @article{CTT100916696, author = {Maho Kaminaga and Shuta Otomo and Seisyu Tsunozaki and Tetsuya Kadonosono and Toru Omata}, title = {Fabrication of a Cancer Cell Aggregate Culture Device That Facilitates Observations of Nutrient and Oxygen Gradients}, journal = {Micromachines (Basel)}, year = 2024, } @article{CTT100916697, author = {Ning Lin and Kotaro Miyamoto and Takumi Ogawara and Saki Sakurai and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {Epitope binning for multiple antibodies simultaneously using mammalian cell display and DNA sequencing}, journal = {Communications Biology}, year = 2024, } @article{CTT100916695, author = {John Clyde CoSoriano and Shiho Tsutsumi and Daiya Ohara and Keiji Hirota and Gen Kondoh and Tatsuya Niwa and Hideki Taguchi and Tetsuya Kadonosono* and Shinae Kizaka-Kondoh}, title = {Identification of surface markers and functional characterization of myeloid derived suppressor cell-like adherent cells}, journal = {Adv Biol (Weinh)}, year = 2024, } @article{CTT100916694, author = {M. Minegishi and T. Kuchimaru and K. Nishikawa and T. Isagawa and S. Iwano and K. Iida and H. Hara and S. Miura and M. Sato and S. Watanabe and A. Shiomi and Y. Mabuchi and H. Hamana and H. Kishi and T. Sato and D. Sawaki and S. Sato and Y. Hanazono and A. Suzuki and T. Kohro and T. Kadonosono and T. Shimogori and A. Miyawaki and N. Takeda and H. Shintaku and S. Kizaka-Kondoh and S. Nishimura}, title = {Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches}, journal = {Nature Communications}, year = 2023, } @article{CTT100916693, author = {H. Miyabara and R. Hirano and S. Watanabe and J.C. CoSoriano and H. Watanabe and T. Kuchimaru and N. Kitada and T. Kadonosono and S.A. Maki and G. Kondoh and S. Kizaka-Kondoh}, title = {In vivo optical imaging of tumor stromal cells with hypoxia-inducible factor activity}, journal = {Cancer Science}, year = 2023, } @article{CTT100887276, author = {Yuichi Kida and Toshiki Sawada and Tomio Iwasaki and Tetsuya Kadonosono and Takeshi Serizawa}, title = {Identification of peptides as a molecular glue for polytetrafluoroethylene}, journal = {Polymer journal}, year = 2023, } @article{CTT100887277, author = {R. Hirano and K. Okamoto and M. Shinke and M. Sato and S. Watanabe and H. Watanabe and G. Kondoh and T. Kadonosono and S. Kizaka-Kondoh}, title = {Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases}, journal = {Communications Biology}, year = 2023, } @article{CTT100877103, author = {T. Kadonosono and K. Miyamoto and S. Sakai and Y. Matsuo and S. Kitajima and Q. Wang and M. Endo and M. Niibori and T. Kuchimaru and T. Soga and K. Hirota and S. Kizaka-Kondoh}, title = {AGE/RAGE axis regulates reversible transition to quiescent states of ALK-rearranged NSCLC and pancreatic cancer cells in monolayer cultures}, journal = {Sci. Rep.}, year = 2022, } @article{CTT100869024, author = {Tsuyohi Sato and Akira Hamai and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Toru Omata}, title = {Droplet-based valveless microfluidic system for phage-display screening against spheroids}, journal = {Biomicrofluidics}, year = 2022, } @article{CTT100863448, author = {K. See and T. Kadonosono and K. Miyamoto and T. Tsubaki and Y. Ota and M. Katsumi and S. Ryo and K. Aida and M. Minegishi and T. Isozaki and T. Kuchimaru and S. Kizaka-Kondoh}, title = {Antibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display}, journal = {Sci. Rep.}, year = 2021, } @article{CTT100863447, author = {Y. Matsuzaki and W. Aoki and T. Miyazaki and S. Aburaya and Y. Ohtani and K. Kajiwara and N. Koike and H. Minakuchi and N. Miura and T. Kadonosono and M. Ueda}, title = {Peptide barcoding for one-pot evaluation of sequence-function relationships of nanobodies}, journal = {Sci. Rep.}, year = 2021, } @article{CTT100855598, author = {Masayoshi Tanaka and Mirei Hayashi and Roach Lucien and Yuka Kiriki and Tetsuya Kadonosono and Takahiro Nomoto and Nobuhiro Nishiyama and Choi Jonghoon and Critchley Kevin and D. Evans Stephen and Mina Okochi}, title = {Synthesis of near-infrared absorbing triangular Au nanoplates using biomineralisation peptides}, journal = {ACTA Biomaterialia}, year = 2021, } @article{CTT100854462, author = {M. Minegishi and T. Kuchimaru and K. Nakagawa and T. Isozaki and S. Fujimori and T. Kadonosono and S. Kizaka-Kondoh}, title = {Multiplexed bioluminescence imaging of cancer cell response to hypoxia and inflammation in the caudal-artery injection model of bone metastasis during zoledronic acid treatment}, journal = {Journal of Cancer Metastasis and Treatment}, year = 2021, } @article{CTT100849456, author = {Diem Thi Phuong Tran and Takahiro Kuchimaru and Mongkol Pongsuchart and Kha The Nguyen and John Clyde L.Co Soriano and Tetsuya Kadonosono and Shinae Kizaka-Kondoh.}, title = {ROR2 regulates the survival of murine osteosarcoma cells in lung capillaries}, journal = {Journal of Cancer Metastasis and Treatment}, year = 2020, } @article{CTT100834999, author = {Kyra See and Tetsuya Kadonosono and Yumi Ota and Kotaro Miyamoto and Wanaporn Yimchuen and Shinae Kizaka-Kondoh}, title = {Reconstitution of an anti-HER2 antibody paratope by grafting dual CDR-derived peptides onto a small protein scaffold}, journal = {Biotechnology Journal}, year = 2020, } @article{CTT100826200, author = {Satoru Kuriu and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Tadashi Ishida}, title = {Slicing spheroids in microfluidic devices for morphological and immunohistochemical analysis}, journal = {Micromachines (Basel)}, year = 2020, } @article{CTT100826199, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Yumi Ota and Shinichi Sato and Maika Kitazawa and Tadashi Shiozawa and Takahiro Kuchimaru and Masumi Taki and Yuji Ito and Hiroyuki Nakamura and Shinae Kizaka-Kondoh}, title = {Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold}, journal = {RSC Advances}, year = 2020, } @article{CTT100826198, author = {Shinichi Sato and Masaki Matsumura and Tetsuya Kadonosono and Satoshi Abe and Takafumi Ueno and Hiroshi Ueda and Hiroyuki Nakamura}, title = {Site-selective protein chemical modification of exposed tyrosine residues using tyrosine click reaction}, journal = {Bioconjugate Chemistry}, year = 2020, } @article{CTT100826196, author = {K. Okuda and B. G. M. Youssif and R. Sakai and T. Ueno and T. Sakai and T. Kadonosono and Y. Okabe and O. I. Abdel R. Salem and A. M. Hayallah and M. A. Hussein and S. Kizaka-Kondoh and H. Nagasawa}, title = {Development of Near-Infrared Fluorescent Probes with Large Stokes Shifts for Non-Invasive Imaging of Tumor Hypoxia}, journal = {Heterocycles}, year = 2020, } @article{CTT100826197, author = {T. Kadonosono and S. Kizaka-Kondoh}, title = {Semi-rational Design of Target-binding Small Proteins for Cancer Treatment}, journal = {Yakugaku Zasshi}, year = 2020, } @article{CTT100814829, author = {Tetsuya Kadonosono and Wanaporn Yimchuen and Yumi Ota and Kyra See and Tadaomi Furuta and Tadashi Shiozawa and Maika Kitazawa and Yu Goto and Akash Patil and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use}, journal = {Sci. Rep.}, year = 2020, } @article{CTT100810170, author = {S. Fuse and K. Suzuki and T. Kuchimaru and T. Kadonosono and H. Ueda and S. Sato and S. Kizaka-Kondoh and H. Nakamura}, title = {Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity}, journal = {Bioorg. Med. Chem}, year = 2019, } @article{CTT100810127, author = {Maho Kaminaga and Tadashi Ishida and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Toru Omata}, title = {Microfluidic device for screening for target cell-specific binding molecules by using adherent cells}, journal = {Micromachines (Basel)}, year = 2019, } @article{CTT100774027, author = {Mongkol Pongsuchart and Takahiro Kuchimaru and Sakiko Yonezawa and Diem Thi Phuong Tran and Nguyen The Kha and Ngoc Thi Hong Hoang and Tetsuya Kadonosono and Shinae Kondoh}, title = {Novel lymphoid enhancer-binding factor 1-cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs}, journal = {Cancer Science}, year = 2018, } @article{CTT100774026, author = {Koh K. Takita and Kazunori K. Fujii and Tetsuya Kadonosono and Ryo Masuda and Takaki Koide}, title = {Cyclic Peptides for Efficient Detection of Collagen}, journal = {Chembiochem}, year = 2018, } @article{CTT100774028, author = {Takahiro Kuchimaru and Naoya Kataoka and Kenji Nakagawa and Tatsuhiro Isozaki and Hitomi Miyabara and Misa Minegishi and Tetsuya Kadonosono and Shinae Kondoh}, title = {A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries}, journal = {Nat Commun}, year = 2018, } @article{CTT100766717, author = {Takuya Tsubaki and Tetsuya Kadonosono and Shimon Sakurai and Tadashi Shiozawa and Toshiki Goto and Shiori Sakai and Takahiro Kuchimaru and Takeharu Sakamoto and Hitomi Watanabe and Gen Kondoh and Shinae Kizaka-Kondoh}, title = {Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment}, journal = {Oncotarget}, year = 2018, } @article{CTT100745064, author = {T. Kadonosono and W. Yimchuen and T. Tsubaki and T. Shiozawa and Y. Suzuki and T. Kuchimaru and Y. Sato and S. Kizaka-Kondoh}, title = {Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release}, journal = {Protein Sci}, year = 2017, } @article{CTT100745068, author = {T. Kuchimaru and T. Suka and K. Hirota and T. Kadonosono and S. Kizaka-Kondoh}, title = {A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system}, journal = {Sci Rep}, year = 2016, } @article{CTT100745075, author = {近藤 科江 and 口丸 高弘 and 門之園 哲哉}, title = {生体光イメージング研究「生体の窓」活用の最前線}, journal = {実験医学}, year = 2016, } @article{CTT100712113, author = {Hoang NT and Kadonosono T and Kuchimaru T and Kizaka-Kondoh S.}, title = {Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model.}, journal = {Cancer Science}, year = 2016, } @article{CTT100712114, author = {Kuchimaru T. and Iwano S. and Kiyama M. and Mitsumata S. and Kadonosono T. and Niwa H. and Maki S. and Kizaka-Kondoh S.}, title = {A luciferin analog generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.}, journal = {Nat Commun,}, year = 2016, } @article{CTT100709403, author = {Sachiko Horie and Yasuhiro Suzuki and Miho Kobayashi and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Tetsuya Kodama and Yasufumi Sato}, title = {Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis}, journal = {Cancer Gene Therapy}, year = 2016, } @article{CTT100712738, author = {近藤科江 and 口丸高弘 and 門之園哲哉}, title = {がん間質における低酸素応答が悪性化を駆動する}, journal = {実験医学}, year = 2016, } @article{CTT100709398, author = {Ayumi Yoshida and Akio Shimizu and Hirotsugu Asano and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Elena Geretti and Akiko Mammoto and Michael Klagsbrun and Misuzu Kurokawa-Seo}, title = {VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells}, journal = {Biology Open}, year = 2015, } @article{CTT100709395, author = {Hiromi Kurokawa and Hidehiro Ito and Mai Inoue and Yoshifumi Sato and Shinae Kizaka-Kondoh and Tetsuya Kadonosono and Shigenobu Yano and Masahiro Inoue and Toshiaki Kamachi}, title = {High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime}, journal = {Scientific Reports}, year = 2015, } @article{CTT100709391, author = {Tetsuya Kadonosono and Akihiro Yamano and Toshiki Goto and Takuya Tsubaki and Mizuho Niibori and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {Cell penetrating peptides improve tumor delivery of cargos through Neuropilin-1-dependent extravasation}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100674916, author = {Tetsuya Kadonosono and Etsuri Yabe and Tadaomi Furuta and Akihiro Yamano and Takuya Tsubaki and Takuya Sekine and Takahiro Kuchimaru and Minoru Sakurai and Shinae Kizaka-Kondoh}, title = {A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides}, journal = {PLOS ONE}, year = 2014, } @article{CTT100681495, author = {Takahiro Kuchimaru and Takuya Hoshino and Tomoya Aikawa and Hisataka Yasuda and Tatsuya Kobayashi and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia.