@book{CTT100750434,
  author = {MIKOSHIBA, K and FURUICHI, T and MIYAWAKI, A and YOSHIKAWA, S and NAKADE, S and MICHIKAWA, T and NAKAGAWA, T and OKANO, H and KUME, S and MUTO, A and ARUGA, J and YAMADA, N and HAMANAKA, Y and FUJINO, I and KOBAYASHI, M and Higashida, H and Yoshioka, T and Shoen Kume},
  title = {STRUCTURE AND FUNCTION OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR},
  publisher = {},
  year = 1993,
}

@article{CTT100915689,
  author = {Helena Aprilia Grace and Shoen Kume.},
  title = {A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome.},
  journal = {J Diabetes Investigation},
  year = 2024,
}

@article{CTT100916683,
  author = {Dhimas Agung Kurniawan and Sylvia Leo and Mutsumi Inamatsu and Sohei Funaoka and Taichi Aihara and Mizuno Aiko and Inoue Rei and Takeshi Sakura and Hiroshi Arakawa and Yukio Kato and Tomoaki Matsugi and Katsuhiro Esashika and Nobuaki Shiraki and Shoen Kume and Kenta Shinha and Hiroshi Kimura and Masaki Nishikawa and Yasuyuki Sakai},
  title = {Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism},
  journal = {PNAS Nexus},
  year = 2024,
}

@article{CTT100916685,
  author = {Kenta Ouchi and Kaori Isono and Yuki Ohya and Nobuaki Shiraki and Masayoshi Tasaki and Yukihiro Inomata and Mitsuharu Ueda and Takumi Era and Shoen Kume and Yukio Ando and Hirofumi Jono},
  title = {Characterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced pluripotent stem cells},
  journal = {Heliyon},
  year = 2024,
}

@article{CTT100915687,
  author = {Tokuma H and Sakano D and Shiraki N and Kume S},
  title = {Selective proteasome degradation of the C-terminally-truncated human WFS1 mutants in the pancreatic beta cells.},
  journal = {FEBS Open Bio.},
  year = 2023,
}

@article{CTT100915694,
  author = {Hiyoshi N and Enomoto T and Uefune F and Kato Y and Wu Y and Araki K and Sakano D and Shiraki N and Kume S.},
  title = {A specific plasma amino acid profile in the Insulin2Q104del Kuma mice at the diabetic state and reversal from hyperglycemia.},
  journal = {Biochem. Biophys. Res. Commun.},
  year = 2023,
}

@article{CTT100915691,
  author = {Helena Aprilia Grace and Teruhiko Watanabe and Kato Y and Shiraki N and Kume S.},
  title = {Activation of cAMP(EPAC2) signaling pathway promotes hepatocyte attachment.},
  journal = {Scientific Reports},
  year = 2023,
}

@article{CTT100895352,
  author = {Sylvia Leo and Yusuke Kato and Yumeng Wu and Mutsumi Yokota and Masato Koike and Shiro Yui and Kiichiro Tsuchiya and Nobuaki Shiraki and Shoen Kume},
  title = {The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells.},
  journal = {Stem Cells},
  year = 2023,
}

@article{CTT100895355,
  author = {Yukihiro Shimaya and Nobuaki Shiraki and Shoen Kume},
  title = {Promoting pancreatic β cell proliferation: a powerful key for realizing regenerative therapy for diabetes. hionine and zinc deprivation.},
  journal = {J Diabetes Investig},
  year = 2023,
}

@article{CTT100895354,
  author = {Zixuan Erinn Sim and Takayuki Enomoto and Nobuaki Shiraki and Shoen Kume},
  title = {Protocol to generate human PSC-derived pancreatic beta-cells through methionine and zinc deprivation.},
  journal = {STAR Protocols},
  year = 2023,
}

@article{CTT100895353,
  author = {Ozawa H. and Kambe A and Hibi K and Murakami S and Oikawa A and Handa T and Fujiki K and Nakato R and Shirahige K and Kimura H and Shiraki N and Kume S.},
  title = {Transient methionine deprivation triggers histone modification and potentiated differentiation of induced pluripotent stem cells.},
  journal = {Stem Cells},
  year = 2023,
}

@article{CTT100895351,
  author = {Marwa ALI Ahmed and Yusuke Kato and Nobuaki Shiraki and Shoen Kume},
  title = {Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium.},
  journal = {Biology Open},
  year = 2023,
}

@article{CTT100882633,
  author = {Fumiya Uefune and Toru Aonishi and Tetsuya Kitaguchi and Harumi Takahashi and Susumu Seino and Daisuke Sakano and Shoen Kume},
  title = {Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer},
  journal = {Diabetes},
  year = 2022,
}

@article{CTT100883011,
  author = {Zixuan Erinn Sim and Takayuki Enomoto and Nobuaki Shiraki and Nao Furuta and Azusa Kambe and Hiroki Ozawa and Masayuki Miura and Shoen Kume},
  title = {Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization.},
  journal = {Cell Reports},
  year = 2022,
}

@article{CTT100863388,
  author = {Yasunobu Asawa and Kei Nishida and Kazuki Kawai and Kiyotaka Domae and Hyun Seung Ban and Akihiro Kitazaki and Hiroya Asami and Jun-Ya Kohno and Satoshi Okada and Hiraku Tokuma and Daisuke Sakano and Shoen Kume and Masaru Tanaka and Hiroyuki Nakamura},
  title = {Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation},
  journal = {Bioconjugate Chemistry},
  year = 2021,
}

@article{CTT100852291,
  author = {Taki K, Takagi H, Hirose T, Sun R., Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H},
  title = {Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet},
  journal = {PLOS ONE},
  year = 2021,
}

@article{CTT100852303,
  author = {Yoshida S, Honjo T, Iino K, Ishibe R, Leo S, Shimada T, Watanabe T, Ishikawa M, Maeda K, Kusuhara H, Shiraki N, Kume S},
  title = {Generation of human induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies},
  journal = {Stem Cell Reports},
  year = 2021,
}

@article{CTT100852301,
  author = {Shinohara M, Arakawa H, Oda Y, Shiraki N, Sugiura S, Nishiuchi T, Satoh T, Iino K, Leo S, Kato Y, Araya K, Kawanishi T, Nakatsuji T, Mitsuta M, Inamura K, Goto T, Shinha K, Nihei W, Komori K, Nishikawa M, Kume S, Kato Y, Kanamori T, Sakai Y, Kimura H},
  title = {Coculture of hiPS-derived intestinal cells and enhanced human hepatocyte functions in a pneumatic pressure-driven two-organ microphysiological system},
  journal = {Scientific Reports},
  year = 2021,
}

@article{CTT100852292,
  author = {Sim Z.E, Shiraki N, Kume S.},
  title = {Recent progress in pancreatic islet cell therapy},
  journal = {Inflammation and Regeneration},
  year = 2021,
}

@article{CTT100835587,
  author = {Sakano D, Uefune F, Tokuma H, Sonoda Y, Matsuura K, Takeda N, Nakagata N, Kume K, Shiraki N, Kume S.},
  title = {VMAT2 safeguards beta-cells against dopamine cytotoxicity under high-fat diet induced stress},
  journal = {Diabetes},
  year = 2020,
}

