The aim of this paper is to introduce a project for emulsion generation device in Okayama University. We have generated sub-micrometer size droplets by using an ultrasonic vibration and microchannel plates. Especially, the device and system is for the generation of drug droplets. The ultrasonic vibration is oscillated by PZT plates and microchannel plates are made of stainless steel. The distribution of pressure depends on cross sectional pattern of the microchannel. As the applied voltage increased, emulsion became smaller and distribution became sharper. When the vibrator was oscillated in 2.25 MHz, the generated emulsion has an average diameter of 200 nm.