}, journal = {Cancer Science}, year = 2014, } @article{CTT100745074, author = {口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {血管系のin vivoイメージング:腫瘍HIFのイメージング}, journal = {血管医学}, year = 2013, } @article{CTT100745071, author = {須加 智也 and 山口 鉄郎 and 口丸 高弘 and 廣田 圭佑 and 石川 龍太郎 and 門之園 哲哉 and 近藤 科江}, title = {BRETを利用した機能性タンパク質プローブによる排泄臓器近傍における腫瘍内HIF活性の高コントラスト光イメージング}, journal = {JSMI report}, year = 2013, } @article{CTT100745073, author = {口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {低酸素がん特異的イメージングプローブの開発}, journal = {PET Journal}, year = 2013, } @article{CTT100681461, author = {Takahiro Kuchimaru and Tetsuya Kadonosono and Cesear Corona and Stephen Dwight and Mark McDougall and shuntaro takahashi and TOSHIAKI MORI and YOSHIO OKAHATA and Shinae Kizaka-Kondoh}, title = {Importance of the physicochemical properties of fluorescent dyes for obtaining target-specific in vivo images by membrane-permeable macromolecular imaging probes.}, journal = {Journal of Pharmaceutical Technology & Drug Research}, year = 2013, } @article{CTT100745070, author = {門之園 哲哉 and 近藤 科江}, title = {HIFs活性化細胞のバイオセンシングによる腫瘍内低酸素微小環境の可視化と治療薬開発}, journal = {医学のあゆみ}, year = 2012, } @article{CTT100681487, author = {Kensuke Okuda and Yasuyuki Okabe and Tetsuya Kadonosono and Takahiro Ueno and Bahaa Youssif and Shinae Kizaka-Kondoh and Hideko Nagasawa}, title = {2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.}, journal = {Bioconjugate Chamistry}, year = 2012, } @article{CTT100681457, author = {Youshi Fujita and Takahiro Kuchimaru and Tetsuya Kadonosono and Shotaro Tanaka and Yoshiki Hase and Hidekazu Tomimoto and Masahiro Hiraoka and Shinae Kizaka-Kondoh and Masafumi Ihara and Ryosuke Takahashi}, title = {In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe.}, journal = {PLOS ONE}, year = 2012, } @article{CTT100629746, author = {門之園哲哉 and 口丸高弘 and 近藤科江}, title = {がん低酸素微小環境を標的とする治療薬・可視化プローブの開発}, journal = {臨床放射線}, year = 2011, } @article{CTT100629747, author = {口丸高弘 and 門之園哲哉 and 近藤科江}, title = {癌微小環境における低酸素癌細胞のライブイメージング}, journal = {Surgery Frontier}, year = 2011, } @article{CTT100681480, author = {Tetsuya Kadonosono and Takahiro Kuchimaru and Shuichi Yamada and Yumi Takahashi and Atsushi Murakami and Taeko Tani and Hitomi Watanabe and Tomoharu Tanaka and Kiichi Hirota and Masahiro Inoue and Tetsuya Tsukamoto and Takeshi Toyoda and Koji Urano and Kazuhiko Machida and Tomoo Eto and Tomoyuki Ogura and Hideki Tsutsumi and Mamoru Ito and Masahiro Hiraoka and Gen Kondoh and Shinae Kizaka-Kondoh}, title = {Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging.}, journal = {PLOS ONE}, year = 2011, } @article{CTT100629745, author = {門之園哲哉 and 口丸高弘 and 近藤科江}, title = {すい臓がん治療効果の経時的光イメージング}, journal = {PETジャーナル}, year = 2010, } @article{CTT100629744, author = {門之園哲哉 and 口丸高弘 and 近藤科江}, title = {すい臓がんの進行とプロドラッグ治療効果の光イメージング}, journal = {日本分子イメージング学会誌}, year = 2010, } @article{CTT100629743, author = {門之園 哲哉 and 植田充美}, title = {次世代医療に向けたタンパク質デザインの展開}, journal = {日本生物工学会誌(ライフサーベイヤ特集)}, year = 2008, } @article{CTT100629742, author = {門之園 哲哉 and 村井(加藤) 倫子 and 植田 充美}, title = {抗体モデル機能タンパク質の創出}, journal = {抗体医薬の最前線}, year = 2007, } @inproceedings{CTT100916733, author = {松本真愛 and 近藤科江 and 門之園 哲哉}, title = {抗原親和性の異なるCAR-T細胞の活性化および疲弊マーカー発現パターン解析}, booktitle = {}, year = 2024, } @inproceedings{CTT100916705, author = {門之園 哲哉}, title = {抗原親和性エンジニアリングによる次世代バイオ医薬品デザイン}, booktitle = {}, year = 2024, } @inproceedings{CTT100916706, author = {門之園 哲哉}, title = {スマートデザインによる抗体模倣中分子ペプチドの創出}, booktitle = {}, year = 2024, } @inproceedings{CTT100916732, author = {上條航生 and 宮本康太郎 and 近藤科江 and 門之園 哲哉}, title = {RNA-seq遺伝子発現解析による休眠がん細胞マーカーの探索}, booktitle = {}, year = 2024, } @inproceedings{CTT100916735, author = {オンゴノ スワンディ and 近藤科江 and 門之園 哲哉}, title = {抗原密度依存的に結合するタンデム三量体Nanobodyの創出とADCC活性評価}, booktitle = {}, year = 2024, } @inproceedings{CTT100916734, author = {長谷川佳保 and 門之園 哲哉 and 近藤科江}, title = {細胞障害性の高い細胞を腫瘍へ誘導する二重特異性抗体の創製}, booktitle = {}, year = 2024, } @inproceedings{CTT100916731, author = {上條航生 and 宮本康太郎 and 近藤科江 and 門之園 哲哉}, title = {遺伝子発現解析による休眠がん細胞のバイオマーカー探索}, booktitle = {}, year = 2024, } @inproceedings{CTT100916704, author = {門之園 哲哉}, title = {哺乳類細胞ディスプレイを利用する高性能抗原結合分子の創出と評価}, booktitle = {}, year = 2024, } @inproceedings{CTT100916703, author = {門之園 哲哉}, title = {哺乳類細胞分子ディスプレイによる高性能バイオ医薬デザイン}, booktitle = {}, year = 2024, } @inproceedings{CTT100916702, author = {Tetsuya Kadonosono}, title = {Smart design system for developing high-performance biologics}, booktitle = {}, year = 2024, } @inproceedings{CTT100916727, author = {星慶吾 and Lin Ning and 門之園哲哉}, title = {生理活性ペプチドKp10の細胞表層ディスプレイと細胞増殖促進効果の解析}, booktitle = {}, year = 2023, } @inproceedings{CTT100916728, author = {Yuki Sakamoto and Mahiro Matsumoto and Tetsuya Kadonosono}, title = {抗原親和性の異なるHER2標的CAR-T細胞の活性化レベルおよび疲弊レベル解析}, booktitle = {}, year = 2023, } @inproceedings{CTT100916729, author = {山川 萌恵 and 小川原 巧 and 坂本 祐基 and Lin Ning and 門之園 哲哉}, title = {ナノ膜小胞による膜タンパク質標的抗体の結合親和性評価法の開発}, booktitle = {}, year = 2023, } @inproceedings{CTT100916725, author = {Suwandi Onggono and 門之園 哲哉}, title = {Development and binding-mode analysis of tandem trimeric nanobody to bind specifically on antigen-overexpressing cells}, booktitle = {}, year = 2023, } @inproceedings{CTT100916726, author = {Takumi Ogawara and Ning Lin and Tetsuya Kadonosono}, title = {Development of binding affinity scoring system for mammalian cell-surface displayed antibody library}, booktitle = {}, year = 2023, } @inproceedings{CTT100916724, author = {Ning Lin and Kotaro Miyamoto and Takumi Ogawara and Tetsuya Kadonosono}, title = {A Monoclonal Antibody-guided Screening Platform for the Efficient Identification of Epitope-specific Antibodies}, booktitle = {}, year = 2023, } @inproceedings{CTT100916722, author = {Keigo Hoshi and Takumi Ogawara and Lin Ning and Tetsuya Kadonosono}, title = {Evaluation of kisspeptin-10 activity using a mammalian cell-surface display system}, booktitle = {}, year = 2023, } @inproceedings{CTT100916721, author = {Takumi Ogawara and Lin Ning and Tetsuya Kadonosono}, title = {Development of affinity scoring system for mammalian cell-displayed antibody library}, booktitle = {}, year = 2023, } @inproceedings{CTT100916713, author = {Suwandi Onggono and Tetsuya Kadonosono}, title = {Development of nanobody for specific binding on antigen-high-expressing cells by affinity optimization and tandem trimerization}, booktitle = {}, year = 2023, } @inproceedings{CTT100916723, author = {Yuki Sakamoto and Mahiro Matsumoto and Tetsuya Kadonosono}, title = {抗原結合残基の置換によるHER2標的Nanobody型CAR-T細胞の親和性最適化}, booktitle = {}, year = 2023, } @inproceedings{CTT100916712, author = {門之園 哲哉}, title = {細胞ディスプレイを基軸とするバイオ医薬デザインシステムの開拓}, booktitle = {}, year = 2023, } @inproceedings{CTT100916708, author = {Ning Lin and Tetsuya Kadonosono}, title = {Development of Evaluation System for Antibody Epitopes by Co-display of Antibodies and Antigen on Mammalian Cells}, booktitle = {}, year = 2023, } @inproceedings{CTT100916711, author = {坂本 祐基 and 門之園 哲哉}, title = {CAR-T 細胞の活性化および疲弊レベル解析による抗原親和性最適化技術の開発}, booktitle = {}, year = 2023, } @inproceedings{CTT100916710, author = {小川原 巧 and 門之園 哲哉}, title = {抗体誘導スクリーニング法による抗体代替ナノボディの同定}, booktitle = {}, year = 2023, } @inproceedings{CTT100916709, author = {Onggono Suwandi and 門之園 哲哉}, title = {親和性最適化による標的細胞特異的な直列三量体ナノボディの創出}, booktitle = {}, year = 2023, } @inproceedings{CTT100916719, author = {山川 萌恵 and 小川原 巧 and 坂本 祐基 and Lin Ning and 門之園 哲哉}, title = {ナノ膜小胞MNVによる膜タンパク質標的抗体の親和性評価法の構築}, booktitle = {}, year = 2023, } @inproceedings{CTT100916717, author = {小川原 巧 and Lin Ning and 門之園 哲哉}, title = {細胞ディスプレイによるHER2結合分子ライブラリーの親和性一括スコア化}, booktitle = {}, year = 2023, } @inproceedings{CTT100916718, author = {星 慶吾 and Lin Ning and 門之園 哲哉}, title = {細胞表層にディスプレイしたKp10ペプチドの細胞増殖促進効果の解析}, booktitle = {}, year = 2023, } @inproceedings{CTT100916707, author = {Onggono Suwandi and 門之園 哲哉}, title = {親和性最適化による抗原過剰発現細胞に特異的な直列三量体ナノボディの創出}, booktitle = {}, year = 2023, } @inproceedings{CTT100916720, author = {上條 航生 and 宮本 康太郎 and 門之園 哲哉}, title = {休眠がん細胞を検出するためのバイオマーカーの探索}, booktitle = {}, year = 2023, } @inproceedings{CTT100916701, author = {門之園 哲哉}, title = {中分子ペプチド医薬の開発戦略と臨床応用への展望}, booktitle = {}, year = 2023, } @inproceedings{CTT100916716, author = {坂本 祐基 and 近藤 科江 and 門之園 哲哉}, title = {抗原親和性の異なるナノボディ型CAR-T細胞の活性化および疲弊レベル解析}, booktitle = {}, year = 2023, } @inproceedings{CTT100916714, author = {オンゴノ スワンディ and 近藤 科江 and 門之園 哲哉}, title = {抗原過剰発現細胞に特異的に結合する直列三量体ナノボディの創出}, booktitle = {}, year = 2023, } @inproceedings{CTT100916715, author = {小川原 巧 and 近藤 科江 and 門之園 哲哉}, title = {抗体誘導スクリーニング技術による抗体代替ナノボディの探索}, booktitle = {}, year = 2023, } @inproceedings{CTT100916700, author = {Tetsuya Kadonosono}, title = {Engineering of antibody-mimetic HER2-binding small proteins by Smart Design technology}, booktitle = {}, year = 2023, } @inproceedings{CTT100916699, author = {門之園 哲哉 and 近藤 科江}, title = {腫瘍内HIF活性化細胞を検出するナノ量子センサーの開発}, booktitle = {}, year = 2023, } @inproceedings{CTT100887290, author = {門之園哲哉 and 齋藤裕 and Lin Ning and 近藤科江}, title = {スマートデザインによる抗体代替HER2結合小型タンパク質の創出}, booktitle = {}, year = 2023, } @inproceedings{CTT100887298, author = {John Clyde Co Soriano and Daiya Ohara and Keiji Hirota and Gen Kondoh and Tatsuya Niwa and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Identification of Surface Markers and Functional activities of MDSC-like Adherent Cells (MLAC)}, booktitle = {}, year = 2022, } @inproceedings{CTT100887301, author = {Ng Sin Ying and Eriko Takano and Alex Nguyen and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {Evaluation of activation and exhaustion levels of CD25-targeting CAR-T cells with different binding affinities}, booktitle = {}, year = 2022, } @inproceedings{CTT100887300, author = {Ning Lin and Saki Sakurai and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {Development of an antibody-guided screening system for identifying epitope-directed anti-HER2 antibody mimetics}, booktitle = {}, year = 2022, } @inproceedings{CTT100887299, author = {Fahsai Nakarin and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {Development of a design system for T-cell receptor mimic antibodies targeting cancer neoantigens}, booktitle = {}, year = 2022, } @inproceedings{CTT100887289, author = {NG SIN YING and 高野 恵理子 and Alex Nguyen and 近藤 科江 and 門之園 哲哉}, title = {結合親和性の異なるCD25標的CAR-T細胞の活性化と疲弊レベルの評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100887279, author = {門之園 哲哉}, title = {抗体医薬代替分子のスマートデザインによる小型タンパク質創薬}, booktitle = {}, year = 2022, } @inproceedings{CTT100887288, author = {平野龍一郎 and 岡本浩輝 and 渡邊仁美 and 近藤玄 and 門之園哲哉 and 近藤科江}, title = {乳腺組織常在性マクロファージ阻害はトリプルネガティブ乳がん再発を抑制する}, booktitle = {}, year = 2022, } @inproceedings{CTT100887287, author = {櫻井咲季 and Lin Ning and 門之園哲哉 and 近藤科江}, title = {細胞表層ディスプレイによるHER2 結合分子群の親和性一括評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100887286, author = {高野 恵理子 and Ng Sin Ying and Alex Nguyen and 門之園 哲哉 and 近藤 科江}, title = {CD25 標的CAR-T 細胞の活性化および疲弊状態評価システムの開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100887285, author = {武藤昌也 and 佘一誠 and 平山明由 and 北島正二郎 and 曽我朋義 and 門之園哲哉 and 近藤科江}, title = {腫瘍内ネクローシス領域が関与する悪性化機構の解明}, booktitle = {}, year = 2022, } @inproceedings{CTT100887284, author = {佘一誠 and 武藤昌也 and 平山明由 and 北島正二郎 and 曽我朋義 and 門之園哲哉 and 近藤科江}, title = {腫瘍内ネクローシス領域の成分によるマクロファージ極性化作用の検証}, booktitle = {}, year = 2022, } @inproceedings{CTT100887281, author = {K Okamoto and Masaya Muto and Tetsuya Kadonosono and Kiichi Kaminaga and Ryuji Igarashi and Shinae Kizaka-Kondoh}, title = {Evaluation of the surface-modified nanodiamond probes by in vivo fluorescence imaging}, booktitle = {}, year = 2022, } @inproceedings{CTT100887283, author = {岡本浩輝 and 平野龍一郎 and 門之園哲哉 and 近藤科江}, title = {乳腺組織常在性間質細胞によるTNBC 増殖促進作用}, booktitle = {}, year = 2022, } @inproceedings{CTT100890906, author = {菊本要 and 門之園哲哉 and 小俣透}, title = {がん細胞スフェロイドを対象としたエンドサイトーシス抑制ファージディスプレイスクリーニングマイクロ流体デバ イス}, booktitle = {}, year = 2022, } @inproceedings{CTT100890907, author = {角崎青周 and 大友秀太 and 門之園哲哉 and 小俣透}, title = {低酸素低栄養領域の観察とアクセスが容易ながん細胞培養デバイス}, booktitle = {}, year = 2022, } @inproceedings{CTT100887297, author = {Saki Sakurai and Lin Ning and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {DEVELOPMENT OF AFFINITY EVALUATION SYSTEM FOR CELL-SURFACE DISPLAYED ANTIBODIES}, booktitle = {}, year = 2022, } @inproceedings{CTT100887296, author = {Eriko Takano and Ng Sin Ying and Alex Nguyen and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {Development of evaluation system for activation and exhaustion levels of CD25-targeting CAR-T cells}, booktitle = {}, year = 2022, } @inproceedings{CTT100887295, author = {Takumi Ogawara and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {ANTIBODY-GUIDED IDENTIFICATION OF ANTIBODY MIMETIC NANOBODIES}, booktitle = {}, year = 2022, } @inproceedings{CTT100887294, author = {岡本 浩輝 and 平野 龍一郎 and 門之園 哲哉 and 近藤 科江}, title = {乳腺組織常在性間質細胞による TNBC 増殖促進作用}, booktitle = {}, year = 2022, } @inproceedings{CTT100887293, author = {平野 龍一郎 and 岡本 浩輝 and 門之園 哲哉 and 近藤 科江}, title = {乳腺組織常在性マクロファージ阻害はトリプルネガティブ乳がん再発を抑制する}, booktitle = {}, year = 2022, } @inproceedings{CTT100887292, author = {武藤 昌也 and シェ 一誠 and 平山 明由 and 北島 正二朗 and 曽我 朋義 and 門之園 哲哉 and 近藤 科江}, title = {腫瘍内ネクローシス領域を介した悪性化機構におけるマクロファージの関与の解明}, booktitle = {}, year = 2022, } @inproceedings{CTT100887280, author = {Sin Ying Ng and Eriko Takano and Shinae Kizaka-Kondoh and Tetsuya Kadonosono}, title = {Development of evaluation system for the activity of CD25-targeting CAR-T cells}, booktitle = {}, year = 2022, } @inproceedings{CTT100887282, author = {Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Development of CD25-targeting antibody mimetics by antibody-guided library design and screening}, booktitle = {}, year = 2022, } @inproceedings{CTT100887291, author = {小川原 巧 and Lin Ning and 近藤 科江 and 門之園 哲哉}, title = {抗体誘導スクリーニングシステムによるPertuzumab代替Nanobodyの探索}, booktitle = {}, year = 2022, } @inproceedings{CTT100877115, author = {Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Display and selection of peptide library on mammalian cell surface for developing CD25-binding antibody mimetics}, booktitle = {}, year = 2022, } @inproceedings{CTT100877118, author = {門之園 哲哉 and 岡本 浩輝 and 武藤 昌也 and 神長 輝一 and 五十嵐 龍治 and 近藤 科江}, title = {In vivo蛍光イメージングによる表面修飾ナノダイヤモンドプローブの残留性評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100901437, author = {稲葉千尋 and 澤田敏樹 and 門之園哲哉 and 芹澤武}, title = {高分子結合性ペプチドの細胞表層ディスプレイとその温度依存的な親和性評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100877113, author = {Tetsuya Kadonosono}, title = {MAGPIE system for efficient development of small antibody mimetics}, booktitle = {}, year = 2022, } @inproceedings{CTT100865044, author = {Misa Minegishi and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Takahiro Kuchimaru}, title = {Novel technology for fluorescent protein labeling of stromal cells in close proximity to cancer cells in living tissues}, booktitle = {}, year = 2021, } @inproceedings{CTT100865043, author = {Tetsuya Kadonosono and Wanaporn Yimchuen and Kyra See and Shinae Kizaka-Kondoh}, title = {Strategic design to create clinically applicable HER2-targeting small proteins with immobilized target-binding peptides}, booktitle = {}, year = 2021, } @inproceedings{CTT100865047, author = {新毛 実結 and 平野 龍一郎 and 門之園 哲哉 and 渡邊 仁美 and 近藤 玄 and 近藤 科江}, title = {トリプルネガティブ乳がんの血管新生および局所再発における乳腺組織常在性細胞の関与}, booktitle = {}, year = 2021, } @inproceedings{CTT100865046, author = {岡本 浩輝 and 平野 龍一郎 and 門之園 哲哉 and 渡邊 仁美 and 近藤 玄 and 近藤 科江}, title = {乳腺組織常在性間質細胞によるTNBC増殖促進作用}, booktitle = {}, year = 2021, } @inproceedings{CTT100865045, author = {武藤 昌也 and 平山 明由 and 北島 正二郎 and 曽我 朋義 and 門之園 哲哉 and 近藤 科江}, title = {腫瘍内ネクローシス領域が関与する悪性化亢進メカニズムの解明}, booktitle = {}, year = 2021, } @inproceedings{CTT100865042, author = {Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Development of CD25-binding antibody mimetics by antibody-guided library design and screening}, booktitle = {}, year = 2021, } @inproceedings{CTT100863454, author = {門之園 哲哉}, title = {スマートデザインによるT細胞増殖促進ペプチドの創製}, booktitle = {}, year = 2021, } @inproceedings{CTT100863461, author = {宮本 康太郎 and 門之園 哲哉 and 北島 正二朗 and 曽我 朋義 and 近藤 科江}, title = {誘導性休眠がん細胞の低酸素低血清条件下でのトランスクリプトームおよびメタボローム解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100876436, author = {稲葉千尋 and 澤田敏樹 and 門之園哲哉 and 芹澤武}, title = {Polymer-binding peptide as a molecular tool for cell imaging}, booktitle = {}, year = 2021, } @inproceedings{CTT100863455, author = {平野 龍一郎 and 岡本 浩輝 and 新毛 実結 and 門之園 哲哉 and 近藤 科江}, title = {組織常在性細胞はトリプルネガティブ乳がんの増殖を促進する}, booktitle = {}, year = 2021, } @inproceedings{CTT100863453, author = {門之園 哲哉}, title = {スマートデザインによるCD25結合抗体代替ペプチドの創製}, booktitle = {}, year = 2021, } @inproceedings{CTT100863452, author = {Misa Minegishi and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Takahiro Kuchimaru}, title = {A Fluorescent labeling system of proximal cells for single-cell omics analysis of cellular interactions in metastasis}, booktitle = {}, year = 2021, } @inproceedings{CTT100863460, author = {武藤 昌也 and 平山 明由 and 北島 正二朗 and 曽我 朋義 and 門之園 哲哉 and 近藤 科江}, title = {腫瘍内ネクローシス領域が関与する悪性化機構の解明}, booktitle = {}, year = 2021, } @inproceedings{CTT100863451, author = {Shinae Kizaka-Kondoh and Hitomi Miyabara and Ryuichiro Hirano and Tetsuya Kadonosono and Takahiro Kuchimaru}, title = {Identification and elucidation of therapeutic targets by in vivo optical imaging}, booktitle = {}, year = 2021, } @inproceedings{CTT100876432, author = {茂呂健太 and 滝澤実咲 and 澤田敏樹 and 門之園哲哉 and 芹澤武}, title = {ペプチドの親和性に基づく機能性分子と医用高分子との効率的な複合化}, booktitle = {}, year = 2021, } @inproceedings{CTT100863450, author = {門之園 哲哉}, title = {抗体代替ペプチドのスマートデザインと革新的モダリティ創発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863457, author = {本間滉也 and 門之園哲哉 and 佐藤伸一 and 近藤科江}, title = {KISS1R発現がん細胞を検出する生物発光イメージングプローブの創製}, booktitle = {}, year = 2021, } @inproceedings{CTT100863459, author = {宮本康太郎 and 門之園哲哉 and 長谷川拓哉 and 近藤科江}, title = {担がんマウスにおけるアルブミン結合ドメイン融合ナノボディの動態評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100863458, author = {Kyra See and 門之園哲哉 and 宮本康太郎 and 近藤科江}, title = {抗体誘導スクリーニングによるCD25結合抗体代替ペプチドの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863456, author = {峯岸美紗 and 門之園 哲哉 and 近藤 科江 and 口丸 高弘}, title = {転移過程のがん-間質細胞相互作用の一細胞オミクス解析技術の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100854468, author = {峯岸美紗 and 門之園哲哉 and 近藤科江 and 口丸高弘}, title = {細胞間相互作用可視化光技術を使ったがん転移形成過程の 1 細胞オミクス解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100854469, author = {平野 龍一郎 and 岡本 浩輝 and 新毛 実結 and 渡邉 仁美 and 近藤 玄 and 門之園 哲哉 and 近藤 科江}, title = {TNBC腫瘍における組織常在性間質細胞の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100854465, author = {門之園 哲哉}, title = {スマートデザインによる高性能標的結合の創製}, booktitle = {}, year = 2021, } @inproceedings{CTT100854467, author = {Ryuichiro Hirano and Kouki Okamoto and Tetsuya Kadonosono and 渡邊仁美 and 近藤玄 and Shinae Kizaka-Kondoh}, title = {Analysis of intratumor stromal cells using early-stage triple-negative breast cancer before angiogenesis}, booktitle = {}, year = 2021, } @inproceedings{CTT100856648, author = {平野龍一郎 and 岡本浩輝 and 門之園哲哉 and 渡邊仁美 and 近藤玄 and 近藤科江}, title = {血管新生前の早期トリプルネガティブ乳がんを用いた腫瘍内間質細胞の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100876416, author = {稲葉千尋 and 澤田敏樹 and 門之園哲哉 and 芹澤武}, title = {高分子結合性ペプチドを利用する細胞イメージングの基盤構築}, booktitle = {}, year = 2021, } @inproceedings{CTT100854466, author = {門之園 哲哉}, title = {抗体構造情報を利用した分子標的ペプチドの創製}, booktitle = {}, year = 2021, } @inproceedings{CTT100854464, author = {Tetsuya Kadonosono}, title = {Novel biopharmaceuticals for molecular target therapy of cancer. In silico design and evaluation of biopharmaceuticals}, booktitle = {}, year = 2021, } @inproceedings{CTT100854463, author = {門之園 哲哉}, title = {スマートデザインによる抗原結合小型タンパク質FLAPの創製}, booktitle = {}, year = 2020, } @inproceedings{CTT100834820, author = {宮本康太郎 and 門之園哲哉 and 井上正宏 and 近藤科江}, title = {ミトコンドリア機能評価による休眠がん細胞標的薬剤の作用機構解析}, booktitle = {}, year = 2020, } @inproceedings{CTT100855866, author = {木田勇一 and 丹羽達也 and 澤田敏樹 and 門之園哲哉 and 丸山優史 and 岩崎富生 and 芹澤武}, title = {ファージディスプレイ法を利用したポリテトラフルオロエチレン結合性ペプチドの探索}, booktitle = {}, year = 2020, } @inproceedings{CTT100835004, author = {Kyra See and Tetsuya Kadonosono and Kotaro Miyamoto and Wanaporn Yimchuen and Shinae Kizaka-Kondoh}, title = {Development of small HER2-binding proteins by paratope reconstitution}, booktitle = {}, year = 2020, } @inproceedings{CTT100835003, author = {平野龍一郎 and 岡本浩輝 and 門之園哲哉 and 星野歩子 and 渡邊仁美 and 近藤玄 and 近藤科江}, title = {トリプルネガティブ乳がんの早期悪性化に関与する間質細胞の解析}, booktitle = {}, year = 2020, } @inproceedings{CTT100834883, author = {栗生 識 and 門之園哲哉 and 近藤 科江 and 石田 忠}, title = {スフェロイドの免疫組織学的解析を可能とするマイクロ流体デバイス}, booktitle = {}, year = 2020, } @inproceedings{CTT100834819, author = {Kotaro Miyamoto and Tetsuya Kadonosono and Tomoyoshi Soga and Shinae Kondoh}, title = {Elucidation of mitochondrial energy metabolism in dormant cancer cells by multi-omics analysis}, booktitle = {}, year = 2020, } @inproceedings{CTT100835001, author = {門之園 哲哉}, title = {スマートデザインによる抗体医薬代替小型タンパク質の創製}, booktitle = {}, year = 2020, } @inproceedings{CTT100835002, author = {Tetsuya Kadonosono}, title = {A smart design of target-binding small proteins for molecular target therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835000, author = {門之園 哲哉}, title = {構造計算による抗原結合小型タンパク質デザインと創薬研究}, booktitle = {}, year = 2020, } @inproceedings{CTT100835005, author = {本間 滉也 and 門之園 哲哉 and YIMCHUEN WANAPORN and 近藤 科江}, title = {Development of a bioluminescent imaging probe for detecting KISS1R-expressing cancers in vivo}, booktitle = {}, year = 2020, } @inproceedings{CTT100835006, author = {Kyra See and Tetsuya Kadonosono and Wanaporn Yimchuen and Shinae Kizaka-Kondoh}, title = {Double-CDR grafting for the development of small HER2-targeting proteins}, booktitle = {}, year = 2020, } @inproceedings{CTT100855860, author = {木田勇一 and 丹羽達也 and 澤田敏樹 and 門之園哲哉 and 丸山優史 and 岩崎富生 and 芹澤武}, title = {ポリ(テトラフルオロエチレン)に結合するペプチドの探索と特性評価}, booktitle = {}, year = 2020, } @inproceedings{CTT100835007, author = {Hitomi Miyabara and