@article{CTT100883764, author = {S. Ogawa and Y. Asawa and M. Iiyama and A. Yoshimori and H. Nakamura and M. Oda}, title = {Regulation of binding between CD28 cytoplasmic region and SH2 domains of Grb2 and PI3K by carborane compounds for T-cell activation}, journal = {BIOORG. MED. CHEM. LETT.}, year = 2022, } @article{CTT100866095, author = {T. Morita and H. Murakami and Y. Asawa and H. Nakamura}, title = {Enantioselective Synthesis of Oxazaborolidines by Palladium-Catalyzed N−H/B−H Double Activation of 1,2-Azaborines}, journal = {Angew. Chem. Int. Ed.}, year = 2022, } @article{CTT100864841, author = {Y. Asawa and S. Hatsuzawa and A. Yoshimori and K. Yamada and A. Katoh and H. Kouji and H. Nakamura}, title = {Comprehensive Exploration of Chemical Space Using Trisubstituted Carboranes}, journal = {Sci. Rep.}, year = 2021, } @article{CTT100863388, author = {Yasunobu Asawa and Kei Nishida and Kazuki Kawai and Kiyotaka Domae and Hyun Seung Ban and Akihiro Kitazaki and Hiroya Asami and Jun-Ya Kohno and Satoshi Okada and Hiraku Tokuma and Daisuke Sakano and Shoen Kume and Masaru Tanaka and Hiroyuki Nakamura}, title = {Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation}, journal = {Bioconjugate Chemistry}, year = 2021, } @article{CTT100845898, author = {Y. Asawa and A. V. Arsent’eva and S. A. Anufriev and A. A. Anisimov and K. Yu. Suponitsky and O. A. Filippov and H. Nakamura and I. B. Sivaev}, title = {Synthesis of Bis(Carboranyl)amides 1,1’-μ-(CH2NH(O)C(CH2)n- 1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide}, journal = {Molecules}, year = 2021, } @article{CTT100853226, author = {R. Yudi Utomo and Y. Asawa and S. Okada and A. Yoshimori and J. Bajorath and H. Nakamura}, title = {Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix-approach}, journal = {Bioorg. Med. Chem.}, year = 2021, } @article{CTT100842476, author = {Takahiro Shimizu and NorihitoTakahashi and Vincent J.Huber and Yasunobu Asawa and Hiroki Ueda and Atsushi Yoshimori and Yukiko Muramatsu and Hiroyuki Seimiya and Hiroyuki Kouji and Hiroyuki Nakamura and Hiroki Oguri}, title = {Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α}, journal = {Bioorg. Med. Chem.}, year = 2021, } @article{CTT100833117, author = {Yasunobu. Asawa and A. Yoshimori and J. Bajorath and Hiroyuki. Nakamura}, title = {Prediction of an MMP-1 Inhibitor Activity Cliff Using the SAR Matrix Approach and Its Experimental Validation}, journal = {Sci. Rep}, year = 2020, } @article{CTT100833116, author = {Sei-ichi Tanuma and Takahiro Oyama and Atsushi Yoshimori and Kiyotaka Katsuragi and Yuri Shibasaki and Yasunobu Asawa and Hiroaki Yamazaki and Kosho Makino and Miwa Okazawa and Yoko Ogino and Yoshimi Sakamoto and Miyuki Nomura and Akira Sato and Hideaki Abe and Hiroyuki Nakamura and Hideyo Takahashi and Nobuhiro Tanuma and Fumiaki Uchiumi}, title = {Structural insights into the tunnel-shaped cavity of human nicotinamide phosphoribosyltransferase using a close structural set of azacyclohexane-motif inhibitors}, journal = {Molecules}, year = 2020, } @article{CTT100809192, author = {Y. Asawa and K. Katsuragi and A. Sato and A. Yoshimori and S. Tanuma and H. Nakamura}, title = {Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors}, journal = {Bioorg. Med. Chem.}, year = 2019, } @article{CTT100734669, author = {S. Fuse and T. Ohuchi and Y. Asawa and S. Sato and H. Nakamura}, title = {Development of 1-Aryl-3-furanyl/Thienyl-imidazopyridine Templates for Inhibitors against Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity}, journal = {Bioorganic and Medicinal Chemistry Letters}, year = 2016, } @inproceedings{CTT100881418, author = {Hiroyuki Nakamura and Yasunobu Asawa}, title = {Comprehensive Exploration of Chemical Space Using Trisubstituted Carboranes}, booktitle = {}, year = 2022, } @inproceedings{CTT100864816, author = {Yasunobu Asawa and Saki Hatsuzawa and Atsushi Yoshimori and Kentaro Yamada and Akira Katoh and