@article{CTT100835589,
  author = {Sakano D, Inoue A, Enomoto T, Imasaka M, Okada S, Yokota M, Koike M, Araki K, Kume S.},
  title = {Insulin2 Q104del (Kuma) mutant mice develop diabetes with dominant inheritance,},
  journal = {Scientific Reports},
  year = 2020,
}

@article{CTT100835585,
  author = {Yoshida S, Hirota M, Kawachi T, Kume S, Takahashi K},
  title = {Generation of intestinal organoids derived from human pluripotent stem cells for drug testing},
  journal = {Scientific Reports},
  year = 2020,
}

@article{CTT100852305,
  author = {Shoen Kume},
  title = {Detailed analysis at a single-cell level of cells undergoing pancreatic differentiation.},
  journal = {J Diabetes Investig},
  year = 2020,
}

@article{CTT100810685,
  author = {Shoen Kume},
  title = {Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells},
  journal = {Biology Open},
  year = 2019,
}

@article{CTT100810684,
  author = {Shoen Kume},
  title = {A Culture Substratum with Net-like Polyamide Fibers Promotes the Differentiation of Mouse and Human Pluripotent Stem Cells to Insulin-Producing Cells.},
  journal = {Biomedical Materials},
  year = 2019,
}

@article{CTT100780714,
  author = {Shoen Kume},
  title = {Future perspectives for the treatment of diabetes: importance of a regulatory framework.},
  journal = {Therapeutic Innovation & Regulatory Science},
  year = 2018,
}

@article{CTT100780715,
  author = {Shoen Kume},
  title = {iPS cell elimination in a cell sheet by methionine-free and 42 °C condition for tumor prevention.},
  journal = {Tissue Eng Part C Methods},
  year = 2018,
}

@article{CTT100780711,
  author = {Shoen Kume},
  title = {Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells.},
  journal = {Plos One},
  year = 2018,
}

@article{CTT100780713,
  author = {Daisuke Sakano and Shoen Kume and Andersson O},
  title = {Inhibition of Cdk5 Promotes β-cell differentiation from ductal progenitors.},
  journal = {Diabetes},
  year = 2018,
}

@article{CTT100780716,
  author = {Shoen Kume},
  title = {Sweetness induces sleep through gustatory signaling independent of nutritional value in a starved fruit fly.},
  journal = {Scientific Reports},
  year = 2017,
}

@article{CTT100750380,
  author = {Shoen Kume},
  title = {Erythropoietin facilitates definitive endodermal differentiation of mouse embryonic stem cells via activation of ERK signaling.},
  journal = {Am. J. of Physiology - Cell Physiology},
  year = 2017,
}

@article{CTT100750382,
  author = {Shoen Kume},
  title = {Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm.},
  journal = {BMC Biotechnology},
  year = 2017,
}

@article{CTT100724016,
  author = {Daisuke Sakano and Choi S and Kataoka M and Shiraki N and Uesugi M and Kume K and Shoen Kume},
  title = {Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.},
  journal = {Stem cell reports},
  year = 2016,
}

@article{CTT100780721,
  author = {Arakawa A and Shiraki N and Tsuyama T and Shoen Kume and Iwahata D and Yamada N},
  title = {Quantification of intracellular Zn, Fe, Cu within both iPS cells and differentiated cells using HPLC coupled to ICP-MS.},
  journal = {J. Anal Bioanal Tech},
  year = 2016,
}

@article{CTT100712648,
  author = {Omori, H. and Ogaki, S. and Daisuke Sakano and Sato, M. and Umeda, K. and Takeda, N. and Nakagata, N. and Shoen Kume},
  title = {Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development},
  journal = {FEBS Letters},
  year = 2016,
}

@article{CTT100780719,
  author = {Nakahara Y and Muto A and Sakuma T and Yamamoto T and Shoen Kume and Kikuchi Y},
  title = {Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish.},
  journal = {Genes to Cells},
  year = 2016,
}

@article{CTT100723369,
  author = {Soichiro Ogaki and Hisayoshi Omori and Mayu Morooka and Nobuaki Shiraki and Seiichi Ishida and Shoen Kume},
  title = {Late stage definitive endodermal differentiation can be defined by Daf1 expression},
  journal = {BMC Developmental Biology},
  year = 2016,
}

@article{CTT100780724,
  author = {Nakashima R and Shiraki N and Daisuke Sakano and Ogaki S and Kume K and Shoen Kume},
  title = {Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.},
  journal = {Genes to Cells},
  year = 2015,
}

@article{CTT100713317,
  author = {Jun Tomita and Taro Ueno and Madoka Mitsuyoshi and Shoen Kume and Kazuhiko Kume},
  title = {The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster},
  journal = {Plos One},
  year = 2015,
}

@article{CTT100713319,
  author = {Soichiro Ogaki and Mayu Morooka and Kaito Otera and Shoen Kume},
  title = {A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells},
  journal = {Scientific Reports},
  year = 2015,
}

@article{CTT100704221,
  author = {Shahjalal HM and Shiraki N and Daisuke Sakano and Kikawa K and Ogaki S and Baba H and Kume K and Shoen Kume},
  title = {Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system.},
  journal = {Journal of Molecular Cellular and Biology},
  year = 2014,
}

@article{CTT100713325,
  author = {Kaitsuka, Taku and Noguchi, Hirofumi and Nobuaki Shiraki and Kubo, Takuya and Wei, Fan-Yan and Hakim, Farzana and Shoen Kume and Kazuhito Tomizawa},
  title = {Generation of Functional Insulin-Producing Cells From Mouse Embryonic Stem Cells Through 804G Cell-Derived Extracellular Matrix and Protein Transduction of Transcription Factors},
  journal = {Stem Cells Translational Medicine},
  year = 2014,
}

@article{CTT100713321,
  author = {Nobuaki Shiraki and Soichiro Ogaki and Shoen Kume},
  title = {Profiling of embryonic stem cell differentiation.},
  journal = {The review of diabetic studies : RDS},
  year = 2014,
}

@article{CTT100713322,
  author = {Nobuaki Shiraki and Yasuko Shiraki and Tomonori Tsuyama and Fumiaki Obata and Masayuki Miura and Genta Nagae and Hiroyuki Aburatani and Kazuhiko Kume and Fumio Endo and Shoen Kume},
  title = {Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells},
  journal = {Cell Metabolism},
  year = 2014,
}

@article{CTT100713323,
  author = {Hakim, Farzana and Kaitsuka, Taku and Raeed, Jamiruddin Mohd and Wei, Fan-Yan and Nobuaki Shiraki and Akagi, Tadayuki and Yokota, Takashi and Shoen Kume and Kazuhito Tomizawa},
  title = {High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells*},
  journal = {Journal of Biological Chemistry},
  year = 2014,
}

@article{CTT100724018,
  author = {Kazuhide Kikawa and Daisuke Sakano and Nobuaki Shiraki and Tomonori Tsuyama and Kazuhiko Kume and Fumio Endo and Shoen Kume},
  title = {Beneficial Effect of Insulin Treatment on Islet Transplantation Outcomes in Akita Mice},
  journal = {Plos One},
  year = 2014,
}

@article{CTT100713326,
  author = {Isono, Kaori and Jono, Hirofumi and Ohya, Yuki and Nobuaki Shiraki and Taiji Yamazoe and Sugasaki, Ayaka and Era, Takumi and Fusaki, Noemi and Tasaki, Masayoshi and Ueda, Mitsuharu and Shinriki, Satoru and Inomata, Yukihiro and Shoen Kume and Ando, Yukio},
  title = {Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells},
  journal = {Stem Cell Research},
  year = 2014,
}