Ryuichiro Hirano and Takahiro Kuchimaru and Tetsuya Kadonosono and Hitomi Watanabe and Gen Kondoh and Shinae Kizaka-Kondoh}, title = {In vivo imaging of HIF-active cells in tumors using transgenic mice with a HIF-dependent reporter gene}, booktitle = {}, year = 2020, } @inproceedings{CTT100810156, author = {吉田有沙 and 渡邊重明 and 板倉祥子 and 田中武雄 and 門之園哲哉 and 近藤科江}, title = {生体適合性ナノデバイスを用いた腫瘍封止療法の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100810134, author = {門之園 哲哉}, title = {標的結合ペプチドを利用する小型タンパク質医薬デザイン}, booktitle = {}, year = 2019, } @inproceedings{CTT100810157, author = {相田一希 and 門之園哲哉 and Kyra See and 近藤科江}, title = {PD-1/PD-L1 シグナル阻害ペプチドのフェノタイプ・スクリーニング系の構築}, booktitle = {}, year = 2019, } @inproceedings{CTT100810155, author = {平野龍一郎 and 宮原瞳 and 門之園哲哉 and 口丸高弘 and 渡邊仁美 and 近藤玄 and 近藤科江}, title = {腫瘍内間質細胞のHIF 活性可視化による悪性化機構の解明}, booktitle = {}, year = 2019, } @inproceedings{CTT100810154, author = {宮本康太郎 and 門之園哲哉 and 松尾禎之 and 広田喜一 and 近藤科江}, title = {エネルギー代謝測定による休眠がん細胞のミトコンドリア機能解析}, booktitle = {}, year = 2019, } @inproceedings{CTT100810144, author = {Tetsuya Kadonosono and Wanaporn Yimchuen and Kyra See and Shinae Kizaka-Kondoh}, title = {A design strategy for developing practical antibody mimetic small proteins for cancer therapy}, booktitle = {}, year = 2019, } @inproceedings{CTT100810168, author = {See Kyra and Kadonosono Tetsuya and Yimchuen Wanaporn and Shinae Kondoh}, title = {Development of a small anti-HER2 antibody mimetic by double-CDR grafting}, booktitle = {}, year = 2019, } @inproceedings{CTT100810153, author = {門之園 哲哉}, title = {産学異分野融合で挑む創薬技術の革新}, booktitle = {}, year = 2019, } @inproceedings{CTT100810167, author = {See Kyra and Kadonosono Tetsuya and Yimchuen Wanaporn and Shinae Kondoh}, title = {Design of a small and high-affinity anti-HER2 antibody mimetic by double-CDR grafting}, booktitle = {}, year = 2019, } @inproceedings{CTT100810133, author = {門之園 哲哉}, title = {抗体医薬の代替となる小型タンパク質の半合理デザイン}, booktitle = {}, year = 2019, } @inproceedings{CTT100810169, author = {門之園 哲哉}, title = {標的結合ペプチドを搭載した小型タンパク質FLAPのデザイン}, booktitle = {}, year = 2019, } @inproceedings{CTT100810130, author = {Tetsuya Kadonosono}, title = {A design strategy for generating cancer marker-binding small proteins}, booktitle = {}, year = 2019, } @inproceedings{CTT100811102, author = {Tetsuya Kadonosono and Kyra See and Wanaporn Yimchuen and Shinae Kizaka-Kondoh}, title = {A design strategy for creating a small and high-affinity antibody mimetics by double-CDR grafting}, booktitle = {}, year = 2019, } @inproceedings{CTT100811104, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Shinichi Sato and Takahiro Nomoto and Kyra See and Hiroyuki Nakamura and Nobuhiro Nishiyama and Shinae Kizaka-Kondoh}, title = {Development of photoimmunotherapy probe using a small antibody mimetic with structurally constrained anti-HER2 CDR peptides}, booktitle = {}, year = 2019, } @inproceedings{CTT100810131, author = {門之園 哲哉}, title = {抗体医薬品を代替する標的結合小型タンパク質デザイン}, booktitle = {}, year = 2019, } @inproceedings{CTT100810132, author = {門之園 哲哉 and 近藤 科江}, title = {構造計算に基づく標的結合小型タンパク質の創製とがん治療への応用}, booktitle = {}, year = 2019, } @inproceedings{CTT100810152, author = {門之園 哲哉}, title = {小型タンパク質FLAPの半合理的デザインと医薬応用}, booktitle = {}, year = 2019, } @inproceedings{CTT100810151, author = {門之園 哲哉}, title = {抗原結合小型タンパク質のsemi-rationalデザインと医薬応用}, booktitle = {}, year = 2019, } @inproceedings{CTT100810135, author = {Tetsuya Kadonosono}, title = {A design strategy for creating antibody mimetic small proteins for cancer treatment}, booktitle = {}, year = 2019, } @inproceedings{CTT100810137, author = {Yumi Ota and Tetsuya Kadonosono and Takahiro Kuchimaru and Masumi Taki and Yuji Ito and Shinae Kizaka-Kondoh}, title = {Development of high affinity HER2-targeting small protein harboring a structurally constrained peptide}, booktitle = {}, year = 2018, } @inproceedings{CTT100810138, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Shinichi Sato and Kyra See and Takahiro Kuchimaru and Hiroyuki Nakamura and Shinae Kizaka-Kondoh}, title = {Creation of a small antibody mimetic immunoprobe with structurally constrained anti-HER2 CDR peptides}, booktitle = {}, year = 2018, } @inproceedings{CTT100810139, author = {Kazuki Aida and Tetsuya Kadonosono and Takahiro Kuchimaru and Masumi Taki and Yuji Ito and Shinae Kizaka-Kondoh}, title = {Binding mode analysis of PD-1 targeting small protein having structurally constrained peptide}, booktitle = {}, year = 2018, } @inproceedings{CTT100810140, author = {Ryo Masuda and Tetsuya Kadonosono and Takaki Koide}, title = {Selection of bioactive peptides from a random triple-helical peptide library in yeast cells}, booktitle = {}, year = 2018, } @inproceedings{CTT100810143, author = {Kyra See and Tetsuya Kadonosono and Wanaporn Yimchuen and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {Production of a small and high-affinity HER2-binding protein by double-CDR grafting}, booktitle = {}, year = 2018, } @inproceedings{CTT100810142, author = {Marina Katsumi and Tetsuya Kadonosono and Kyra See and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {Development of platform for generating antibody mimetics harboring constrained CDR peptides}, booktitle = {}, year = 2018, } @inproceedings{CTT100810136, author = {Tetsuya Kadonosono and Wanaporn Yimchuen and Kyra See and Yumi Ota and Marina Katsumi and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {A design strategy for creating practical middle-molecular-mass antibody mimetics having structurally constrained HER2-binding peptides}, booktitle = {}, year = 2018, } @inproceedings{CTT100810141, author = {Kazuto Mochizuki and Tetsuya Kadonosono and Yuji Ito and Masumi Taki}, title = {Development of general method to obtain targeted fluorescent covalent binder}, booktitle = {}, year = 2018, } @inproceedings{CTT100810160, author = {遠藤 みのり and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {休眠がん細胞に細胞死を誘導できる薬剤の作用機序解析と薬効評価}, booktitle = {}, year = 2018, } @inproceedings{CTT100810166, author = {瀬尾 美鈴 and 吉田 亜佑美 and 上野 信洋 and Gargi Palashikar and 早田 優香 and 太田 成美 and 永安 良多 and 栃尾 凌太 and 福光 一生 and 中西 聖磨 and 米倉 寛人 and 山口 淳史 and 浅野 弘嗣 and 門之園 哲哉 and 近藤 科江 and 扇田 久和 and 清水 昭男}, title = {VEGF-A/ニューロピリン1のシグナル伝達を阻害する細胞透過性ペプチドはがん細胞の浸潤と転移を抑制する。}, booktitle = {}, year = 2018, } @inproceedings{CTT100810165, author = {平野 龍一郎 and 宮原 瞳 and 門之園 哲哉 and 口丸 高弘 and 渡邉 仁美 and 近藤 玄 and 近藤 科江}, title = {高感度発光イメージングによる腫瘍内間質細胞のHIF可視化による免疫抑制機構の解明}, booktitle = {}, year = 2018, } @inproceedings{CTT100810164, author = {相田 一希 and 門之園 哲哉 and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {構造ゆらぎ抑制ペプチドを組み込んだPD-1結合小型タンパク質の結合解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100810163, author = {藤森 慧 and 口丸 高弘 and 峯岸 美紗 and 門之園 哲哉 and 近藤 科江}, title = {間葉系幹細胞による骨転移巣の形成制御メカニズムの解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100810162, author = {太田 優美 and 門之園 哲哉 and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {ヒトフィブロネクチンIII型ドメインを足場とする高親和性HER2結合小型分子の創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100810161, author = {勝見 茉莉奈 and Kyra See and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {CDRペプチドを組み込んだ抗体医薬代替中分子の創薬プラットフォーム構築}, booktitle = {}, year = 2018, } @inproceedings{CTT100810150, author = {平野 龍一郎 and 宮原 瞳 and 門之園 哲哉 and 口丸 高弘 and 渡邉 仁美 and 近藤 玄 and 近藤 科江}, title = {高感度発光イメージングによる腫瘍内間質細胞のHIF可視化による免疫抑制機構の解明}, booktitle = {}, year = 2018, } @inproceedings{CTT100810149, author = {門之園 哲哉 and Wanaporn Yimchuen and 太田 優美 and Kyra See and 口丸 高弘 and 近藤 科江}, title = {転写因子HIF活性を抑制するHER2結合小型タンパク質の創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100810148, author = {相田 一希 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {T細胞活性化抗体医薬の代替となるPD-1結合小型タンパク質の創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100810147, author = {平野 龍一郎 and 宮原 瞳 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内間質細胞のHIF活性可視化による免疫抑制機構の解明のための高感度発光イメージングレポーター遺伝子の構築}, booktitle = {}, year = 2018, } @inproceedings{CTT100810146, author = {藤森 慧 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {間葉系幹細胞による骨転移巣の形成制御メカニズムの解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100774099, author = {平野 龍一郎 and 宮原 瞳 and 門之園 哲哉 and 口丸 高弘 and 渡邊 仁美 and 近藤 玄 and 近藤 科江}, title = {腫瘍内間質細胞のHIF活性可視化による免疫抑制機構の解明のための高感度発光イメージングレポータ遺伝子の構築}, booktitle = {}, year = 2018, } @inproceedings{CTT100810159, author = {神永 真帆 and 石田 忠 and 門之園 哲哉 and 近藤 科江 and 小俣 透}, title = {ペプチド探索マイクロ流路デバイスにおける非標的細胞結合ペプチド除去性能の向上}, booktitle = {}, year = 2018, } @inproceedings{CTT100774046, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Kyra See and Takahiro Kuchimaru and Shinae Kondoh}, title = {Functional analysis of high-affinity antibody mimetics with structurally constrained CDR peptides for tumor imaging}, booktitle = {}, year = 2018, } @inproceedings{CTT100774045, author = {門之園 哲哉}, title = {Drug discovery cloudによる創薬技術革新への挑戦}, booktitle = {}, year = 2018, } @inproceedings{CTT100810145, author = {近藤 科江 and 口丸 高弘 and 門之園 哲哉}, title = {新規MDSC様接着細胞の腫瘍免疫抑制環境形成における機能解析}, booktitle = {}, year = 2018, } @inproceedings{CTT100774029, author = {Shinae Kizaka-Kondoh and Mongkol Pongsuchart and Diem Thi Phuong Tran and Tetsuya Kadonosono and Takahiro Kuchimaru}, title = {Osteosarcoma cell lines with different metastatic potential isolated by Image-guided screening revealed a novel LEF1-CYGB axis that promotes extravasation of osteosarcoma cells into the lungs}, booktitle = {}, year = 2018, } @inproceedings{CTT100774044, author = {Mongkol Pongsuchart and Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kondoh}, title = {Involvement of lymphoid enhancer binding factor 1/Cytoglobin axis in lung metastasis of osteosarcoma}, booktitle = {}, year = 2018, } @inproceedings{CTT100774043, author = {遠藤 みのり and 門之園 哲哉 and 口丸 高弘 and Inoue Masahiro and 近藤 科江}, title = {休眠がん細胞に細胞死を誘導できる薬剤の作用機序解析", 第77回日本癌学会学術集会}, booktitle = {}, year = 2018, } @inproceedings{CTT100774042, author = {太田 優美 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {構造ゆらぎ抑制標的結合ペプチドを組み込んだ小型HER2結合分子の機能評価}, booktitle = {}, year = 2018, } @inproceedings{CTT100774041, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Takahiro Kuchimaru and Shinae Kondoh}, title = {Functional analysis of high-affinity antibody mimetics with structurally constrained CDR peptides for tumor imaging}, booktitle = {}, year = 2018, } @inproceedings{CTT100774040, author = {相田 一希 and 門之園 哲哉 and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {足場小型タンパク質により構造ゆらぎを抑制したPD-1結合ペプチドの機能評価と配列最適化}, booktitle = {}, year = 2018, } @inproceedings{CTT100774039, author = {勝見 茉莉奈 and 門之園 哲哉 and Kyra See and 口丸 高弘 and 近藤 科江}, title = {抗体CDRペプチドを組み込んだ抗原結合中分子の迅速創製プラットフォームの構築}, booktitle = {}, year = 2018, } @inproceedings{CTT100774038, author = {太田 優美 and 門之園 哲哉 and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {標的結合ペプチドの構造ゆらぎ抑制によるHER2結合小型タンパク質の創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100774037, author = {Wanaporn Yimchuen and Tetsuya Kadonosono and Kyra See and Takahiro Kuchimaru and Shinae Kondoh}, title = {Development of high-affinity tumor imaging probes with structurally constrained CDR peptides}, booktitle = {}, year = 2018, } @inproceedings{CTT100774036, author = {藤森 慧 and 礒崎 達大 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {生物発光イメージングに基づいた骨転移成長を促進する因子の同定}, booktitle = {}, year = 2018, } @inproceedings{CTT100774035, author = {宮原 瞳 and 口丸 高弘 and 