@book{CTT100853247, author = {H. S. Ban and H. Nakamura}, title = {Design of Carborane-Based Hypoxia-Inducible Factor Inhibitors}, publisher = {}, year = 2021, } @article{CTT100864841, author = {Y. Asawa and S. Hatsuzawa and A. Yoshimori and K. Yamada and A. Katoh and H. Kouji and H. Nakamura}, title = {Comprehensive Exploration of Chemical Space Using Trisubstituted Carboranes}, journal = {Sci. Rep.}, year = 2021, } @article{CTT100863388, author = {Yasunobu Asawa and Kei Nishida and Kazuki Kawai and Kiyotaka Domae and Hyun Seung Ban and Akihiro Kitazaki and Hiroya Asami and Jun-Ya Kohno and Satoshi Okada and Hiraku Tokuma and Daisuke Sakano and Shoen Kume and Masaru Tanaka and Hiroyuki Nakamura}, title = {Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation}, journal = {Bioconjugate Chemistry}, year = 2021, } @article{CTT100875392, author = {H. Yanagie and M. Yanagawa and K. Mouri and Y. Morishita and A. Shinohara and N. Dewi and Y. Nonaka and Y. Furuya and R. Mizumachi and Y. Murata and H. Nakamura and M. Suzuki and Y. Sakurai and H. Tanaka and S. Masunaga and K. Ono and T. Sugihara and M. Nashimoto and H. Yamauchi and M. Ono and J. Nakajima and H. Terada and H. Takahashi}, title = {Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems}, journal = {In Vivo}, year = 2021, } @article{CTT100864837, author = {H. Kashiwagi and S. Kawabata and K. Yoshimura and Y. Fukuo and T. Kanemitsu and K. Takeuchi and R. Hiramatsu and K. Nishimura and K. Kawai and T. Takata and H. Tanaka and T. Watanabe and M. Suzuki and S. Miyatake and H. Nakamura and M. Wanibuchi}, title = {Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model}, journal = {Investigational new drugs}, year = 2021, } @article{CTT100864834, author = {Y. Tsuji and N. Nonoguchi and D. Okuzaki and Y. Wada and D. Motooka and Y. Hirota and T. Toho and N. Yoshikawa and M. Furuse and S. Kawabata and S.-I. Miyatake and H. Nakamura and R. Yamamoto and S. Nakamura and T. Kuroiwa and M. Wanibuchi}, title = {Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression}, journal = {Sci. Rep}, year = 2021, } @article{CTT100864832, author = {Satoshi OKADA and Satoko TAKAYASU and Akira SUMIYOSHI and Ichio AOKI and Hiroyuki NAKAMURA}, title = {MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors}, journal = {Anal. Sci.}, year = 2021, } @article{CTT100861229, author = {Shinichi Sato and Masaki Matsumura and Hiroshi Ueda and Hiroyuki Nakamura}, title = {Preparation of an antigen-responsive fluorogenic immunosensor by tyrosine chemical modification of the antibody complementarity determining region}, journal = {Chemical Communications}, year = 2021, } @article{CTT100858990, author = {N. Sugisawa and H. Sugisawa and Y. Otake and R. V. Krems and H. Nakamura and S. Fuse}, title = {Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization}, journal = {Chemistry Methods}, year = 2021, } @article{CTT100859004, author = {津田 正仁 and 盛田 大輝 and 中村 浩之}, title = {Suzuki-Miyaura Cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles}, journal = {Tetrahedron Letters}, year = 2021, } @article{CTT100852986, author = {Paviter Singh and Manjot Kaur and Kulwinder Singh and Gurpreet Kaur and Ramovatar Meena and Manpreet Kaur and Bikramjeet Singh and Anup Thakur and Jeewan Sharma and Ajay Singh and Manjeet Kumar and Ju-Hyung Yun and Fumiko Nakagawa and Minoru Suzuki and Hiroyuki Nakamura and Akshay Kumar}, title = {Fluorescent Boron Carbide Quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy}, journal = {Physica E: Low-Dimensional Systems and Nanostructures.