@book{CTT100917286, author = {Junichi Yamamoto and Tomoko Asatsuma-Okumura and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {History of IMiDs and Protein Degradation as a Pharmacological Modality}, publisher = {John Wiley & Sons}, year = 2022, } @article{CTT100917288, author = {Noriyuki Azuma and Tadashi Yokoi and Taku Tanaka and Emiko Matsuzaka and Yuki Saida and Sachiko Nishina and Miho Terao and Shuji Takada and Maki Fukami and Kohji Okamura and Kayoko Maehara and Tokiwa Yamasaki and Jun Hirayama and Hiroshi Nishina and Hiroshi Handa and Yuki Yamaguchi}, title = {Integrator complex subunit 15 controls mRNA splicing and is critical for eye development}, journal = {Hum. Mol. Genet.}, year = 2023, } @article{CTT100879617, author = {Nobuyuki Shimizu and Tomoko Asatsuma-Okumura and Junichi Yamamoto and Yuki Yamaguchi and Hiroshi Handa and Takumi Ito}, title = {PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates}, journal = {Commun. Biol.}, year = 2021, } @article{CTT100832156, author = {Junichi Yamamoto and Tetsufumi Suwa and Yuki Murase and Shunpei Tateno and Hirotaka Mizutome and Tomoko Asatsuma-Okumura and Nobuyuki Shimizu and Tsutomu Kishi and Shuji Momose and Masahiro Kizaki and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells}, journal = {Nature Chemical Biology}, year = 2020, } @article{CTT100832458, author = {Cho, J. and Hiramoto, M. and Masaike, Y. and Satoshi Sakamoto and Imai, Y. and Imai, Y. and Hiroshi Handa and Imai, T.}, title = {UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner}, journal = {Biochem. Biophys. Res. Commun.}, year = 2020, } @article{CTT100819548, author = {Shunpei Tateno and Midori Iida and Satoshi Fujii and Miki Katayama and Haruka Tokuyama and Junichi Yamamoto and Takumi Ito and Satoshi Sakamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide }, journal = {Scientific Reports}, year = 2020, } @article{CTT100832459, author = {Sekino, M. and Kuwahata, A. and Fujita, S. and Matsuda, S. and Kaneko, M. and Chikaki, S. and Sakamoto, S. and Saito, I. and Hiroshi Handa and Kusakabe, M.}, title = {Development of an optimized dome-shaped magnet for rapid magnetic immunostaining}, journal = {Development of an optimized dome-shaped magnet for rapid magnetic immunostaining}, year = 2020, } @article{CTT100832460, author = {Sekino, M. and Kuwahata, A. and Yoshibe, A. and Imai, K. and Kaneko, M. and Chikaki, S. and Saito, I. and Tsuruma, A. and Sakamoto, S. and Handa, H. and Matsuda, A. and Kusakabe, M.}, title = {Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis}, journal = {Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis}, year = 2020, } @article{CTT100807675, author = {Asatsuma-Okumura T and Ando H and De Simone M and Yamamoto J and Sato T and Shimizu N and Asakawa K and Yamaguchi Y and Takumi Ito and Guerrini L and Hiroshi Handa}, title = {p63 is a cereblon substrate involved in thalidomide teratogenicity}, journal = {Nature Chemical Biology}, year = 2019, } @article{CTT100798250, author = {Ando, H. and Sato, T. and Ito, T. and Yamamoto, J. and Sakamoto, S. and Nitta, N. and Asatsuma-Okumura, T. and Shimizu, N. and Mizushima, R. and Aoki, I. and Imai, T. and Yamaguchi, Y. and Berk, A.J. and Hiroshi Handa}, title = {Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation}, journal = {iScience}, year = 2019, } @article{CTT100778476, author = {Yasuaki kabe and Satoshi Sakamoto and Mamoru Hatakeyama and Yuki Yamaguchi and Makoto Suematsu and Makoto Itonaga and Hiroshi Handa}, title = {Application of high-performance magnetic nano-beads to biological sensing devices}, journal = {Anal. Bioanal. Chem.}, year = 2019, } @article{CTT100723497, author = {Qing-Fu Cao and Junichi Yamamoto and Tomoyasu Isobe and Shunpei Tateno and Yuki Murase and Yexi Chen and Hiroshi Handa and Yuki Yamaguchi}, title = {Characterization of the human transcription elongation factor Rtf1: evidence for non-overlapping functions of Rtf1 and the Paf1 complex}, journal = {Mol. Cell. Biol.}, year = 2015, } @article{CTT100723496, author = {Clelia Laitem and Justyna Zaborowska and Michael Tellier and Yuki Yamaguchi and Seifuku Sou and Sylvain Egloff and Hiroshi Handa and Shona Murphy}, title = {CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription}, journal = {Transcription}, year = 2015, } @article{CTT100723498, author = {Masa-aki Kawano and Koji Doi and Hajime Fukuda and Yoshinori Kita and Imai Kensuke and Takamasa Inoue and Teruya Enomoto and Masanori Matsui and Mamoru Hatakeyama and Yuki Yamaguchi and Hiroshi Handa}, title = {SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes}, journal = {Biotechnol. Rep.}, year = 2015, } @inproceedings{CTT100884046, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {レナリドマイド耐性多発性骨髄腫細胞の生存に重要なポマリドマイド依存性CRL4CRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100879610, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {ポマリドミド依存的なCRBNのネオ基質ARID2の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100879603, author = {山本淳一 and 山口雄輝 and 半田宏}, title = {ポマリドミド依存的な CRBN のネオ基質 ARID2 の解析}, booktitle = {}, year = 2021, } @inproceedings{CTT100777907, author = {山本 淳一 and Fajar Muhamad and 瑞慶覧 安里 and 舘野 峻平 and 半田宏 and 山口 雄輝}, title = {NELFを中心としたポリ(A)付加部位の選択機構の解析}, booktitle = {}, year = 2017, } @inproceedings{CTT100777904, author = {Fajar Muhamad and Ari Zukeran and Shunpei Tateno and Junichi Yamamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Mechanisms that affect post-transcriptional fate of RNA polymerase II-transcribed genes}, booktitle = {}, year = 2017, } @inproceedings{CTT100777370, author = {山口 雄輝 and 伊藤拓水 and 山本淳一 and 半田宏}, title = {サリドマイドの多様な薬理作用の分子メカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100779842, author = {山本淳一 and 半田宏 and 山口 雄輝}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes}, booktitle = {}, year = 2015, } @inproceedings{CTT100777826, author = {片山 美樹 and 伊藤拓水 and 安藤 秀樹 and 山口 雄輝 and 半田宏}, title = {E3ユビキチンリガーゼの基質認識レセプター CRBNとポマリドマイド依存的な基質Aiolosの生化学的解析}, booktitle = {}, year = 2014, } @inproceedings{CTT100779840, author = {山本淳一 and 半田宏 and 山口雄輝}, title = {DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes}, booktitle = {}, year = 2014, } @inproceedings{CTT100779841, author = {柴田 紘孝 and 半田宏 and 山口 雄輝}, title = {転写伸長因子DSIFおよびNELFがES細胞の多分化能維持に果たす役割}, booktitle = {}, year = 2014, } @misc{CTT100879615, author = {Junichi Yamamoto and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.}, year = 2022, } @misc{CTT100856883, author = {Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology}, year = 2021, }