@article{CTT100895476, author = {Tomori T and Uekusa K and Koyama A and Kanagawa T and Masaki Y and Seio K}, title = {Synthesis of 2'-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2'-modified nucleoside for antisense oligonucleotides}, journal = {Bioorg Med Chem .}, year = 2022, } @article{CTT100895472, author = {Masaki Y and Tabira A and Hattori S and Wakatsuki S and Seio K}, title = {Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H}, journal = {Org. Biomol Chem.}, year = 2022, } @article{CTT100895471, author = {Masaki Y and Onishi Y and Seio K}, title = {Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides}, journal = {Sci Rep.}, year = 2022, } @article{CTT100878703, author = {Okamura H and Trinh GH and Dong Z and Masaki Y and Seio K and Nagatsugi F.}, title = {Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface}, journal = {Nucleic Acids Res.}, year = 2022, } @article{CTT100878704, author = {Masaki Y and Maruyama A and Yoshida K and Tomori T and Kishimura T and Seio K.}, title = {Oligodeoxynucleotides Modified with 2'- O-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions}, journal = {Bioconjug. Chem.}, year = 2022, } @inproceedings{CTT100895469, author = {Tabira A and Masaki Y and Hattori S and Wakatsuki S and Seio K}, title = {Effects of inserting methylene group in the interaction of RNase H and ASO}, booktitle = {}, year = 2022, } @inproceedings{CTT100895464, author = {Masaki Y and Onishi Y and Seio K}, title = {Systemic comparison of DNA chemical synthesis conditions by next-generation sequencing}, booktitle = {}, year = 2022, } @inproceedings{CTT100895465, author = {Ohnishi R and Sekiya S and Edamura W and Tachibana S and Masaki Y and Seio K}, title = {Synthesis and structural analysis of sulfonamide linkage-containing oligonucleotides for the development of antisense nucleic acids}, booktitle = {}, year = 2022, } @inproceedings{CTT100895466, author = {Uekusa K and Tomori T and Koyama A and Masaki Y and Seio K}, title = {Synthesis of nucleoside and oligonucleotide derivatives incorporating 2’-O-sulfamoylpropyl or 2’-O-sulfamoylbutyl modifications}, booktitle = {}, year = 2022, } @inproceedings{CTT100895467, author = {Yagata T and Masaki Y and Onishi Y and Seio K}, title = {Synthesis and property of alkoxytrityl type protecting group having reactive moiety}, booktitle = {}, year = 2022, } @inproceedings{CTT100895468, author = {Tachibana S and Kanagawa T and Ohnishi R and Masaki Y and Seio K}, title = {Synthesis and the structural analysis of a cyclic sulfonamide thymidine derivative}, booktitle = {}, year = 2022, } @inproceedings{CTT100895461, author = {金川峻幸 and 小山彩 and 正木慶昭 and 清尾康志}, title = {塩基部修飾グアニン導入によるアンチセンス核酸の標的切断変化とオフターゲット抑制}, booktitle = {}, year = 2022, } @inproceedings{CTT100895463, author = {金川峻幸 and 立花茂載 and 大西里絵 and 正木慶昭 and 清尾康志}, title = {スルホンアミド構造を有する環状チミジン誘導体の合成とその構造解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100895462, author = {植草宏哉 and 友利貴人 and 正木慶昭 and 清尾康志}, title = {2’-O-スルファモイルアルキル修飾を導入したオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2022, } @inproceedings{CTT100895460, author = {正木慶昭 and 田平彩乃 and 金川峻幸 and 若月駿介 and 服部詩萌里 and 小山彩 and 井上敦 and 清尾康志}, title = {RNase H依存型アンチセンス核酸の安全性向上に向けた化学修飾の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100877684, author = {正木慶昭 and 矢形太一 and 清尾康志}, title = {次世代シーケンサーをもちいた化学合成DNAの副生成物解析}, booktitle = {}, year = 2022, } @inproceedings{CTT100877685, author = {井分彩乃 and 赤井恒 and 友利貴人 and 清尾康志 and 正木慶昭}, title = {リンカーを介して2´-水酸基にビオチンを有するグアノシンテトラリン酸誘導体の合成}, booktitle = {}, year = 2022, } @inproceedings{CTT100877686, author = {小山彩 and 友利貴人 and 江利川友紀 and 正木慶昭 and 清尾康志}, title = {2´カルバモイルエチルリンカーの脂溶性残基を導入したアンチセンスオリゴヌクレオチドの合成と特性評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100877687, author = {大西里絵 and 関谷彰太 and 枝村亘 and 正木慶昭 and 清尾康志}, title = {スルホンアミド骨格を含む人工核酸の合成とアンチセンス活性の評価}, booktitle = {}, year = 2022, } @inproceedings{CTT100877688, author = {矢形太一 and 正木慶昭 and 清尾康志}, title = {末端アルキンを有するアルコキシトリチル型保護基の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100877689, author = {金川峻幸 and 立花茂載 and 大西里絵 and 正木慶昭 and 清尾康志}, title = {塩基部と5´位をスルホンアミド結合で架橋したチミジン誘導体の合成法の検討}, booktitle = {}, year = 2022, } @inproceedings{CTT100877690, author = {正木慶昭 and 田平彩乃 and 服部詩萌里 and 清尾康志}, title = {5´-デオキシ-5´-ヒドロキシメチルチミジン及び3´-デオキシ-3´-ヒドロキシメチルチミジンを含むリン酸骨格を伸長したオリゴヌクレオチドの合成と性質}, booktitle = {}, year = 2022, } @misc{CTT100907829, author = {清尾康志 and 正木慶昭 and 友利貴人 and 植草宏哉}, title = {2’位にアミノスルホニルアルコキシ基を有する新規人工核酸}, howpublished = {公開特許}, year = 2023, month = {}, note = {特願2022-031303(2022/03/01), 特開2023-127483(2023/09/13)} } @misc{CTT100885378, author = {正木慶昭}, title = {非天然塩基を利用した長鎖DNA合成}, howpublished = {公開特許}, year = 2022, month = {}, note = {PCT/JP2022/012843(2022/03/18), WO 2022/220019(2022/10/20)} } @misc{CTT100907817, author = {清尾康志 and 正木慶昭 and 金川峻幸 and 小山彩}, title = {塩基部修飾ヌクレオシドを含む新規アンチセンス核酸}, howpublished = {公開特許}, year = 2023, month = {}, note = {特願2022-031307(2022/03/01), 特開2023-127484(2023/09/13)} } @misc{CTT100846525, author = {清尾康志 and 正木慶昭 and 山本恵士 and 吉田圭汰 and 入山 友輔 and 中嶋 宏之 and 金木 達朗}, title = {人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド}, howpublished = {登録特許}, year = 2022, month = {}, note = {特願2020-202186(2020/12/04), 特開2021-046433(2021/03/25), 特許第7085739号(2022/06/09)} }