@article{CTT100780621,
  author = {Daisuke Sakano and Shiraki N and Kikawa K and Yamazoe T and Kataoka M and Umeda K and Araki K and Mao D and Matsumoto S and Nakagata N and Andersson O and Stainier D and Endo F and Kume K and Uesugi M and Shoen Kume},
  title = {VMAT2 identified as a regulator of late-stage β-cell differentiation.},
  journal = {Nature Chemical Biology},
  year = 2014,
}

@article{CTT100704230,
  author = {Ogaki S and Shiraki N and Kume K and Shoen Kume},
  title = {Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages.},
  journal = {Stem Cells},
  year = 2013,
}

@article{CTT100713331,
  author = {Taiji Yamazoe and Nobuaki Shiraki and Toyoda, Masashi and Kiyokawa, Nobutaka and Okita, Hajime and Miyagawa, Yoshitaka and Akutsu, Hidenori and Umezawa, Akihiro and Sasaki, Yutaka and Kazuhiko Kume and Shoen Kume},
  title = {A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells},
  journal = {Journal of Cell Science},
  year = 2013,
}

@article{CTT100713330,
  author = {Kahoko Umeda and Suzuki, Keiichiro and Taiji Yamazoe and Nobuaki Shiraki and Higuchi, Yuichiro and Tokieda, Kumiko and Kazuhiko Kume and Mitani, Kohnosuke and Shoen Kume},
  title = {Albumin gene targeting in human embryonic stem cells and induced pluripotent stem cells with helper-dependent adenoviral vector to monitor hepatic differentiation},
  journal = {Stem Cell Research},
  year = 2013,
}

@article{CTT100713329,
  author = {Iwashita, Hidefumi and Nobuaki Shiraki and Daisuke Sakano and Ikegami, Takashi and Shiga, Masanobu and Kazuhiko Kume and Shoen Kume},
  title = {Secreted Cerberus1 as a Marker for Quantification of Definitive Endoderm Differentiation of the Pluripotent Stem Cells},
  journal = {Plos One},
  year = 2013,
}

@article{CTT100713328,
  author = {Kawabata, Minako and Taro Ueno and Jun Tomita and Kawatani, Junko and Tomoda, Akemi and Shoen Kume and Kazuhiko Kume},
  title = {Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children},
  journal = {Bmc Psychiatry},
  year = 2013,
}

@article{CTT100704232,
  author = {Kataoka M and Kawamuro Y and Shiraki N and Miki R and Daisuke Sakano and Yoshida T and Yasukawa T and Kume K and Shoen Kume},
  title = {Recovery from diabetes in neonatal mice after a low-dose streptozotocin treatment.},
  journal = {},
  year = 2013,
}

@article{CTT100713332,
  author = {Takahama, Kazuhiro and Jun Tomita and Taro Ueno and Yamazaki, Masako and Shoen Kume and Kazuhiko Kume},
  title = {Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila},
  journal = {Biochemical and Biophysical Research Communications},
  year = 2012,
}

@article{CTT100713334,
  author = {Yamazaki, Masako and Jun Tomita and Takahama, Kazuhiro and Taro Ueno and Madoka Mitsuyoshi and Sakamoto, Erina and Shoen Kume and Kazuhiko Kume},
  title = {High calorie diet augments age-associated sleep impairment in Drosophila},
  journal = {Biochemical and Biophysical Research Communications},
  year = 2012,
}

@article{CTT100713333,
  author = {Taro Ueno and Jun Tomita and Tanimoto, Hiromu and Endo, Keita and Ito, Kei and Shoen Kume and Kazuhiko Kume},
  title = {Identification of a dopamine pathway that regulates sleep and arousal in Drosophila},
  journal = {Nature Neuroscience},
  year = 2012,
}

@article{CTT100713336,
  author = {Taro Ueno and Jun Tomita and Shoen Kume and Kazuhiko Kume},
  title = {Dopamine Modulates Metabolic Rate and Temperature Sensitivity in Drosophila melanogaster},
  journal = {Plos One},
  year = 2012,
}

@article{CTT100713335,
  author = {Taro Ueno and Masuda, Naoki and Shoen Kume and Kazuhiko Kume},
  title = {Dopamine Modulates the Rest Period Length without Perturbation of Its Power Law Distribution in Drosophila melanogaster},
  journal = {Plos One},
  year = 2012,
}

@article{CTT100704234,
  author = {Nagae G and Isagawa T and Shiraki N and Fujita T and Yamamoto S and Tsutsumi S and Nonaka A and Yoshiba S and Matsusaka K and Midorikawa Y and Ishikawa S and Soejima H and Fukayama M and Suemori H and Nakatsuji N and Shoen Kume and Aburatani H},
  title = {Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.},
  journal = {Human Molecular Genetics},
  year = 2011,
}

@article{CTT100713339,
  author = {Taro Ueno and Shoen Kume and Kazuhiko Kume},
  title = {Dopaminergic sleep regulation in Drosophila melanogaster},
  journal = {Neuroscience Research},
  year = 2011,
}

@article{CTT100704235,
  author = {Higuchi Y and Shiraki N and Shoen Kume},
  title = {In vitro models of pancreatic differentiation using embryonic stem or induced pluripotent stem cells.},
  journal = {Congenital Anomalies},
  year = 2011,
}

@article{CTT100713338,
  author = {Matsuo, Akira and Yoshida, Tetsu and Yasukawa, Takanori and Miki, Rika and Kazuhiko Kume and Shoen Kume},
  title = {Epiplakin1 is expressed in the cholangiocyte lineage cells in normal liver and adult progenitor cells in injured liver},
  journal = {Gene Expression Patterns},
  year = 2011,
}

@article{CTT100704236,
  author = {Shiraki N and Yamazoe T and Qin Z and Ohgomori K and Mochitate K and Kume K and Shoen Kume},
  title = {Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.},
  journal = {Plos One},
  year = 2011,
}

@article{CTT100704237,
  author = {Isagawa T and Nagae G and Shiraki N and Fujita T and Sato N and Ishikawa S and Shoen Kume and Aburatani H},
  title = {DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.},
  journal = {PLoS ONE},
  year = 2011,
}

@article{CTT100704238,
  author = {Ogaki S and Harada S and Shiraki N and Kume K and Shoen Kume},
  title = {An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.},
  journal = {BMC Developmental Biology},
  year = 2011,
}

@article{CTT100704239,
  author = {Higuchi Y and Shiraki N and Yamane K and Qin Z and Mochitate K and Araki K and Senokuchi T and Yamagata K and Hara M and Kume K and Shoen Kume},
  title = {Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages.},
  journal = {Journal of Cell Sciences},
  year = 2010,
}

@article{CTT100704240,
  author = {Katsumoto K and Shiraki N and Miki R and Shoen Kume},
  title = {Embryonic and adult stem cell systems in mammals: ontology and regulation.},
  journal = {Development Growth Differentiation},
  year = 2010,
}

@article{CTT100704241,
  author = {Shiraki N and Harada S and Ogaki S and Kume K and Shoen Kume},
  title = {Identification of DAF1/CD55, a novel definitive endoderm marker.},
  journal = {Cell Structure Function},
  year = 2010,
}

