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Title
Japanese: 
English:Subpiconewton Intermolecular Force Microscopy 
Author
Japanese: 徳永 万喜洋, Takaaki Aoki, Michio Hiroshima, Kazuo Kitamura, Toshio Yanagida.  
English: Makio Tokunaga, Takaaki Aoki, Michio Hiroshima, Kazuo Kitamura, Toshio Yanagida.  
Language English 
Journal/Book name
Japanese: 
English:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
Volume, Number, Page Vol. 231    No. 3    pp. 566-569
Published date Feb. 1997 
Publisher
Japanese: 
English:Academic Press 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Abstract We refined scanning probe force microscopy to improve the sensitivity of force detection and control of probeposition. Force sensitivity was increased by incorporatinga cantilever with very low stiffness, 0.1pN/nm, which is over 1000-fold more flexible than is typically used in conventional atomic force microscopy. Thermal bending motions of the cantilever were reduced to less than 1 nm by exerting feed-back positioning with laser radiation pressure. The system was tested by measuring electrostatic repulsive forces or hydrophobic attractive forces in aqueous solutions. Subpiconewton intermolecular forces were resolved at controlled gaps in the nanometer range between the probe and a material surface. These levels of force and position sensitivity meet the requirements needed for future investigations of intermolecular forces between biological macromolecules such as proteins, lipids and DNA.

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