Home >

news Help

Publication Information


Title
Japanese:Efficient stereo- and regioselective hydroxylation of alkanes catalyzed by a bulky polyoxometalate. 
English:Efficient stereo- and regioselective hydroxylation of alkanes catalyzed by a bulky polyoxometalate. 
Author
Japanese: Keigo Kamata, Kazuhiro Yonehara, Yoshinao Nakagawa, Kazuhiro Uehara, Noritaka. Mizuno.  
English: Keigo Kamata, Kazuhiro Yonehara, Yoshinao Nakagawa, Kazuhiro Uehara, Noritaka. Mizuno.  
Language English 
Journal/Book name
Japanese:Nature Chemistry 
English:Nature Chemistry 
Volume, Number, Page Vol. 2    No. 6    pp. 478-483
Published date 2010 
Publisher
Japanese:Nature Publishing Group 
English:Nature Publishing Group 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1038/nchem.648
Abstract Direct functionalization of alkanes by oxidn. of C-H bonds to form alcs. under mild conditions is a challenge for synthetic chem. Most alkanes contain a large no. of C-H bonds that present difficulties for selectivity, and the oxidants employed often result in overoxidn. A divanadium-substituted phosphotungstate catalyzes the stereo- and regioselective hydroxylation of alkanes with H2O2 as the sole oxidant. Both cyclic and acyclic alkanes were oxidized to form alcs. with greater than 96% selectivity. The bulky polyoxometalate framework of the catalyst results in an unusual selectivity that can lead to the oxidn. of secondary rather than the weaker tertiary C-H bonds. The catalyst also avoids wasteful decompn. of the stoichiometric oxidant, which can result in the prodn. of hydroxyl radicals and lead to non-selective oxidn. and overoxidn. of the desired products. [on SciFinder(R)]

©2007 Tokyo Institute of Technology All rights reserved.