@article{CTT100704242,
  author = {Yoshida T and Murata K and Shiraki N and Kume K and Shoen Kume},
  title = {Analysis of gene expressions of embryonic stem-derived Pdx1-expressing cells: implications of genes involved in pancreas differentiation.},
  journal = {Development Growth Differentiation},
  year = 2009,
}

@article{CTT100704243,
  author = {Shiraki N and Higuchi Y and Harada S and Umeda K and Isagawa T and Aburatani H and Kume K and Shoen Kume},
  title = {Differentiation and characterization of embryonic stem cells into three germ layers.},
  journal = {Biochemical and Biophysical Research Communications},
  year = 2009,
}

@article{CTT100713340,
  author = {Taro Ueno and Jun Tomita and Yamazaki, Masako and Shoen Kume and Kazuhiko Kume},
  title = {Three state model for the evaluation of arousal and sleep in fruit fly},
  journal = {Journal of Neurogenetics},
  year = 2009,
}

@article{CTT100704245,
  author = {Shiraki N and Umeda K and Sakashita N and Takeya M and Kume K and Shoen Kume},
  title = {Differentiation of mouse and human embryonic stem cells into hepatic lineages.},
  journal = {Genes to Cells},
  year = 2008,
}

@article{CTT100704244,
  author = {Yoshida T and Shiraki N and Baba H and Goto M and Fujiwara S and Kume K and Shoen Kume},
  title = {Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.},
  journal = {Genes to Cells},
  year = 2008,
}

@article{CTT100704246,
  author = {Shiraki N and Yoshida T and Araki K and Umezawa A and Higuchi Y and Goto H and Kume K and Shoen Kume},
  title = {Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.},
  journal = {Stem Cells},
  year = 2008,
}

@article{CTT100713342,
  author = {Shiraki, N and Lai, CJ and Hishikari, Y and Shoen Kume},
  title = {TGF-beta signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells},
  journal = {Genes To Cells},
  year = 2005,
}

@article{CTT100780707,
  author = {Shoen Kume},
  title = {Stem cell-based approaches for regenerative medicine.},
  journal = {Development Growth & Differentiation},
  year = 2005,
}

@article{CTT100713341,
  author = {Shoen Kume},
  title = {The molecular basis and prospects in pancreatic development},
  journal = {Development Growth & Differentiation},
  year = 2005,
}

@article{CTT100713346,
  author = {Ohmuraya, M and Hirota, M and Araki, M and Mizushima, N and Matsui, M and Mizumoto, T and Haruna, K and Shoen Kume and Takeya, M and Ogawa, M and Araki, K and Yamamura, K},
  title = {Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice},
  journal = {Gastroenterology},
  year = 2005,
}

@article{CTT100713345,
  author = {Kume, K and Shoen Kume and Park, SK and Hirsh, J and Jackson, FR},
  title = {Dopamine is a regulator of arousal in the fruit fly},
  journal = {Journal of Neuroscience},
  year = 2005,
}

@article{CTT100713344,
  author = {Kodama, S and Toyonaga, T and Kondo, T and Matsumoto, K and Tsuruzoe, K and Kawashima, J and Goto, H and Kume, K and Shoen Kume and Sakakida, M and Araki, E},
  title = {Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice},
  journal = {Biochemical and Biophysical Research Communications},
  year = 2005,
}

@article{CTT100713343,
  author = {Kume, S and Shoen Kume},
  title = {Stem-cell-based approaches for regenerative medicine},
  journal = {Development Growth & Differentiation},
  year = 2005,
}

@article{CTT100713349,
  author = {Saneyoshi, T and Shoen Kume and Mikoshiba, K},
  title = {Calcium/calmodulin-dependent protein kinase I in Xenopus laevis},
  journal = {Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology},
  year = 2003,
}

@article{CTT100713348,
  author = {Rajagopal, J and Anderson, WJ and Shoen Kume and Martinez, OI and Melton, DA},
  title = {Insulin staining of ES cell progeny from insulin uptake},
  journal = {Science},
  year = 2003,
}

@article{CTT100810679,
  author = {Saneyoshi, T and Kume, S and Amasaki, Y and Mikoshiba, K and Shoen Kume},
  title = {The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos},
  journal = {Nature},
  year = 2002,
}

@article{CTT100783614,
  author = {Kume, S and Saneyoshi, T and Mikoshiba, K and Shoen Kume},
  title = {Desensitization of IP3-induced Ca2+ release by overexpression of a constitutively active Gq alpha protein converts ventral to dorsal fate in Xenopus early embryos},
  journal = {Development Growth & Differentiation},
  year = 2000,
}

@article{CTT100713351,
  author = {Shoen Kume and Inoue, T and Mikoshiba, K},
  title = {G alpha s family G proteins activate IP3-Ca2+ signaling via G beta gamma and transduce ventralizing signals in Xenopus},
  journal = {Developmental Biology},
  year = 2000,
}

@article{CTT100713353,
  author = {Shoen Kume},
  title = {Role of the inositol 1,4,5-trisphosphate receptor in early embryonic development},
  journal = {Cellular and Molecular Life Sciences},
  year = 1999,
}

@article{CTT100713355,
  author = {Shoen Kume and Mikoshiba, K},
  title = {[Role of PI signaling in early development].},
  journal = {Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme},
  year = 1998,
}

@article{CTT100713354,
  author = {Mikoshiba, Katsuhiko and Shoen Kume and Muto, Akira},
  title = {Role of IP3 receptor/Ca2+ channel on egg and embryo development},
  journal = {Zygote},
  year = 1998,
}

@article{CTT100783613,
  author = {Kume, S and Muto, A and Inoue, T and Suga, K and Okano, H and Mikoshiba, K and Shoen Kume},
  title = {Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos},
  journal = {Science},
  year = 1997,
}

@article{CTT100783610,
  author = {Kume, S and Yamamoto, A and Inoue, T and Muto, A and Okano, H and Mikoshiba, K and Shoen Kume},
  title = {Developmental expression of the inositol 1,4,5-trisphosphate receptor and structural changes in the endoplasmic reticulum during oogenesis and meiotic maturation of Xenopus laevis},
  journal = {Developmental Biology},
  year = 1997,
}

@article{CTT100783611,
  author = {Kume, S and Muto, A and Okano, H and Mikoshiba, K and Shoen Kume},
  title = {Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis},
  journal = {Mechanisms of Development},
  year = 1997,
}

@article{CTT100783612,
  author = {Umemori, H and Inoue, T and Kume, S and Sekiyama, N and Nagao, M and Itoh, H and Nakanishi, S and Mikoshiba, K and Yamamoto, T and Shoen Kume},
  title = {Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunit},
  journal = {Science},
  year = 1997,
}

@article{CTT100783609,
  author = {Muto, A and Kume, S and Inoue, T and Okano, H and Mikoshiba, K and Shoen Kume},
  title = {Calcium waves along the cleavage furrows in cleavage-stage Xenopus embryos and its inhibition by heparin},
  journal = {Journal of Cell Biology},
  year = 1996,
}

