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Title
Japanese:Ligand-Directed Selective Protein Modification Based on Local Single-Electron-Transfer Catalysis 
English:Ligand-Directed Selective Protein Modification Based on Local Single-Electron-Transfer Catalysis 
Author
Japanese: Shinichi Sato, Hiroyuki Nakamura.  
English: Shinichi Sato, Hiroyuki Nakamura.  
Language English 
Journal/Book name
Japanese:Angewandte Chemie-International Edition 
English:Angewandte Chemie-International Edition 
Volume, Number, Page Vol. 52    No. 33    pp. 8681-8684
Published date July 3, 2013 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1002/anie.201303831
Abstract A photocatalyst ([Ru(bpy)3]2+) bound to a protein ligand was essential for the title method. Local single-electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N′-Acetyl-N,N-dimethyl-1,4-phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein.

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