}, year = 2021, } @article{CTT100852987, author = {K. Nakane and S. Sato and T. Niwa and M. Tsushima and S. Tomoshige and H. Taguchi and M. Ishikawa and H. Nakamura}, title = {Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen}, journal = {J. Am. Chem. Soc.}, year = 2021, } @article{CTT100845898, author = {Y. Asawa and A. V. Arsent’eva and S. A. Anufriev and A. A. Anisimov and K. Yu. Suponitsky and O. A. Filippov and H. Nakamura and I. B. Sivaev}, title = {Synthesis of Bis(Carboranyl)amides 1,1’-μ-(CH2NH(O)C(CH2)n- 1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide}, journal = {Molecules}, year = 2021, } @article{CTT100853226, author = {R. Yudi Utomo and Y. Asawa and S. Okada and A. Yoshimori and J. Bajorath and H. Nakamura}, title = {Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix-approach}, journal = {Bioorg. Med. Chem.}, year = 2021, } @article{CTT100844781, author = {中村浩之}, title = {BNCTの薬剤と中性子の反応}, journal = {月刊インナービジョン特集号}, year = 2021, } @article{CTT100859003, author = {K. Umedera and T. Morita and A. Yoshimori and K. Yamada and A. Katoh and H. Koji and H. Nakamura}, title = {Synthesis of Three-Dimensional (3D) (Di)azatricyclododecene Scaffold and its Application to Peptidomimetics}, journal = {Chem. Eur. J}, year = 2021, } @article{CTT100845899, author = {S. Fuse and K. Komuro and Y. Otake and H. Masui and H. Nakamura}, title = {Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Micro-Flow Reactor}, journal = {Chem. Eur. J}, year = 2021, } @article{CTT100844777, author = {H. S. Ban and Y. Uto and H. Nakamura}, title = {Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)}, journal = {Expert Opin. Ther. Pat.}, year = 2021, } @article{CTT100842473, author = {北村 宙士 and 小竹 佑磨 and 川村 淳 and 布施 新一郎 and 中村 浩之}, title = {入手容易なマイクロミキサーを用いたリポソーム調製法の開発}, journal = {製剤機械技術学会誌}, year = 2021, } @article{CTT100859006, author = {M. Tsuda and S. Fukuhara and Taiki Morita and H. Nakamura}, title = {Synthesis of 4-Amino-5-allenylisoxazoles via Gold(I)-Catalyzed Propar-gyl Aza-Claisen Rearrangement: Application to an Isoxazoloazaborine Ring System}, journal = {Org. Biomol. Chem}, year = 2021, } @article{CTT100842476, author = {Takahiro Shimizu and NorihitoTakahashi and Vincent J.Huber and Yasunobu Asawa and Hiroki Ueda and Atsushi Yoshimori and Yukiko Muramatsu and Hiroyuki Seimiya and Hiroyuki Kouji and Hiroyuki Nakamura and Hiroki Oguri}, title = {Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α}, journal = {Bioorg. Med. Chem.}, year = 2021, } @article{CTT100861651, author = {G. Li and Y. Shao and Y. Pan and Y. Li and Y. Wang and L. Wan] and K. Shao and S. Wang and H. Dong and X. W and X. Guo and W. Zhao and H. Nakamura}, title = {Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy}, journal = {BIOORG. MED. CHEM. LETT.}, year = 2021, } @inproceedings{CTT100864825, author = {Kohei Umedera and Taiki Morita and Hiroyuki Nakamura}, title = {Synthesis of sp3-carbon rich azatricyclododecene framework via gold-catalized Conia-ene reaction}, booktitle = {}, year = 2021, } @inproceedings{CTT100864824, author = {Masato Tsuda and Taiki Morita and Shintaro Fukuhara and Hiroyuki Nakamura}, title = {Cationic Gold(I)-Catalyzed Propargyl Aza-Claisen Rearrangement: Synthesis of 5-Allenyl-4-aminoisoxazoles}, booktitle = {}, year = 2021, } @inproceedings{CTT100864823, author = {Taiki Morita and Shinichiro Fuse and Hiroyuki Nakamura}, title = {Photochemical conversion of isoxazoles