@article{CTT100783608,
  author = {HONDA, Z and TAKANO, T and HIROSE, N and SUZUKI, T and MUTO, A and KUME, S and MIKOSHIBA, K and ITOH, K and SHIMIZU, T and Shoen Kume},
  title = {G(Q) PATHWAY DESENSITIZES CHEMOTACTIC RECEPTOR-INDUCED CALCIUM SIGNALING VIA INOSITOL TRISPHOSPHATE RECEPTOR DOWN-REGULATION},
  journal = {Journal of Biological Chemistry},
  year = 1995,
}

@article{CTT100783607,
  author = {KUME, S and MUTO, A and ARUGA, J and NAKAGAWA, T and MICHIKAWA, T and FURUICHI, T and NAKADE, S and OKANO, H and MIKOSHIBA, K and Shoen Kume},
  title = {THE XENOPUS IP(3) RECEPTOR - STRUCTURE, FUNCTION, AND LOCALIZATION IN OOCYTES AND EGGS},
  journal = {Cell},
  year = 1993,
}

@article{CTT100713363,
  author = {YAMAMOTO, T and MASUKO, K and TAKADA, S and OBINATA, M and Shoen Kume},
  title = {A BALANCE BETWEEN SELF-RENEWAL AND COMMITMENT IN THE MURINE ERYTHROLEUKEMIA-CELLS WITH THE TRANSFERRED C-MYC GENE - AN INVITRO STOCHASTIC-MODEL},
  journal = {Cell Differentiation and Development},
  year = 1989,
}

@article{CTT100750436,
  author = {YAMAMOTO, T and MASUKO, K and TAKADA, S and KUME, TU and OBINATA, M and Shoen Kume},
  title = {A BALANCE BETWEEN SELF-RENEWAL AND COMMITMENT IN THE MURINE ERYTHROLEUKEMIA-CELLS WITH THE TRANSFERRED C-MYC GENE - AN INVITRO STOCHASTIC-MODEL},
  journal = {Cell Differentiation and Development},
  year = 1989,
}

@article{CTT100750440,
  author = {KUME, TU and TAKADA, S and OBINATA, M and Shoen Kume},
  title = {PROBABILITY THAT THE COMMITMENT OF MURINE ERYTHROLEUKEMIA CELL-DIFFERENTIATION IS DETERMINED BY THE C-MYC LEVEL},
  journal = {Journal of Molecular Biology},
  year = 1988,
}

@article{CTT100713365,
  author = {KANEKOISHINO, T and KUME, TU and SASAKI, H and OBINATA, M and OISHI, M and Shoen Kume},
  title = {EFFECT OF C-MYC GENE-EXPRESSION ON EARLY INDUCIBLE REACTIONS REQUIRED FOR ERYTHROID-DIFFERENTIATION INVITRO},
  journal = {Molecular and Cellular Biology},
  year = 1988,
}

@inproceedings{CTT100916690,
  author = {富永成海 and 上船史弥 and 井上愛⾥ and 板⾕勇輝 and 徳間啓 and ⽩⽊伸明 and 坂野⼤介 and 粂昭苑},
  title = {膵臓β細胞における不均⼀なドーパミン合成能の⽣理学的役割の解明},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916688,
  author = {鈴木秀宜 and 小倉俊一郎 and 白木伸明 and 粂昭苑},
  title = {5-アミノレブリン酸を用いた光線力学療法のヒト iPS 膵臓分化誘導への応用},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916691,
  author = {木村莉瑠 and 西藤巧 and 渡邊輝彦 and 長田優菜 and 白木伸明 and 粂昭苑},
  title = {共培養系を用いた iPS-小腸細胞と肝細胞との相互作用の解析},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916692,
  author = {岸本 恵理子 and 徳間 啓 and 井上 愛里 and 白木 伸明 and 坂野 大介 and 粂 昭苑},
  title = {HSVTK-GCV スイッチを利用した iPS 細胞由来β細胞における造腫瘍抑制},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100917218,
  author = {図師菜々美 and 田熊 めぐみ and Yumeng Wu and 遠藤 貴南 and 粂 昭苑 and 白木 伸明 and 藤枝 俊宣},
  title = {多孔質高分子ナノシートの積層によるタンパク質透過性の制御},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100916689,
  author = {Nobuaki Shiraki and Erinn Zixuan Sim and Takayuki Enomoto and Nao Furuta and Soshiro Kashio and Taiho Kambe and Tomonori Tsuyama and Akihiro Arakawa and Hiroki Ozawa and Mizuho Yokoyama and Masayuki Miura and Shoen Kume},
  title = {Methionine metabolism regulates pluripotent stem cell through zinc mobilization},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895366,
  author = {門倉瑶乃 and 荒川哲大 and 山崎淳子 and Erinn Zixuan Sim and 白木伸明 and 粂昭苑},
  title = {多能性幹細胞の未分化および分化状態における細胞内亜鉛動態解析},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895363,
  author = {渡邊輝彦 and Grace A. Helena and 白木伸明 and 粂昭苑},
  title = {浮遊型初代ヒト肝細胞を培養容器に接着させる培地の開発とそのアプリケーション},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895362,
  author = {白木伸明 and 粂昭苑},
  title = {ヒト多能性幹細胞由来膵β細胞の成熟化},
  booktitle = {},
  year = 2023,
}

@inproceedings{CTT100895360,
  author = {Marwa Ali and Yusuke Kato and Nobuaki Shiraki and Shoen Kume},
  title = {Generation of induced pluripotent stem cell-derived Beta cells in blood amino acids-like medium},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895359,
  author = {Dwina Juliana Warman and Takami Watanabe and Nobuaki Shiraki and Shoen Kume and Huijuan Jia and Hisanori Kato},
  title = {Effects of two-day prenatal methionine deficiency on pancreatic development in newborn rats},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895367,
  author = {Leo Sylvia and Kato Yusuke and Wu Yumeng and Shiraki Nobuaki and Kume Shoen},
  title = {The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895368,
  author = {Naoya Hiyoshi and Takayuki Enomoto and Airi Inoue and Yusuke Kato and Daisuke Sakano and Kimi Araki and Nobuaki Shiraki and Shoen Kume},
  title = {Investigation of metabolite profile in plasma from Kuma mice using LC-MS/MS},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895365,
  author = {金子 知代 and 榎本 孝幸 and 小島 慧理果 and 白木 伸明 and 粂 昭苑},
  title = {メチオニン制限を組み込んだ新規iPS細胞膵臓分化方法の開発},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100895364,
  author = {渡邊輝彦 and 白木伸明 and 粂昭苑},
  title = {ad-MEDビトリゲル2とciKIC IEC MMを用いて構築したヒトiPS細胞由来腸管上皮モデルの消化管吸収評価モデルとしての有用性},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883018,
  author = {白木伸明 and 小澤弘樹 and 神戸梓沙 and 粂 昭苑},
  title = {メチオニンは亜鉛代謝を介して多能性幹細胞を制御する},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883016,
  author = {Shiraki Nobuaki and Shoen Kume},
  title = {Characterization of heterozygous ATTR Y114C amyloidosis-specific iPS cells},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883017,
  author = {Shiraki Nobuaki and Shoen Kume},
  title = {Characterization of heterozygous ATTR Y114C amyloidosis-specific iPS cells},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883015,
  author = {粂 昭苑},
  title = {Metabolic control of pluripotent stem cells in the generation of pancreatic endocrine beta cells.},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883014,
  author = {Kato Yusuke and Shiraki Nobuaki and Shoen Kume},
  title = {Generation of functional pancreatic beta cells derived from human induced pluripotent Stem Cell-with physiological cell culture medium},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100883013,
  author = {粂 昭苑},
  title = {ヒトiPS細胞由来膵島の作成とインスリン分泌の制御機構解明},
  booktitle = {},
  year = 2022,
}