Hiroyuki Kouji and Hiroyuki Nakamura}, title = {Comprehensive exploration of three-dimensional chemical space by trisubstituted carboranes for discovery of bioactive molecule}, booktitle = {}, year = 2021, } @inproceedings{CTT100858346, author = {浅輪 泰允 and 中村 浩之}, title = {カルボランを基盤とした立体的分子による3次元ケミカルスペースの探索と新規PPI制御分子の創成}, booktitle = {}, year = 2021, } @inproceedings{CTT100864739, author = {浅輪泰允 and 中村浩之}, title = {疎水性ホウ素クラスターによる新規タンパク質分解誘導剤の開発とその機構解明}, booktitle = {}, year = 2021, } @inproceedings{CTT100853233, author = {村上弘樹 and 盛田大輝 and 浅輪泰允 and 中村浩之}, title = {パラジウム触媒を用いた1,2-アザボリン類のN-H/B-H二官能基化法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853239, author = {浅輪泰允 and 吉森篤史 and 山田健太郎 and 小路弘行 and 中村浩之}, title = {カルボランを基盤とした立体的分子による3次元ケミカルスペースの探索とそのPPI制御機能評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100853240, author = {初澤早貴 and 浅輪泰允 and 吉森篤史 and 山田健太郎 and 小路弘行 and 真崎康博 and 中村浩之}, title = {PPI阻害剤を志向した三置換メタカルボランライブラリー化合物の合成とその生物活性評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100836667, author = {浅輪 泰允 and 吉森 篤史 and BAJORATH J?rgen and 中村 浩之}, title = {SAR空間の可視化によるActivity cliffの予測とその実験的検証}, booktitle = {}, year = 2020, } @inproceedings{CTT100836664, author = {Rohmad Yudi Utomo and Yasunobu Asawa and Atsushi Yoshimori and Hiroyuki Nakamura}, title = {Novel Curcumin Derivatives Generated from SAR Matrix Possess as Amyloid β Inhibitors for Alzheimer?s Disease}, booktitle = {}, year = 2020, } @inproceedings{CTT100823567, author = {浅輪泰允 and 吉森篤史 and 山田健太郎 and 邵玉潔 and 李廣晢 and 加藤明良 and 小路弘行 and 中村浩之}, title = {タンパク質の2次構造を模倣した新規カルボランPPI制御分子の設計・合成とその機能評価}, booktitle = {}, year = 2020, } @inproceedings{CTT100823568, author = {Rohmad Yudi Utomo and Yasunobu Asawa and Shinichi Sato and Atsushi Yoshimori and Hiroyuki Nakamura}, title = {Novel Curcumin Derivatives Generated from SAR Matrix Possess as Amyloid β Inhibitors}, booktitle = {}, year = 2020, } @inproceedings{CTT100822793, author = {Yasunobu Asawa and Kiyotaka Katsuragi and Akira Sato and Atsushi Yoshimori and Sei-ichi Tanuma and Hiroyuki Nakamura}, title = {Structure-based Drug Design of Novel Carborane-containing NAMPT Inhibitors}, booktitle = {}, year = 2019, } @inproceedings{CTT100822779, author = {浅輪泰允 and 吉森篤史 and 中村浩之}, title = {SBDDによる新規カルボラン含有NAMPT阻害剤の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813254, author = {浅輪泰允 and 中村浩之}, title = {ジカルボラン骨格を有する新規NAMPT阻害剤の理論的設計と合成、生物活性評価}, booktitle = {}, year = 2019, } @inproceedings{CTT100822843, author = {浅輪泰允 and 葛城粛貴 and 佐藤聡 and 吉森篤史 and 田沼靖一 and 中村浩之}, title = {疎水性ファーマコフォアとしてカルボランを導入した新規NAMPT阻害剤の開発}, booktitle = {}, year = 2018, } @inproceedings{CTT100813232, author = {浅輪泰允 and 葛城粛貴 and 佐藤聡 and 吉森篤史 and 田沼靖一 and 中村浩之}, title = {疎水性ファーマコフォアとしてカルボランを導入した新規NAMPT阻害剤の開発}, booktitle = {}, year = 2018, } @inproceedings{CTT100822984, author = {浅輪泰允 and 葛城粛貴 and 佐藤聡 and 吉森篤史 and 田沼靖一 and 中村浩之}, title = {疎水性ファーマコフォアとしてカルボランを導入した新規NAMPT阻害剤の開発}, booktitle = {}, year = 2018, } @inproceedings{CTT100822972, author = {浅輪泰允 and 葛城粛貴 and 佐藤聡 and 吉森篤史 and 田沼靖一 and 中村浩之}, title = {疎水性ファーマコフォアとしてカルボランを導入した新規Nampt阻害剤の開発}, booktitle = {}, year = 2017, } @misc{CTT100866337, author = {浅輪泰允}, title = {低分子医薬品の標的分子拡充を志向したカルボランの創薬研究}, year = 2022, } @misc{CTT100907129, author = {浅輪泰允}, title = {低分子医薬品の標的分子拡充を志向したカルボランの創薬研究}, year = 2022, } @misc{CTT100866647, author = {浅輪泰允}, title = {低分子医薬品の標的分子拡充を志向したカルボランの創薬研究}, year = 2022, } @misc{CTT100881786, author = {中村浩之 and 浅輪泰允 and 織田 昌幸}, title = {カルボラン化合物若しくはその塩又はこれらの溶媒和物}, howpublished = {公開特許}, year = 2022, month = {}, note = {PCT/JP2021/039442(2021/10/26), WO 2022/092068(2022/05/05)} } @phdthesis{CTT100866337, author = {浅輪泰允}, title = {低分子医薬品の標的分子拡充を志向したカルボランの創薬研究}, school = {東京工業大学}, year = 2022, } @phdthesis{CTT100907129, author = {浅輪泰允}, title = {低分子医薬品の標的分子拡充を志向したカルボランの創薬研究}, school = {東京工業大学}, year = 2022, } @phdthesis{CTT100866647, author = {浅輪泰允}, title = {低分子医薬品の標的分子拡充を志向したカルボランの創薬研究}, school = {東京工業大学}, year = 2022, }