to 5-hydroxyimidazolines}, booktitle = {}, year = 2021, } @inproceedings{CTT100864822, author = {Hiroyuki Nakamura and Yijin Wen and Kazuki Miura and Michihiko Tsushima and Hideya Yuasa}, title = {Target protein knockdown using photocatalysts: Application to photodynamic therapy}, booktitle = {}, year = 2021, } @inproceedings{CTT100864821, author = {Hiroyuki Nakamura and Michihiko Tsushima and Shinichi Sato and Kazuki Miura}, title = {Development of photocatalytic-proximity protein labeling for profiling protein-protein interaction in intracellular microenvironments}, booktitle = {}, year = 2021, } @inproceedings{CTT100864818, author = {Hiroyuki Nakamura}, title = {Development of PBC-IP as a Novel Boron Agent: Unexpectedly High BNCT Effect on Rat Brain Tumor}, booktitle = {}, year = 2021, } @inproceedings{CTT100864819, author = {Natsumi Okada and Masayuki Iwamoto and Akira Takado and Hiroyuki Nakamura and Shigetoshi Oiki and Koichi Iwata}, title = {The effect of local anesthetics on lipid bilayer membranes evaluated by picosecond time-resolved fluorescence spectroscopy}, booktitle = {}, year = 2021, } @inproceedings{CTT100864820, author = {Haruna Shiono and Akira Takakado and Hiroyuki Nakamura and Koichi Iwata}, title = {Evaluation of viscosity of lipid bilayer nanodiscs}, booktitle = {}, year = 2021, } @inproceedings{CTT100858346, author = {浅輪 泰允 and 中村 浩之}, title = {カルボランを基盤とした立体的分子による3次元ケミカルスペースの探索と新規PPI制御分子の創成}, booktitle = {}, year = 2021, } @inproceedings{CTT100864817, author = {Kohei Umedera and Taiki Morita and Atsushi Yoshimori and Kentaro Yamada and Akira Katoh and Hiroyuki Kouji and Hiroyuki Nakamura}, title = {Synthesis of Three-Dimensional Diazatricyclododecene Scaffold and Design of Peptidomimetics}, booktitle = {}, year = 2021, } @inproceedings{CTT100864816, author = {Yasunobu Asawa and Saki Hatsuzawa and Atsushi Yoshimori and Kentaro Yamada and Akira Katoh and Hiroyuki Kouji and Hiroyuki Nakamura}, title = {Comprehensive exploration of three-dimensional chemical space by trisubstituted carboranes for discovery of bioactive molecule}, booktitle = {}, year = 2021, } @inproceedings{CTT100864815, author = {中村浩之 and 岡田智 and Jeff D. Dela Cruz}, title = {3D細胞培養系の構築と抗がん剤ライブラリースクリーニング}, booktitle = {}, year = 2021, } @inproceedings{CTT100864146, author = {Kai Nishimura and Taiki Morita and Satoshi Okada and Takumi Ogawara and Takushi Takata and Minoru Suzuki and Hiroyuki Nakamura}, title = {Development of an albumin-based boron delivery system for neutron capture therapy}, booktitle = {}, year = 2021, } @inproceedings{CTT100864144, author = {高島由佳 and 髙安聡子 and 岡田智 and 中村浩之}, title = {磁場による薬物徐放を志向したポリマーコーティング酸化鉄ナノ粒子の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100864143, author = {村上弘樹 and 盛田大輝 and 中村浩之}, title = {パラジウム触媒を用いた1,2-アザボリン類のN-H/B-H二官能基化法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863325, author = {Satoshi Okada and Vivian Hsieh and Satoko Takayasu and Akira Sumiyoshi and Ichio Aoki and Alan Jasanoff and Hiroyuki Nakamura}, title = {Development of neurotransmitter-responsive magnetic nanoprobes}, booktitle = {}, year = 2021, } @inproceedings{CTT100864814, author = {北村宙士 and 小竹佑磨 and 杉澤直斗 and 杉澤宏樹 and 井田朋智 and 中村浩之 and 布施新一郎}, title = {マイクロフローリアクターを用いる非対称リン酸トリエステルの高速合成}, booktitle = {}, year = 2021, } @inproceedings{CTT100864813, author = {梅寺倖平 and 盛田大輝 and 吉森篤史 and 山田健太郎 and 小路弘之 and 中村浩之}, title = {三次元骨格ジアザトリシクロドデセンの開発とペプチド模倣分子への応用}, booktitle = {}, year = 2021, } @inproceedings{CTT100863326, author = {植原彩奈 and 盛田大輝 and 佐々木雄彦 and 中村浩之}, title = {リゾホスファチジルイノシトール(4,5)ビスリン酸の合成研究}, booktitle = {}, year = 2021, } @inproceedings{CTT100863322, author = {岡田 智 and Vivian Hsieh and 髙安 聡子 and 住吉 晃 and Alan Jasanoff and 青木 伊知男 and 中村 浩}, title = {磁場照射で脳機能を観察・操作する磁性ナノツールの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100875473, author = {M. Tsuda and T. Morita and S. Fukuhara and H. Nakamura}, title = {Gold(I)-Catalyzed Intramolecular Electrophilic Aromatic Substitution of Isoxazoles}, booktitle = {}, year = 2021, } @inproceedings{CTT100875471, author = {T. Morita and S. Yugandar and H. Nakamura}, title = {Novel Direct Functionalization and Photochemical Reaction of Isoxazoles}, booktitle = {}, year = 2021, } @inproceedings{CTT100863324, author = {Kai Nishimura and Taiki Morita and Satoshi Okada and Takumi Ogawara and Takushi Takata and Minoru Suzuki and Hiroyuki Nakamura}, title = {Development of an albumin-based boron delivery system for neutron capture therapy}, booktitle = {}, year = 2021, } @inproceedings{CTT100863321, author = {H. Nakamura and M. Tsushima and M. Matsumura and S. Sato}, title = {Boron Neutron Capture Therapy: A New Modality of Radiation Therapy}, booktitle = {}, year = 2021, } @inproceedings{CTT100863323, author = {中村浩之}, title = {チロシン残基特異的ラベル化技術の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863257, author = {西村開 and 盛田大輝 and 岡田智 and 小川原巧 and 柏木秀基 and 福尾祐介 and 松本孔貴 and 高田卓志 and 鈴木実 and 中井啓 and 川端信司 and 中村浩之}, title = {中性子捕捉療法のためのアルブミンをプラットホームとした低分子ホウ素薬剤PBC-IPの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863255, author = {中村浩之}, title = {中性子捕捉療法:承認までの軌跡と今後の展望}, booktitle = {}, year = 2021, } @inproceedings{CTT100863320, author = {中村浩之 and 西村開 and 盛田大輝 and 岡田智 and 磯山翔 and 玉城尚美 and 旦慎吾}, title = {低分子ホウ素薬剤PBC-IPの細胞選択性評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100864741, author = {中根啓太 and 丹羽達也 and 對馬理彦 and 田口英樹 and 友重秀介 and 中村浩之 and 石川稔 and 佐藤伸一}, title = {一重項酸素を活用したヒスチジン残基近接標識法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863253, author = {三浦一輝 and 對馬理彦 and 佐藤伸一 and 丹羽達也 and 田口英樹 and 中村浩之}, title = {細胞内タンパク質間相互作用解析のための光触媒近接タンパク質標識法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100864738, author = {梶原将 and Tenagy and 土田周治 and 植原彩奈 and 陳馨玥 and 中村浩之}, title = {抗マラセチア薬開発に資する脂肪酸取込阻害}, booktitle = {}, year = 2021, } @inproceedings{CTT100864739, author = {浅輪泰允 and 中村浩之}, title = {疎水性ホウ素クラスターによる新規タンパク質分解誘導剤の開発とその機構解明}, booktitle = {}, year = 2021, } @inproceedings{CTT100864740, author = {梅寺倖平 and 中村浩之}, title = {含窒素三環性骨格を基盤としたHIF転写活性阻害剤の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100875358, author = {津田正仁 and 盛田大輝 and 中村浩之}, title = {金(I)触媒およびパラジウム触媒を用いたイソオキサゾール5位修飾反応の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863252, author = {植田大樹 and Peter Wipf and 中村浩之}, title = {ケミカルスペースの開拓を志向した三次元骨格の新規構築反応開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100863251, author = {中村浩之}, title = {細胞内タンパク質-タンパク質相互作用解析を可能とする光ラベル化技術の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853241, author = {梅寺倖平 and 盛田大輝 and 吉森篤史 and 山田健太郎 and 小路弘行 and 中村浩之}, title = {含窒素三環性骨格を足場とするペプチド模倣分子の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853242, author = {西村開 and 川井一輝 and 岡田智 and 佐藤伸一 and 鈴木実 and 高田卓志 and 中村浩之}, title = {中性子捕捉療法のための、インテグリンをターゲットとしたホウ素キャリア、環状RGDペプチド結合型ホウ素化アルブミンの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853240, author = {初澤早貴 and 浅輪泰允 and 吉森篤史 and 山田健太郎 and 小路弘行 and 真崎康博 and 中村浩之}, title = {PPI阻害剤を志向した三置換メタカルボランライブラリー化合物の合成とその生物活性評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100853239, author = {浅輪泰允 and 吉森篤史 and 山田健太郎 and 小路弘行 and 中村浩之}, title = {カルボランを基盤とした立体的分子による3次元ケミカルスペースの探索とそのPPI制御機能評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100853238, author = {植原彩奈 and 盛田大輝 and 佐々木雄彦 and 中村浩之}, title = {リゾホスファチジルイノシトール(4,5)ビスリン酸の合成研究}, booktitle = {}, year = 2021, } @inproceedings{CTT100853236, author = {小室敬史 and 小竹佑磨 and 中村浩之 and 布施新一郎}, title = {マイクロフローリアクター内でのトリホスゲンを用いた迅速なラクタム合成法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853235, author = {對馬理彦 and 佐藤伸一 and 中村浩之}, title = {細胞内微小空間で起こるタンパク質間相互作用の解析を可能にする光触媒近接タンパク質ラベル化法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853234, author = {Aaron Li Hsin Chang and Michihiko Tsushima and Hiroyuki Nakamura}, title = {Photocatalytic proximity labelling of ligand-binding proteins utilizing single-electron transfer mediate radical reaction}, booktitle = {}, year = 2021, } @inproceedings{CTT100853233, author = {村上弘樹 and 盛田大輝 and 浅輪泰允 and 中村浩之}, title = {パラジウム触媒を用いた1,2-アザボリン類のN-H/B-H二官能基化法の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100853232, author = {北村宙士 and 小竹佑磨 and 中村浩之 and 布施新一郎}, title = {マイクロフローリアクターを用いる非対称リン酸トリエステルの高速合成}, booktitle = {}, year = 2021, } @inproceedings{CTT100853231, author = {杉澤直斗 and 中村浩之 and 布施新一郎}, title = {マイクロフローリアクター内での瞬間両基質活性化を駆使したβ-アミノ酸誘導体の合成}, booktitle = {}, year = 2021, } @inproceedings{CTT100853230, author = {植田大樹 and Peter WIPF and 中村浩之}, title = {ケミカルスペースの開拓を志向した三次元骨格の新規構築反応開発とタンパク質間相互作用(Protein-proteinInteraction, PPI)阻害活性評価}, booktitle = {}, year = 2021, } @inproceedings{CTT100853229, author = {津田正仁 and 盛田大輝 and 福原信太郎 and 中村浩之}, title = {プロパルギルアザClaisen転位反応による5-アレニルイソオキサゾールの合成とイソオキサゾロアザボリン環構築への展開}, booktitle = {}, year = 2021, } @inproceedings{CTT100853227, author = {盛田大輝 and Somaraju Yugandar and 中村浩之}, title = {ロジウム(III)触媒を用いた脱炭酸を伴うイソオキサゾールのC-H官能基化反応の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100844792, author = {中村 浩之}, title = {中性子捕捉療法:承認までの奇跡と今後の展望}, booktitle = {}, year = 2021, } @inproceedings{CTT100844793, author = {Hiroyuki Nakamura}, title = {Boron Neutron Capture Therapy: A New Modality of Radiation Therapy}, booktitle = {}, year = 2021, } @inproceedings{CTT100844791, author = {Hiroyuki Nakamura}, title = {Boron Neutron Capture Therapy: A New Modality of Radiation Therapy}, booktitle = {}, year = 2021, } @misc{CTT100881786, author = {中村浩之 and 浅輪泰允 and 織田 昌幸}, title = {カルボラン化合物若しくはその塩又はこれらの溶媒和物}, howpublished = {公開特許}, year = 2022, month = {}, note = {PCT/JP2021/039442(2021/10/26), WO 2022/092068(2022/05/05)} } @misc{CTT100868492, author = {布施新一郎 and 増田耕志郎 and 小竹佑磨 and 中村浩之}, title = {アミドの製造方法}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2021-501811(2020/02/03), 再表2020/175023(2021/12/16)} } @misc{CTT100866375, author = {布施新一郎 and 小竹佑磨 and 中村浩之}, title = {アミドの製造方法}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-563042(2019/12/11), 再表2020/137545(2021/11/04)} } @misc{CTT100864142, author = {佐藤伸一 and 中村浩之 and 上田宏}, title = {蛍光標識抗体又は抗体断片}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-534145(2019/07/10), 再表2020/026733(2021/08/19)} } @misc{CTT100845903, author = {布施新一郎 and 中村浩之 and 小竹佑磨 and 宮崎 俊一 and 伊東 篤志 and 小川 潤一}, title = {アミドの製造方法}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-525410(2019/05/28), 再表2019/239879(2021/02/12)} } @misc{CTT100845916, author = {布施新一郎 and 中村浩之 and 小竹佑磨 and 宮崎 俊一 and 伊東 篤志 and 小川 潤一}, title = {アミドの製造方法}, howpublished = {公開特許}, year = 2021, month = {}, note = {特願2020-525411(2019/05/28), 再表2019/239880(2021/02/12)} }