@article{CTT100900217, author = {Yuto Honda and Sayaka Onodera and Hiroyasu Takemoto and Faizah Noor and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Yudi Sun and Yutaka Miura and Nobuhiro Nishiyama}, title = {Thermo-responsive polymer-siRNA conjugates enabling artificial control of gene silencing around body temperature}, journal = {Pharmaceutical Research}, year = 2022, } @article{CTT100900205, author = {Yijung Sung and Haochen Guo and Aria Ghasemizadeh and Xin Shen and Wanphiwat Chintrakulchai and Motoaki Kobayashi and Masahiro Toyoda and Koichi Ogi and Junya Michinishi and Tokoyuki Ohtake and Makoto Matsui and Yuto Honda and Takahiro Nomoto and Hiroyasu Takemoto and Yutaka Miura and Nobuhiro Nishiyama}, title = {Cancerous pH-responsive polycarboxybetaine-coated lipid nanoparticle for smart delivery of siRNA against subcutaneous tumor model}, journal = {Cancer Science}, year = 2022, } @article{CTT100876895, author = {Aziz Awaad and Hiroyasu Takemoto and Muneaki Iizuka and Koichi Ogi and Yuki Mochida and Abdul-Hackam Ranneh and Masahiro Toyoda and Makoto Matsui and Takahiro Nomoto and Yuto Honda and Kotaro Hayashi and Keishiro Tomoda and Tomoyuki Ohtake and Yutaka Miura and Nobuhiro Nishiyama}, title = {Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration}, journal = {Journal of Controlled Release}, year = 2022, } @article{CTT100875965, author = {Guo H. and Nomoto T. and Muttaqien S.E. and Sun X. and Komoto K. and Matsui M. and Miura Y. and Nishiyama N.}, title = {A polymeric iron chelator enhancing pro-oxidant antitumor efficacy of vitamin C by inhibiting extracellular Fenton reaction}, journal = {Molecular Pharmaceutics}, year = 2021, } @article{CTT100863940, author = {Yuto Honda* and Takahiro Nomoto and Makoto Matsui and Hiroyasu Takemoto and Yutaka Miura and Nobuhiro Nishiyama*}, title = {Sequentially Self-Assembled Nanoreactor Comprising Tannic Acid and Phenylboronic Acid-Conjugated Polymers Inducing Tumor-Selective Enzymatic Activity}, journal = {ACS Applied Materials and Interfaces}, year = 2021, } @article{CTT100878463, author = {Yutaka Miura}, title = {PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity.}, journal = {}, year = 2021, } @article{CTT100863939, author = {Yuto Honda* and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Kaori Taniwaki and Haochen Guo and Yutaka Miura and Nobuhiro Nishiyama*}, title = {Systemically Applicable Glutamine-Functionalized Polymer Exerting Multivalent Interaction with Tumors Overexpressing ASCT2.}, journal = {ACS Applied Bio Materials}, year = 2021, } @article{CTT100853184, author = {Komoto Kana and Takahiro Nomoto and Muttaqien S. and Takemoto Hiroyasu and Matsui Makoto and Miura Yutaka and Nishiyama Nobuhiro}, title = {Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine}, journal = {Cancer Science}, year = 2021, } @article{CTT100856225, author = {Yutaka Miura}, title = {Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol).}, journal = {Nature communications}, year = 2020, } @article{CTT100837301, author = {Natsumi Fukuhara and Yuto Honda and Nao Ukita and Makoto Matsui and Yutaka Miura and Katsuyuki Hoshina}, title = {Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine}, journal = {International Journal of Molecular Sciences}, year = 2020, } @article{CTT100835414, author = {Yuto Honda and Takahiro Nomoto and Makoto Matsui and Hiroyasu Takemoto and Yuka Kaihara and Yutaka Miura and Nobuhiro Nishiyama}, title = {Sequential Self-Assembly Using Tannic Acid and Phenylboronic Acid-Modified Copolymers for Potential Protein Delivery}, journal = {Biomacromolecules}, year = 2020, } @article{CTT100835413, author = {Xiaohang Sun and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Haochen Guo and Yudi Sun and Yutaka Miura and Nobuhiro Nishiyama}, title = {Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives}, journal = {Journal of Controlled Release}, year = 2020, } @article{CTT100829006, author = {Yutaka Miura}, title = {Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors}, journal = {Journal of Controlled Release}, year = 2019, } @article{CTT100829128, author = {Yutaka Miura}, title = {Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release}, journal = {Journal of Controlled Release}, year = 2018, } @article{CTT100829133, author = {Yutaka Miura}, title = {Targeting ability of self-assembled nanomedicines in rat acute limb ischemia model