Home >

news Help

Publication Information


Title
Japanese:Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity 
English:Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity 
Author
Japanese: Hiroyuki Nakamura, Yuka Yasui, Hyun Seung Ban.  
English: Hiroyuki Nakamura, Yuka Yasui, Hyun Seung Ban.  
Language English 
Journal/Book name
Japanese:Journal of Organometallic Chemistry 
English:Journal of Organometallic Chemistry 
Volume, Number, Page Vol. 747        pp. 189-194
Published date Apr. 2013 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1016/j.jorganchem.2013.04.007
Abstract ortho-Carborane and adamantane containing benzoxazoles were synthesized by intramolecular dehydration of the corresponding phenoxyacetanilides. Among the compounds synthesized, ortho-carborane containing benzoxazole 2b which has a carboxylic group on the benzoxazole ring, exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity with the IC50 value of 14.4 μM toward HeLa cell-based reporter gene assay.

©2007 Tokyo Institute of Technology All rights reserved.