門之園 哲哉 and 水島 友子 and 浦野 浩司 and 近藤 科江}, title = {HIF 活性可視化トランスジェニックマウスを用いた腫瘍内 HIF 活性化細胞のイメージング}, booktitle = {}, year = 2018, } @inproceedings{CTT100774034, author = {Mongkol Pongsuchart and Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kondoh}, title = {In vivo image-guided screening and genome-wide meta-analysis revealed involvement of LEF1/Cytoglobin axis in lung metastasis of osteosarcoma}, booktitle = {}, year = 2018, } @inproceedings{CTT100774033, author = {太田 優美 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {標的結合ペプチドの構造ゆらぎ抑制による高親和性HER2結合小型タンパク質の創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100774032, author = {遠藤 みのり and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {ALK陽性非小細胞肺がん細胞株を用いた休眠がん細胞標的薬剤の薬効評価}, booktitle = {}, year = 2018, } @inproceedings{CTT100774031, author = {相田 一希 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {T細胞活性化抗体医薬の代替となる低分子量PD-1結合タンパク質の創製}, booktitle = {}, year = 2018, } @inproceedings{CTT100769747, author = {第6回蛋白質間相互作用研究会 and 門之園 哲哉}, title = {抗体代替中分子の半合理的デザイン}, booktitle = {}, year = 2018, } @inproceedings{CTT100769758, author = {伊藤 雄大 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {HIFが活性化したがんを標的とした新規融合タンパク質製剤の機能評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100769757, author = {口丸 高弘 and 磯崎 達大 and 宮原 瞳 and 峯岸 美紗 and 門之園 哲哉 and 近藤 科江}, title = {簡便かつ高効率な骨髄への細胞デリバリー手法の開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100769756, author = {峯岸 美紗 and 口丸 高弘 and 藤森 慧 and 磯崎 達大 and 門之園 哲哉 and 近藤 科江}, title = {マルチ生物レポーターシステムを用いた骨転移発症過程における前立腺がんと骨髄間質細胞の相互作用解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100769745, author = {門之園 哲哉 and Wanaporn Yimchuen and Kyra See and 太田 優美 and 口丸 高弘 and 近藤 科江}, title = {抗体CDRペプチドの構造ゆらぎ制御による小型抗体代替分子の創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100769760, author = {太田 優美 and 門之園 哲哉 and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {ヒトフィブロネクチンIII型ドメインを足場とする小型HER2結合分子の創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100769759, author = {遠藤 みのり and 門之園 哲哉 and 酒井 栞 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {ALK陽性肺がん細胞株による休眠がん細胞標的薬剤の薬効評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100756744, author = {YIMCHUEN WANAPORN and 門之園 哲哉 and Kyra See and 古田 忠臣 and 口丸 高弘 and 近藤 科江}, title = {Development of anti-HER2 antibody mimetics with structurally constrained CDR peptides}, booktitle = {}, year = 2017, } @inproceedings{CTT100769755, author = {Yumi Ota and Tetsuya Kadonosono and Takahiro Kuchimaru and Masumi Taki and Yuji Ito and Shinae Kondoh}, title = {Development of HER2-targeting small protein harboring a structurally constrained peptide}, booktitle = {}, year = 2017, } @inproceedings{CTT100769734, author = {酒井 栞 and 門之園 哲哉 and 遠藤 みのり and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {肺がん細胞株を用いた休眠がん細胞標的薬剤の作用機構の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100769733, author = {椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {新規接着性ミエロイド細胞の同定とそれによる腫瘍悪性化機構の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100769602, author = {門之園 哲哉 and Kyra See and 勝見 茉莉奈 and 太田 優美 and Wanaporn Yimchuen and 相田 一希 and 口丸 高弘 and 近藤 科江}, title = {腫瘍悪性化促進因子の活性を中和する抗体代替分子の創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100769743, author = {礒崎 達大 and 藤森 慧 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {早期骨転移形成過程におけるがん細胞と骨髄間質細胞の相互作用の役割}, booktitle = {}, year = 2017, } @inproceedings{CTT100766719, author = {Misa Minegishi and Tatsuhiro Isozaki and Satoshi Fujimori and Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {A multi-bioluminescence reporter system visualizes crosstalk between cancer cells and bone marrow microenvironment}, booktitle = {}, year = 2017, } @inproceedings{CTT100756745, author = {門之園 哲哉 and 太田 優美 and YIMCHUEN WANAPORN and Kyra See and 古田 忠臣 and 口丸 高弘 and 近藤 科江}, title = {Creation of high performance antibody drug alternatives harboring constrained CDR peptides}, booktitle = {}, year = 2017, } @inproceedings{CTT100769601, author = {Shusei Hamamichi and Izumi O Umeda and 門之園 哲哉 and 口丸 高弘 and 近藤 科江 and Hirofumi Fujii}, title = {125I Radiolabeling and Biodistribution Analysis of a Novel Anti-cancer Agent TOP3}, booktitle = {}, year = 2017, } @inproceedings{CTT100745254, author = {片岡 直也 and 口丸 高弘 and 礒崎 達大 and 宮原 瞳 and 門之園 哲哉 and 近藤 科江}, title = {がん細胞の尾動脈移植によるマウス骨転移モデルの簡便な構築}, booktitle = {}, year = 2017, } @inproceedings{CTT100769600, author = {門之園 哲哉 and 太田 優美 and YIMCHUEN WANAPORN and 口丸 高弘 and 近藤 科江}, title = {A screening system for identifying biocompatible low-molecular-mass scaffold proteins to develop small antibody mimetics}, booktitle = {}, year = 2017, } @inproceedings{CTT100769749, author = {Tran D and Kondoh S and Kuchiamru T and Kadonosono T and Pongsuchart M and Yonezawa S}, title = {Analysis of regulatory mechanisms osteosarcoma lung metastasis via Wnt signaling}, booktitle = {}, year = 2017, } @inproceedings{CTT100769750, author = {Pongsuchart M and Kuchimaru T and Kadonosono T and Kondoh S}, title = {Identification and characterization of genes associated with osteosarcoma extravasation into the lung}, booktitle = {}, year = 2017, } @inproceedings{CTT100769751, author = {磯崎 達大 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {早期骨転移形成過程におけるがん細胞と骨髄間質細胞のクロストーク解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100769752, author = {Yumi Ota and Tetsuya Kadonosono and Wanaporn Yimchuen and Takahiro Kuchimaru and Shinae Kondoh}, title = {Development of high affinity anti-HER2 antibody mimetics by use of human fibronectin type III domain}, booktitle = {}, year = 2017, } @inproceedings{CTT100769753, author = {Shiori Sakai and Tetsuya Kadonosono and Minori Endo and Takahiro Kuchimaru and Masahiro Inoue and Shinae Kondoh}, title = {Analysis of the functional mechanism of a drug targeting dormant cancer cells by using a lung cancer cell line}, booktitle = {}, year = 2017, } @inproceedings{CTT100769754, author = {Shusei Hamamichi and Izumi Umeda and Tetsuya Kadonosono and Takahiro Kuchimaru and Shinae Kizaka-Kondoh and Hirofumi Fujii}, title = {Retention of 125I-TOP3 in the Tumor of a HIF1α-positive Cancer Xenograft Model}, booktitle = {}, year = 2017, } @inproceedings{CTT100766720, author = {Tatsuhiro Isozaki and Misa Minegishi and Naoya Kataoka and Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kondoh}, title = {Analysis of molecular mechanisms governing outgrowth of bone metastasis by using a multi-bioluminescence reporter system}, booktitle = {}, year = 2017, } @inproceedings{CTT100769748, author = {太田 優美 and 門之園 哲哉 and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {構造ゆらぎ抑制による抗HER2抗体代替分子の創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100784498, author = {近藤科江 and 口丸高弘 and 門之園哲哉}, title = {体生体光イメージングを用いた創薬研究}, booktitle = {}, year = 2017, } @inproceedings{CTT100748263, author = {門之園哲哉 and 太田優美 and 口丸高弘 and 近藤科江}, title = {小型抗体代替分子の創出に向けた低分子量足場タンパク質の探索}, booktitle = {}, year = 2017, } @inproceedings{CTT100748266, author = {口丸高弘 and 片岡直也 and 門之園哲哉 and 近藤科江}, title = {尾動脈移植による簡便かつ高効率な骨転移モデルマウス}, booktitle = {}, year = 2017, } @inproceedings{CTT100748262, author = {太田優美 and 門之園哲哉 and 口丸高弘 and 近藤科江}, title = {ヒトフィブロネクチンⅢ型ドメインを利用した抗HER2抗体代替分子の開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100745090, author = {門之園哲哉}, title = {構造ゆらぎ制御による小型抗体代替分子の創出}, booktitle = {}, year = 2017, } @inproceedings{CTT100748265, author = {遠藤みのり and 門之園哲哉 and 酒井栞 and 口丸高弘 and 井上 正宏 and 近藤科江}, title = {肺がん細胞株を用いた休眠がん細胞標的薬剤の治療有効性評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100744331, author = {石田忠 and 田中優弥 and 門之園哲哉 and 近藤科江 and 小俣透}, title = {スラグ内部循環流によるペプチドのがん細胞スフェロイドへの付着効率の向上}, booktitle = {}, year = 2017, } @inproceedings{CTT100745206, author = {礒崎 達大 and 峯岸 美紗 and 片岡 直也 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {Analysis of molecular mechanisms governing outgrowth of bone metastasis by using a multi-bioluminescence reporter system}, booktitle = {}, year = 2017, } @inproceedings{CTT100745231, author = {TRAN T.PHUONG DIEM and PONGSUCHART M and 米澤 早紀子 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {Identification of downstream genes of Wnt signaling regulating osteosarcoma extravasation into the lung}, booktitle = {}, year = 2017, } @inproceedings{CTT100745232, author = {椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {in vivo光イメージングを用いた新規ミエロイド細胞F4/80(-)AMCの機能解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100745233, author = {礒崎 達大 and 峯岸 美紗 and 片岡 直也 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {Analysis of molecular mechanisms governing outgrowth of bone metastasis by using a multi-bioluminescence reporter system}, booktitle = {}, year = 2017, } @inproceedings{CTT100745234, author = {遠藤 みのり and 門之園 哲哉 and 酒井 栞 and 口丸 高弘 and 近藤 科江}, title = {再発性肺がんモデルマウスの生体発光イメージング}, booktitle = {}, year = 2017, } @inproceedings{CTT100745205, author = {口丸 高弘 and 片岡 直也 and 礒崎 達大 and 宮原 瞳 and 門之園 哲哉 and 近藤 科江}, title = {尾動脈移植法による新規血行性骨転移モデルマウス}, booktitle = {}, year = 2017, } @inproceedings{CTT100744029, author = {YIMCHUEN WANAPORN and 門之園 哲哉 and 古田 忠臣 and 口丸 高弘 and 近藤 科江}, title = {Development of high-affinity tumor imaging probes based on constrained target-binding peptides}, booktitle = {}, year = 2017, } @inproceedings{CTT100745229, author = {濱道 修生 and 梅田 泉 and 門之園 哲哉 and 近藤 科江 and 藤井 博史}, title = {HIF-1α活性陽性領域を標的とする新規抗がん剤TOP3の体内挙動の検討}, booktitle = {}, year = 2017, } @inproceedings{CTT100745230, author = {口丸 高弘 and 片岡 直也 and 磯崎 達大 and 宮原 瞳 and 門之園 哲哉 and 近藤 科江}, title = {尾動脈移植法による新規血行性骨転移モデルマウス}, booktitle = {}, year = 2017, } @inproceedings{CTT100745088, author = {門之園哲哉}, title = {構造ゆらぎ制御による高親和性PD-1結合ペプチド医薬の創製戦略}, booktitle = {}, year = 2017, } @inproceedings{CTT100745099, author = {門之園哲哉}, title = {構造ゆらぎの抑制による抗体代替分子の創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100745204, author = {門之園 哲哉 and 鈴木 康弘 and 口丸 高弘 and 佐藤 靖史 and 近藤 科江}, title = {細胞外分泌に必須のVASHドメイン構造の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100745098, author = {門之園哲哉}, title = {構造ゆらぎ制御による抗体代替分子の創製}, booktitle = {}, year = 2017, } @inproceedings{CTT100745202, author = {Shinae Kondoh and Takahiro Kuchimaru and Tetsuya Kadonosono}, title = {Symposium 5: The roles of vascular remodeling in tissue hypoxia Imaging strategies for detection of HIF activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100745243, author = {伊藤 雄大 and 門之園 哲哉 and ThiHongNgoc Hoang and 口丸 高弘 and 近藤 科江}, title = {HIF活性化細胞を標的とした新規融合タンパク質製剤の物性評価}, booktitle = {}, year = 2016, } @inproceedings{CTT100745244, author = {酒井 栞 and 門之園 哲哉 and 遠藤 みのり and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {肺がん細胞株による休眠がん細胞標的薬剤の有効性評価}, booktitle = {}, year = 2016, } @inproceedings{CTT100745239, author = {北澤 舞花 and 門之園 哲哉 and 塩澤 唯 and Yimchuen Wanaporn and 口丸 高弘 and 近藤 科江}, title = {構造ゆらぎを抑制した高親和性HER2標的結合分子スクリーニング技術の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100745235, author = {礒崎 達大 and 片岡 直也 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {マルチ生物発光レポーターシステムを用いた骨転移病巣形成の分子機構の解明}, booktitle = {}, year = 2016, } @inproceedings{CTT100745236, author = {北澤 舞花 and 門之園 哲哉 and 塩澤 唯 and 口丸 高弘 and 近藤 科江}, title = {構造ゆらぎの制御によるHER2高親和性抗体代替分子の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745237, author = {塩澤 唯 and 門之園 哲哉 and 北澤 舞花 and Wanaporn Yimchuen and 口丸 高弘 and 瀧 真澄 and 伊東 祐二 and 近藤 科江}, title = {標的結合ペプチドの構造ゆらぎ抑制による高親和性抗PD-1タンパク質の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745238, author = {礒崎 達大 and 片岡 直也 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {定量的生物発光イメージングによる早期骨転移微小環境の解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745097, author = {門之園 哲哉 and Wanaporn Yimchuen and 塩澤 唯 and 北澤 舞花 and 太田 優美 and 口丸 高弘 and 近藤 科江}, title = {「構造ゆらぎ」制御による高性能な抗体医薬品代替分子の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745203, author = {口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {近赤外生物発光を用いたがん組織の非侵襲イメージング}, booktitle = {}, year = 2016, } @inproceedings{CTT100745240, author = {塩澤 唯 and 門之園 哲哉 and 北澤 舞花 and Yimchuen Wanaporn and 口丸 高弘 and 瀧 真清 and 伊東 祐二 and 近藤 科江}, title = {標的結合ペプチドの構造ゆらぎ抑制による高親和性PD-1結合タンパク質の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745241, author = {礒崎 達大 and 片岡 直也 and 峯岸 美紗 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {早期骨転移形成過程におけるがん細胞と骨髄微笑環境の相互作用解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745242, author = {PONGSUCHART M and 米澤 早紀子 and Hoang ThiHongNgoc and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {Identification of genes regulating osteosarcoma extravasation in lung metastasis}, booktitle = {}, year = 2016, } @inproceedings{CTT100741259, author = {YIMCHUEN WANAPORN and 門之園 哲哉 and 古田 忠臣 and 塩澤 唯 and 北澤 舞花 and 口丸 高弘 and 櫻井 実 and 近藤 科江}, title = {Development of IgG-based antibody mimetics with a constrained target-binding peptide}, booktitle = {}, year = 2016, } @inproceedings{CTT100745194, author = {椿 卓也 and 門之園 哲哉 and 塩澤 唯 and 口丸 高弘 and 近藤 科江}, title = {新規接着性ミエロイド細胞による腫瘍悪性化機構の機能解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745195, author = {酒井 栞 and 門之園 哲哉 and 遠藤 みのり and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {肺がん細胞株による休眠がん細胞標的薬剤の有効性評価}, booktitle = {}, year = 2016, } @inproceedings{CTT100745196, author = {片岡 直也 and 口丸 高弘 and 礒崎 達大 and 峯岸 美紗 and 門之園 哲哉 and 近藤 科江}, title = {転移早期過程における前立腺がんと骨髄間質細胞の相互作用解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745197, author = {口丸 高弘 and 岩野 智 and 三股 舜 and 牧 昌次郎 and 門之園 哲哉 and 近藤 科江}, title = {近赤外生物発光イメージングによる生体深部組織の可視化}, booktitle = {}, year = 2016, } @inproceedings{CTT100745198, author = {米澤 早紀子 and Mongkol Pongschart and Diem Tran and 口丸 高弘 and Ngoc Honag and 門之園 哲哉 and 近藤 科江}, title = {骨肉腫細胞の肺転移における血管外浸潤過程を制御する分子機構の解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745199, author = {門之園 哲哉 and Wanaporn Yimchuen and 塩澤 唯 and 北澤 舞花 and 太田 優美 and 口丸 高弘 and 近藤 科江}, title = {腫瘍悪性化促進因子活性を中和する分子標的薬創製に向けた抗体代替分子設計}, booktitle = {}, year = 2016, } @inproceedings{CTT100745200, author = {Shinae Kondoh and Tetsuya Kadonosono and Takahiro Kuchimaru}, title = {In vivo imaging of HIF activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100784501, author = {近藤科江 and 口丸高弘 and 門之園哲哉}, title = {In vivo imaging of HIF activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100745246, author = {濱道 修生 and 梅田 泉 and 門之園 哲哉 and 近藤 科江 and 藤井 博史}, title = {腫瘍内Hypoxia Inducible Factor 1α (HIF1α) 発現領域をターゲットしたTOP3の体内動態の検討}, booktitle = {}, year = 2016, } @inproceedings{CTT100745245, author = {口丸 高弘 and 岩野 智 and 木山 正宏 and 三股 舜 and 門之園 哲哉 and 丹羽 治樹 and 牧 昌次郎 and 近藤 科江}, title = {近赤外発光基質による生体深部組織の高感度イメージング}, booktitle = {}, year = 2016, } @inproceedings{CTT100745096, author = {口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {生物発光を用いた腫瘍組織の低酸素イメージング}, booktitle = {}, year = 2016, } @inproceedings{CTT100745228, author = {Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Bioluminescence imaging in living animals}, booktitle = {}, year = 2016, } @inproceedings{CTT100745251, author = {塩澤 唯 and 門之園 哲哉 and 北澤 舞花 and Wanaporn Yimchuen and 口丸 高弘 and 近藤 科江}, title = {ゆらぎ抑制標的結合ペプチドによるPD-1結合低分子量タンパク質の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745249, author = {椿 卓也 and 門之園 哲哉 and 塩澤 唯 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内新規接着性ミエロイド細胞の機能解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745248, author = {北澤 舞花 and 門之園 哲哉 and 塩澤 唯 and YIMCHUEN WANAPORN and 口丸 高弘 and Masumi Taki and Yuji Ito and 近藤 科江}, title = {Development of fibronectin-based small protein harboring a structurally constrained HER2-binding peptide}, booktitle = {}, year = 2016, } @inproceedings{CTT100745247, author = {塩澤 唯 and 門之園 哲哉 and 北澤 舞花 and YIMCHUEN WANAPORN and 口丸 高弘 and Masumi Taki and Yuji Ito and 近藤 科江}, title = {Development of a high-affinity anti-PD-1 small protein harboring a constrained PD-1-binding peptide}, booktitle = {}, year = 2016, } @inproceedings{CTT100741254, author = {YIMCHUEN WANAPORN and 門之園 哲哉 and 古田 忠臣 and 塩澤 唯 and 北澤 舞花 and 口丸 高弘 and 櫻井 実 and 近藤 科江}, title = {Evaluation of immunoglobulin-based antibody mimetics with a constrained target-binding peptide}, booktitle = {}, year = 2016, } @inproceedings{CTT100745256, author = {米澤 早紀子 and Mongkol Pongsuchart and Diem Tran and Hoang Thi Hong Ngoc and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {骨肉腫の肺転移における血管外浸潤過程を制御する分子機構の解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745257, author = {伊藤 雄大 and 門之園 哲哉 and ThiHongNgoc Hoang and 口丸 高弘 and 近藤 科江}, title = {低酸素がんを標的とした融合タンパク質製剤の物性評価}, booktitle = {}, year = 2016, } @inproceedings{CTT100745193, author = {門之園 哲哉 and YIMCHUEN WANAPORN and 塩澤 唯 and 北澤 舞花 and 太田 優美 and 口丸 高弘 and 近藤 科江}, title = {A protein-engineering method for identifying a scaffold making peptides structurally constrained in order to develop high-affinity antibody mimetics}, booktitle = {}, year = 2016, } @inproceedings{CTT100745192, author = {門之園 哲哉 and Wanaporn Yimchuen and 塩澤 唯 and 北澤 舞花 and 太田 優美 and 口丸 高弘 and 近藤 科江}, title = {標的結合ペプチドのゆらぎ制御による抗体代替分子の創製法}, booktitle = {}, year = 2016, } @inproceedings{CTT100745191, author = {梅田 泉 and 柿島 祐 and 石川 龍太郎 and 濱道 修生 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江 and 藤井 博史}, title = {腫瘍内低酸素誘導転写因子活性の核医学画像診断の試み}, booktitle = {}, year = 2016, } @inproceedings{CTT100745190, author = {口丸 高弘 and 岩野 智 and 三股 舜 and 牧 昌次郎 and 門之園 哲哉 and 近藤 科江}, title = {近赤外生物発光イメージングによる深部組織がんの高感度検出}, booktitle = {}, year = 2016, } @inproceedings{CTT100745255, author = {TRAN T.PHUONG DIEM and PONGSUCHART M and 米澤 早紀子 and Hoang ThiHongNgoc and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {Analysis of Wnt signaling involvement in lung metastasis by using murine osteosarcoma cell lines}, booktitle = {}, year = 2016, } @inproceedings{CTT100745253, author = {礒崎 達大 and 口丸 高弘 and 片岡 直也 and 門之園 哲哉 and 近藤 科江}, title = {早期骨転移形成過程における腫瘍微小環境およびがん細胞と骨髄間質細胞の相互作用解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745252, author = {酒井 栞 and 門之園 哲哉 and 遠藤 みのり and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {肺がん細胞株による休眠がん細胞標的薬剤の薬効評価}, booktitle = {}, year = 2016, } @inproceedings{CTT100745250, author = {YIMCHUEN WANAPORN and 門之園 哲哉 and 塩澤 唯 and 北澤 舞花 and 口丸 高弘 and 近藤 科江}, title = {Development of antibody mimetics with constrained target-binding peptide for cancer therapy}, booktitle = {}, year = 2016, } @inproceedings{CTT100745087, author = {門之園哲哉}, title = {化学合成可能な高性能抗体代替分子の開発技術}, booktitle = {}, year = 2016, } @inproceedings{CTT100745226, author = {Takahiro Kuchimaru and Kenji Nakagawa and Tatsuhiro Isozaki and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {A multi-bioluminescence reporter system visualized molecular basis of bone metastasis}, booktitle = {}, year = 2016, } @inproceedings{CTT100745189, author = {椿 卓也 and 門之園 哲哉 and 塩澤 唯 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内新規接着性ミエロイド細胞による腫瘍悪性化機構の解明}, booktitle = {}, year = 2016, } @inproceedings{CTT100745227, author = {Tetsuya Kadonosono and Tadashi Shiozawa and Takuya Tsubaki and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {In vivo optical imaging of protumoral functions of adherent myeloid cells}, booktitle = {}, year = 2016, } @inproceedings{CTT100745259, author = {北澤 舞花 and 門之園 哲哉 and 塩澤 唯 and 口丸 高弘 and 近藤 科江}, title = {構造ゆらぎ抑制によるHER2高親和性抗体代替分子の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745258, author = {塩澤 唯 and 門之園 哲哉 and 北澤 舞花 and 口丸 高弘 and 近藤 科江}, title = {構造ゆらぎ抑制による高親和性PD-1結合タンパク質の創製}, booktitle = {}, year = 2016, } @inproceedings{CTT100745188, author = {門之園哲哉}, title = {ペプチドの「構造ゆらぎ」抑制による高性能な標的結合分子創製技術}, booktitle = {}, year = 2016, } @inproceedings{CTT100745225, author = {Tatsuhiro Isozaki and Takahiro Kuchimaru and Naoya Kataoka and Kenji Nakagawa and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {A multi-bioluminescence reporter system to decipher ineractions between cancer cells and bone marrow stromal cells in early bone metastasis}, booktitle = {}, year = 2016, } @inproceedings{CTT100709231, author = {神永真帆 and 石田忠 and 門之園哲哉 and 近藤科江 and 小俣透}, title = {がん細胞特異的結合ペプチドスクリーニングのためのマイクロ流体デバイス}, booktitle = {}, year = 2016, } @inproceedings{CTT100745187, author = {椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {新規接着性ミエロイド細胞による腫瘍悪性化機構の解明}, booktitle = {}, year = 2016, } @inproceedings{CTT100745186, author = {酒井 栞 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {休眠がん細胞を標的とする薬剤の特異性評価と標的分子の探索}, booktitle = {}, year = 2016, } @inproceedings{CTT100745184, author = {近藤 科江 and 門之園 哲哉 and Hoang Thi Hong Ngoc and 伊藤雄大 and 口丸高弘}, title = {HIFが活性化したがんを標的にした融合タンパク質製剤を用いた難治がん治療法の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100745262, author = {片岡 直也 and 口丸 高弘 and 中川 賢治 and 礒崎 達大 and 門之園 哲哉 and 近藤 科江}, title = {発光イメージングを用いた骨転移早期過程における前立腺がんと骨髄間質細胞の相互作用解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745261, author = {口丸 高弘 and 岩野 智 and 木山 正啓 and 三股 舜 and 門之園 哲哉 and 丹羽 治樹 and 牧 昌次郎 and 近藤 科江}, title = {深部組織の高感度イメージングを可能にする近赤外ルシフェリンアナログ}, booktitle = {}, year = 2016, } @inproceedings{CTT100745260, author = {門之園 哲哉 and Wanaporn Yimchuen and 塩澤 唯 and 北澤 舞花 and 口丸 高弘 and 近藤 科江}, title = {標的結合ペプチドの「構造ゆらぎ」抑制による高性能な腫瘍イメージングプローブの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100745224, author = {Takahiro Kuchimaru and Sataoshi Iwano and Masahiro Kiyama and Shun Mitsumata and Tetsuya Kadonosono and Haruki Niwa and Shojiro Maki and Shinae Kizaka-Kondoh}, title = {A luciferin analog generating near-infrared bioluminescence improves detection sensitivity of deep-tissue tumor}, booktitle = {}, year = 2016, } @inproceedings{CTT100712747, author = {Shinae Kondoh and Tetsuya Kadonosono and Takahiro Kuchimaru}, title = {Imaging of HIF-active tumors: Exploration tool for malignancy}, booktitle = {}, year = 2016, } @inproceedings{CTT100712748, author = {近藤 科江 and 門之園 哲哉 and Hoang Thi Hong Ngoc and 伊藤雄大 and 口丸高弘}, title = {低酸素誘導転写因子HIFが活性化したがんを標的にした融合タンパク質製剤を用いた}, booktitle = {}, year = 2016, } @inproceedings{CTT100745185, author = {門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {抗体由来標的結合ペプチドの「構造ゆらぎ」抑制による高性能な抗体代替分子の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100745183, author = {PONGSUCHART M and Nguyen KhaThe and 米澤 早紀子 and Hoang ThiHongNgoc and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {Identification of responsible genes for osteosarcoma extravasation in lung metastasis by using in vivo image-guided system}, booktitle = {}, year = 2016, } @inproceedings{CTT100745182, author = {近藤 科江 and 門之園 哲哉 and 口丸 高弘}, title = {Imaging of HIF-active tumors: Exploration tool for malignancy}, booktitle = {}, year = 2016, } @inproceedings{CTT100745181, author = {門之園哲哉}, title = {化学合成可能な高性能抗体代替ペプチドの作製技術}, booktitle = {}, year = 2016, } @inproceedings{CTT100745180, author = {門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {VASHドメイン構造により制御されるSVBP依存的細胞外分泌}, booktitle = {}, year = 2016, } @inproceedings{CTT100745264, author = {塩澤 唯 and 椿 卓也 and 桜井 史門 