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Title
Japanese: 
English:Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development 
Author
Japanese: Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Koji Ogata, 十川 久美子, Michio Hiroshima, David L Wiest, 徳永 万喜洋, Takashi Saito.  
English: Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Koji Ogata, Kumiko Sakata-Sogawa, Michio Hiroshima, David L Wiest, Makio Tokunaga, Takashi Saito.  
Language English 
Journal/Book name
Japanese: 
English:nature immunology 
Volume, Number, Page volume 7    number 1    pp. 67-75
Published date Feb. 2006 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
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DOI https://doi.org/10.1038/ni1290
Abstract The pre-T cell receptor (TCR) is crucial for early T cell development and is proposed to function in a ligand-independent way. However, the molecular mechanism underlying the autonomous signals remains elusive. Here we show that the pre-TCR complex spontaneously formed oligomers. Specific charged residues in the extracellular domain of the pre-TCR α-chain mediated formation of the oligomers in vitro. Alteration of these residues eliminated the ablity of the pre-TCR α-chain to support pre-TCR signaling in vivo. Dimerization but not raft localization of CD3ε was sufficient to simulate pre-TCR function and promote β-selection. These results suggest that the pre-TCR complex can deliver its signal autonomously through oligomerization of the pre-TCR α-chain mediated by charged residues.

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