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Title
Japanese: 
English:Database of the clinical phenotypes, genotypes and mutant arylsulfatase B structures in mucopolysaccharidosis type VI 
Author
Japanese: 齋藤 静司, Kazuki Ohno, 関嶋 政和, Toshihiro Suzuki, 櫻庭 均.  
English: Seiji Saito, Kazuki Ohno, Masakazu Sekijima, Toshihiro Suzuki, Hitoshi Sakuraba.  
Language English 
Journal/Book name
Japanese: 
English:Journal of Human Genetics 
Volume, Number, Page Vol. 57        pp. 280-282
Published date Apr. 2012 
Publisher
Japanese: 
English:Nature Publishing Group 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://www.ncbi.nlm.nih.gov/pubmed/22336888
 
DOI https://doi.org/10.1038/jhg.2012.6
Abstract Mucopolysaccharidosis type VI (MPS VI) is a genetic disorder caused by a deficiency of arylsulfatase B (ARSB). In our previous study, we investigated the structural changes in ARSB caused by amino acid substitutions associated with MPS VI, and revealed that such structural changes in ARSB were correlated with the clinical phenotypes. To the best of our knowledge, there is no database containing the structures of mutant ARSBs. Here, we built a database of clinical phenotypes, genotypes and structures of mutant ARSBs (http://mps6-database.org). This database can be accessed via the Internet, and is user friendly being equipped with powerful computational tools. This database will be useful for a better understanding of MPS VI.

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