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {光イメージングによる腫瘍関連骨髄系細胞の機能解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100745263, author = {北澤 舞花 and 門之園 哲哉 and 塩澤 唯 and 口丸 高弘 and 近藤 科江}, title = {高性能な腫瘍標的結合ペプチドスクリーニング法の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100745222, author = {Shinae Kizaka-Kondoh and Takahiro Kuchimaru and Tomoya Suka and Tetsuya Kadonosono}, title = {A novel injectable bioluminescence resonance energy transfer-based in vivo imaging probe for HIF-active cancer cells}, booktitle = {}, year = 2016, } @inproceedings{CTT100745223, author = {Takahiro Kuchimaru and Satoshi Iwano and Masahiro Kiyama and Shun Mitsumata and Tetsuya Kadonosono and Haruki Niwa and Shojiro Maki and Shinae Kizaka-Kondoh}, title = {A luciferin analog improves detection sensitivity of deep-tissue tumor using near-infrared bioluminescence}, booktitle = {}, year = 2016, } @inproceedings{CTT100745179, author = {口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {発光イメージングによるがん転移機構の分子的解明}, booktitle = {}, year = 2016, } @inproceedings{CTT100745177, author = {口丸 高弘 and 片岡 直也 and 礒崎 達大 and 門之園 哲哉 and 近藤科江}, title = {骨転移早期過程を制御する分子機構を明らかにする新規マウスモデル}, booktitle = {}, year = 2015, } @inproceedings{CTT100745178, author = {門之園 哲哉 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {Cell-penetrating peptides improve tumor delivery of proteins by enhanced extravasation}, booktitle = {}, year = 2015, } @inproceedings{CTT100745175, author = {椿 卓也 and 桜井 史門 and 塩澤 唯 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {Functional analysis of macrophage-like cells in tumor}, booktitle = {}, year = 2015, } @inproceedings{CTT100745176, author = {門之園 哲哉 and 酒井 栞 and 後藤 優 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {Drug screening and evaluation for targeting dormant primary cancer cells by using cancer tissue-originated spheroids}, booktitle = {}, year = 2015, } @inproceedings{CTT100712742, author = {Takahiro Kuchimaru and Satoshi Iwano and Msahiro Kiyama and Shun Mitsumata and Tetsuya Kadonosono and Haruki Niwa and Shojiro Maki and Shinae Kizaka-Kondoh}, title = {A luciferin analog achieves highly sensitive deep-tissue tumor imaging using near-infrared bioluminescence}, booktitle = {}, year = 2015, } @inproceedings{CTT100745085, author = {門之園哲哉}, title = {ペプチドのゆらぎ制御による抗体医薬代替分子の創製}, booktitle = {}, year = 2015, } @inproceedings{CTT100712744, author = {Tetsuya Kadonosono and Takuya Tsubaki and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {Cell penetrating peptides improve tumor delivery of imaging probes through Neuropilin-1-dependent extravasation}, booktitle = {}, year = 2015, } @inproceedings{CTT100745084, author = {門之園 哲哉}, title = {ゆらぎの制御による高性能な分子標的ペプチド医薬の創出}, booktitle = {}, year = 2015, } @inproceedings{CTT100745171, author = {Hoang ThiHongNgoc and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {Enhanced antitumor effect of TOP3 and Gemcitabine combination therapy for pancreatic cancer treatment}, booktitle = {}, year = 2015, } @inproceedings{CTT100745172, author = {椿 卓也 and 桜井 史門 and 塩澤 唯 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内マクロファージ様細胞による悪性化機構の解明}, booktitle = {}, year = 2015, } @inproceedings{CTT100745174, author = {門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がんスフェロイドによる休眠がん細胞標的薬剤の探索と評価}, booktitle = {}, year = 2015, } @inproceedings{CTT100745173, author = {門之園 哲哉 and 酒井 栞 and 後藤 優 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {休眠状態の初代培養がんスフェロイドによる標的薬剤スクリーニング}, booktitle = {}, year = 2015, } @inproceedings{CTT100745170, author = {口丸 高弘 and 中川 賢治 and 片岡 直也 and 門之園 哲哉 and 近藤 科江}, title = {定量発光イメージングによる骨転移早期過程を制御する分子機構の解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100745164, author = {門之園 哲哉 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {細胞膜透過ペプチド融合タンパク質の腫瘍血管透過メカニズム}, booktitle = {}, year = 2015, } @inproceedings{CTT100745265, author = {塩澤 唯 and 椿 卓也 and 桜井 史門 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {光イメージングによる腫瘍関連免疫細胞の機能解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100745266, author = {新堀 瑞穂 and 後藤 優 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がんスフェロイドによる休眠がん細胞標的薬剤スクリーニング}, booktitle = {}, year = 2015, } @inproceedings{CTT100745221, author = {Takahiro Kuchimaru and Tomoya Aikawa and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Noninvasive imaging of activation of HIF and TGF-beta/Smad signaling in breast cancer progression}, booktitle = {}, year = 2015, } @inproceedings{CTT100712743, author = {Takahiro Kuchimaru and Tomoya Aikawa and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Noninvasive imaging of activation of HIF and TGF-beta/Smad signaling in breast cancer progression}, booktitle = {}, year = 2015, } @inproceedings{CTT100745158, author = {新堀 瑞穂 and 後藤 優 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がんスフェロイドによる休眠がん細胞標的薬剤の探索}, booktitle = {}, year = 2014, } @inproceedings{CTT100745267, author = {新堀 瑞穂 and 後藤 優 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がんスフェロイドによる休眠がん細胞標的薬剤の探索と評価}, booktitle = {}, year = 2014, } @inproceedings{CTT100745268, author = {後藤 優 and 新堀 瑞穂 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {蛍光イメージングによる初代培養がんスフェロイドのHIF活性評価}, booktitle = {}, year = 2014, } @inproceedings{CTT100745269, author = {桜井 史門 and 椿 卓也 and 塩澤 唯 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {マクロファージ様細胞の採取と腫瘍増殖促進効果の光イメージング}, booktitle = {}, year = 2014, } @inproceedings{CTT100745270, author = {門之園 哲哉 and 北澤 舞花 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {ゆらぎの抑制による高性能な標的結合ペプチドスクリーニング}, booktitle = {}, year = 2014, } @inproceedings{CTT100745083, author = {口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {骨転移微小環境のイメージング解析による新規治療標的の探索}, booktitle = {}, year = 2014, } @inproceedings{CTT100745146, author = {Hoang ThiHongNgoc and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {Enhanced antitumor effects of TOP-3 and TS-1 combination therapy for pancreatic cancer treatment}, booktitle = {}, year = 2014, } @inproceedings{CTT100745148, author = {中川 賢治 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {前立腺がん骨転移の進行過程におけるHIFとNF-κB活性の非侵襲モニタリング}, booktitle = {}, year = 2014, } @inproceedings{CTT100745151, author = {口丸 高弘 and 中川 賢治 and 門之園 哲哉 and 近藤 科江}, title = {骨転移における低酸素誘導因子HIFの治療標的としての可能性}, booktitle = {}, year = 2014, } @inproceedings{CTT100745161, author = {門之園 哲哉 and 北澤 舞花 and 後藤 優 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内微小環境特異的ドッラグデリバリーに向けた標的結合ペプチドスクリーニング}, booktitle = {}, year = 2014, } @inproceedings{CTT100745155, author = {椿 卓也 and 桜井 史門 and 塩澤 唯 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {in vivo光イメージングによる腫瘍関連マクロファージの機能解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100745145, author = {門之園 哲哉 and 北澤 舞花 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {Constrained peptide scaffold for identification of target-binding peptides with high affinity}, booktitle = {}, year = 2014, } @inproceedings{CTT100745273, author = {新堀 瑞穂 and 後藤 優 and 門之園 哲哉 and 口丸 高弘 and Masahiro Inoue and 近藤 科江}, title = {Drug screening for targeting dormant primary cancer cells by using cancer tissue-originated spheroids}, booktitle = {}, year = 2014, } @inproceedings{CTT100745217, author = {Tetsuya Kadonosono and Takuya Tsubaki and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {PTD enhances extravasation of a fused imaging probe from tumor blood vessels in vivo}, booktitle = {}, year = 2014, } @inproceedings{CTT100745215, author = {Kenji Nakagawa and Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {In vivo bioluminescence imaging of cancer cell response to hypoxia and inflammation during tumor progression}, booktitle = {}, year = 2014, } @inproceedings{CTT100745218, author = {Takuya Tsubaki and Toshiki Goto and Shimon Sakurai and Tetsuya Kadonosono and Takahiro Kuchimaru and Shinae Kizaka-Kondoh}, title = {Functional analysis of macrophage-like cells in tumor using optical imaging in vivo}, booktitle = {}, year = 2014, } @inproceedings{CTT100745142, author = {門之園 哲哉 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {Constrained peptide screening system for identification of cancer-binding peptides with high affinity}, booktitle = {}, year = 2014, } @inproceedings{CTT100745219, author = {Mizuho Niibori and Yu Goto and Tetsuya Kadonosono and Takahiro Kuchimaru and Masahiro Inoue and Shinae Kizaka-Kondoh}, title = {Imaging of HIF-active cells in cancer tissue-originated spheroids by fluorescent protein probes}, booktitle = {}, year = 2014, } @inproceedings{CTT100745271, author = {桜井 史門 and 椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {In vivo imaging of malignant tumor growth enhanced by macrophage-like cells}, booktitle = {}, year = 2014, } @inproceedings{CTT100745214, author = {Takahiro Kuchimaru and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Bone resorption facilitates osteoblastic bone metastatic colonization by the functional cooperation between IGF signaling and hypoxia-inducible factor}, booktitle = {}, year = 2014, } @inproceedings{CTT100745272, author = {後藤 優 and 新堀 瑞穂 and 門之園 哲哉 and 口丸 高弘 and Masahiro Inoue and 近藤 科江}, title = {Evaluation of HIF-activity in cancer tissue-originated spheroids with a fluorescent imaging probe specific to HIF-active cells}, booktitle = {}, year = 2014, } @inproceedings{CTT100745274, author = {門之園 哲哉 and 新堀 瑞穂 and 後藤 優 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がんスフェロイド用いた休眠がん細胞標的薬剤スクリーニング法}, booktitle = {}, year = 2014, } @inproceedings{CTT100745140, author = {門之園 哲哉 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {ゆらぎ抑制型ペプチドライブラリーを用いた標的結合ペプチドの高効率スクリーニング法の開発}, booktitle = {}, year = 2014, } @inproceedings{CTT100745275, author = {新堀 瑞穂 and 後藤 優 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がんスフェロイド用いた休眠がん細胞標的薬剤スクリーニング法の開発}, booktitle = {}, year = 2014, } @inproceedings{CTT100745137, author = {口丸 高弘 and 中川 賢治 and 門之園 哲哉 and 近藤 科江}, title = {骨転移初期過程におけるがん細胞と骨微小環境の動的相互作用のin vivoイメージング解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100745277, author = {後藤 優 and 新堀 瑞穂 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {初代培養がん細胞スフェロイドの蛍光イメージングによる腫瘍内HIF活性評価法の構築}, booktitle = {}, year = 2014, } @inproceedings{CTT100745278, author = {新堀 瑞穂 and 後藤 優 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {休眠がん細胞を標的とした抗がん剤スクリーニング法の開発}, booktitle = {}, year = 2014, } @inproceedings{CTT100745276, author = {椿 卓也 and 後藤 俊樹 and 桜井 史門 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {光イメージングによる腫瘍関連マクロファージの機能解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100745279, author = {後藤 優 and 新堀 瑞穂 and 門之園 哲哉 and 口丸 高弘 and 井上 正宏 and 近藤 科江}, title = {HIF活性阻害剤スクリーニングに向けた初代培養がん細胞スフェロイドの蛍光イメージング}, booktitle = {}, year = 2014, } @inproceedings{CTT100712741, author = {Shinae Kondoh and Takahiro Kuchimaru and Tetsuya Kadonosono}, title = {Significance of hypoxia-inducible factor activity during tumor development and malignant progression.