@inproceedings{CTT100878696,
  author = {上船史弥 and 坂野大介 and 粂 昭苑},
  title = {膵β細胞におけるD1-D2ヘテロ多量体を介したドーパミンによるインスリン分泌抑制機構の解明},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878698,
  author = {徳間啓 and 坂野大介 and 粂 昭苑},
  title = {WFS1の発現低下とインスリン分泌の関連性の解明},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878697,
  author = {井上愛里 and 下道隆広 and 坂野大介 and 粂 昭苑},
  title = {ドパミンによる膵臓発生機構の解明},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878695,
  author = {Grace Aprilia Helena and Nobuaki Shiraki and Shoen Kume},
  title = {Improvement of Primary Human Hepatocyte Cell Attachment},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878693,
  author = {小澤弘樹 and 神戸梓沙 and 日比滉大 and 木村宏 and 白木伸明 and 粂 昭苑},
  title = {メチオニン除去培養によるエピジェネティック変化を伴うヒトiPS細胞分化促進},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878691,
  author = {粂 昭苑},
  title = {アミノ酸の代謝を活用したiPS細胞の分化誘導系の構築},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878690,
  author = {Shoen Kume},
  title = {Metabolic control of pluripotent stem cells for the generation of pancreatic beta-cells},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878688,
  author = {粂 昭苑},
  title = {多能性幹細胞の維持と膵臓β細胞分化における亜鉛シグナルの関与},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878687,
  author = {粂 昭苑},
  title = {ヒト多能性幹細胞を用いた糖尿病の再生医療},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100878686,
  author = {粂 昭苑},
  title = {ヒトiPS細胞からの膵島作成とモデル細胞としての利用},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852319,
  author = {粂 昭苑},
  title = {夢の再生医療},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852318,
  author = {粂 昭苑},
  title = {ヒトiPS細胞を用いた糖尿病の再生医療研究},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852311,
  author = {白木 伸明 and 粂 昭苑},
  title = {コラーゲンビトリゲル膜と新規培地で培養したヒトiPS細胞由来小腸細胞の有用性},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852310,
  author = {萩本隆之介 and LeoSylvia Han Yun and 白木 伸明 and 粂 昭苑},
  title = {吸収腸上皮細胞への分化を促進する低分子化合物のスクリーニング},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852309,
  author = {滝波那拓 and 榎本孝幸 and 白木 伸明 and 粂 昭苑},
  title = {ヒ膵島移植に用いるための免疫隔離カプセルの評価},
  booktitle = {},
  year = 2021,
}

@inproceedings{CTT100852317,
  author = {粂 昭苑},
  title = {メチオニン代謝による幹細胞制御、および膵臓β細胞分化に与える影響},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100852312,
  author = {芝江柾葵 and 上船史弥 and 坂野大介 and 粂 昭苑},
  title = {マウス膵内分泌細胞のVMAT2による膵島の機能制御},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100852313,
  author = {吉田晋平 and 本荘貴之 and 白木 伸明 and 粂 昭苑},
  title = {薬物動態評価モデルとしてのヒトiPS細胞由来小腸上皮細胞の開発},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100852316,
  author = {Shoen Kume},
  title = {Directed differentiation of pluripotent stem cell-derived pancreatic beta cells},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100852314,
  author = {粂 昭苑},
  title = {ヒト多能性幹細胞を用いた膵島再生研究},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100852315,
  author = {粂 昭苑},
  title = {多能性幹細胞からの腸管細胞の作製と利用},
  booktitle = {},
  year = 2020,
}

@inproceedings{CTT100811491,
  author = {柴田 伊真 and 下道 隆広 and 渡邊 輝彦 and 山口 宏之 and 白木 伸明 and 粂 昭苑},
  title = {メチオニン除去培地とコラーゲンビトリゲル薄膜を用いて分化誘導したヒト iPS 細胞由来肝臓細胞を利用した薬物毒性試験系の構築},
  booktitle = {},
  year = 2019,
}

@inproceedings{CTT100811496,
  author = {小田 雄一 and 篠原 満利恵 and 飯生 啓太 and 新谷 華梨 and 進 和美 and 佐藤 琢 and 荒川 大 and 白木 伸明 and 立野 知世 and 杉浦 慎治 and 粂 昭苑 and 加藤 将 夫 and 金森 敏幸 and 木村 啓志 and 酒井 康行},
  title = {二臓器連結モデル型 Microphysiological System を用いた新鮮ヒト肝細胞とヒト iPS 細胞由来腸管上皮細胞の灌流共培養},
  booktitle = {},
  year = 2019,
}

@inproceedings{CTT100811536,
  author = {小田 雄一 and 篠原 満利恵 and 飯生 啓太 and 新谷 華梨 and 進 和美 and 佐藤 琢 and 荒川 大 and 白木 伸明 and 立野 知世 and 杉浦 慎治 and 粂 昭苑 and 加藤 将 夫 and 金森 敏幸 and 木村 啓志 and 酒井 康行},
  title = {二臓器連結－圧力駆動型Microphysiological Systemを用いたヒト肝細胞とヒトiPS細胞由来腸管上皮細胞のリアルタイム灌流共培養},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100784188,
  author = {井上愛里 and 坂野大介 and 榎本孝幸 and 中原  舞 and 岡田  誠治 and 荒木喜美 and 粂昭苑},
  title = {Insulin2タンパクへのQ104del変異導入による自然発症１型糖尿病モデルマウスの作製},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811501,
  author = {本荘 貴之 and 飯生 啓太 and 前田 和哉 and 渡邊 輝彦 and 石川 晶也 and 楠原 洋之 and 白木 伸明 and 粂 昭苑},
  title = {ヒトiPS細胞から機能的な小腸吸収上皮細胞への新規分化誘導系の構築},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811499,
  author = {日比 滉大 and 秋山 智彦 and 洪実 and 白木 伸明 and 粂 昭苑},
  title = {メチオニン除去培養によるヒトiPS細胞分化促進の機序解明},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811519,
  author = {Zixuan Erinn Sim and Nobuaki Shiraki and Shoen Kume},
  title = {Insulin supplement is essential in differentiating human induced pluripotent stem cells into pancreatic beta cells},
  booktitle = {},
  year = 2018,
}

@inproceedings{CTT100811427,
  author = {白木 伸明 and 粂昭苑},
  title = {ES/iPS細胞から膵β細胞への分化制御と糖尿病再生医療の現状と展開 (特集 代謝関連疾患と合併症の再生医療の最前線)},
  booktitle = {内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism},
  year = 2018,
}