is affected by size}, journal = {Journal of Controlled Release}, year = 2018, } @article{CTT100829140, author = {Yutaka Miura}, title = {Proteasome Inhibitor–Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition}, journal = {Journal of Pharmaceutical Sciences}, year = 2017, } @article{CTT100829142, author = {Yutaka Miura}, title = {cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells}, journal = {Journal of Controlled Release}, year = 2017, } @article{CTT100829143, author = {Yutaka Miura}, title = {cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors}, journal = {Journal of Controlled Release}, year = 2017, } @article{CTT100829145, author = {Yutaka Miura}, title = {Nanomedicines Eradicating Cancer Stem-like Cells in Vivo by pH-Triggered Intracellular Cooperative Action of Loaded Drugs}, journal = {ACS Nano}, year = 2016, } @article{CTT100829150, author = {Yutaka Miura}, title = {Adequately-Sized Nanocarriers Allow Sustained Targeted Drug Delivery to Neointimal Lesions in Rat Arteries}, journal = {Molecular Pharmaceutics}, year = 2016, } @article{CTT100829147, author = {Yutaka Miura}, title = {Nanoparticles Effectively Target Rapamycin Delivery to Sites of Experimental Aortic Aneurysm in Rats}, journal = {PLOS ONE}, year = 2016, } @article{CTT100829126, author = {Yutaka Miura}, title = {Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery}, journal = {Nature Nanotechnology}, year = 2016, } @article{CTT100829146, author = {Yutaka Miura}, title = {Nanoparticles Effectively Target Rapamycin Delivery to Sites of Experimental Aortic Aneurysm in Rats}, journal = {PLOS ONE}, year = 2016, } @article{CTT100829153, author = {Yutaka Miura}, title = {Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines}, journal = {Journal of Controlled Release}, year = 2016, } @article{CTT100829156, author = {Yutaka Miura}, title = {Intracellular Delivery of Charge-Converted Monoclonal Antibodies by Combinatorial Design of Block/Homo Polyion Complex Micelles}, journal = {Biomacromolecules}, year = 2016, } @article{CTT100856227, author = {Yutaka Miura}, title = {siRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal pHs for Exerting Enhanced RNAi Efficacy}, journal = {Biomacromolecules}, year = 2016, } @article{CTT100829160, author = {Yutaka Miura}, title = {cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100829220, author = {Yutaka Miura}, title = {Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer}, journal = {ACS Biomaterials Science & Engineering}, year = 2015, } @article{CTT100829159, author = {Yutaka Miura}, title = {Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas}, journal = {Science and Technology of Advanced Materials}, year = 2015, } @article{CTT100829214, author = {Yutaka Miura}, title = {Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers}, journal = {ACS Nano}, year = 2015, } @article{CTT100829219, author = {Yutaka Miura}, title = {Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer}, journal = {Biomaterials}, year = 2015, } @article{CTT100856228, author = {Yutaka Miura}, title = {Light-Induced Cytosolic Activation of Reduction-Sensitive Camptothecin-Loaded Polymeric Micelles for Spatiotemporally Controlled in Vivo Chemotherapy}, journal = {ACS Nano}, year = 2014, } @article{CTT100829210, author = {Yutaka Miura}, title = {Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation}, journal = {Journal of Controlled Release}, year = 2014, } @article{CTT100829211, author = {Yutaka Miura}, title = {Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors}, journal = {Biomaterials}, year = 2014, } @article{CTT100829208, author = {Yutaka Miura}, title = {Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy}, journal = {Journal of Controlled Release}, year = 2014, } @article{CTT100829197, author = {Yutaka Miura}, title = {Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor}, journal = {ACS Nano}, year = 2014, } @article{CTT100829198, author = {Yutaka Miura}, title = {Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors}, journal = {Journal of the American Chemical Society}, year = 2013, } @article{CTT100829130, author = {Yutaka Miura}, title = {Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier}, journal = {ACS Nano}, year = 2013, } @article{CTT100829196, author = {Yutaka Miura}, title = {Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1  in a p53-Independent Manner}, journal = {Cancer Research}, year = 2013, } @article{CTT100829195, author = {Yutaka Miura}, title = {Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions}, journal = {Gene Therapy}, year = 2012, } @article{CTT100829193, author = {Yutaka Miura}, title = {Precise synthesis of poly(1-adamantyl methacrylate) by atom transfer radical polymerization}, journal = {Polymer Journal}, year = 2010, } @article{CTT100829192, author = {Yutaka Miura}, title = {Graphene/Polyurethane Nanocomposites for Improved Gas Barrier and Electrical Conductivity}, journal = {Chemistry of Materials}, year = 2010, } @article{CTT100829191, author = {Yutaka Miura}, title = {Synthesis of Stable Block-Copolymer-Protected NaYF4:Yb3+, Er3+Up-Converting Phosphor Nanoparticles}, journal = {Chemistry of Materials}, year = 2010, } @article{CTT100829190, author = {Yutaka Miura}, title = {Fluorescence Resonance Energy Transfer in Host–Guest Inclusion Complexes of Cyclodextrin–Porphyrin Composite in Aqueous Solution}, journal = {Chemistry Letters}, year = 2008, } @article{CTT100829188, author = {Yutaka Miura}, title = {End-functionalization of polystyrene by malto-oligosaccharide generating aggregation-tunable polymeric reverse micelle}, journal = {Journal of Polymer Science Part A: Polymer Chemistry}, year = 2006, } @article{CTT100829189, author = {Yutaka Miura}, title = {Glycoconjugated polymer: Synthesis and characterization of poly(vinyl saccharide)-block-polystyrene-block-poly(vinyl saccharide) as an amphiphilic ABA triblock copolymer}, journal = {Journal of Polymer Science Part A: Polymer Chemistry}, year = 2006, } @article{CTT100829187, author = {Yutaka Miura}, title = {Polystyrene Microgel Amphiphiles with Maltohexaose. Synthesis, Characterization, and Potential Applications}, journal = {Biomacromolecules}, year = 2006, } @article{CTT100829186, author = {Yutaka Miura}, title = {Polystyrene Microgel Amphiphiles with Maltohexaose. Synthesis, Characterization, and Potential Applications}, journal = {Biomacromolecules}, year = 2006, } @article{CTT100829116, author = {Yutaka Miura}, title = {Synthesis of polystyrene microgel with glucose as hydrophilic segment via controlled free-radical polymerization}, journal = {Polymer}, year = 2006, } @article{CTT100829129, author = {Yutaka Miura}, title = {Thermoresponsive Property Controlled by End-Functionalization of Poly(N-isopropylacrylamide) with Phenyl, Biphenyl, and Triphenyl Groups}, journal = {Polymer Journal}, year = 2006, } @article{CTT100829078, author = {Yutaka Miura}, title = {Synthesis of well-defined syndiotactic poly(methyl methacrylate) with low-temperature atom transfer radical polymerization in fluoroalcohol}, journal = {Journal of Polymer Science Part A: Polymer Chemistry}, year = 2006, } @article{CTT100829112, author = {Yutaka Miura}, title = {Synthesis and thermoresponsive property of end-functionalized poly(N-isopropylacrylamide) with pyrenyl group}, journal = {Journal of Polymer Science Part A: Polymer Chemistry}, year = 2006, } @article{CTT100829111, author = {Yutaka Miura}, title = {Star-shaped polystyrenes with glycoconjugated periphery and interior: Synthesis and entrapment of hydrophilic molecule}, journal = {Journal of Polymer Science Part A: Polymer Chemistry}, year = 2005, } @article{CTT100829108, author = {Yutaka Miura}, title = {Synthesis of well-defined AB20-type star polymers with cyclodextrin-core by combination of NMP and ATRP}, journal = {Journal of Polymer Science Part A: Polymer Chemistry}, year = 2005, } @article{CTT100829101, author = {Yutaka Miura}, title = {Atom Transfer Radical Polymerization of Methyl Methacrylate in Fluoroalcohol:  Simultaneous Control of Molecular Weight and Tacticity}, journal = {Macromolecules}, year = 2005, } @article{CTT100829100, author = {Yutaka Miura}, title = {Glycoconjugated Polymer. 4. Synthesis and Aggregation Property of Well-Defined End-Functionalized Polystyrene with β-Cyclodextrin}, journal = {Macromolecules}, year = 2003, } @article{CTT100829099, author = {Yutaka Miura}, title = {Glycoconjugated Polymer. 