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Title
Japanese:Enantioselective Cycloisomerization of 1,6-Enynes to Bicyclo[3.1.0]hexanes Catalyzed by Rhodium and Benzoic Acid. 
English:Enantioselective Cycloisomerization of 1,6-Enynes to Bicyclo[3.1.0]hexanes Catalyzed by Rhodium and Benzoic Acid. 
Author
Japanese: Koji Masutomi, Keiichi Noguchi, Ken. Tanaka.  
English: Koji Masutomi, Keiichi Noguchi, Ken. Tanaka.  
Language English 
Journal/Book name
Japanese:Journal of the American Chemical Society 
English:Journal of the American Chemical Society 
Volume, Number, Page Vol. 136    No. 21    pp. 7627-7630
Published date 2014 
Publisher
Japanese:American Chemical Society 
English:American Chemical Society 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1021/ja504048u
Abstract It has been established that a cationic Rh(I)/(S)-Segphos or (S)-DTBM-Segphos complex and benzoic acid catalyze the enantioselective cycloisomerization of 1,6-enynes, possessing carbonyl groups at the enyne linkage, to 2-alkylidenebicyclo[3.1.0]hexanes [e.g., I 竊�II in 96% yield, 81% ee in presence of Rh/(S)-Segphos/BzOH]. The present cycloisomerization may involve site selective ﾎｳ-hydrogen elimination. The one-pot enantioselective cycloisomerization and lactonization of 1,6-enynes, leading to bicyclic lactones, has also been accomplished. [on SciFinder(R)]

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