@inproceedings{CTT100784180,
  author = {荒木菜 and 豊田悠暉 and 坂野大介 and 粂昭苑},
  title = {膵β細胞発生におけるモノアミンシグナル伝達経路の解明},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100784189,
  author = {Uefune F and Sonoda Y and Sakano D and Aonishi T and Kume S},
  title = {Analysis of Vmat2 mediated regulation in insulin secretion},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100784182,
  author = {坂野大介 and 豊田悠暉 and 荒木菜 and 粂昭苑},
  title = {モノアミンシグナルによる膵β細胞の分化・増殖制御},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100784181,
  author = {豊田悠暉 and 荒木菜 and 坂野大介 and 粂昭苑},
  title = {モノアミンによる膵β細胞の分化及び成熟化調節機構に関する研究},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744755,
  author = {Erinn Sim Zixuan and Saeko Momma and Nobuaki Shiraki and Shoen Kume},
  title = {A NOVEL 3D SPHEROID CULTURE SYSTEM FOR GENERATING FUNCTIONAL PANCREATIC beta CELLS DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744663,
  author = {Hiraku Tokuma and Zixuan Erinn Sim and Fumiya Uefune and Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {Establishment and analysis of hiPSC that visualize the INSULIN producing cells},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744655,
  author = {D.Sakano and S.Kume},
  title = {Monoamine signals control beta-cell differentiation, maturation and function},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744670,
  author = {Hiraku Tokuma and Erinn Sim Zixuan and Fumiya Uefune and Daisuke Sakano and Nobuaki Shiraki and Shoen Kume.},
  title = {Generation and Characterization of an INSULIN promoter driven mCherry Reporter Human iPS Cell Lines Using CRISPR/Cas9 system},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744753,
  author = {門馬紗英子 and 白木伸明 and 粂昭苑},
  title = {多能性幹細胞から膵臓β細胞への分化誘導過程におけるアミノ酸要求性},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744666,
  author = {Uefune F and Sonoda Y and Sakano D and Aonishi T and Kume S},
  title = {Role of vesicular monoamine transporter 2 in insulin secretion},
  booktitle = {},
  year = 2017,
}

@inproceedings{CTT100744745,
  author = {神戸梓沙 and 白木伸明 and 木村宏 and 粂昭苑},
  title = {ヒトiPS細胞におけるメチオニン代謝とヒストン修飾の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744746,
  author = {古田奈央 and 荒川哲大 and 岩畑大悟 and 白木伸明 and 粂昭苑},
  title = {未分化iPS細胞および分化過程おける亜鉛の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100724024,
  author = {Daisuke Sakano and 園田雄輝 and Fumiya Uefune and Shoen Kume},
  title = {Monoamine signals that control differentiation and proliferation of pancreatic beta cells},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100724026,
  author = {坂野大介 and 園田雄輝 and 上船史弥 and 粂昭苑},
  title = {モノアミンシグナルによる膵β細胞の増殖・分化の制御},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100724028,
  author = {Daisuke Sakano and 園田雄輝 and Fumiya Uefune and Shoen Kume},
  title = {Monoamine signaling controls cell proliferation and differentiation state of  pancreatic beta cell},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100744744,
  author = {門馬紗英子 and 白木伸明 and 及川彰 and 粂昭苑},
  title = {幹細胞の未分化維持及び分化におけるメチオニン代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100723357,
  author = {白木伸明 and 門馬紗英子 and 粂昭苑},
  title = {幹細胞分化におけるアミノ酸代謝の役割},
  booktitle = {},
  year = 2016,
}

@inproceedings{CTT100724023,
  author = {坂野大介 and 園田雄輝 and 上船史弥 and 粂昭苑},
  title = {モノアミンを介したシグナルによる膵β細胞の増殖・機能調節},
  booktitle = {},
  year = 2015,
}

@inproceedings{CTT100712033,
  author = {白木 伸明 and 粂昭苑},
  title = {糖尿病の再生医療 (第5土曜特集 糖尿病のすべて) -- (糖尿病対策と将来の根治・予防)},
  booktitle = {医学のあゆみ},
  year = 2015,
}

@inproceedings{CTT100712674,
  author = {坂野 大介 and 粂昭苑},
  title = {VMAT2と膵β細胞分化},
  booktitle = {内分泌・糖尿病・代謝内科},
  year = 2014,
}

@inproceedings{CTT100712677,
  author = {坂野 大介 and 粂昭苑},
  title = {膵β細胞研究の進化と展望(第1回)多能性幹細胞から膵β細胞への分化を制御するシグナル},
  booktitle = {Islet equality},
  year = 2014,
}

@inproceedings{CTT100712675,
  author = {坂野 大介 and 粂昭苑},
  title = {ES細胞・iPS細胞を用いた発生分化の研究と再生医学への応用 (特集 器官の発生と再生の基礎)},
  booktitle = {生体の科学},
  year = 2014,
}

@inproceedings{CTT100791681,
  author = {池 道彦 and 坂東 昌子 and 粂昭苑 and 近藤科江 and 大垣 昌夫 and 大竹 文雄},
  title = {シンポジウム『保育と行動経済学―学内保育園を通じて―』},
  booktitle = {行動経済学},
  year = 2014,
}

@inproceedings{CTT100712038,
  author = {白木 伸明 and 粂昭苑},
  title = {ES/iPS細胞から膵臓への分化誘導(最前線,<特集>躍進する幹細胞研究)},
  booktitle = {ファルマシア},
  year = 2012,
}

@inproceedings{CTT100712042,
  author = {山添 太士 and 白木 伸明 and 粂昭苑},
  title = {ES細胞由来分化肝細胞の創出 (AYUMI ヒト幹細胞による薬物代謝・トランスポート・副作用予測--iPS・ES細胞・間葉系細胞を用いた新たな創薬スクリーニング)},
  booktitle = {医学のあゆみ},
  year = 2010,
}

@inproceedings{CTT100712045,
  author = {樋口 裕一郎 and 白木 伸明 and 粂昭苑},
  title = {iPS細胞を用いた膵臓細胞の作製と, その移植医療への応用},
  booktitle = {移植},
  year = 2009,
}

@inproceedings{CTT100712047,
  author = {粂昭苑 and 白木 伸明},
  title = {膵の発生分化と幹細胞系を用いた膵の再生医学},
  booktitle = {臨床病理 = THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE},
  year = 2006,
}

@misc{CTT100916684,
  author = {白木 伸明 and 粂昭苑},
  title = {メチオニンと亜鉛は多能性幹細胞の多能性および分化を制御する},
  year = 2023,
}

@misc{CTT100895356,
  author = {坂野大介 and 粂 昭苑},
  title = {新しい時代の1型糖尿病治療―再生医療の現状もふまえて},
  year = 2022,
}

@misc{CTT100895358,
  author = {坂野大介 and 粂 昭苑},
  title = {膵臓内分泌細胞の発生と分化における1細胞レベルにおける理解},
  year = 2020,
}

@misc{CTT100835591,
  author = {白木伸明 粂昭苑},
  title = {臓器チップに要求される細胞組織ソースと細胞共用培地},
  year = 2020,
}

@misc{CTT100835590,
  author = {坂野大介 粂昭苑},
  title = {膵β細胞再生療法の最前線},
  year = 2020,
}

@misc{CTT100810693,
  author = {粂昭苑},
  title = {多能性幹細胞を用いた内胚葉由来の組織の作製},
  year = 2019,
}

@misc{CTT100810692,
  author = {粂昭苑},
  title = {創薬応用へ向けた幹細胞由来ヒト腸細胞研究の現状},
  year = 2018,
}

@misc{CTT100750381,
  author = {Shoen Kume},
  title = {Heterogeneity of beta-cells.},
  year = 2017,
}

