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Title
Japanese:Synthesis of protoporphyrin lipids and biological evaluation of micelles and liposomes 
English:Synthesis of protoporphyrin lipids and biological evaluation of micelles and liposomes 
Author
Japanese: Shoji Tachikawa, Mohamed E. El-Zaria, Ryu Inomata, Shinichi Sato, Hiroyuki Nakamura.  
English: Shoji Tachikawa, Mohamed E. El-Zaria, Ryu Inomata, Shinichi Sato, Hiroyuki Nakamura.  
Language English 
Journal/Book name
Japanese:Bioorganic & Medicinal Chemistry 
English:Bioorganic & Medicinal Chemistry 
Volume, Number, Page Vol. 22        pp. 4745-4751
Published date June 8, 2014 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://www.sciencedirect.com/science/article/pii/S0968089614005069
 
DOI https://doi.org/10.1016/j.bmc.2014.07.003
Abstract Protoporphyrin IX (PPIX) lipids were synthesized by introducing a long alkyl chain, such as C13, C15, and C17, at each vinyl group on PPIX via hydrobromination. The PPIX lipids exhibited a water-soluble property by forming their micelles in water and the PPIX–lipid micelles showed relatively low cytotoxicity toward HeLa cells (IC50 = 151.7–379.9 μM) without light irradiation. PL-C17 liposomes (post-inserted liposomes) were readily prepared by adding PL-C17 micelle solution to the liposome solution. The IC50 values of PPIX, PL-C17 micelles, and PL-C17 liposomes toward HeLa cells were 0.53, 5.65, and 12.9 μM, respectively, after irradiation with a xenon lamp in the 400–800 nm range for 2 min. PL-C17 liposomes were selectively accumulated in the Golgi apparatus in cells.

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