@book{CTT100917286, author = {Junichi Yamamoto and Tomoko Asatsuma-Okumura and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {History of IMiDs and Protein Degradation as a Pharmacological Modality}, publisher = {John Wiley & Sons}, year = 2022, } @article{CTT100879617, author = {Nobuyuki Shimizu and Tomoko Asatsuma-Okumura and Junichi Yamamoto and Yuki Yamaguchi and Hiroshi Handa and Takumi Ito}, title = {PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates}, journal = {Commun. Biol.}, year = 2021, } @article{CTT100832156, author = {Junichi Yamamoto and Tetsufumi Suwa and Yuki Murase and Shunpei Tateno and Hirotaka Mizutome and Tomoko Asatsuma-Okumura and Nobuyuki Shimizu and Tsutomu Kishi and Shuji Momose and Masahiro Kizaki and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells}, journal = {Nature Chemical Biology}, year = 2020, } @article{CTT100819548, author = {Shunpei Tateno and Midori Iida and Satoshi Fujii and Miki Katayama and Haruka Tokuyama and Junichi Yamamoto and Takumi Ito and Satoshi Sakamoto and Hiroshi Handa and Yuki Yamaguchi}, title = {Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide }, journal = {Scientific Reports}, year = 2020, } @article{CTT100807675, author = {Asatsuma-Okumura T and Ando H and De Simone M and Yamamoto J and Sato T and Shimizu N and Asakawa K and Yamaguchi Y and Takumi Ito and Guerrini L and Hiroshi Handa}, title = {p63 is a cereblon substrate involved in thalidomide teratogenicity}, journal = {Nature Chemical Biology}, year = 2019, } @inproceedings{CTT100777370, author = {山口 雄輝 and 伊藤拓水 and 山本淳一 and 半田宏}, title = {サリドマイドの多様な薬理作用の分子メカニズム}, booktitle = {}, year = 2016, } @inproceedings{CTT100777826, author = {片山 美樹 and 伊藤拓水 and 安藤 秀樹 and 山口 雄輝 and 半田宏}, title = {E3ユビキチンリガーゼの基質認識レセプター CRBNとポマリドマイド依存的な基質Aiolosの生化学的解析}, booktitle = {}, year = 2014, } @misc{CTT100879615, author = {Junichi Yamamoto and Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.}, year = 2022, } @misc{CTT100856883, author = {Takumi Ito and Yuki Yamaguchi and Hiroshi Handa}, title = {Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology}, year = 2021, }