@misc{CTT100723363,
  author = {Tomonori Tsuyama and Nobuaki Shiraki and Shoen Kume},
  title = {Definitive Endoderm Differentiation of Human Embryonic Stem Cells Combined with Selective Elimination of Undifferentiated Cells by Methionine Deprivation.},
  year = 2016,
}

@misc{CTT100723316,
  author = {白木伸明 and 粂昭苑},
  title = {iPS細胞と肝胆膵疾患ー膵臓・肝臓への分化ー},
  year = 2016,
}

@misc{CTT100723312,
  author = {白木伸明 and 粂昭苑},
  title = {アミノ酸代謝によるヒト多能性幹細胞の維持・分化誘導},
  year = 2016,
}

@misc{CTT100723343,
  author = {白木伸明 and 粂昭苑},
  title = {iPS細胞の内胚葉系への誘導},
  year = 2015,
}

@misc{CTT100723326,
  author = {白木伸明 and 粂昭苑},
  title = {幹細胞維持と分化におけるメチオニン代謝},
  year = 2015,
}

@misc{CTT100712681,
  author = {坂野大介 and 粂昭苑},
  title = {-ヒト多能性幹細胞からの機能的な膵β細胞の作出-},
  year = 2015,
}

@misc{CTT100712673,
  author = {坂野 大介 and 粂昭苑},
  title = {ケミカルバイオロジーを応用した機能的β細胞作製 (特集 糖尿病領域における再生医療の現状と展望)},
  year = 2015,
}

@misc{CTT100723365,
  author = {Daisuke Sakano and Nobuaki Shiraki and Shoen Kume},
  title = {Pancreatic differentiation from murine embryonic stem cells},
  year = 2015,
}

@misc{CTT100723319,
  author = {白木伸明 and 粂昭苑},
  title = {糖尿病の再生医学},
  year = 2015,
}

@misc{CTT100723331,
  author = {白木伸明 and 粂昭苑},
  title = {ES/iPS細胞からの膵臓β細胞への分化誘導},
  year = 2015,
}

@misc{CTT100704216,
  author = {Yamazoe T and Shiraki N and Shoen Kume},
  title = {Hepatic Differentiation from Murine and Human iPS Cells Using Nanofiber Scaffolds.},
  year = 2014,
}

@misc{CTT100704217,
  author = {Umeda K and Shiraki N and Shoen Kume},
  title = {Hepatic Differentiation from Human Ips Cells Using M15 Cells.},
  year = 2014,
}

@misc{CTT100712034,
  author = {白木 伸明 and 粂昭苑},
  title = {iPS細胞研究最前線 : 疾患モデルから臓器再生まで(Vol.10)ES/iPS細胞を用いた内胚葉細胞(膵,肝,小腸)への分化誘導},
  year = 2014,
}

@misc{CTT100712676,
  author = {坂野 大介 and 粂 昭苑},
  title = {膵β細胞・膵島の再生研究 (特集 糖尿病 : 診断・治療Update)},
  year = 2014,
}

@misc{CTT100712039,
  author = {坂野大介 and 白木 伸明 and 粂昭苑},
  title = {多能性幹細胞から膵β細胞への分化 (特集 発生・分化・再生と代謝関連臓器)},
  year = 2013,
}

@misc{CTT100712037,
  author = {山添 太士 and 白木 伸明 and 佐々木 裕 and 粂昭苑},
  title = {肝臓の再生医療 (特集 再生医療)},
  year = 2013,
}

@misc{CTT100712678,
  author = {坂野 大介 and 粂昭苑},
  title = {多能性幹細胞からの膵β細胞分化誘導 (特集 臨床医にもわかる糖尿病基礎研究)},
  year = 2012,
}

@misc{CTT100712041,
  author = {坂野大介 and 白木 伸明 and 粂昭苑},
  title = {１型糖尿病治療の新しい知見  ６．ｉＰＳ細胞による糖尿病医療研究のこれから},
  year = 2011,
}

@misc{CTT100712040,
  author = {坂野大介 and 白木 伸明 and 粂昭苑},
  title = {iPS細胞による糖尿病医療研究のこれから},
  year = 2011,
}

@misc{CTT100712044,
  author = {梅田 香穂子 and 白木 伸明 and 粂昭苑},
  title = {最新医学講座 iPS細胞(9)ES細胞やiPS細胞からの膵臓分化誘導と臨床への応用},
  year = 2009,
}

@misc{CTT100712046,
  author = {白木 伸明 and 粂昭苑},
  title = {再生医療・遺伝子治療 ES細胞を用いた膵臓の再生医学 (新時代の糖尿病学(3)病因・診断・治療研究の進歩) -- (糖尿病治療学の進歩)},
  year = 2008,
}

@misc{CTT100882391,
  author = {粂昭苑 and 白木伸明 and 渡邊　輝彦},
  title = {肝細胞の培養方法},
  howpublished = {公開特許},
  year = 2022,
  month  = {},
  note   = {PCT/JP2021/048217(2021/12/24), WO 2022/138922(2022/06/30)}
}


@misc{CTT100869580,
  author = {粂昭苑 and 白木伸明 and 矢野　辰也 and 木方　俊宏},
  title = {ジヒドロインドリジノン誘導体を用いたインスリン産生細胞の作製法},
  howpublished = {公開特許},
  year = 2021,
  month  = {},
  note   = {PCT/JP2020/026543(2020/07/07), WO 2021/006268(2021/01/14)}
}


@misc{CTT100828293,
  author = {粂昭苑 and 白木伸明 and 楠原　洋之　 and 前田　和哉　 and 石川　晶也 and 渡邊　輝彦　},
  title = {多能性幹細胞から腸細胞の作製方法},
  howpublished = {登録特許},
  year = 2023,
  month  = {},
  note   = {特願2019-117748(2019/06/25), 特開2020-039337(2020/03/19), 特許第7377486号(2023/11/01)}
}


@misc{CTT100861476,
  author = {粂昭苑 and 白木伸明 and 榎本孝幸 and 千葉  明},
  title = {多能性幹細胞の分化促進方法},
  howpublished = {公開特許},
  year = 2021,
  month  = {},
  note   = {特願2020-515575(2019/04/25), 再表2019/208713(2021/05/13)}
}


@misc{CTT100845253,
  author = {粂昭苑 and 白木伸明 and 山口　宏之 and 井上　智彰 and 中川　俊人 and 清川　順平},
  title = {多能性幹細胞から肝細胞への分化誘導方法},
  howpublished = {登録特許},
  year = 2023,
  month  = {},
  note   = {特願2019-548186(2018/10/09), 再表2019/073951(2020/12/03), 特許第7315150号(2023/07/18)}
}


@misc{CTT100815586,
  author = {粂昭苑 and 坂野大介 and 榎本孝幸 and 荒木　喜美　 and 岡田　誠治　},
  title = {糖尿病モデル動物},
  howpublished = {公開特許},
  year = 2019,
  month  = {},
  note   = {特願2018-076855(2018/04/12), 特開2019-180315(2019/10/24)}
}


@misc{CTT100746395,
  author = {粂昭苑 and 白木伸明},
  title = {インスリン産生細胞の分化誘導方法},
  howpublished = {登録特許},
  year = 2019,
  month  = {},
  note   = {特願2016-521118(2015/05/19), 再表2015/178397(2017/04/20), 特許第6596708号(2019/10/11)}
}