5. Synthesis and Characterization of a Seven-Arm Star Polystyrene with a β-Cyclodextrin Core Based on TEMPO-Mediated Living Radical Polymerization}, journal = {Macromolecules}, year = 2003, } @article{CTT100856226, author = {Yutaka Miura}, title = {Fundamental Study on FRP Recycling using Several Solvent}, journal = {TANSO}, year = 2003, } @article{CTT100829096, author = {Yutaka Miura}, title = {Synthesis and hydration properties of copolymers having sugar side chains and their oxygen permeability in the wet state}, journal = {Journal of Membrane Science}, year = 2000, } @article{CTT100829097, author = {Yutaka Miura}, title = {Oxygen permeability and the state of water in Nafion® membranes with alkali metal and amino sugar counterions}, journal = {Journal of Membrane Science}, year = 1999, } @article{CTT100829093, author = {Yutaka Miura}, title = {The Effect of Amino Sugars on the Water Vapor Permeability and the Mobility of Water in Nafion Membranes.}, journal = {NIPPON KAGAKU KAISHI}, year = 1999, } @inproceedings{CTT100900269, author = {Yuto Honda and Shuhei Nagao and Hiroaki Kinoh and Nozomi Matsudaira and Xueying Liu and Takahiro Nomoto and Anjaneyulu Dirisala and Yutaka Miura and Kazunori Kataoka and Nobuhiro Nishiyama}, title = {集束超音波と高分子複合体を組み合わせた脳選択的AAV送達システムの構築}, booktitle = {}, year = 2023, } @inproceedings{CTT100900272, author = {Nozomi Matsudaira and Yuto Honda and Shuhei Nagao and Hiroaki Kinoh and Takahiro Nomoto and Xueying Liu and Anjaneyulu Dirisala and Yutaka Miura and Kazunori Kataoka and Nobuhiro Nishiyama}, title = {腫瘍細胞標的機能を備えた全身投与型アデノ随伴ウイルス(AAV)三元系複合体の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100836393, author = {Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {高分子修飾によるsiRNA周囲の空間支配と薬理機構制御}, booktitle = {}, year = 2020, } @inproceedings{CTT100836392, author = {Masahiro Toyoda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {腫瘍内pH応答性の獲得を目指した高分子ベタイン内の両イオン性基の種類・間隔の検討}, booktitle = {}, year = 2020, } @inproceedings{CTT100836391, author = {Yudi Sun and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {ASO-分岐PEG結合体を内包する小分子キャリアの開発および機能評価}, booktitle = {}, year = 2020, } @inproceedings{CTT100836389, author = {Kana Komoto and Takahiro Nomoto and S Muttaqien and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {がん鉄キレート療法のための効率的な除鉄を実現する機能性高分子の開発}, booktitle = {}, year = 2020, } @inproceedings{CTT100836388, author = {I Dewa Agung Panji Dwipayana and Yuto Honda and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Development of a versatile drug delivery system using tannic acid and boronic acid-conjugated polymer}, booktitle = {}, year = 2020, } @inproceedings{CTT100836387, author = {ムツタキンシャイクリザルエル and Yutaka Miura and Haochen Guo and Takahiro Nomoto and Kana Komoto and S Muttaqien and Xiaohang Sun and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Polymeric iron-chelators for improving high- dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835426, author = {Guo Haochen and Takahiro Nomoto and Kana Komoto and Sun Xiaohang and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Development of polymeric iron-chelators for enhancing high-dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835427, author = {Masahiro Toyoda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {高分子ベタイン内のイオン性基の種類・間隔の制御と腫瘍内pH応答性への展開}, booktitle = {}, year = 2020, } @inproceedings{CTT100835417, author = {Yuto Honda and Takahiro NOMOTO and Makoto MATSUI and Hiroyasu TAKEMOTO and Yuka KAIHARA and Yutaka MIURA and Nobuhiro NISHIYAMA}, title = {Development of intracellular pH- responsive protein delivery system utilizing boronic acid-conjugated polymer and tannic acid}, booktitle = {}, year = 2020, } @inproceedings{CTT100835418, author = {Kana Komoto and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Iron chelation cancer therapy using functional polymers targeting tumors}, booktitle = {}, year = 2020, } @inproceedings{CTT100813624, author = {Hiroyasu Takemoto and Takanori Inaba and Takahiro Nomoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {環状アセタール構造に基づくゲムシタビンの高分子修飾と制がん効果増大及び副作用低減}, booktitle = {}, year = 2019, } @misc{CTT100892274, author = {Nobuhiro Nishiyama and Hiroyasu Takemoto and Yutaka Miura and Takahiro Nomoto and Makoto Matsui and Masahiro Toyoda and Aria Ghasemizadeh}, title = {高純度pH応答性ポリマー及びその製造方法}, howpublished = {PublishedPatent}, year = 2023, month = {}, note = {PCT/JP2022/026864(2022/07/06), WO 2023/282297(2023/01/12)} } @misc{CTT100892275, author = {Nobuhiro Nishiyama and Hiroyasu Takemoto and Yutaka Miura and Takahiro Nomoto and Makoto Matsui and Masahiro Toyoda and Aria Ghasemizadeh}, title = {pH応答性脂質誘導体}, howpublished = {PublishedPatent}, year = 2023, month = {}, note = {PCT/JP2022/026863(2022/07/06), WO 2023/282296(2023/01/12)} }