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Title
Japanese:ホウ素高集積化リポソームによる中性子捕捉治療抗腫瘍効果の改善 
English:Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy 
Author
Japanese: Hiroyuki Nakamura.  
English: Hiroyuki Nakamura.  
Language Japanese 
Journal/Book name
Japanese:Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan 
English:Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan 
Volume, Number, Page Vol. 133        pp. 1297-1306
Published date 2013 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Abstract High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve the efficient cell-killing effect of boron neutron capture therapy (BNCT) that relies on the nuclear reaction of two essentially nontoxic species, boron-10 (10B) and thermal neutrons in boron-loaded tissues. Recent development of boron cluster lipids and their liposomal boron delivery system (BDS) are summarized in this article. Boron compounds that have no affinity to tumor can potentially be delivered to tumor tissues by liposomes, therefore, liposomal BDS would be one of the most attractive approaches for efficient BNCT of various cancers. There are two approaches for BDS: encapsulation of boron compounds into liposomes and incorporation of boron-conjugated lipids into the liposomal bilayer. The combination of both approaches has a potential for reduction of the total dose of liposomes without reducing the efficacy of BNCT.

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