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Title
Japanese:Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity 
English:Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity 
Author
Japanese: Hidemitsu Minegishi, Takuya Matsukawa, Hiroyuki Nakamura.  
English: Hidemitsu Minegishi, Takuya Matsukawa, Hiroyuki Nakamura.  
Language English 
Journal/Book name
Japanese:Chemmedchem 
English:Chemmedchem 
Volume, Number, Page Vol. 8        pp. 265-271
Published date Jan. 28, 2013 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1002/cmdc.201200502
Abstract The inside cover picture shows diaromatic-substituted icosahedral carborane, a mimic of manassantin A, which induces hypoxia inducible factor (HIF)-1α protein degradation via the proteasome pathway, leading to inhibition of hypoxia-induced HIF-1 transcriptional activity and suppression of angiogenesis necessary for tumor growth. For more details, see the Full Paper by Hiroyuki Nakamura et al. on p. 265

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