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Title
Japanese:Rhodium-Catalyzed Asymmetric [2+2+2] Cyclization of 1,6-Enynes and Aldehydes. 
English:Rhodium-Catalyzed Asymmetric [2+2+2] Cyclization of 1,6-Enynes and Aldehydes. 
Author
Japanese: Mana Ishida, Yu Shibata, 野口恵一, 田中健.  
English: Mana Ishida, Yu Shibata, Keiichi Noguchi, Ken Tanaka.  
Language English 
Journal/Book name
Japanese:Chemistry - A European Journal 
English:Chemistry - A European Journal 
Volume, Number, Page Vol. 17    No. 45    pp. 12578-12581
Published date 2011 
Publisher
Japanese:Wiley-VCH Verlag GmbH & Co. KGaA 
English:Wiley-VCH Verlag GmbH & Co. KGaA 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1002/chem.201102418
Abstract Asym. rhodium-catalyzed [2+2+2]-cyclization of 1,6-enynes with aldehydes gives five-membered rings, such as pyrrolidines, tetrahydrofurans, cyclopentanes, in good yield and high enantiomeric excess. As an example of the process, the cyclization of benzyloxyacetaldehyde with N-allyl-N-[3-(4-bromophenyl)prop-2-ynyl]-4-methylbenzenesulfonamide in the presence of [Rh(cod)2]BF4 and (R)-BINAP gave I in 59% yield and 93% ee. [on SciFinder(R)]

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