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Title
Japanese:ミオシン頭部１分子はＡＴＰ分解１回で複数ステップ動く－１分子捕捉・操作によるルースカップリングの直接証拠－ 
English: 
Author
Japanese: 喜多村和郎, 岩根敦子, 徳永万喜洋.  
English: 喜多村和郎, 岩根敦子, makio tokunaga.  
Language Japanese 
Journal/Book name
Japanese:生物物理 
English: 
Volume, Number, Page Vol. 40    No. 2    pp. 89-93
Published date 2000 
Publisher
Japanese:生物物理学会 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
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DOI https://doi.org/10.2142/biophys.40.89
Abstract To resolve the individual mechanical events of force generation by actomyosin, we have developed a new technique to capture and directly manipulate individual myosin subfragment-1 (S1) molecules using a scanning probe. The unitary mechanical step during sliding along an actin filament is 5.3nm, but 2 to 5 rapid steps in succession often end up with total displacements of ～11 to　～30nm. Multiple steps are produced by single heads during the hydrolysis of a single ATP molecule.

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