}, booktitle = {}, year = 2014, } @inproceedings{CTT100745213, author = {Takuya Tsubaki and Toshiki Goto and Shimon Sakurai and Tetsuya Kadonosono and Takahiro Kuchimaru and Shinae Kondoh}, title = {Isolation and characterization of macrophage-like cells associated with malignant growth and metastasis}, booktitle = {}, year = 2014, } @inproceedings{CTT100745212, author = {Tetsuya Kadonosono and Toshiki Goto and Takuya Tsubaki and Takahiro Kuchimaru and Shinae Kondoh}, title = {PTD enhances extraversion of a fused protein from tumor blood vessels in neuropilin-dependent manner}, booktitle = {}, year = 2014, } @inproceedings{CTT100745131, author = {相川 友弥 and 中川 賢治 and 口丸 高弘 and 石川 龍太郎 and 門之園 哲哉 and 近藤 科江}, title = {乳がん微小環境のHIF-TGF-βシグナルをイメージングするマルチレポーターシステムの構築}, booktitle = {}, year = 2013, } @inproceedings{CTT100745133, author = {口丸 高弘 and 星野 卓也 and 相川 友弥 and 保田 尚孝 and 門之園 哲哉 and 近藤 科江}, title = {IGF/IGFRシグナルと低酸素環境の協調的な作用を介して骨吸収は造骨性骨転移におけるがん細胞のコロニー形成を促進する}, booktitle = {}, year = 2013, } @inproceedings{CTT100745136, author = {門之園 哲哉 and 新堀 瑞穂 and 後藤 優 and 口丸 高弘 and 近藤 科江}, title = {腫瘍由来スフェロイドによる腫瘍内HIF活性評価法の構築}, booktitle = {}, year = 2013, } @inproceedings{CTT100745135, author = {椿 卓也 and 後藤 俊樹 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {マクロファージ様細胞による腫瘍進行のin vivoイメージング解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100745134, author = {後藤 俊樹 and 椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {細胞膜透過ペプチドを融合した低酸素腫瘍イメージングプローブの血管膜透過機構}, booktitle = {}, year = 2013, } @inproceedings{CTT100745280, author = {門之園 哲哉 and 関根 拓哉 and 椿 卓也 and 口丸 高弘 and 近藤 科江}, title = {標的タンパク質に高い特異性と結合性を有するペプチドのスクリーニング技術}, booktitle = {}, year = 2013, } @inproceedings{CTT100745129, author = {須加 智也 and 口丸 高弘 and 石川 龍太郎 and 門之園 哲哉 and 近藤 科江}, title = {BRETを利用したタンパク質プローブによる腫瘍内HIF活性の特異的in vivoイメージング}, booktitle = {}, year = 2013, } @inproceedings{CTT100709680, author = {高木哲史 and 石田忠 and 口丸高弘 and 門之園哲哉 and 近藤科江 and 小俣透}, title = {マイクロ流路を用いたグルコース濃度勾配下におけるがん細胞応答の観察}, booktitle = {}, year = 2013, } @inproceedings{CTT100745281, author = {後藤 俊樹 and 椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {細胞膜透過ペプチドの血管透過を利用した高効率ドラッグデリバーシステム}, booktitle = {}, year = 2013, } @inproceedings{CTT100745283, author = {新堀 瑞穂 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {MCSを利用したサイトカインによる腫瘍内HIF活性の評価}, booktitle = {}, year = 2013, } @inproceedings{CTT100745128, author = {須加 智也 and 口丸 高弘 and 廣田 圭佑 and 石川 龍太郎 and 門之園 哲哉 and 近藤 科江}, title = {BRETを利用した機能性タンパク質プローブによる腫瘍内HIF活性の高コントラスト光イメージング}, booktitle = {}, year = 2013, } @inproceedings{CTT100745282, author = {椿 卓也 and 後藤 俊樹 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {マクロファージ様細胞による腫瘍進行のin vivoイメージング解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100745284, author = {後藤 俊樹 and 椿 卓也 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {VEGF受容体NRP1との相互作用による細胞膜透過ペプチド融合タンパク質の血管透過機構}, booktitle = {}, year = 2013, } @inproceedings{CTT100745126, author = {門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {Neuropilin-1を介した細胞膜透過ペプチド融合プローブの血管透過機構の解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100745125, author = {門之園 哲哉 and 後藤 俊樹 and 口丸 高弘 and 近藤 科江}, title = {細胞膜透過ペプチド融合イメージングプローブのNeuropilin-1依存的血管透過機構の解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100745285, author = {関根 拓哉 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {タンパク質分子動力学シミュレーションによるGTPaseシグナル活性化腫瘍イメージングプローブの開発}, booktitle = {}, year = 2013, } @inproceedings{CTT100745082, author = {門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内HIF活性化細胞を標的とする治療薬・可視化プローブの開発}, booktitle = {}, year = 2013, } @inproceedings{CTT100745124, author = {山野 晃弘 and 後藤 俊樹 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {Neuropilin-1を介した細胞膜透過ペプチド融合プローブの低酸素腫瘍デリバリー}, booktitle = {}, year = 2012, } @inproceedings{CTT100745120, author = {星野 卓哉 and 口丸 高弘 and 相川 友弥 and 保田 尚孝 and 門之園 哲哉 and 近藤 科江}, title = {低酸素環境においてRANKLによる骨吸収は骨肉腫細胞LM8の造骨性骨転移を促進する}, booktitle = {}, year = 2012, } @inproceedings{CTT100745123, author = {須加 智也 and 口丸 高弘 and 廣田 圭佑 and 山口 鉄郎 and 門之園 哲哉 and 近藤 科江}, title = {BRETを用いた融合タンパク質プローブによる腫瘍内HIF活性の生体光イメージング}, booktitle = {}, year = 2012, } @inproceedings{CTT100745081, author = {口丸 高弘 and 星野 卓哉 and 相川 友弥 and 安田 尚孝 and 門之園 哲哉 and 近藤 科江}, title = {低酸素骨髄環境においてRANKLによって誘導される骨吸収は骨肉種細胞の造骨性骨転移を促進する}, booktitle = {}, year = 2012, } @inproceedings{CTT100745080, author = {口丸 高弘 and 廣田 圭佑 and 須加 智也 and 山口 鉄郎 and 門之園 哲哉 and 近藤 科江}, title = {高い標的特異性を実現するBRETを用いた融合タンパク質イメージングプローブの開発}, booktitle = {}, year = 2012, } @inproceedings{CTT100745209, author = {Takahiro Kuchimaru and Keisuke Hirota and Tomoya Suka and Tetsuya Kadonosono and Shinae Kizaka-Kondoh}, title = {Fusion protein-based BRET probes for highly specific in vivo imaging of HIF-active tumor cells}, booktitle = {}, year = 2012, } @inproceedings{CTT100745211, author = {Tetsuya Kadonosono and Takahiro Kuchimaru and Tomoharu Tanaka and Kiichi Hirota and Hideki Tsutsumi and Mamoru Ito and Koji Urano and Gen Kondoh and Shinae Kizaka-Kondoh}, title = {In vivo optical imaging of carcinogenesis by the detection of HIF-active cells using HOL transgenic mice}, booktitle = {}, year = 2012, } @inproceedings{CTT100745287, author = {門之園 哲哉 and 関根 拓哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内低酸素微小環境イメージングのためのActivatableタンパク質プローブの開発}, booktitle = {}, year = 2012, } @inproceedings{CTT100745079, author = {門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {トランスジェニックマウスを用いた腫瘍内HIF活性の生体光イメージング}, booktitle = {}, year = 2012, } @inproceedings{CTT100745286, author = {矢部 越理 and 関根 拓哉 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {アポトーシスを検知するレポータータンパク質の開発}, booktitle = {}, year = 2012, } @inproceedings{CTT100745210, author = {Kensuke Okuda and Itsuki Kawano and Tasuku Hirayama and Bunji Uno and Tetsuya Kadonosono and Shinae Kizaka-Kondoh and Hideko Nagasawa}, title = {Development of a novel hypoxia-activatable near-infrared fluorescent probe for tumor hypoxia imaging}, booktitle = {}, year = 2012, } @inproceedings{CTT100745288, author = {門之園 哲哉 and 口丸 高弘 and Tomoharu Tanaka and Kiichi Hirota and Masahiro Inoue and Koji Urano and Gen Kondoh and 近藤 科江}, title = {In vivo bioluminescence imaging of hypoxia-related diseases by the detection of HIF-active cells using HOL transgenic mice}, booktitle = {}, year = 2012, } @inproceedings{CTT100745290, author = {後藤 俊樹 and 山野 晃弘 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍血管浸透性ペプチドを利用した低酸素がんの生体イメージング}, booktitle = {}, year = 2012, } @inproceedings{CTT100745289, author = {関根 拓哉 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍内低酸素微小環境イメージングのための立体構造依存的タンパク質プローブの開発}, booktitle = {}, year = 2012, } @inproceedings{CTT100745094, author = {Tetsuya Kadonosono and Takahiro Kuchimaru and Shinae Kondoh}, title = {In vivo imaging of HIFs-active tumors by optical protein probes}, booktitle = {}, year = 2012, } @inproceedings{CTT100745119, author = {門之園 哲哉 and 山野 晃弘 and 後藤 俊樹 and 口丸 高弘 and 近藤 科江}, title = {HIF-1活性化腫瘍細胞内を標的とするドラッグデリバリーシステムの構築}, booktitle = {}, year = 2011, } @inproceedings{CTT100745118, author = {山野 晃弘 and 後藤 俊樹 and 門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {腫瘍血管選択的浸透性ペプチドiRGDを利用した低酸素がんの生体イメージング}, booktitle = {}, year = 2011, } @inproceedings{CTT100745112, author = {坂井 良輔 and Bahaa G.M. Youssif and 奥田 健介 and 門之園 哲哉 and 近藤 科江 and 平山 祐 and 永澤 秀子}, title = {低酸素がんのin vivoイメージングを目指す近赤外蛍光プローブの開発}, booktitle = {}, year = 2011, } @inproceedings{CTT100745077, author = {門之園 哲哉 and 口丸 高弘 and 近藤 科江}, title = {生物発光による低酸素腫瘍進展の継時的in vivoイメージング}, booktitle = {}, year = 2011, } @inproceedings{CTT100745117, author = {廣田 圭祐 and 口丸 高弘 and 須賀 智也 and 門之園 哲哉 and 近藤 科江}, title = {HIF活性細胞特異的生体イメージングのためのBRETプローブの開発}, booktitle = {}, year = 2011, } @inproceedings{CTT100745115, author = {星野 卓哉 and 口丸 高弘 and 門之園 哲哉 and 近藤 科江}, title = {骨転移病巣におけるHIF活性のイメージングとHIF isoformの役割解析}, booktitle = {}, year = 2011, } @inproceedings{CTT100745111, author = {Shinae Kondoh and Takahiro Kuchimaru and Tetsuya Kadonosono}, title = {Novel strategies for targeting hypoxic cancer cells}, booktitle = {}, year = 2011, } @inproceedings{CTT100745109, author = {門之園 哲哉 and 口丸 高弘 and 浦野 浩司 and 近藤 玄 and 近藤 科江}, title = {HIF活性化細胞の検出による内因性腫瘍の生体光イメージング}, booktitle = {}, year = 2011, } @inproceedings{CTT100745107, author = {口丸 高弘 and 星野 卓哉 and 門之園 哲哉 and 安田 尚孝 and 近藤 科江}, title = {可溶性RANKLを用いた短期骨転移モデルの構築とインビボイメージング評価}, booktitle = {}, year = 2011, } @inproceedings{CTT100745093, author = {Shinae Kizaka-Kondoh and Takahiro Kuchimaru and Tetsuya Kadonosono}, title = {In vivo imaging of HIF-active cancers by an oxygen-dependent degradative probe with an interchangeable labeling system}, booktitle = {}, year = 2010, } @inproceedings{CTT100745208, author = {Tetsuya Kadonosono and Takahiro Kuchimaru and Takashi Ushiki and Shinae Kizaka-Kondoh and Masahiro Hiraoka}, title = {Molecular evaluation of imaging probe specific to HIF-active cancer cells and influence of cell permeable property of fluorescent dye on in vivo optical imaging}, booktitle = {}, year = 2010, } @inproceedings{CTT100745106, author = {近藤 科江 and 口丸 高弘 and 門之園 哲哉 and 平岡 眞寛}, title = {低酸素誘導因子HIF-活性の生体イメージング:シンポジウム「慢性炎症を基盤とする生活習慣病病態へのアプローチ」}, booktitle = {}, year = 2010, } @inproceedings{CTT100745105, author = {門之園 哲哉 and 口丸 高弘 and 牛木 隆志 and 近藤 科江 and 平岡 眞寛}, title = {HIF活性化細胞特異的プローブの分子評価と標識蛍光色素の特性による生体イメージングの変化}, booktitle = {}, year = 2010, } @inproceedings{CTT100745207, author = {Tetsuya Kadonosono and Takahiro Kuchimaru and Takashi Ushiki and Mark McDougall and Shinae Kizaka-Kondoh and Masahiro Hiraoka}, title = {Influence of cell permeable property of fluorescent dye on the POH in vivo imaging probe specific to HIF-active cancer cells}, booktitle = {}, year = 2010, } @inproceedings{CTT100745104, author = {近藤 科江 and 口丸 高弘 and 門之園哲哉 and 平岡 眞寛}, title = {低酸素誘導因子HIFを標的としたイメージング・ターゲティング:シンポジウム『Molecular Imaging の現状と将来展望』}, booktitle = {}, year = 2010, } @inproceedings{CTT100745102, author = {近藤 科江 and 口丸 高弘 and 門之園 哲哉 and 平岡 眞寛}, title = {低酸素誘導因子HIFを標的としたイメージング・ターゲティング}, booktitle = {}, year = 2010, } @inproceedings{CTT100745100, author = {近藤 科江 and 口丸 高弘 and 門之園 哲哉 and 平岡 眞寛}, title = {小動物を用いた生体光イメージング}, booktitle = {}, year = 2009, } @misc{CTT100916698, author = {門之園 哲哉}, title = {T細胞のがん攻撃スイッチ}, year = 2023, } @misc{CTT100877106, author = {門之園 哲哉}, title = {中分子ペプチド創薬の新展開-抗体代替ペプチドのデザイン戦略}, year = 2022, } @misc{CTT100863449, author = {門之園 哲哉}, title = {スマートデザインによる高性能標的結合中分子の創製}, year = 2021, } @misc{CTT100854470, author = {門之園 哲哉}, title = {知識・技術・人財融合による次世代医療モダリティ創発}, year = 2021, } @misc{CTT100791772, author = {Shinae Kizaka-Kondoh and Kuchimaru, Takahiro and Tetsuya Kadonosono}, title = {In vivo optical bioimaging of hypoxia inducible factor activity}, year = 2012, } @misc{CTT100902695, author = {門之園哲哉 and 近藤科江}, title = {抗体代替分子のスクリーニング方法}, howpublished = {公開特許}, year = 2023, month = {}, note = {PCT/JP2022/039963(2022/10/26), WO 2023/074749(2023/05/04)} } @misc{CTT100892238, author = {門之園哲哉 and 近藤科江 and 牛木 隆志 }, title = {T細胞増殖促進ペプチド}, howpublished = {公開特許}, year = 2022, month = {}, note = {特願2021-097735(2021/06/11), 特開2022-189249(2022/12/22)} } @misc{CTT100880515, author = {門之園哲哉 and 近藤科江}, title = {足場ペプチド}, howpublished = {公開特許}, year = 2022, month = {}, note = {特願2020-206671(2020/12/14), 特開2022-061931(2022/04/19)} } @misc{CTT100798363, author = {門之園哲哉 and 近藤科江}, title = {休眠がん細胞治療用医薬組成物及び休眠がん細胞治療用物質のスクリーニング方法}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2017-135573(2017/07/11), 特開2019-019057(2019/02/07)} } @misc{CTT100787101, author = {門之園哲哉 and 近藤科江}, title = {標的結合ペプチドの安定化方法}, howpublished = {登録特許}, year = 2021, month = {}, note = {特願2017-559228(2016/12/28), 再表2017/115828(2018/10/18), 特許第6872797号(2021/04/22)} } @misc{CTT100742404, author = {門之園哲哉 and 近藤科江}, title = {ペプチド提示タンパク質及びそれを用いたペプチドライブラリー}, howpublished = {登録特許}, year = 2019, month = {}, note = {特願2015-513781(2014/04/23), 再表2014/175305(2017/02/23), 特許第6478410号(2019/02/15)} }