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Title
Japanese:One-Pot Cycloisomerization/Hetero-Diels-Alder Reaction of 1,6-Enynes with Aldehydes Catalyzed by Rhodium and a Bronsted Acid. 
English:One-Pot Cycloisomerization/Hetero-Diels-Alder Reaction of 1,6-Enynes with Aldehydes Catalyzed by Rhodium and a Bronsted Acid. 
Author
Japanese: Mana Ishida, Ken. Tanaka.  
English: Mana Ishida, Ken. Tanaka.  
Language English 
Journal/Book name
Japanese:Organic Letters 
English:Organic Letters 
Volume, Number, Page Vol. 15    No. 9    pp. 2120-2123
Published date 2013 
Publisher
Japanese:American Chemical Society 
English:American Chemical Society 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1021/ol4005849
Abstract A rhodium and Bronsted acid catalyzed one-pot cycloisomerization/hetero-Diels-Alder reaction of 1,6-enynes with unactivated aldehydes was established under mild conditions. This one-pot catalytic protocol produced a wide variety of annulated dihydropyrans from readily available starting materials in a highly atom economical manner. E.g., in presence of [Rh(cod)2]BF4, BINAP, and PhCO2H, cycloisomerization/hetero-Diels-Alder reaction of 1,6-enyne (I) with 2-MeC6H4CHO gave 85% annulated dihydropyrans (II, III) in a 71:29 ratio. [on SciFinder(R)]

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