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Title
Japanese:Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity 
English:Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity 
Author
Japanese: Ayano Takeuchi, Makihito Hori, Shinichi Sato, Hyun Seung Ban, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Takao Yamori, Hiroyuki Nakamura.  
English: Ayano Takeuchi, Makihito Hori, Shinichi Sato, Hyun Seung Ban, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Takao Yamori, Hiroyuki Nakamura.  
Language English 
Journal/Book name
Japanese:MedChemComm 
English:MedChemComm 
Volume, Number, Page Vol. 3        pp. 1455-1461
Published date Sept. 21, 2012 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://dx.doi.org/10.1039/C2MD20134H
 
DOI https://doi.org/10.1039/c2md20134h
Abstract New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.

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